WO2008041045A1 - A multi chamber container for the production and dispensing of carbon dioxide foam, process for production and use of said foam - Google Patents

A multi chamber container for the production and dispensing of carbon dioxide foam, process for production and use of said foam Download PDF

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Publication number
WO2008041045A1
WO2008041045A1 PCT/HU2006/000113 HU2006000113W WO2008041045A1 WO 2008041045 A1 WO2008041045 A1 WO 2008041045A1 HU 2006000113 W HU2006000113 W HU 2006000113W WO 2008041045 A1 WO2008041045 A1 WO 2008041045A1
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WO
WIPO (PCT)
Prior art keywords
container
carbon dioxide
compartment
foam
carbonate
Prior art date
Application number
PCT/HU2006/000113
Other languages
French (fr)
Inventor
István Piller
Original Assignee
Piller Istvan
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Publication date
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Publication of WO2008041045A1 publication Critical patent/WO2008041045A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits

Definitions

  • the invention relates to a two-compartment container providing stable carbon dioxide foam, and by the help of this a process for production of carbon dioxide foam from two components on a skin surface. These two components fusing on the skin surface form carbon dioxide where this carbon dioxide takes on the form of stable foam in consequence of the delaying and stabilizing effect of the present surface-active
  • the invention further relates to a process for using the foam to cause vasodilatation in the subcutaneous tissues from cosmetic and/or therapeutic aim.
  • HU 220349 and HU 1974729 Hungarian patents relate to possibilities of domestic application of the carbon dioxide baths according to which carbon dioxide is introduced to the domestic bath water from a container or a siphon cartridge available in the trade.
  • U 3015 Hungarian utility model is connected with the gas chamber ("mofette") treatment which gives a solution for gas chamber treatment with carbon dioxide gas; this consists of a house applied around a part of body into which the carbon dioxide can be introduced from outside, from a gas cylinder.
  • mofette effect which is the basis of the solution of the present invention, too
  • a lot of literary data can be found on address http://hu.wikipedia.org.wiki/Mofetta.
  • a Hungarian patent application filed on N° P9000163 and published on N° 58649 deals with the insufflating treatment and its instrument; its essence is an insufflating treatment by a needle from which itself the sterile carbon dioxide gas originates from reagents of suitable composition and of suitable quality.
  • the present invention is classed among the above specified forms into the category of "direct topical intake of the carbon dioxide gas through skin”. It can really be considered as a sub-category of the solution of "staying in a room containing carbon dioxide gas” but this solution deviates in that from the other solution that it deals with carbon dioxide treatment of smaller parts of body or skin surfaces instead of the exposure of the whole body or bigger parts of body to the carbon dioxide gas.
  • Patent document US 2003/0139696 makes known an in situ applicable pillow by the help of which it is possible to place serious wounds under carbon dioxide pressure.
  • the role of the carbon dioxide is to press tightly the wound to avoid the loss of blood.
  • Both the aim (to guarantee pressure) and the technical execution (e.g. providing carbon dioxide from cylinder and using closed bandage) deviate from the solution of the present invention.
  • the essence according to the solution of the present invention is, however, that the carbon dioxide gas is formed in the skin surface in such manner that two components, staying in a two-compartment container where one of the compartments contains some kind of preferably sterile acid and the other compartment contains some kind of preferably sterile carbonate or hydrogen carbonate, are pressed out together from the container, they combine together in the skin surface and step into reaction here with each other.
  • the toxicological and microbiological quality of the carbon dioxide can be guaranteed with the purity of the starting acid and carbonate and by possible sterilising to the desired extent.
  • the surface-active materials (detergents) also placed in one or both container compartment guarantee that the formation of the carbon dioxide should be retarded and the formed foam should be preserved at least as long as the formed carbon dioxide exposes its therapeutic (vasodilator) effect under the skin surface. For this aim 5-10 minutes is sufficient, and this period can be guaranteed with the stable foam.
  • the foam containing carbon dioxide is able to give that minimal pressure surplus which facilitates the penetration of the carbon dioxide into the skin.
  • the present invention is based on the employment of the carbon dioxide gas directly evolving by the double decomposition reaction.
  • the already activating chemical reaction is maintained by the continuously releasing water on the basis of the following reaction: CO 3 " + 2H + -» CO 2 + H 2 O
  • reaction partners to be found in the foam-forming mixture is not too essential; it is important only that at the meeting of the reaction partners and the water carbon dioxide of suitable amount should be formed.
  • the conditions are the same as in the case of effervescent tablets, powders or granules based on similar reaction, although the point of views of the selection are not exactly the same.
  • the main thing is that the formed ions should not be caustic, toxic or bad-tasting (rather should be good to the taste, respectively), in the present situation the main point of view is that the generating ions should not exercise caustic or toxic influence to the skin; the point of views of flavour does not play role here.
  • the calcium carbonate can be advantageous not only from point of view of the costs but from the point of views of optionally necessary retardation of the foam-forming, since the generation of the carbon dioxide gas is relatively slow from the calcium carbonate granules. It is inevitably necessary to take into consideration at the selection of the ingredients that the ingredients should be able to get across the opening of a feeding equipment. Of course, it is possible to draw up reversely: such feeding equipment should be employed which fits to the physicochemical properties of the given advantageous mixture.
