WO1991005561A1 - Head lice treatment - Google Patents
Head lice treatment Download PDFInfo
- Publication number
- WO1991005561A1 WO1991005561A1 PCT/AU1990/000487 AU9000487W WO9105561A1 WO 1991005561 A1 WO1991005561 A1 WO 1991005561A1 AU 9000487 W AU9000487 W AU 9000487W WO 9105561 A1 WO9105561 A1 WO 9105561A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- azadirachtin
- solution
- solvent
- composition
- humans
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/26—Meliaceae [Chinaberry or Mahogany family], e.g. mahogany, langsat or neem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Definitions
- HEAD LICE TREATMENT TECHNICAL FIELD relates to a treatment composition for humans, and it relates particularly to a novel composition containing neem extract to repel and/or treat head lice in humans.
- Neem trees - Azadirachta indica - are known to grow in many countries around the world, including Kenya, Mauritius- India- Thailand, Indonesia and Australia. There may be slight variations in trees from one location to another, but they all have one thing in common - they all produce a naturally occurring insecticide called azadirachtin. Most of the azadirachtin is produced in the seeds of the tree, although some is contained in the bark and leaves. Whilst neem seed extract is used as an insecticide and repellant in farm animals, its application to humans has not been fully explored. In Australian Patent Application No. 26320/88, reference is made to application of azadirachtin to humans.
- the azadirachtin is applied to humans as an ointment for the hair and scalp. Ointments are generally not acceptable to users who do not wish to have them in their hair for abnormally long periods of time. Accordingly, investigations were carried out with the principal object of developing a composition which could be regularly applied to the hair and scalp of a human, not be greasy and its presence being generally understated by other humans. To have the best possible chance of success, the composition should be capable of being sprayed directly onto the scalp using a volatile solvent that would not be an irritant to the scalp and would evaporate away, leaving the active ingredient behind to do its intended job. The criteria selected for success were that the composition should be -
- a composition comprising a solution of azadirachtin including up to about 1% of azadirachtin and the balance substantially all solvent suitable for permitting application of the solution to the human head.
- the solution includes at least 80% of an alcoholic or spirit solvent.
- azadirachtin is present in amounts of about 200-2000 parts per million (ppm) . Whilst acting as a repellent, azadirachtin is typically present in amounts of 10-1000 ppm.
- any solvent that lends itself to providing a suitable vehicle to deliver the neem extract to the head by means of spraying would be acceptable in the formula, the solvent properties required being that it must dissolve the neem extract, must produce a fine mist when sprayed, and must be acceptable to use on a human scalp.
- alcohols are suitable solvents.
- the type of alcohol used may be of any variety such as isopropyl alcohol or ethyl alcohol.
- Other additives may be in the solution, such as perfumes, conditioners and colours, as referred to hereinafter.
- the solution may comprise neem seed extract (5%) to 1.00 parts and mixed fruit perfume to 0.5 parts, the balance to 100 parts being industrial methylated spirits.
- the application of the spray was carried out only after the hair and scalp had been thoroughly dried should the participant have washed or wet his/her head.
- the hair was parted to expose the scalp and the repellant sprayed onto the scalp itself.
- One spray was applied to the front of the head, and one to the back of the head, and massaged into the scalp. The participants were advised that washing of the hair washed out the active ingredient.
- the trial results were also assessed to establish effectiveness for two purposes: (1) to kill and eradicate the lice, and (2) to repel lice and thereby avoid further re-infestation.
- ethyl alcohol was used as the carrier solvent for several reasons - (a) It is an effective solvent of azadirachtin;
- Test solutions was made containing various strengths of azadirachtin content. Strengths used varied from 200 parts per million (ppm) to 1000 ppm of azadirachtin. Solvents used were light liquid paraffin and 90% ethyl alcohol. It was found that as soon as water was added to the alcoholic solution, the azadirachtin started to "throw out” of solution. Any dilution of the alcohol base below 80% alcohol content rendered it useless as a solvent for azadirachtin. A simple pump top spray bottle was used to deliver the product to the scalp.
