WO2003015699A3 - Topical compositions and methods for treating pain - Google Patents

Topical compositions and methods for treating pain Download PDF

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Publication number
WO2003015699A3
WO2003015699A3 PCT/US2002/025871 US0225871W WO03015699A3 WO 2003015699 A3 WO2003015699 A3 WO 2003015699A3 US 0225871 W US0225871 W US 0225871W WO 03015699 A3 WO03015699 A3 WO 03015699A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
topical compositions
treating pain
pain
treating
Prior art date
Application number
PCT/US2002/025871
Other languages
French (fr)
Other versions
WO2003015699A2 (en
Inventor
Robert O Williams
Feng Zhang
Original Assignee
Epicept Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2457780A priority Critical patent/CA2457780C/en
Priority to MXPA04001368A priority patent/MXPA04001368A/en
Priority to IL16038802A priority patent/IL160388A0/en
Priority to JP2003520460A priority patent/JP2005501844A/en
Priority to EP02770398A priority patent/EP1438020A4/en
Priority to KR10-2004-7002327A priority patent/KR20040053112A/en
Application filed by Epicept Corp filed Critical Epicept Corp
Priority to NZ531547A priority patent/NZ531547A/en
Priority to AU2002335635A priority patent/AU2002335635B2/en
Publication of WO2003015699A2 publication Critical patent/WO2003015699A2/en
Publication of WO2003015699A3 publication Critical patent/WO2003015699A3/en
Priority to IL160388A priority patent/IL160388A/en
Priority to HK06109763.0A priority patent/HK1089364A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.
PCT/US2002/025871 2001-08-17 2002-08-14 Topical compositions and methods for treating pain WO2003015699A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
MXPA04001368A MXPA04001368A (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain.
IL16038802A IL160388A0 (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain
JP2003520460A JP2005501844A (en) 2001-08-17 2002-08-14 Topical compositions and methods for the treatment of pain
EP02770398A EP1438020A4 (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain
KR10-2004-7002327A KR20040053112A (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain
CA2457780A CA2457780C (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain
NZ531547A NZ531547A (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain
AU2002335635A AU2002335635B2 (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain
IL160388A IL160388A (en) 2001-08-17 2004-02-12 Emulsions comprising amitriptyline and ketamine
HK06109763.0A HK1089364A1 (en) 2001-08-17 2006-09-01 Topical compositions and methods for treating pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/931,293 2001-08-17
US09/931,293 US6638981B2 (en) 2001-08-17 2001-08-17 Topical compositions and methods for treating pain

Publications (2)

Publication Number Publication Date
WO2003015699A2 WO2003015699A2 (en) 2003-02-27
WO2003015699A3 true WO2003015699A3 (en) 2003-08-14

Family

ID=25460543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/025871 WO2003015699A2 (en) 2001-08-17 2002-08-14 Topical compositions and methods for treating pain

Country Status (13)