  • a container (bottle, tube, flacon and the like) which is provided with a separation wall and suitable dosing equipment. Its function is to receive acidic and carbonate ingredients, respectively, and foam-forming surface-active (detergent) materials, further ingredients and optionally different pharmacons, respectively, and it have to able to place the different materials onto the skin surface in a suitable proportion by the help of a suitably formed dosing equipment from the two container compartments; Neither the empty container itself nor the dosing equipment itself nor their formation constitutes the subject-matter of the invention; every solution is applicable which is able to perform the above functions.
  • the dosing equipment has not to be a complicated construction.
  • the dosing equipment e.g. can be a dosing equipment which can be screwed onto the container.
  • the outflow of the material is provided by the pressure, mainly hand-power pressure applied onto the container.
  • an extrusive roll can provide the getting out from the two container compartments in suitable proportion.
  • the formation of the two-compartment container can be solved in various ways.
  • One of the solutions can be that the separation wall is formed in advance from the container's material.
  • a bag made from some kind of plastic, preferably a polyalkylene, first of all polyethylene, can be placed into a suitable container. This is a suitable solution first of all for that reason since it is not necessary to modify the production technique of a very cheaply available container, only a filling have to be used into it.
  • the main point of view is that this equipment should be able to dispatch the materials from both container compartment in the in advance suitably adjusted proportion taking into consideration the physical condition (consistency, grain size and the like) of the individual materials (material compositions). Consequently at the selection of the two-compartment container and its dosing equipment the main point of views are the fitting to the components, the steady convej ⁇ ng of the materials as well as economic point of views.
  • Figure 1 is a section of a scheme of a possible execution example.
  • Figure 1 makes known schematically a possible solution to a suitable container.
  • the device outlined in Figure 1. is an elastic- walled 1 container (bottle, flacon) which is divided into two parts with a 2 separation wall and is supplied with a 5 dosing equipment which represents an elastic-walled compressible material.
  • the figure shows the 3 and 4 container compartments of 1 container supplied the 2 separation wall, the 6 lower closing valve, the 7 outer closing valve and the 8 outlet opening.
  • the surface-active materials (detergents) providing the foam formation and foam stability promote both the stability of the foam and necessary delaying or maybe accelerating the evolution of the carbon dioxide.
  • these materials can be sodium lauryl sulphate, triethanolamine, polysorbates (e.g. Polysorbate 20) and sterols e.g. cholesterol.
  • Delaying and accelerating the chemical reaction depends on the hydrophilic-hydrophilic combination of the ingredients. The most retarded reaction takes place in the lipophilic-lipophilic suspension combination of the materials in the two 3, 4 container compartments. The quickest reaction can be realized by the mixture of the hydrophilic-hydrophilic combination containing dissolved carbonates.
  • cosmetic basic materials which form the suitable consistence of the preparation (cream, shampoo and other cosmetic preparations) in the condition after disappearance of the formed foam.
  • These preparations i.e. should not be removed after leaving of the carbon dioxide but they can remain on the skin surface as cosmetics.
  • To these ingredients examples can be - without the intention of limitation - cetyl alcohol stearate, glycerine, methyl cellulose, vaseline, solid and/or liquid paraffin, white wax, castor oil, gelatine, xanthan gum, etc., but the water itself, too.
  • the pharmacons intensifying the healing power intensify the healing power of the preparation first of all in that 5-10 minutes until the carbon dioxide gas performs its vasodilator effect but also after removing the carbon dioxide together with the cosmetics actually as a part of the cosmetics.
  • the pharmacons being in question can move in a wide domain depending in the given therapeutic field; e.g. preparations recommendable to the treatment of locomotor's diseases can contain volatile oils, e.g. the volatile oils of camomile, eucalyptus and Scotch fir, but they can contain also capsaicin, camphor, menthol and methyl salicylate.
  • the acid and the carbonate should not get into the same compartment.
  • the solution that which of the further ingredients (detergents providing foam formation and foam stability, cosmetic basic materials, pharmacons intensifying healing power) gets into the acidic compartment and which of the further ingredients gets into the carbonate compartment, is decided only according to technological advantages (compatibility, the ease of getting out). It is imaginable, too, that individual ingredients can be found both in the 3 container compartment and the 4 container compartment, if this solution has a technological advantage.
  • a filled two-compartment 1 container flacon, flask, bottle, tube
  • container contains in its 3 container compartment an acid of suitable amount and its other 4 container compartment some kind of carbonate or hydrogen carbonate, it contains further in its 3 container compartment or in its 4 container compartment or in both 3, 4 container compartments surface-active materials (detergents), cosmetic basic materials and optionally different pharmacons.
  • the filled two-compartment 1 container is provided with such a 5 dosing equipment which guarantees that the ingredients should get from two 3, 4 container compartments to the selected surface, in this situation to skin surface, in an in advance adjusted proportion.
  • the said filled 1 container have to satisfy the following point of views:
  • the filling into the bottles and the closing of the bottle with the 5 dosing equipment is a well mechanized technology having almost century-old tradition.
  • the employment of the filled 1 container as a product is accomplishable easily by simple pushing a button.
  • the filled 1 container as a product is strong and firm, well storable and maintainable for a long time without quality deterioration since the ingredients being in the individual 3, 4 container compartments are not able to react with each other within the container compartment.
  • the said product however, can be » produced from cheap basic materials and by an established technology.
  • the 1 container- filled with the said ingredients and suitable for forming stable foam is not only new but it can become to a product producible cheaply and saleable well in trade.
  • the filling of the elastic-walled, two-compartment 1 containers, tubes does not imply technological problem, neither, since there are available established technologies for this aim, too.