- the test solution was spirit based containing 800 ppm azadirachtin. From day 1 the test repelled lice. Whereas in the past, the participant was susceptible to be re- infested every three or four weeks, the participant became lice free for the term of the test (approximately three months) notwithstanding being exposed to lice. The participant's parents reported that the participant's hair condition had improved as well. The participant was happy to use the composition. Participant 2
- the solution supplied was paraffin oil based, with 500ppm of azadirachtin. The participant reported results consistent with the experiences of Participant 1. Participant 3 The solution was spirit based and contained 500 ppm of azadirachtin. The participant reported results consistent with the experiences of Participant 1. Participant 4
- This household was made up of two women, each with two children, living together, with a never ending problem of head lice infestation.
- One of the women and her children had very thick wavy long hair, which is very difficult to treat.
- the woman and child with wavy hair also had oily hair and so were treated with a spirit based composition containing 400 ppm of azadirachtin in 90% ethyl alcohol.
- the other woman and her children had dry hair, and so were treated with an oil based composition containing 400 ppm in light liquid paraffin. For the first two weeks no lice were evident. However, subsequently one of the daughter's hair was heavily infested.
- the light liquid paraffin was only given to two participants to try, as it was considered to be likely to be less successful than the spirit base due to its oiliness on the scalp and less effective vaporisation when sprayed from a pump spray. Of the two participants supplied with the oil based test samples, only one persisted with it. That participant, however, reported complete success.
- the ethyl alcohol used as the spirit base needs to be at least 80% alcohol content.
- Other alcohols such as isopropyl alcohol may be suitable as a solvent base to deliver the azadirachtin to the scalp.
- Perfume may be added to hide the rather offensive smell of the neem extract, but since the neem extract is required in such low concentrations, it is not difficult to hide the smell.
- the solution is easily dispersed in a pump top spray, which makes the product easy to use for the parents and is readily acceptable by the children. Aerosol spray application would have equal acceptance.
- the important aspect of the invention is that the solution allows the neem extract to be delivered directly to the hair and scalp by a solvent that thereafter evaporates away, leaving the active ingredient - the neem extract.
- the solution according to the invention is effective as both a repellant and a treatment for the killing and eradicating of head lice and their eggs from the human head. Any perfume that hides the bad smell of the neem extract would be acceptable.
- One unexpected additional advantage of use of the neem extract is apparently its effect as a hair conditioner, so it would not be necessary to add extra conditioners to the formula,such as lanoline, in order to condition the hair.
- neem extract on its own has proven to be completely effective for the purposes outlined above, it is extremely expensive. Accordingly, it is also envisaged that activity enhancers, such as pyrethrums, may be added to the formula in order that the strength of the neem extract may be reduced without detracting from the efficacy of the product.
- activity enhancers such as pyrethrums
Abstract
There is provided a novel composition containing neem extract to repel and/or treat head lice in humans. The composition can be regularly applied to the hair and scalp of a human without being greasy and with its presence being generally understated by other humans. The composition broadly comprises a solution of azadirachtin including up to about 1 % of azadirachtin and the balance substantially all solvent suitable for permitting application of the solution to the human head. The solution may include at least 80 % of an alcoholic or spirit solvent, but non-alcoholic solvents may be used to provide a suitable vehicle to deliver the neem extract to the head preferably by means of spraying. The solvent must be able to dissolve the neem extract to produce a fine mist when sprayed and it must be acceptable to use on a human scalp.
Description
HEAD LICE TREATMENT TECHNICAL FIELD THIS INVENTION relates to a treatment composition for humans, and it relates particularly to a novel composition containing neem extract to repel and/or treat head lice in humans.