Country Link
US (2) US6638981B2 (en)
EP (1) EP1438020A4 (en)
JP (1) JP2005501844A (en)
KR (1) KR20040053112A (en)
CN (1) CN100496472C (en)
AR (1) AR035131A1 (en)
AU (1) AU2002335635B2 (en)
CA (1) CA2457780C (en)
HK (1) HK1089364A1 (en)
IL (2) IL160388A0 (en)
MX (1) MXPA04001368A (en)
NZ (1) NZ531547A (en)
WO (1) WO2003015699A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9549898B2 (en) 2007-12-07 2017-01-24 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US9572775B2 (en) 2009-07-29 2017-02-21 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10179159B2 (en) * 1999-10-22 2019-01-15 Scott Wepfer Topical anesthetic formulation
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
US20050013853A1 (en) * 2000-11-29 2005-01-20 Irit Gil-Ad Anti-proliferative drugs
IL139975A0 (en) * 2000-11-29 2002-02-10 Univ Ramot Anti proliferative drugs
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
AU2003213009A1 (en) * 2002-02-12 2003-09-04 Cypress Bioscience, Inc. Methods of treating attention deficit/hyperactivity disorder (adhd)
PT1513532E (en) * 2002-06-10 2007-05-31 Euro Celtique Sa Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein
CN1214785C (en) * 2002-08-27 2005-08-17 孙丽琴 Yanming qingsong plaster and it preparation method
US7273889B2 (en) * 2002-09-25 2007-09-25 Innovative Drug Delivery Systems, Inc. NMDA receptor antagonist formulation with reduced neurotoxicity
US20040106681A1 (en) * 2002-10-03 2004-06-03 Cypress Bioscience, Inc. Dosage escalation and divided daily dose of anti-depressants to treat neurological disorders
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7820145B2 (en) 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
KR101108439B1 (en) 2002-10-25 2012-01-31 포믹스 리미티드 Cosmetic and pharmaceutical foam
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20040138204A1 (en) * 2002-10-30 2004-07-15 Harrington James Frederick Compositions and methods for pain reduction
JP2006514934A (en) 2002-11-26 2006-05-18 アレックザ ファーマシューティカルズ， インコーポレイテッド Use of loxapine or amoxapine for the manufacture of drugs for the treatment of pain
EP1610742B1 (en) 2003-04-10 2015-01-21 Neurogesx, Inc. Uses and compositions for administration of capsaicin
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
JP2007516404A (en) 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド Optically or electrically ignited built-in heating unit and drug supply unit using the same
US20050095277A1 (en) * 2003-06-25 2005-05-05 Binnur Ozturk Neuropathy cream
US20040265364A1 (en) * 2003-06-25 2004-12-30 Binnur Ozturk Neuropathy cream
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
DE10338174A1 (en) * 2003-08-20 2005-03-24 Lts Lohmann Therapie-Systeme Ag Transdermal drug formulations with drug combinations for the treatment of Parkinson's disease
US20050075407A1 (en) * 2003-08-25 2005-04-07 Foamix Ltd. Foam incorporating eutetic mixture
US20050113365A1 (en) * 2003-11-10 2005-05-26 Sir Isaac Newton Enterprises Llc Method and medicine for treating gastrointestinal disorder including irritable bowel syndrome
US20060148781A1 (en) * 2003-11-10 2006-07-06 Lundeen James E Method and medicine for treating gastrointestinal disorder in a non-human mammal
US20060148783A1 (en) * 2003-11-10 2006-07-06 Lundeen James E Method and medicine for treating gastrointestinal disorder including fecal incontinence
WO2005058319A1 (en) * 2003-12-16 2005-06-30 Cnsbio Pty Ltd Methods and compositions
AU2004298288B2 (en) * 2003-12-16 2011-06-30 Relevare Aust. Pty Ltd Methods and compositions
WO2005082054A2 (en) * 2004-02-26 2005-09-09 Sosei Co., Ltd. Combinations for the treatment of fungal infections
