WO2006024095A8 - Microemulsion & sub-micron emulsion process & compositions - Google Patents

Microemulsion & sub-micron emulsion process & compositions

Info

Publication number
WO2006024095A8
WO2006024095A8 PCT/AU2005/001321 AU2005001321W WO2006024095A8 WO 2006024095 A8 WO2006024095 A8 WO 2006024095A8 AU 2005001321 W AU2005001321 W AU 2005001321W WO 2006024095 A8 WO2006024095 A8 WO 2006024095A8
Authority
WO
WIPO (PCT)
Prior art keywords
microemulsion
sub
micron emulsion
surfactant
phase assembly
Prior art date
Application number
PCT/AU2005/001321
Other languages
French (fr)
Other versions
WO2006024095A1 (en
Inventor
Maria Graziella Larm
Ronald Harding
Michael Johnston
Prema Vijayakumar
Phoebe Sun
Albert Zorko Abram
Original Assignee
Connetics Australia Pty Ltd
Maria Graziella Larm
Ronald Harding
Michael Johnston
Prema Vijayakumar
Phoebe Sun
Albert Zorko Abram
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35999634&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006024095(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to BRPI0514806-5A priority Critical patent/BRPI0514806A/en
Priority to AU2005279704A priority patent/AU2005279704B2/en
Priority to PL05775966T priority patent/PL1796636T5/en
Priority to CA2578594A priority patent/CA2578594C/en
Priority to KR1020077007513A priority patent/KR101243526B1/en
Application filed by Connetics Australia Pty Ltd, Maria Graziella Larm, Ronald Harding, Michael Johnston, Prema Vijayakumar, Phoebe Sun, Albert Zorko Abram filed Critical Connetics Australia Pty Ltd
Priority to ES05775966.4T priority patent/ES2429040T5/en
Priority to JP2007528524A priority patent/JP4972553B2/en
Priority to CN2005800372056A priority patent/CN101048136B/en
Priority to EP05775966.4A priority patent/EP1796636B2/en
Publication of WO2006024095A1 publication Critical patent/WO2006024095A1/en
Priority to IL181632A priority patent/IL181632A/en
Publication of WO2006024095A8 publication Critical patent/WO2006024095A8/en
Priority to HK07113698.1A priority patent/HK1110198A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/062Oil-in-water emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • A61K8/068Microemulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Abstract

There is provided a process for the preparation of an oil in water (O/W) microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, the method including the steps of a) Admixing a first part including at least one of the group consisting of animal, mineral or vegetable oils, silanes, siloxanes, esters, fatty acids, fats, halogen compounds or alkoxylated alcohols; and one or more lipophilic surfactants, and a second part including water and at least one hydrophilic surfactant to achieve homogeneity, b) heating the mix of step a) to a phase assembly temperature in the range of 40 - 99°C, preferably 45 - 950C, more preferably 65 - 850C with continuous mixing to obtain a microemulsion or sub-micron emulsion, c) allowing said microemulsion or sub-micron emulsion to cool, and d) adding a third part to said microemulsion or sub-micron emulsion at a temperature between 2°C and said phase assembly temperature, said third part if necessary being premixed and heated until the components are dissolved and including at least one component selected from the group consisting of non-surfactant amphiphilic type compound, surfactant and water with the proviso that when the third part includes water it also includes a non-surfactant amphiphilic type compound and/or surfactant. The phase assembly temperature can be determined visually by the achievement of translucence in the composition or by measures such as conductivity which peaks and then is maintained at a plateau whilst phase assembly occurs. It has been found that whilst if a non-surfactant amphiphilic type compound such as the polyol is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.
PCT/AU2005/001321 2004-08-31 2005-08-31 Microemulsion & sub-micron emulsion process & compositions WO2006024095A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP05775966.4A EP1796636B2 (en) 2004-08-31 2005-08-31 Microemulsion & sub-micron emulsion process & compositions
JP2007528524A JP4972553B2 (en) 2004-08-31 2005-08-31 Process for producing microemulsion and submicron emulsion and composition
PL05775966T PL1796636T5 (en) 2004-08-31 2005-08-31 Microemulsion & sub-micron emulsion process & compositions
CA2578594A CA2578594C (en) 2004-08-31 2005-08-31 Microemulsion & sub-micron emulsion process & compositions
KR1020077007513A KR101243526B1 (en) 2004-08-31 2005-08-31 Microemulsion and Sub-Micron Emulsion Process and Compositions
BRPI0514806-5A BRPI0514806A (en) 2004-08-31 2005-08-31 microemulsion and sub-micron emulsion compositions and process
ES05775966.4T ES2429040T5 (en) 2004-08-31 2005-08-31 Method and compositions of microemulsion and submicron emulsion
AU2005279704A AU2005279704B2 (en) 2004-08-31 2005-08-31 Microemulsion and sub-micron emulsion process and compositions
CN2005800372056A CN101048136B (en) 2004-08-31 2005-08-31 Microemulsion and sub-micron emulsion process and compositions
IL181632A IL181632A (en) 2004-08-31 2007-02-28 Microemulsion and sub-micron emulsion process and compositions
HK07113698.1A HK1110198A1 (en) 2004-08-31 2007-12-17 Microemulsion & sub-micron emulsion process & compositions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60627804P 2004-08-31 2004-08-31
US60/606,278 2004-08-31
US67072205P 2005-04-12 2005-04-12
US60/670,722 2005-04-12