BACKGROUND ART Neem trees - Azadirachta indica - are known to grow in many countries around the world, including Kenya, Mauritius- India- Thailand, Indonesia and Australia. There may be slight variations in trees from one location to another, but they all have one thing in common - they all produce a naturally occurring insecticide called azadirachtin. Most of the azadirachtin is produced in the seeds of the tree, although some is contained in the bark and leaves. Whilst neem seed extract is used as an insecticide and repellant in farm animals, its application to humans has not been fully explored. In Australian Patent Application No. 26320/88, reference is made to application of azadirachtin to humans. However, the azadirachtin is applied to humans as an ointment for the hair and scalp. Ointments are generally not acceptable to users who do not wish to have them in their hair for abnormally long periods of time. Accordingly, investigations were carried out with the principal object of developing a composition which could be regularly applied to the hair and scalp of a human, not be greasy and its presence being generally understated by other humans. To have the best possible chance of success, the composition should be capable of being sprayed directly onto the scalp using a volatile solvent that would not be an irritant to the scalp and would evaporate away, leaving the active ingredient behind to do its intended job. The criteria selected for success were that the composition should be -
1. acceptable for the human to wear as a preventative virtually 24 hours a day;
2. capable of easy and convenient application to use;
3. a successful repellant, and
4. unable to damage the hair as present lice treatments can do. Initially traditional repellants were investigated such as eucalyptus oil, citronella oil and similar products, to compare them with azadirachtin. However, it was quickly established that these were unacceptable for application to hair due to either their offensive smell or potential toxicity to humans. Whilst neem has an offensive odour, it is effective in such low concentrations that it is easy to hide the offending smell using natural fragrances such as a mixture of green apple and lemon.
DISCLOSURE OF THE INVENTION In one preferred aspect of the invention, a composition is provided comprising a solution of azadirachtin including up to about 1% of azadirachtin and the balance substantially all solvent suitable for permitting application of the solution to the human head. Preferably the solution includes at least 80% of an alcoholic or spirit solvent.
This solution has, in testing, been found to be an excellent treatment and repellant of head lice in humans. More particularly, typically when acting as a treatment, azadirachtin is present in amounts of about 200-2000 parts per million (ppm) . Whilst acting as a repellent, azadirachtin is typically present in amounts of 10-1000 ppm.
Any solvent that lends itself to providing a suitable vehicle to deliver the neem extract to the head by means of spraying would be acceptable in the formula, the solvent properties required being that it must dissolve the neem extract, must produce a fine mist when sprayed, and must be acceptable to use on a human scalp. Typically alcohols are suitable solvents. The type of alcohol used may be of any variety such as isopropyl alcohol or ethyl alcohol.
Other additives may be in the solution, such as perfumes, conditioners and colours, as referred to hereinafter.
As an illustrative example of the composition for sale as a chemist's line, the solution may comprise neem seed extract (5%) to 1.00 parts and mixed fruit perfume to 0.5 parts, the balance to 100 parts being industrial methylated spirits.
BEST MODE FOR CARRYING OUT THE INVENTION The invention is now described with reference to the following trials. An important fact in such trials was "Patient ComplianceA It is very important that the patient complies with the instructions and if the instructions are not followed, false results will occur. The repellant was sprayed onto two places on the scalp of a number of participants in the trials, on two mornings a week, Monday and Wednesday.
The application of the spray was carried out only after the hair and scalp had been thoroughly dried should the participant have washed or wet his/her head. The hair was parted to expose the scalp and the repellant sprayed onto the scalp itself. One spray was applied to the front of the head, and one to the back of the head, and massaged into the scalp. The participants were advised that washing of the hair washed out the active ingredient.
The tests were designed to establish:
1. whether the participants would take the trouble to apply the spray as directed;
2. whether the participant would be happy to wear the product, and
3. the optimum strength and frequency of application for best results. In each test case, the participants were asked to apply the product as directed, and observe reactions and results as accurately as possible.
The trial results were also assessed to establish effectiveness for two purposes: (1) to kill and eradicate
the lice, and (2) to repel lice and thereby avoid further re-infestation.
In some of the trials, ethyl alcohol was used as the carrier solvent for several reasons - (a) It is an effective solvent of azadirachtin;
(b) It is non-toxic to humans when applied to the skin;
(c) It evaporates quickly, leaving the active ingredient behind on the hair and scalp, and
(d) It lends itself to easy and effective vaporisation when used in a non-aerosol pump spray.
As there is a proportion of any population who have dry hair, and an alcoholic spray may exacerbate the dry hair condition, it was decided to also conduct similar tests using light liquid paraffin as a carrier solvent. When preparing the test solutions, a perfume was added comprising equal parts of green apple and lemon fragrances, and the fragrance of the composition was found acceptable to all the participants.