US20060063802A1 (en) 2004-03-29 2006-03-23 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US8268866B2 (en) * 2004-03-29 2012-09-18 Matthieu Guitton Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US9072662B2 (en) 2004-03-29 2015-07-07 Auris Medical Ag Methods for the treatment of tinnitus induced by cochlear excitotoxicity
US20080241082A1 (en) * 2004-04-05 2008-10-02 Lonza Inc. Method for the Preparation of Cosmetic Emulsion
EP1755614A4 (en) * 2004-04-08 2009-06-10 Vela Pharmaceuticals Inc Compositions and methods for treatment of neuropathic pain, fibromyalgia and chronic fatigue syndrome
MXPA06012563A (en) * 2004-04-29 2007-03-21 Caldwell Galer Inc Topical methadone compositions and methods for using the same.
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006022611A2 (en) * 2004-06-26 2006-03-02 Binnur Ozturk Neuropathy cream
US7704522B2 (en) * 2004-09-08 2010-04-27 Clyde Morgan Topical medicament
US20060078580A1 (en) * 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US20070298089A1 (en) * 2004-11-10 2007-12-27 Masakazu Saeki Drug for External Use and Adhesive Patch
MX2007008279A (en) * 2005-01-25 2008-02-15 Epix Delaware Inc Substituted arylamine compounds and their use as 5-ht6 modulators.
DE102005004343A1 (en) * 2005-01-25 2006-08-10 Eberhard-Karls-Universität Tübingen Universitätsklinikum Treatment of phantom phenomena
CA2597651A1 (en) * 2005-02-14 2006-08-24 Neurogesx, Inc. Device for delivery of trpv1 agonists
US20060205789A1 (en) * 2005-03-04 2006-09-14 Neurosystec Corporation Gacyclidine formulations
WO2006102267A2 (en) * 2005-03-21 2006-09-28 The Trustees Of Columbia University In The City Of New York New neuronal pain pathway
US20060223788A1 (en) * 2005-03-29 2006-10-05 Cathcart Clifton H Analgesic composition for topical use
WO2006105481A1 (en) * 2005-03-30 2006-10-05 Neurogesx, Inc. Low-concentration capsaicin patch and methods for treating neuropathic pain
US20060223786A1 (en) * 2005-04-01 2006-10-05 Smith David J Transdermal pain control method and device
US20070027152A1 (en) * 2005-07-27 2007-02-01 Clark Kathleen L Topical anti-pruritic compositions and methods of action of same
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
AU2005337107B2 (en) 2005-09-28 2012-05-24 Auris Medical Ag Pharmaceutical compositions for the treatment of inner ear disorders
WO2007062186A2 (en) * 2005-11-21 2007-05-31 The Board Of Trustees Of The University Of Alabama For And On Behalf Of The University Of Alabama Methods of using small molecule compounds for neuroprotection
US20070148194A1 (en) * 2005-11-29 2007-06-28 Amiji Mansoor M Novel nanoemulsion formulations
US20090306050A1 (en) * 2006-02-03 2009-12-10 Timothy Dinan Treatment and prevention of depression with pain, depression secondary to pain, and of neuropathic pain
WO2007103555A2 (en) * 2006-03-08 2007-09-13 Nuviance, Inc. Transdermal drug delivery compositions and topical compositions for application on the skin
KR20090004980A (en) * 2006-04-18 2009-01-12 디에스엠 아이피 어셋츠 비.브이. Cosmetic compositions comprising salicylic acid and ascorbic acid
US20070248657A1 (en) * 2006-04-25 2007-10-25 Smith David J Multi-compartment transdermal pain control device
US20070270413A1 (en) * 2006-05-22 2007-11-22 N.V. Organon Mirtazapine for the treatment of neuropathic pain
TWI392670B (en) * 2006-06-22 2013-04-11 Ucb Pharma Gmbh Use of substituted 2-aminotetralines for the manufacture of a medicament for the prevention, alleviation and/or treatment of various types of pain
US20080014247A1 (en) * 2006-06-30 2008-01-17 Nucryst Pharmaceuticals Metal-containing formulations and methods of use
EP2117521B1 (en) 2006-11-03 2012-06-27 Durect Corporation Transdermal delivery systems comprising bupivacaine
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