  • Another subject-matter of the present invention is the production of a preparation including stable foam containing carbon dioxide gas for causing vasodilatation under the skin.
  • the evolving carbon dioxide gas should quickly reach to the skin surface from the site of the reaction; • the carbon dioxide gas should be in contact uniformly and continuously with the skin surface; • it is necessary that the carbon dioxide gas should evolve permanently at least during 5-10 minutes;
  • the instrument providing carbon dioxide here the preparation itself originating on the skin surface and including stable foam containing carbon dioxide gas.
  • the originating carbon dioxide gas has not to "reach" the surface of skin, either, since it originates there. For the same reason the uniform, continuous contact is guaranteed with the skin surface.
  • the stability of the foam guarantees that minimal pressure surplus compared to the atmospheric pressure which promotes the penetration of the carbon dioxide into the skin.
  • the foam containing carbon dioxide gas is suitable as a- vasodilator preparation from every point of view. Its production is easily realisable by the help of the two-compartment 1 container which is the previous subject- ⁇ matter of the invention.
  • the carbon dioxide gas prepared on this way does not contain the (first of all pyrogenic) impurities of the industrial carbon dioxide gas; the purity of the gas can be guaranteed according to the demands by the suitable purity of the reaction partners fmdable in granules or powder; by their sterilization, however, it is possible to guarantee the sterility of the gas if necessary.
  • a further subject-matter of the invention is the use of the foam containing carbon- dioxide gas for causing vasodilatation in the tissues to be found under skin.
  • the penetration of the carbon dioxide under skin surface causes vasodilatation.
  • the penetration of the carbon dioxide is promoted by the stable foam according to the invention during the necessary 5-10 minutes
  • the stable foam containing carbon dioxide can be taken up to the selected skin surfaces and only to the selected skin surfaces, by the help of this solution the skin surface to be treated can be well surrounded. This is especially advantageous where the forwarding the carbon dioxide is realizable by other means only with serious difficulties as e.g. on the hairy on non-hairy scalp, but this preparation can be utilized every other treatable skin surface, too.
  • the stable foam containing carbon dioxide gas can occur e.g. in massaging ("warming") creams used by sportsmen, in preparations used on surfaces requiring physiotherapy, in cosmetic products (e.g. face-packs) and the like.
  • the application consists in that the stable foam containing carbon dioxide and prepared on the way introduced previously is carried up to the selected areas (surfaces) where the carbon dioxide to be found in the foam displays its vasodilator effect under the skin surface during 5-10 minutes.
  • the question whether the foam containing carbon dioxide should be carried up in what thickness onto the surface to be treated is very difficult to be decided since it strongly depend on the nature of the ingredients. The essence is that this thickness of layer should guarantee the penetration of the carbon dioxide gas for 5- 10 minutes. After leaving the carbon dioxide gas the preparation can remain on the skin surface and can display its further therapeutic- and cosmetic effect.
  • Example 1 Filled two-compartment container as a commercial product for preparing a stable shampoo containing carbon dioxide gas
  • the above prescription relates to 1000 g of product; the concrete amount is decided depending on whether the two-compartment 1 container putting on the market has what dimension. The proportions of the ingredients, however, are acceptable at whatever dimension, consequently at this packaging of 300 g, too.
  • the two-compartment 1 container is supplied with a suitable 5 dosing equipment.
  • the 5 dosing equipment indicates such a solution which can be opened by pressing down an usual springy closing valve.
  • An expanded spring moves the piston placed at the end of 1 container which empties uniformly the content of the two 3, 4 container compartments.
  • the product obtained in this manner and being able to put into the trade is the subject-matter of the invention.
  • Example 2 Filled two-compartment container as a commercial product for preparing massaging ("warming") sport cream containing carbon dioxide
  • a two-compartment, elastic-walled 1 container (tube) of 200 millilitre available in the trade is filled. Into the two 3, 4 container compartments the followings are fed:
  • the above prescription relates to 1000 g of product, the concrete amount is decided depending on whether what dimension has the two-compartment 1 container putting on the market.
  • the proportions of the ingredients are acceptable at whatever dimension, consequently at this tube of 200 ml, too.
  • the material can be helped to get out by manual pressure from the tube, from the two 3, 4 container compartments.
  • the product obtained in this manner is the subject-matter of the invention.
  • Example 3 Process for production of a medicinal shampoo including stable foam containing carbon dioxide on a skin surface to be treated
  • the ingredients from the 3, 4 container compartments of the two-compartment 1 container introduced in Example 1. are helped onto the hairy skin (scalp) surface to get out in a suitable amount in thickness of layer of 2-3 centimetres by the help of the 5 dosing equipment by pressing the 9 press-button of the 5 dosing equipment, where the ingredients stepping into reaction form carbon dioxide gas, this causes vasodilatation during 5-10 minutes in the venous network under the skin. After leaving of the carbon dioxide it is not necessary to wash down the shampoo immediately from the hairy scalp but it is possible to leave on it until it is reasonable according to the therapeutic and/or cosmetic effect.
  • Example 4 Process for the production of a massaging (“warming") cream including stable foam containing carbon dioxide on a skin surface to be treated
  • the ingredients from the 3, 4 container compartments of the two-compartment 1 container (tube) introduced in Example 2 are helped onto the skin surface covering a group of muscles to be massaged to get out in a suitable amount in thickness of layer of 1,5 - 2 centimetres by manual pressure of the 10 side wall; these ingredients stepping into reaction form carbon dioxide which causes vasodilatation during 5-10 minutes in the venous network under the skin. After leaving of the carbon dioxide it is not necessary to wash down the cream immediately from the covered skin surface but it is possible to leave on it until it is reasonable according to the therapeutic and/or cosmetic effect.