Test solutions was made containing various strengths of azadirachtin content. Strengths used varied from 200 parts per million (ppm) to 1000 ppm of azadirachtin. Solvents used were light liquid paraffin and 90% ethyl alcohol. It was found that as soon as water was added to the alcoholic solution, the azadirachtin started to "throw out" of solution. Any dilution of the alcohol base below 80% alcohol content rendered it useless as a solvent for azadirachtin. A simple pump top spray bottle was used to deliver the product to the scalp.
Eleven participants were tested and given a set of printed instructions. Results Participant 1
The test solution was spirit based containing 800 ppm azadirachtin. From day 1 the test repelled lice. Whereas in the past, the participant was susceptible to be re- infested every three or four weeks, the participant became lice free for the term of the test (approximately three
months) notwithstanding being exposed to lice. The participant's parents reported that the participant's hair condition had improved as well. The participant was happy to use the composition. Participant 2
The solution supplied was paraffin oil based, with 500ppm of azadirachtin. The participant reported results consistent with the experiences of Participant 1. Participant 3 The solution was spirit based and contained 500 ppm of azadirachtin. The participant reported results consistent with the experiences of Participant 1. Participant 4
The solution was spirit based and contained 500 ppm of azadirachtin. From day 1, lice infestation was inhibited and the participant was happy to wear it. Again hair condition improved. Participants 5 and 6
The solution was spirit based and contained 400 ppm of azadirachtin. Participants 5 and 6 were from the same family and lived in the same household. Both reported results consistent with the experiences of Participant 1. Participant 7
The solution was spirit based and contained 600 ppm of azadirachtin. Again the results indicated the solution maintained Participant 7 lice free over the test period compared to consistent lice problems in the last few years. Participant 8 - was a family.
This household was made up of two women, each with two children, living together, with a never ending problem of head lice infestation. One of the women and her children had very thick wavy long hair, which is very difficult to treat. In view of the number of persons in the house, there was always someone in the house with lead lice. Further the woman and child with wavy hair also had oily hair and so were treated with a spirit based composition containing 400 ppm of azadirachtin in 90% ethyl alcohol.
The other woman and her children had dry hair, and so were treated with an oil based composition containing 400 ppm in light liquid paraffin. For the first two weeks no lice were evident. However, subsequently one of the daughter's hair was heavily infested. That child had very thick wavy long oily hair, which was so curly that the parent has never been able to totally eradicate the lice and eggs. Consequently, treatment was carried out with a stronger solution being spirit based containing 1000 ppm of azadirachtin with instructions to use it as a treatment rather than a repellant. The daughter was told to spray it all over the head rather than in just two spots, to ensure that the whole head, scalp and hair were covered by the treatment. Within two weeks the daughter was completely free from any infestation for the first time. Further her hair was also looking better than it had ever looked, apparently as a result of the treatment. All in the household were then free of infestation and commented that all their hair was looking better than ever. Participant 9
The solution was spirit based containing 500 ppm of azadirachtin. No lice were evident from day 1 for the duration of the test period (three months) . The participant reported consistently with Participant 1. Participant 10
The solution was spirit based containing 200 ppm of azadirachtin. This was by far the lowest strength solution tested and was used to try to eradicate the lice. It failed to achieve this within seven days. Once lice were eradicated, the solution was again applied according to the testing procedure. Participant 10 reported no more lice problems. Participant 11
The solution was spirit based containing 500 ppm azadirachtin. Early reports were very enthusiastic and the hair condition had improved. However, after four weeks Participant 11 reported a severe outbreak, with mobile lice
and eggs aplenty. The participant had found them on the Saturday, so had immediately treated them with Lindane. He was supplied with the new high strength test solution which was spirit based, 1000 ppm of azadirachtin, with instructions to use it to ensure complete eradication of the lice and eggs, then to stay on the higher strength as a bi-weekly repellant. Results were completely satisfactory, the higher strength eradicated the problem and the repellant was effective. The formulae used in the trials used ethyl alcohol 90% and light liquid paraffin. The light liquid paraffin was only given to two participants to try, as it was considered to be likely to be less successful than the spirit base due to its oiliness on the scalp and less effective vaporisation when sprayed from a pump spray. Of the two participants supplied with the oil based test samples, only one persisted with it. That participant, however, reported complete success.