WO2008085711A1 (en) * 2007-01-03 2008-07-17 Konova Synergy of sodium channel blockers and calcium channel blockers
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
WO2008139484A2 (en) * 2007-05-16 2008-11-20 R. L. Fine Chem New process for the synthesis of loferpramine maleate: a stable salt of loferpramine
US9511016B2 (en) * 2007-06-12 2016-12-06 Epicentrx, Inc. Topical composition for treating pain
WO2009000038A1 (en) * 2007-06-28 2008-12-31 Cnsbio Pty Ltd Combination methods and compositions for treatment of neuropathic pain
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US8784872B2 (en) 2007-11-19 2014-07-22 Comgenrx, Inc. Formulation for decreasing tobacco, alcohol, drug or food consumption
US20090130048A1 (en) * 2007-11-19 2009-05-21 Oronsky Bryan Todd Topical Composition for Treating Pain
WO2010041141A2 (en) 2008-10-07 2010-04-15 Foamix Ltd. Oil-based foamable carriers and formulations
CA2712120A1 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
ITMI20080316A1 (en) * 2008-02-27 2009-08-28 Aboca Spa USE OF HYPERICUM PERFORATUM EXTRACTS IN THE TREATMENT OF NEUROPATHIC PAIN
US20100104614A1 (en) * 2008-06-27 2010-04-29 Oronsky Bryan T Providone compositions for wound healing
EP2334176A4 (en) 2008-09-27 2012-05-02 Taraxos Inc Topical formulations for treatment of neuropathy
US8198268B2 (en) * 2008-10-31 2012-06-12 Janssen Biotech, Inc. Tianeptine sulfate salt forms and methods of making and using the same
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
US8454877B2 (en) * 2009-04-03 2013-06-04 Pelican Products, Inc. Method and apparatus for molding an article
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
WO2011064631A1 (en) 2009-10-02 2011-06-03 Foamix Ltd. Surfactant-free, water-free, foamable compositions and breakable foams and their uses
US8174881B2 (en) 2009-11-24 2012-05-08 Micron Technology, Inc. Techniques for reducing disturbance in a semiconductor device
CA2782472C (en) * 2009-12-15 2019-04-16 The Hospital For Sick Children Method of treating scars and beta-catenin-mediated disorders
DE102010024105A1 (en) 2010-06-17 2011-12-22 Grünenthal GmbH Transdermal administration of memantine
JP2013528632A (en) * 2010-06-18 2013-07-11 メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン Gel formulations for topical use of 1-amino-alkylcyclohexane derivatives
CN101966151B (en) * 2010-09-06 2011-11-09 海南美大制药有限公司 Trimipramine maleate liposome solid preparation
SI3287123T1 (en) 2011-03-04 2020-07-31 Gruenenthal Gmbh Aqueous pharmaceutical formulation of tapentadol for oral administration
CA2850964C (en) * 2011-10-05 2021-02-02 Jennifer L. Sanders Methods and compositions for treating foot or hand pain
US9012486B2 (en) * 2011-11-14 2015-04-21 Alex Chervinsky Topical composition for pain relief
JP5941159B2 (en) 2011-12-12 2016-06-29 オトラーヌム アーゲー Treatment of tinnitus by regulation of chloride ion symporter NKCC1 in the auditory system
WO2013138520A1 (en) * 2012-03-13 2013-09-19 University Of Tennessee Research Foundation Composition and system for transdermal delivery
ES2484068B1 (en) * 2013-02-08 2015-04-16 Ana MÍNGUEZ MARTÍ A pharmaceutical composition containing ketamine and amitriptyline
EP2968270A4 (en) * 2013-03-14 2016-08-17 Univ California Modulation of k2p channels
US9597099B2 (en) 2013-07-29 2017-03-21 Covidien Lp Energy-based treatment methods for refractory gout
WO2015081007A1 (en) 2013-11-26 2015-06-04 Humco Holding Group, Inc. Transdermal silicone gel (silogel) compositions and methods of preparation
EP3134106A1 (en) * 2014-02-24 2017-03-01 The Arizona Board Of Regents On Behalf Of The University Of Arizona Multivalent/multifunctional ligands with agonist activities at opioid receptors and antagonist activities at nk1 receptor for relief of pain