  • the group of muscles prepared by the dilatation of the blood vessels can be effectively massaged.

Abstract

The invention relates to a filled two-compartment container providing carbon dioxide foam. The invention is characterized in that one compartment (3) contains an acid, and the other compartment (4) contains a carbonate or hydrogen carbonate. Further, it also contains (in at least one of the compartments (3)) a surface-active (detergent) material, cosmetic base materials, water and optionally 'pharmacons' where the release of the ingredients is aided through the dosing equipment (5) to a given surface, preferably to the skin. The invention also relates to process for preparing foam composition containing carbon dioxide gas.

Description

A MULTI CHAMBER CONTAINER FOR THE PRODUCTION
AND DISPENSING OF CARBON DIOXIDE FOAM, PROCESS FOR PRODUCTION AND USE OF SAID FOAM
The invention relates to a two-compartment container providing stable carbon dioxide foam, and by the help of this a process for production of carbon dioxide foam from two components on a skin surface. These two components fusing on the skin surface form carbon dioxide where this carbon dioxide takes on the form of stable foam in consequence of the delaying and stabilizing effect of the present surface-active
(detergent) materials. This carbon-dioxide foam stably remains at least so long as its advantageous physiological (vasodilator effect) terminates. As a consequence the invention further relates to a process for using the foam to cause vasodilatation in the subcutaneous tissues from cosmetic and/or therapeutic aim.
The treatment with carbon dioxide has age-old traditions. Already at the beginning of the XIX. century the treatment with carbon dioxide were known and accepted, first of all in the bigger healthy resorts. Numerous of these treatments are known among them it is worthy emphasizing the followings:
- bath in water enriched with carbon dioxide;
- staying in a room containing carbon dioxide gas ("mofette" effect); - direct topical intake of the carbon dioxide gas through the skin; and
- injection of carbon dioxide gas intravenously (insufflation).
The advantageous effects of the treatment with carbon dioxide are indisputable, should its any form be in question. Dozens of communications have been published in the technical literature for centuries which is not surprising since the insufflating techniques meaning bolder intervention have been already known for thirties of XIX. century. From each of the almost innumerable communications it has been found out that the vasodilator effect of the carbon dioxide is extremely advantageous first of all at patients with antipathy and cardiac illnesses, and it manifests in the rehabilitation after cardiac infarction. An article referring about advantageous effect of the carbon dioxide therapy is the following: Hartmann, Wagner and Friedel: Z. Physiother. Jg. 41, 343-349 (1989). In connection with popular and useful course a variety of technologies is known in all the abovementioned fields. The quality of carbon dioxide - maybe with the exception of the natural carbon dioxide sources of the thermal baths - can give a trouble everywhere. Only that carbon dioxide mixture is suitable for therapeutic aim which is pure (pyro genetic-free) and its carbon dioxide content is at least 96%. All this is especially true for carbon dioxide mixtures useful for injection (insufflation). The industrial carbon dioxides don't meet these requirements, that is why it is necessary to clean powerfully them which fact significantly increases the costs of the treatment. This is the explanation of the significant difference in the prices between the carbon dioxide gas suitable for medical aim and the industrial carbon dioxide gas.
While earlier therapeutic treatment with carbon dioxide went on in big bath complexes, first of all German, Austrian or Czech bathing resorts, according to the tendency of the last decades the demand increases to domestic or small communal treatment, that is people should not move to sanatoriums or bath complexes. This tendency is supported by the increasing member the patents relating to domestic instruments and furniture which are connected with carbon dioxide treatment.
In order to support this tendency we make known some patents as a random test, without demand of the completeness, from the harvest of the last decades, from that fields, too, which are although connected with the carbon dioxide therapy but are far away from the present invention as far as their implementation are concerned; we are able, however, to place in our invention to the prior art only with such a wide immersion.
HU 220349 and HU 1974729 Hungarian patents relate to possibilities of domestic application of the carbon dioxide baths according to which carbon dioxide is introduced to the domestic bath water from a container or a siphon cartridge available in the trade. U 3015 Hungarian utility model is connected with the gas chamber ("mofette") treatment which gives a solution for gas chamber treatment with carbon dioxide gas; this consists of a house applied around a part of body into which the carbon dioxide can be introduced from outside, from a gas cylinder. In connection with the mofette effect (which is the basis of the solution of the present invention, too) a lot of literary data can be found on address http://hu.wikipedia.org.wiki/Mofetta. A Hungarian patent application filed on N° P9000163 and published on N° 58649 deals with the insufflating treatment and its instrument; its essence is an insufflating treatment by a needle from which itself the sterile carbon dioxide gas originates from reagents of suitable composition and of suitable quality.
The present invention is classed among the above specified forms into the category of "direct topical intake of the carbon dioxide gas through skin". It can really be considered as a sub-category of the solution of "staying in a room containing carbon dioxide gas" but this solution deviates in that from the other solution that it deals with carbon dioxide treatment of smaller parts of body or skin surfaces instead of the exposure of the whole body or bigger parts of body to the carbon dioxide gas.
In all the till now known relevant solutions of the intake through the skin such solutions of closed bandage character are in question by the help of which carbon dioxide gas arrives onto the skin surface for a given aim. The published Hungarian patent application N° PO 105418 relates to a flexible operating bag into space of which carbon dioxide gas is leak-proof introduced. From this bag the gas arriving to the surface exerts its effect. The difference between this solution and the solution of the present invention is not only that the carbon dioxide arrives into the surface in a closed space, but that fact, too, that from outside introduced carbon dioxide is in question.