Publications (2)

Publication Number Publication Date
WO2006024095A1 WO2006024095A1 (en) 2006-03-09
WO2006024095A8 true WO2006024095A8 (en) 2007-04-19

Family

ID=35999634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2005/001321 WO2006024095A1 (en) 2004-08-31 2005-08-31 Microemulsion & sub-micron emulsion process & compositions

Country Status (15)

Country Link
US (1) US8460641B2 (en)
EP (2) EP2438910A1 (en)
JP (1) JP4972553B2 (en)
KR (1) KR101243526B1 (en)
AR (1) AR051197A1 (en)
AU (1) AU2005279704B2 (en)
BR (1) BRPI0514806A (en)
CA (1) CA2578594C (en)
ES (1) ES2429040T5 (en)
HK (1) HK1110198A1 (en)
IL (1) IL181632A (en)
PL (1) PL1796636T5 (en)
RU (1) RU2381023C2 (en)
TW (1) TWI397427B (en)
WO (1) WO2006024095A1 (en)

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Also Published As

Publication number Publication date
IL181632A (en) 2015-01-29
KR101243526B1 (en) 2013-03-20
KR20070069155A (en) 2007-07-02
RU2381023C2 (en) 2010-02-10
ES2429040T3 (en) 2013-11-12
BRPI0514806A (en) 2008-06-24
PL1796636T3 (en) 2014-01-31
EP1796636A1 (en) 2007-06-20
US20060057168A1 (en) 2006-03-16
TWI397427B (en) 2013-06-01
RU2007111706A (en) 2008-10-10
EP1796636B1 (en) 2013-08-14
CA2578594A1 (en) 2006-03-09
JP4972553B2 (en) 2012-07-11
PL1796636T5 (en) 2017-10-31
EP2438910A1 (en) 2012-04-11
EP1796636A4 (en) 2011-03-02
EP1796636B2 (en) 2016-12-14
AU2005279704A1 (en) 2006-03-09
TW200624124A (en) 2006-07-16
WO2006024095A1 (en) 2006-03-09
ES2429040T5 (en) 2017-06-13
HK1110198A1 (en) 2008-07-11
US8460641B2 (en) 2013-06-11
CA2578594C (en) 2012-04-17
JP2008511550A (en) 2008-04-17
IL181632A0 (en) 2007-07-04
AR051197A1 (en) 2006-12-27
AU2005279704B2 (en) 2010-05-13

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