EP2946776A1 (en) * 2014-05-20 2015-11-25 LTS LOHMANN Therapie-Systeme AG Transdermal therapeutic system for the release of amitriptylin
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
JP6891118B2 (en) 2014-12-23 2021-06-18 インテレクチュアル プロパティ アソシエイツ エルエルシーＩｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ａｓｓｏｃｉａｔｅｓ， ＬＬＣ Methods and formulations for transdermal administration
PT3273953T (en) 2015-03-27 2019-04-01 Gruenenthal Gmbh Stable formulation for parenteral administration of tapentadol
US20160367491A1 (en) * 2015-06-22 2016-12-22 Johnson & Johnson Consumer Inc. Method for providing a benefit to skin
AU2016323977B9 (en) * 2015-09-16 2021-03-04 The Trustees Of Columbia University In The City Of New York Carboxylic diarylthiazepineamines as mu-opioid receptor agonists
WO2017070017A1 (en) * 2015-10-23 2017-04-27 Rush University Medical Center Topical compositions providing pain relief and methods of use thereof
US10004734B2 (en) 2016-01-26 2018-06-26 Warren Scherer Compositions and methods for treating rebound erythema associated with topical alpha-adrenergic agonists
WO2017173442A1 (en) * 2016-04-01 2017-10-05 Good Pharmaceutical Development Company, Llc Topical compositions for neuropathic pain
US10463699B2 (en) 2016-04-04 2019-11-05 Omeza LLC Fish oil topical composition
CN106243096B (en) * 2016-07-29 2019-11-29 上海璃道医药科技有限公司 The new application of tricyclic drugs
MX2020012139A (en) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Compositions and methods for treating rosacea and acne.
EA201990744A1 (en) 2016-09-23 2019-08-30 Грюненталь Гмбх STABLE MEDICINAL FORM FOR Parenteral Administration of TAPENTADOL
US11147799B2 (en) 2016-12-06 2021-10-19 Jan Marius Keppel Hesselink Topical pharmaceutical composition containing phenytoin and a (co-) analgesic for the treatment of chronic pain
FR3065371B1 (en) * 2017-04-25 2021-05-21 Laboratoires Mayoly Spindler TOPICAL PHARMACEUTICAL COMPOSITION INCLUDING AT LEAST AMITRIPTYLINE FOR THE TREATMENT OF PERIPHERAL NEUROPATHIC PAIN
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface
DE102017215154A1 (en) * 2017-08-30 2019-02-28 Markus Bläss Composition for the topical treatment of non-microorganism-caused inflammatory skin and mucous membrane diseases
WO2019055880A2 (en) 2017-09-15 2019-03-21 Ampersand Biopharmaceuticals, Inc. Method of administration and treatment
US10959975B1 (en) 2017-11-02 2021-03-30 The Tetra Corporation Antifungal composition, method of making composition, and method of using composition
WO2019112964A1 (en) * 2017-12-04 2019-06-13 Sienna Biopharmaceuticals, Inc. Formulations for dermal delivery of polymer conjugates of indolocarbazole compounds with reduced exposure
WO2020188457A1 (en) * 2019-03-15 2020-09-24 Ftf Pharma Private Limited Solutions for oral dosage
US11752114B2 (en) * 2019-04-17 2023-09-12 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
PL430531A1 (en) * 2019-07-09 2021-01-11 Biotts Spółka Akcyjna Substrate and pharmaceutical composition containing it
FR3108841B1 (en) * 2020-04-06 2023-11-03 Algotherapeutix TOPICAL PHARMACEUTICAL COMPOSITION IN AQUEOUS GEL FORM COMPRISING AT LEAST AMITRIPTYLINE
EP3949956A1 (en) * 2020-08-06 2022-02-09 LTS Lohmann Therapie-Systeme AG Esketamine-suspension-tts
CN114225039A (en) * 2021-12-29 2022-03-25 中国科学院深圳先进技术研究院 Antagonist composition and application thereof in preparation of medicine for treating sleep disorder and mental disease
CN117384000A (en) * 2022-07-05 2024-01-12 湖南洞庭药业股份有限公司 Dibenzocycloheptadiene and application thereof in preparation of amitriptyline hydrochloride composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
US6461600B1 (en) * 2000-07-19 2002-10-08 Peter R. Ford Topical pain relief composition and carrier