Patent document US 2003/0139696 makes known an in situ applicable pillow by the help of which it is possible to place serious wounds under carbon dioxide pressure. The role of the carbon dioxide is to press tightly the wound to avoid the loss of blood. Both the aim (to guarantee pressure) and the technical execution (e.g. providing carbon dioxide from cylinder and using closed bandage) deviate from the solution of the present invention.
The essence according to the solution of the present invention is, however, that the carbon dioxide gas is formed in the skin surface in such manner that two components, staying in a two-compartment container where one of the compartments contains some kind of preferably sterile acid and the other compartment contains some kind of preferably sterile carbonate or hydrogen carbonate, are pressed out together from the container, they combine together in the skin surface and step into reaction here with each other. The toxicological and microbiological quality of the carbon dioxide can be guaranteed with the purity of the starting acid and carbonate and by possible sterilising to the desired extent. The surface-active materials (detergents) also placed in one or both container compartment guarantee that the formation of the carbon dioxide should be retarded and the formed foam should be preserved at least as long as the formed carbon dioxide exposes its therapeutic (vasodilator) effect under the skin surface. For this aim 5-10 minutes is sufficient, and this period can be guaranteed with the stable foam. The foam containing carbon dioxide is able to give that minimal pressure surplus which facilitates the penetration of the carbon dioxide into the skin.
As we have made known in the foregoing our invention is well separable from not only the remoter solutions of the carbon dioxide treatment but from the formally closer solutions, too.
Further on we make known the invention in detail. The basis of the invention is given by the long ago known and employed carbon dioxide , gas treatments which are based on the so-called mofette effect that is on the fact that the gas is easily absorbed from the space containing carbon dioxide gas through skin surface. The therapy in its original form, however, is accessible only for few people and is expansive and difficult, and it is utilizable only with the employment of therapeutic centres (thermal baths) established for this aim. Therefore much simpler, cheaper procedures also employable under domestic circumstances are needed. This problem was solved in the near past by the employment of portable cabins. In these procedures the carbon dioxide is developed at the place of the employment mostly from carbon dioxide cylinders, in this manner the carbon dioxide therapy becomes possible in a wide-spread scope. At the same time these procedures are relatively difficult and expansive, too. The present invention is based on the employment of the carbon dioxide gas directly evolving by the double decomposition reaction. The already activating chemical reaction is maintained by the continuously releasing water on the basis of the following reaction: CO3 " + 2H+ -» CO2 + H2O
Consequently to enforce the reaction partners physically separated in dry conditions to step into reaction it is necessary some amount of water since the physical separation ends in dissolved condition. After addition of the first detail of water which starts the reaction, the reaction, in turn, becomes to self-supporting since the reaction itself produces the necessary water, Still it is imaginable, too, that the water necessary to the reaction is supplied by the possible crystal water of the carbonate employed.
The nature of the reaction partners to be found in the foam-forming mixture is not too essential; it is important only that at the meeting of the reaction partners and the water carbon dioxide of suitable amount should be formed. As a matter of fact the conditions are the same as in the case of effervescent tablets, powders or granules based on similar reaction, although the point of views of the selection are not exactly the same. While at the effervescent tablets the main thing is that the formed ions should not be caustic, toxic or bad-tasting (rather should be good to the taste, respectively), in the present situation the main point of view is that the generating ions should not exercise caustic or toxic influence to the skin; the point of views of flavour does not play role here. Of course, from the point of view of the selection the economic point of views are very significant, too. Quite like at the effervescent (sparkling) tablets, powders or granules the combination of citric acid and sodium hydrogen carbonate can be considered as an excellent combination. Instead of citric acid succinic acid, malic acid or ascorbic acid are suitable, too. As a carbonate generating carbon dioxide above all the calcium carbonate comes into question from the point of view of costs but among others sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate or magnesium carbonate are suitable, too. The selection can be determined by economical point of views and technological point of views (e.g. solubility). The calcium carbonate can be advantageous not only from point of view of the costs but from the point of views of optionally necessary retardation of the foam-forming, since the generation of the carbon dioxide gas is relatively slow from the calcium carbonate granules. It is inevitably necessary to take into consideration at the selection of the ingredients that the ingredients should be able to get across the opening of a feeding equipment. Of course, it is possible to draw up reversely: such feeding equipment should be employed which fits to the physicochemical properties of the given advantageous mixture.
To the solution according to the invention the followings are necessary.
It is necessary a container (bottle, tube, flacon and the like) which is provided with a separation wall and suitable dosing equipment. Its function is to receive acidic and carbonate ingredients, respectively, and foam-forming surface-active (detergent) materials, further ingredients and optionally different pharmacons, respectively, and it have to able to place the different materials onto the skin surface in a suitable proportion by the help of a suitably formed dosing equipment from the two container compartments; Neither the empty container itself nor the dosing equipment itself nor their formation constitutes the subject-matter of the invention; every solution is applicable which is able to perform the above functions. The dosing equipment has not to be a complicated construction. It have to be simply only an outlet which guarantees that the pressure developed in whatever form should be able to help the materials to get out from both container compartments in the necessary proportion that these materials should step into reaction on the skin surface. In the simplest case it can be a simple opening which places the materials incoming from both container compartments onto skin surface to be treated in a single flow of materials. In the case of rigid- walled containers the dosing equipment e.g. can be a dosing equipment which can be screwed onto the container. In the case of a container with a wall which can be compressed, first of all a tube, the outflow of the material is provided by the pressure, mainly hand-power pressure applied onto the container. In the case of rigid-walled container an extrusive roll can provide the getting out from the two container compartments in suitable proportion.