As indicated previously, the ethyl alcohol used as the spirit base needs to be at least 80% alcohol content. Other alcohols such as isopropyl alcohol may be suitable as a solvent base to deliver the azadirachtin to the scalp. Perfume may be added to hide the rather offensive smell of the neem extract, but since the neem extract is required in such low concentrations, it is not difficult to hide the smell.
It would appear from the testing programme that the solution is easily dispersed in a pump top spray, which makes the product easy to use for the parents and is readily acceptable by the children. Aerosol spray application would have equal acceptance. The important aspect of the invention is that the solution allows the neem extract to be delivered directly to the hair and scalp by a solvent that thereafter evaporates away, leaving the active ingredient - the neem extract.
In summary, the solution according to the invention is effective as both a repellant and a treatment for the
killing and eradicating of head lice and their eggs from the human head. Any perfume that hides the bad smell of the neem extract would be acceptable. One unexpected additional advantage of use of the neem extract is apparently its effect as a hair conditioner, so it would not be necessary to add extra conditioners to the formula,such as lanoline, in order to condition the hair.
Although the neem extract on its own has proven to be completely effective for the purposes outlined above, it is extremely expensive. Accordingly, it is also envisaged that activity enhancers, such as pyrethrums, may be added to the formula in order that the strength of the neem extract may be reduced without detracting from the efficacy of the product. The various examples described have been given by way of illustrative example only and various changes and modifications may be made thereto without departing from the scope and ambit of the present invention as defined in the appended claims.
Claims
1. A composition for use in repelling and/or treating head lice in humans, comprising a solution of azadirachtin including up to about 1% of azadirachtin, and the balance substantially all solvent suitable for permitting application of the solution to the human head.
2. A composition for use in repelling and/or treating head lice in humans, comprising a solution of azadirachtin including up to about 1% of azadirachtin and at least 80% of an alcoholic or spirit solvent.
3. A composition for use in treating head lice in humans, comprising a solution of azadirachtin including about 200- 2000 parts per million (ppm) of azadirachtin and at least 80% of an alcoholic or spirit solvent.
4. A composition for use in repelling head lice in humans, comprising a solution of azadirachtin including about 10-1000 parts per million (ppm) of azadirachtin and at least 80% of an alcoholic or spirit solvent.
5. A composition according to any one of the preceding claims, wherein the solvent has properties permitting achievement of a fine sprayed mist of the solution of azadirachtin.
6. A composition according to any one of the preceding claims, wherein the solvent is isopropyl alcohol or ethyl alcohol or other equivalent alcoholic solvent.
7. A composition according to Claim 1 wherein the solvent is paraffin or equivalent non-alcoholic solvent.
8. A composition according to any one of the preceding claims, wherein the solution includes natural fragrances or perfumes to mask undesirable odours.
9. A composition according to Claim 8 wherein the perf me is selected from a group including green apple and lemon fragrances and mixed fruit perfume.