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79380B (en) 1982-09-28 1984-10-22 Johnson & Johnson Prod Inc
US4751087A (en) 1985-04-19 1988-06-14 Riker Laboratories, Inc. Transdermal nitroglycerin delivery system
US4615699A (en) 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes
US4755535A (en) 1986-04-23 1988-07-05 Nelson Research & Development Co. Compositions comprising 1-substituted azacycloalkenes
US4801586A (en) 1986-04-23 1989-01-31 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agents
US4808414A (en) 1986-09-29 1989-02-28 Nelson Research & Development Co. Amide penetration enhancers for transdermal delivery of systemic agents
US4920101A (en) 1987-09-30 1990-04-24 Nelson Research & Development Co. Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4989607A (en) 1989-03-30 1991-02-05 Preston Keusch Highly conductive non-stringy adhesive hydrophilic gels and medical electrode assemblies manufactured therefrom
EP0424179A3 (en) 1989-10-20 1991-12-27 John William Olney Use of combined excitatory amino acid and cholinergic antagonists to prevent neurological deterioration
KR100353486B1 (en) 1990-03-02 2003-01-06 스테이트 오브 오레곤,액팅 바이 앤드 쓰로우 디 오레곤 스테이트 보드 오브 하이어 에주케이션,액팅포앤드 온 비해프 오브 디 오레곤 헬쓰 사이언시즈 유니버시티 앤드 더 유니버시티 오브 오레곤,유진,오레곤 Trisubstituted and tetrasubstituted guanidines and pharmaceutical compositions containing them
US5708035A (en) 1991-02-04 1998-01-13 Sepracor Inc. Methods of use and compositions of R(-) fluoxetine
HUT74560A (en) * 1991-10-16 1997-01-28 Richardson Vicks Inc Enhanced skin penetration system for improved topical delivery of drugs
WO1993010163A2 (en) 1991-11-12 1993-05-27 Nepera, Inc. Adhesive hydrogels having extended use lives and process for the preparation of same
IL106142A (en) 1992-06-29 1997-03-18 Merck & Co Inc Morpholine and thiomorpholine tachykinin receptor antagonists, their preparation and pharmaceutical compositions containing them
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
PL175831B1 (en) 1992-12-17 1999-02-26 Pfizer Pyrazoles and prazolopyrimidines exhibiting antagonistic activity in respect to crf
KR19990067704A (en) 1992-12-17 1999-08-25 디. 제이. 우드, 스피겔 알렌 제이 Pharmaceutical composition containing pyrrolopyrimidine as an adrenal cortical stimulating hormone free factor antagonist
ATE187451T1 (en) 1992-12-17 1999-12-15 Pfizer SUBSTITUTED PYRAZOLES AS CRF ANTAGONISTS
TW336932B (en) 1992-12-17 1998-07-21 Pfizer Amino-substituted pyrazoles
TW444018B (en) 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
CA2115792C (en) * 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
CA2159106C (en) 1993-04-20 2009-10-06 Lorrie P. Daggett Human n-methyl-d-aspartate receptor subunits, nucleic acids encoding same and uses therefor
US5631373A (en) 1993-11-05 1997-05-20 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones
IL111960A (en) 1993-12-17 1999-12-22 Merck & Co Inc Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them
US5612337A (en) 1993-12-29 1997-03-18 Merck Sharp & Dohme Limited Substituted morpholine derivatives and their use as therapeutic agents
JPH09510695A (en) 1994-01-03 1997-10-28 エイシア・ファーマシュウティカルズ，インコーポレイテッド 8-Aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and their use as antagonists to the glycine / NMDA receptor
IL112778A0 (en) 1994-03-04 1995-05-26 Merck & Co Inc Substituted heterocycles, their preparation and pharmaceutical compositions containing them
US5962477A (en) 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
CZ290961B6 (en) 1994-08-30 2002-11-13 Sankyo Company, Limited Isoxazole derivatives process of their preparation and intermediate therefor
US5476933A (en) 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction
US5948389A (en) 1995-06-07 1999-09-07 El Khoury & Stein, Ltd. Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics
US6197830B1 (en) 1995-09-22 2001-03-06 Bruce M. Frome Method for achieving relief from sympathetically mediated pain
AU738304B2 (en) 1995-10-13 2001-09-13 Neurogen Corporation Certain pyrrolopyridine derivatives; novel CRF 1 specific ligands
IN184685B (en) 1996-02-14 2000-09-23 Nat Inst Immunology
US5646151A (en) 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5688955A (en) 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5888494A (en) 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
US5667773A (en) 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US6025369A (en) 1996-05-03 2000-02-15 The Board Of Regents Of The University Nebraska N-methyl-D-aspartate (NMDA) receptor blockers for the prevention of atherosclerosis
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
EP0927171B1 (en) 1996-09-16 2002-02-20 Du Pont Pharmaceuticals Company Pyrazinones and triazinones and their derivatives thereof
US6117855A (en) 1996-10-07 2000-09-12 Merck Sharp & Dohme Ltd. Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent
US5798093A (en) 1997-03-14 1998-08-25 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions and pruritus therewith
US5811078A (en) 1997-03-14 1998-09-22 Adolor Corporation Spray formulations of antihyperalgesic opiates and method of treating topical hyperalgesic conditions therewith
US5817699A (en) 1997-05-30 1998-10-06 Flores; John A. Process for the preparation of ketamine ointment
US5783700A (en) 1997-07-03 1998-07-21 Nichols; Alfred C. Quinolic acid derivatives
US5849762A (en) 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
EP0996434A4 (en) 1997-07-14 2001-10-10 Adolor Corp Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US5760023A (en) 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
JP3393991B2 (en) 1997-08-29 2003-04-07 タイコエレクトロニクスアンプ株式会社 Card connector
DE19818924A1 (en) 1998-04-28 1999-11-04 Degussa Surface-modified fillers, processes for their production and their use
US6211171B1 (en) * 1998-05-19 2001-04-03 Dalhousie University Use of antidepressants for local analgesia
US6255302B1 (en) 1998-12-17 2001-07-03 American Home Products Corporation 1,4-piperazine derivatives
US6242448B1 (en) 1998-12-17 2001-06-05 American Home Products Corporation Trisubstituted-oxazole derivatives as serotonin ligands
FR2787450B1 (en) 1998-12-18 2001-01-26 Adir NOVEL SPIROIMIDAZOLINIC DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU771234B2 (en) 1999-01-28 2004-03-18 Bristol-Myers Squibb Company Antidepressant heterocyclic compounds
GB9904163D0 (en) * 1999-02-23 1999-04-14 Bioglan Lab Ltd Pharmaceutical compositions
US6017961A (en) 1999-07-08 2000-01-25 Flores; John Anthony Ketamine and n-butyl-p-aminobezoate in PLO

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
US6461600B1 (en) * 2000-07-19 2002-10-08 Peter R. Ford Topical pain relief composition and carrier

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MICHALUN NATALIA ET AL.: "Milady's Skin Care and Cosmetic Ingredients Dictionary", 1994, pages: 243, XP002962260 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9549898B2 (en) 2007-12-07 2017-01-24 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US9572775B2 (en) 2009-07-29 2017-02-21 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses

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