The formation of the two-compartment container can be solved in various ways. One of the solutions can be that the separation wall is formed in advance from the container's material. As another solution a bag made from some kind of plastic, preferably a polyalkylene, first of all polyethylene, can be placed into a suitable container. This is a suitable solution first of all for that reason since it is not necessary to modify the production technique of a very cheaply available container, only a filling have to be used into it.
At the selection of the dosing equipment the main point of view is that this equipment should be able to dispatch the materials from both container compartment in the in advance suitably adjusted proportion taking into consideration the physical condition (consistency, grain size and the like) of the individual materials (material compositions). Consequently at the selection of the two-compartment container and its dosing equipment the main point of views are the fitting to the components, the steady convejάng of the materials as well as economic point of views.
Further on the invention is illustrated by a figure where
Figure 1. is a section of a scheme of a possible execution example.
Without limiting our inventions to this solution Figure 1. makes known schematically a possible solution to a suitable container. The device outlined in Figure 1. is an elastic- walled 1 container (bottle, flacon) which is divided into two parts with a 2 separation wall and is supplied with a 5 dosing equipment which represents an elastic-walled compressible material. The figure shows the 3 and 4 container compartments of 1 container supplied the 2 separation wall, the 6 lower closing valve, the 7 outer closing valve and the 8 outlet opening. By the pressure and release, respectively, of the upper 9 press button or by the pressure and release, respectively, of the elastic 10 side wall it is possible to start and release, respectively, the outflow.
We have already mentioned the possible acids and possible carbonates. As turned out from the above one of them should reside in the 3 container compartment the other should reside in the 4 container compartment.
As far as the further ingredients are concerned three groups can be distinguished: - materials providing foam formation and foam stability;
- cosmetic basic materials;
- pharmacons increasing healing power which optionally can be the parts of one or other mixture.
The surface-active materials (detergents) providing the foam formation and foam stability promote both the stability of the foam and necessary delaying or maybe accelerating the evolution of the carbon dioxide. To these materials - without the intention of limitation - examples can be sodium lauryl sulphate, triethanolamine, polysorbates (e.g. Polysorbate 20) and sterols e.g. cholesterol. Delaying and accelerating the chemical reaction depends on the hydrophilic-hydrophilic combination of the ingredients. The most retarded reaction takes place in the lipophilic-lipophilic suspension combination of the materials in the two 3, 4 container compartments. The quickest reaction can be realized by the mixture of the hydrophilic-hydrophilic combination containing dissolved carbonates.
There are necessary also cosmetic basic materials which form the suitable consistence of the preparation (cream, shampoo and other cosmetic preparations) in the condition after disappearance of the formed foam. These preparations i.e. should not be removed after leaving of the carbon dioxide but they can remain on the skin surface as cosmetics. To these ingredients examples can be - without the intention of limitation - cetyl alcohol stearate, glycerine, methyl cellulose, vaseline, solid and/or liquid paraffin, white wax, castor oil, gelatine, xanthan gum, etc., but the water itself, too.
The pharmacons intensifying the healing power intensify the healing power of the preparation first of all in that 5-10 minutes until the carbon dioxide gas performs its vasodilator effect but also after removing the carbon dioxide together with the cosmetics actually as a part of the cosmetics. The pharmacons being in question can move in a wide domain depending in the given therapeutic field; e.g. preparations recommendable to the treatment of locomotor's diseases can contain volatile oils, e.g. the volatile oils of camomile, eucalyptus and Scotch fir, but they can contain also capsaicin, camphor, menthol and methyl salicylate. There is a short discussion about the distribution of the different ingredients between the two 3, 4 container compartments. There is only one substantial point of view: the acid and the carbonate should not get into the same compartment. The solution, that which of the further ingredients (detergents providing foam formation and foam stability, cosmetic basic materials, pharmacons intensifying healing power) gets into the acidic compartment and which of the further ingredients gets into the carbonate compartment, is decided only according to technological advantages (compatibility, the ease of getting out). It is imaginable, too, that individual ingredients can be found both in the 3 container compartment and the 4 container compartment, if this solution has a technological advantage.
Another question necessary to discuss is the proportion of the acid and the carbonate. From the point of view of reaction the stoichiometric proportion could be suitable since in. this case only water would remain in the cosmetics. By certain alteration of the stoichiometric proportions the formation of a desired pH value can be guaranteed in both (acidic or alkaline) direction. For the skin surfaces, however, rather the mildly acidic pH suits which can be adjusted by calculation and/or on the way of experiments with an acidic ingredients of increased quantity as compared to the stoichiometric proportions.
One of the actual subject matters as a marketable product is a filled two-compartment 1 container (flacon, flask, bottle, tube) providing stable foam which container contains in its 3 container compartment an acid of suitable amount and its other 4 container compartment some kind of carbonate or hydrogen carbonate, it contains further in its 3 container compartment or in its 4 container compartment or in both 3, 4 container compartments surface-active materials (detergents), cosmetic basic materials and optionally different pharmacons. The filled two-compartment 1 container is provided with such a 5 dosing equipment which guarantees that the ingredients should get from two 3, 4 container compartments to the selected surface, in this situation to skin surface, in an in advance adjusted proportion. As every product the said filled 1 container have to satisfy the following point of views:
- the production technology of their manufacture should be simple;
- their employment should be easily accomplishable;
- their stability and maintenance should be suitable; - the cost of the product should be competitive from commercial point of view, i.e. cheap, marketable in big amount and utilizable.