10. A composition according to any one of Claims 2 to 5 wherein the solution comprises 1.0 parts of neem seed extract (5%), together with 0.5 parts perfume, and the balance to 100 parts being industrial methylated spirits constituting the solvent.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPJ6773 | 1989-10-10 | ||
AUPJ677389 | 1989-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991005561A1 true WO1991005561A1 (en) | 1991-05-02 |
Family
ID=3774264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1990/000487 WO1991005561A1 (en) | 1989-10-10 | 1990-10-10 | Head lice treatment |
Country Status (1)
Country | Link |
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WO (1) | WO1991005561A1 (en) |
Cited By (9)
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DE19532447A1 (en) * | 1995-09-04 | 1997-03-06 | Heinz Prof Dr Rembold | Compsn. contg. insect repellent extract of Azadirachta indica |
WO2000042982A1 (en) * | 1999-01-26 | 2000-07-27 | Pearlman Dale L | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
WO2001060163A2 (en) | 2000-02-17 | 2001-08-23 | Ecosmart Technologies, Inc. | Plant essential oils cointaining pediculicidal compositions |
WO2003057231A1 (en) * | 2002-01-10 | 2003-07-17 | Natural Science.Com Limited | Pediculicidal compound |
DE102004054143A1 (en) * | 2004-11-08 | 2006-05-11 | Alpha-Biocare Gmbh | Agent, useful for combating e.g. animal or plant parasites, parasitic or microbial pathogenic disease, comprises an active agent extracted from plants |
WO2010108680A1 (en) * | 2009-03-27 | 2010-09-30 | Uwe Andresen | Repellent composition for topical application to creatures |
US8178116B2 (en) | 2002-04-29 | 2012-05-15 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US20130253450A1 (en) * | 2012-03-21 | 2013-09-26 | Laura Marie Shelton | System and method for the treatment of lice with a liquid solution |
US8877219B2 (en) | 1998-07-28 | 2014-11-04 | Ecosmart Technologies, Inc. | Pesticidal compositions containing rosemary oil and wintergreen oil |
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AU2632088A (en) * | 1987-11-30 | 1989-06-01 | University Of Queensland, The | Improvements in the inhibition of lice |
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Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19532447A1 (en) * | 1995-09-04 | 1997-03-06 | Heinz Prof Dr Rembold | Compsn. contg. insect repellent extract of Azadirachta indica |
US9497974B2 (en) | 1998-07-28 | 2016-11-22 | Kittrich Corporation | Pesticidal compositions and methods for using same |
US9247751B2 (en) | 1998-07-28 | 2016-02-02 | Kittrich Corporation | Pesticidal compositions containing rosemary oil and wintergreen oil |
US8877219B2 (en) | 1998-07-28 | 2014-11-04 | Ecosmart Technologies, Inc. | Pesticidal compositions containing rosemary oil and wintergreen oil |
WO2000042982A1 (en) * | 1999-01-26 | 2000-07-27 | Pearlman Dale L | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6265384B1 (en) | 1999-01-26 | 2001-07-24 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6303581B2 (en) | 1999-01-26 | 2001-10-16 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pedicul ostatic agents |
US6350734B1 (en) | 1999-01-26 | 2002-02-26 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6541455B2 (en) | 1999-01-26 | 2003-04-01 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
US6974584B2 (en) | 2000-02-17 | 2005-12-13 | Ecosmart Technologies, Inc. | Pesticidal compositions containing plant essential oils against human body louse |
US6969522B2 (en) | 2000-02-17 | 2005-11-29 | Ecosmart Technologies, Inc. | Pesticidal compositions containing plant essential oils against human body louse |
WO2001060163A3 (en) * | 2000-02-17 | 2002-02-07 | Ecosmart Technologies Inc | Plant essential oils cointaining pediculicidal compositions |
WO2001060163A2 (en) | 2000-02-17 | 2001-08-23 | Ecosmart Technologies, Inc. | Plant essential oils cointaining pediculicidal compositions |
WO2003057231A1 (en) * | 2002-01-10 | 2003-07-17 | Natural Science.Com Limited | Pediculicidal compound |
US8178116B2 (en) | 2002-04-29 | 2012-05-15 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
US8815270B2 (en) | 2002-04-29 | 2014-08-26 | Piedmont Pharmaceuticals, Llc | Methods and compositions for treating ectoparasite infestation |
DE102004054143A1 (en) * | 2004-11-08 | 2006-05-11 | Alpha-Biocare Gmbh | Agent, useful for combating e.g. animal or plant parasites, parasitic or microbial pathogenic disease, comprises an active agent extracted from plants |
DE102004054143B4 (en) * | 2004-11-08 | 2010-09-09 | Alpha-Biocare Gmbh | Compositions containing active substances derived from neem seed, neem oil, dried leaves or bark of neem tree and dicarboxylic acid alkyl esters for controlling animal or plant pests or pathogens |
WO2010108680A1 (en) * | 2009-03-27 | 2010-09-30 | Uwe Andresen | Repellent composition for topical application to creatures |
US20130253450A1 (en) * | 2012-03-21 | 2013-09-26 | Laura Marie Shelton | System and method for the treatment of lice with a liquid solution |
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