WO2013078422A3 - Natural combination hormone replacement formulations and therapies - Google Patents
Natural combination hormone replacement formulations and therapies Download PDFInfo
- Publication number
- WO2013078422A3 WO2013078422A3 PCT/US2012/066406 US2012066406W WO2013078422A3 WO 2013078422 A3 WO2013078422 A3 WO 2013078422A3 US 2012066406 W US2012066406 W US 2012066406W WO 2013078422 A3 WO2013078422 A3 WO 2013078422A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- progesterone
- therapies
- solubilized
- hormone replacement
- natural combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES12850845T ES2885523T3 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
RS20211088A RS62297B1 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
AU2012340589A AU2012340589B2 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
PL12850845T PL2782584T3 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
EP21177701.6A EP3936133A1 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
EP12850845.4A EP2782584B1 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
JP2014543585A JP6285866B2 (en) | 2011-11-23 | 2012-11-21 | Natural complex hormone replacement preparations and therapies |
HRP20211377TT HRP20211377T1 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
MX2014006256A MX365818B (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies. |
LTEPPCT/US2012/066406T LT2782584T (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
CA2856520A CA2856520C (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
BR112014012444-2A BR112014012444B1 (en) | 2011-11-23 | 2012-11-21 | A PHARMACEUTICAL COMPOSITION COMPRISING SOLUBILIZED ESTRADIOL, PROGESTERONE AND A SOLUBILIZING AGENT, AND USES THEREOF TO TREAT A MENOPAUSE-RELATED SYMPTOM IN A WOMAN |
FR21C1058C FR21C1058I2 (en) | 2011-11-23 | 2021-12-08 | PREPARATIONS AND SUBSTITUTION THERAPIES FOR COMBINED NATURAL HORMONOTHERAPY |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161563408P | 2011-11-23 | 2011-11-23 | |
US61/563,408 | 2011-11-23 | ||
US201261661302P | 2012-06-18 | 2012-06-18 | |
US61/661,302 | 2012-06-18 | ||
US201261662265P | 2012-06-20 | 2012-06-20 | |
US61/662,265 | 2012-06-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013078422A2 WO2013078422A2 (en) | 2013-05-30 |
WO2013078422A3 true WO2013078422A3 (en) | 2014-12-04 |
Family
ID=48427194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/066406 WO2013078422A2 (en) | 2011-11-23 | 2012-11-21 | Natural combination hormone replacement formulations and therapies |
Country Status (14)
Country | Link |
---|---|
US (12) | US8633178B2 (en) |
EP (2) | EP2782584B1 (en) |
JP (2) | JP6285866B2 (en) |
CA (1) | CA2856520C (en) |
ES (1) | ES2885523T3 (en) |
FR (1) | FR21C1058I2 (en) |
HR (1) | HRP20211377T1 (en) |
HU (1) | HUE055562T2 (en) |
LT (1) | LT2782584T (en) |
MX (1) | MX365818B (en) |
PL (1) | PL2782584T3 (en) |
PT (1) | PT2782584T (en) |
RS (1) | RS62297B1 (en) |
WO (1) | WO2013078422A2 (en) |
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US9795617B2 (en) | 2009-06-18 | 2017-10-24 | Baucom Institute for Longevity and Life Enhancement, Inc. | Hormone delivery system and method |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
WO2013078422A2 (en) | 2011-11-23 | 2013-05-30 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) * | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
MX358435B (en) * | 2012-06-18 | 2018-08-03 | Therapeuticsmd Inc | Soluble estradiol capsule for vaginal insertion. |
US20130338122A1 (en) * | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20140370084A1 (en) * | 2013-06-18 | 2014-12-18 | Therapeuticsmd, Inc. | Estradiol formulations and therapies |
JP6680672B2 (en) * | 2013-10-10 | 2020-04-15 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
WO2015130807A1 (en) * | 2014-02-25 | 2015-09-03 | Baucom Institute for Longevity and Life Enhancement, Inc. | Hormone delivery system and method |
JP6591447B2 (en) * | 2014-05-05 | 2019-10-16 | レプロス セラピューティクス インコーポレイティド | Formulations and methods for intravaginal delivery of antiprogestins |
US10206932B2 (en) | 2014-05-22 | 2019-02-19 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
MX2016013693A (en) * | 2014-07-29 | 2017-10-31 | Therapeuticsmd Inc | Transdermal cream. |
US10328087B2 (en) * | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
MX2018011706A (en) * | 2016-04-01 | 2019-06-10 | Therapeuticsmd Inc | Steroid hormone pharmaceutical composition. |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
WO2020081726A1 (en) * | 2018-10-17 | 2020-04-23 | Stadler Sarah Sheehan | Methods of treating menopausal symptoms using low dose progesterone |
AU2019365255A1 (en) | 2018-10-26 | 2021-06-03 | Viramal Limited | Mucoadhesive gel composition |
EP3947338A4 (en) * | 2019-03-27 | 2023-01-04 | Kemin Industries, Inc. | Methods for preparing metal carboxylates in one-pot reaction |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
US11337987B1 (en) | 2021-05-07 | 2022-05-24 | Lipocine Inc. | Compositions and methods for treating central nervous system disorders |
WO2023057626A1 (en) | 2021-10-08 | 2023-04-13 | Chemo Research, S.L. | Oral pharmaceutical compositions of progesterone and estradiol |
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