If bottles are in question, the filling into the bottles and the closing of the bottle with the 5 dosing equipment is a well mechanized technology having almost century-old tradition. The employment of the filled 1 container as a product is accomplishable easily by simple pushing a button. The filled 1 container as a product is strong and firm, well storable and maintainable for a long time without quality deterioration since the ingredients being in the individual 3, 4 container compartments are not able to react with each other within the container compartment. The said product however, can be » produced from cheap basic materials and by an established technology. The 1 container- filled with the said ingredients and suitable for forming stable foam is not only new but it can become to a product producible cheaply and saleable well in trade. The filling of the elastic-walled, two-compartment 1 containers, tubes does not imply technological problem, neither, since there are available established technologies for this aim, too.
Another subject-matter of the present invention is the production of a preparation including stable foam containing carbon dioxide gas for causing vasodilatation under the skin.
The carbon dioxide is able to display its vasodilator effect under the skin in that case if the instrument providing carbon dioxide is able to correspond to the following technical conditions:
• the evolving carbon dioxide gas should quickly reach to the skin surface from the site of the reaction; • the carbon dioxide gas should be in contact uniformly and continuously with the skin surface; • it is necessary that the carbon dioxide gas should evolve permanently at least during 5-10 minutes;
• the pressure of the gas evolving and being absorbed should exceed possibly the atmospheric pressure.
The instrument providing carbon dioxide here the preparation itself originating on the skin surface and including stable foam containing carbon dioxide gas. The originating carbon dioxide gas has not to "reach" the surface of skin, either, since it originates there. For the same reason the uniform, continuous contact is guaranteed with the skin surface. The stability of the foam guarantees that minimal pressure surplus compared to the atmospheric pressure which promotes the penetration of the carbon dioxide into the skin.
As it can be well observable from the above the foam containing carbon dioxide gas is suitable as a- vasodilator preparation from every point of view. Its production is easily realisable by the help of the two-compartment 1 container which is the previous subject- ■ matter of the invention. The ingredients flowing out by a simple pressure from the two 3, 4 container compartments in a suitable proportion step into reaction on the skin surface and form a stable foam containing carbon dioxide gas.
It is absolutely sure that the carbon dioxide gas prepared on this way does not contain the (first of all pyrogenic) impurities of the industrial carbon dioxide gas; the purity of the gas can be guaranteed according to the demands by the suitable purity of the reaction partners fmdable in granules or powder; by their sterilization, however, it is possible to guarantee the sterility of the gas if necessary.
A further subject-matter of the invention is the use of the foam containing carbon- dioxide gas for causing vasodilatation in the tissues to be found under skin.
As it was readable from the above the penetration of the carbon dioxide under skin surface causes vasodilatation. The penetration of the carbon dioxide is promoted by the stable foam according to the invention during the necessary 5-10 minutes The stable foam containing carbon dioxide can be taken up to the selected skin surfaces and only to the selected skin surfaces, by the help of this solution the skin surface to be treated can be well surrounded. This is especially advantageous where the forwarding the carbon dioxide is realizable by other means only with serious difficulties as e.g. on the hairy on non-hairy scalp, but this preparation can be utilized every other treatable skin surface, too. The stable foam containing carbon dioxide gas can occur e.g. in massaging ("warming") creams used by sportsmen, in preparations used on surfaces requiring physiotherapy, in cosmetic products (e.g. face-packs) and the like.
The application consists in that the stable foam containing carbon dioxide and prepared on the way introduced previously is carried up to the selected areas (surfaces) where the carbon dioxide to be found in the foam displays its vasodilator effect under the skin surface during 5-10 minutes. The question whether the foam containing carbon dioxide should be carried up in what thickness onto the surface to be treated is very difficult to be decided since it strongly depend on the nature of the ingredients. The essence is that this thickness of layer should guarantee the penetration of the carbon dioxide gas for 5- 10 minutes. After leaving the carbon dioxide gas the preparation can remain on the skin surface and can display its further therapeutic- and cosmetic effect.
The invention will be demonstrated with the following executing examples. Depending on the field of the application almost endless ingredient-combinations are imaginable, that is why these examples by no means don't limit the scope of the invention.
Example 1. Filled two-compartment container as a commercial product for preparing a stable shampoo containing carbon dioxide gas
Into the two 3, 4 container compartments of a cylinder-shaped, rigid- walled, in advance two compartment 1 container provided with an impermeable wall and containing 300 millilitre, which is a product available in the trade, are fed the foUowings: "3" container compartment:
25O g of sodium lauryl sulphate 300 g of glycerine 20 g of cetyl alcohol stearate 2 g of xanthan gum 2g of camomile oil 42 g of calcium carbonate "4" container compartment: 30 g of glycerine 40 g of distilled water 44 g citric acid.
The above prescription relates to 1000 g of product; the concrete amount is decided depending on whether the two-compartment 1 container putting on the market has what dimension. The proportions of the ingredients, however, are acceptable at whatever dimension, consequently at this packaging of 300 g, too. The two-compartment 1 container is supplied with a suitable 5 dosing equipment. The 5 dosing equipment indicates such a solution which can be opened by pressing down an usual springy closing valve. An expanded spring moves the piston placed at the end of 1 container which empties uniformly the content of the two 3, 4 container compartments. The product obtained in this manner and being able to put into the trade is the subject-matter of the invention.
Example 2. Filled two-compartment container as a commercial product for preparing massaging ("warming") sport cream containing carbon dioxide
A two-compartment, elastic-walled 1 container (tube) of 200 millilitre available in the trade is filled. Into the two 3, 4 container compartments the followings are fed:
"3" container compartment:
5O g of polysorbate 60
5O g of liquid paraffin
15O g of cetyl alcohol stearate 250 g of white vaseline
5O g of calcium carbonate
"4" container compartment 500 g of distilled water 48 g citric acid 2 g of capsaicin
The above prescription relates to 1000 g of product, the concrete amount is decided depending on whether what dimension has the two-compartment 1 container putting on the market. The proportions of the ingredients, however, are acceptable at whatever dimension, consequently at this tube of 200 ml, too. The material can be helped to get out by manual pressure from the tube, from the two 3, 4 container compartments. The product obtained in this manner is the subject-matter of the invention.
Example 3. Process for production of a medicinal shampoo including stable foam containing carbon dioxide on a skin surface to be treated
The ingredients from the 3, 4 container compartments of the two-compartment 1 container introduced in Example 1. are helped onto the hairy skin (scalp) surface to get out in a suitable amount in thickness of layer of 2-3 centimetres by the help of the 5 dosing equipment by pressing the 9 press-button of the 5 dosing equipment, where the ingredients stepping into reaction form carbon dioxide gas, this causes vasodilatation during 5-10 minutes in the venous network under the skin. After leaving of the carbon dioxide it is not necessary to wash down the shampoo immediately from the hairy scalp but it is possible to leave on it until it is reasonable according to the therapeutic and/or cosmetic effect.
Example 4. Process for the production of a massaging ("warming") cream including stable foam containing carbon dioxide on a skin surface to be treated
The ingredients from the 3, 4 container compartments of the two-compartment 1 container (tube) introduced in Example 2 are helped onto the skin surface covering a group of muscles to be massaged to get out in a suitable amount in thickness of layer of 1,5 - 2 centimetres by manual pressure of the 10 side wall; these ingredients stepping into reaction form carbon dioxide which causes vasodilatation during 5-10 minutes in the venous network under the skin. After leaving of the carbon dioxide it is not necessary to wash down the cream immediately from the covered skin surface but it is possible to leave on it until it is reasonable according to the therapeutic and/or cosmetic effect. The group of muscles prepared by the dilatation of the blood vessels can be effectively massaged.

Claims

1. Filled two-compartment container providing carbon dioxide foam and supplied with dosing equipment, characterized in that in one of its container compartments (3) contains some kind of acid, in its other container compartment (4) contains some kind of carbonate or hydrogen carbonate further it also contains in at least its one of the container compartments (3) surface-active (detergent) materials, cosmetic basic materials and water and optionally pharmacons where the ingredients can be helped to get out from the two container compartments (3, 4) in an in advance adjusted proportion through a dosing equipment (5) to a given surface first of all skin surface in order to originate a stable foam composition containing carbon dioxide gas.
2. Two-compartment container according to claim 1, characterized in that it contains in the two container compartments (3, 4) the different ingredients altogether in the following percentages by weight: surface-active (detergent) material providing foam formation and foam stability: 4-40% by weight; cosmetic basic material: 20-80% by weight; water: 3-60% by weight; acid: 3-10% by weight; carbonate or hydrogen carbonate: 3-10% by weight; and pharmacon: 0-5% by weight.
3. Two-compartment container according to claims 1 or 2, characterized in that it contains as an acid citric acid and as a carbonate calcium carbonate.
4. Two-compartment container according to any of claims 1 — 3, characterized in that it contains as cosmetic basic material ingredients suitable for preparing shampoo.
5. Two-compartment container according to any of claims 1 - 3, characterized in that it contains as cosmetic basic material ingredients suitable for preparing massaging ("warming") cream.
6. Process for preparing foam composition containing carbon dioxide gas, characterized in that from both container compartments (3, 4) of the two-compartment container (1) filled according to any of claims 1 - 5 where in one of its container compartments (3) contains some kind of acid, in its other container compartment (4) contains some kind of carbonate or hydrogen carbonate further it also contains in at least its one of the container compartments (3) surface-active (detergent) materials, cosmetic basic materials and water and optionally pharmacons, the ingredients within it are helped to get out to a given surface through the dosing equipment (5) of the container with a suitable pressure and in this manner a stable foam composition containing carbon dioxide is prepared.
7. Process according to claim 6, characterized in that a shampoo preparation is prepared as a preparation using a two-compartment container (1) according to any of claims 1 - 4.
8. Process according to claim 6, characterized in that a massaging ("warming") preparation is prepared as a preparation using a two-compartment container (1) according to any of claims 1 - 3 and 5.
9. Process for the use of a stable foam composition containing carbon dioxide gas for causing vasodilatation under the skin surface, characterized in that the .foam composition prepared by the process according to any of claims 6 - 8 is kept on the skin surface during 5-10 minutes.
PCT/HU2006/000113 2006-10-06 2006-12-15 A multi chamber container for the production and dispensing of carbon dioxide foam, process for production and use of said foam WO2008041045A1 (en)

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HU0600765A HUP0600765A2 (en) 2006-10-06 2006-10-06 Container for stable carbondioxide foam, process for producing stable carbondioxide foam and method for using of foam

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