US3789118A - Medical adhesive solvent composition - Google Patents
Medical adhesive solvent composition Download PDFInfo
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- US3789118A US3789118A US00163498A US3789118DA US3789118A US 3789118 A US3789118 A US 3789118A US 00163498 A US00163498 A US 00163498A US 3789118D A US3789118D A US 3789118DA US 3789118 A US3789118 A US 3789118A
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- skin
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- composition
- solvent composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 68
- 239000002904 solvent Substances 0.000 title claims abstract description 53
- 239000000853 adhesive Substances 0.000 title claims abstract description 43
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 41
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 24
- 229930195733 hydrocarbon Natural products 0.000 claims description 10
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical group CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 claims description 7
- BOSAWIQFTJIYIS-UHFFFAOYSA-N 1,1,1-trichloro-2,2,2-trifluoroethane Chemical group FC(F)(F)C(Cl)(Cl)Cl BOSAWIQFTJIYIS-UHFFFAOYSA-N 0.000 claims description 6
- -1 alkyl hydrocarbon Chemical class 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- SLGOCMATMKJJCE-UHFFFAOYSA-N 1,1,1,2-tetrachloro-2,2-difluoroethane Chemical compound FC(F)(Cl)C(Cl)(Cl)Cl SLGOCMATMKJJCE-UHFFFAOYSA-N 0.000 claims description 4
- 125000005375 organosiloxane group Chemical group 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 4
- 229940029284 trichlorofluoromethane Drugs 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- 239000000470 constituent Substances 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 abstract description 19
- 229920002050 silicone resin Polymers 0.000 abstract description 19
- 239000012530 fluid Substances 0.000 abstract description 17
- 239000003921 oil Substances 0.000 abstract description 7
- 230000003750 conditioning effect Effects 0.000 abstract description 4
- 229910052799 carbon Inorganic materials 0.000 description 9
- 125000001931 aliphatic group Chemical group 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 239000003925 fat Substances 0.000 description 5
- 150000002430 hydrocarbons Chemical class 0.000 description 5
- 230000002939 deleterious effect Effects 0.000 description 3
- 238000004821 distillation Methods 0.000 description 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- LFEUVBZXUFMACD-UHFFFAOYSA-H lead(2+);trioxido(oxo)-$l^{5}-arsane Chemical compound [Pb+2].[Pb+2].[Pb+2].[O-][As]([O-])([O-])=O.[O-][As]([O-])([O-])=O LFEUVBZXUFMACD-UHFFFAOYSA-H 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 208000037974 severe injury Diseases 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Definitions
- ABSTRACT A solvent composition is provided which will efficiently remove medical adhesives, particularly adhesives containing silicone resins, from skin and simultaneously replace body oils, and prepare the skin to receive subsequent applications of the adhesive
- the solvent composition comprises a major effective amount of a liquid aliphatic hydrocarbon solvent fraction, preferably a C to C aliphatic hydrocarbon fraction, a minor efiective skin conditioning amount (generally comprising at least about 2 weight percent) of silicone fluid, and preferably, a minor effective amount of a flash point suppressant for the liquid aliphatic hydrocarbon fraction.
- This invention relates to solvents. In another aspect, this invention relates to a novel medical solvent and skin preparation composition. In still another aspect, this invention relates to a novel method of applying and removing prosthetic devices and the like from the skin.
- Various medical prosthetic devices and body appliances are utilized which are affixed to the human body with a medical adhesive composition.
- Widely utilized body appliances include cosmetic body appliances for covering scars resulting from severe injuries, for example. These appliances are generally made of silicone rubber and utilize a silicone resin medical adhesive to affix them to the body surface.
- Prosthetic devices in clude male urinal devices which are affixed to the body with medical adhesives.
- the conventional medical adhesive compositions will tenaceously adhere to both the prosthetic device, or body appliance and the skin, it is necessary to apply a solvent for the adhesive in order to remove the device or appliance from the skin.
- a solvent for the adhesive for example, when such device or appliance is made of silicone rubber and a silicone resin is utilized as the medical adhesive, it is conventional to use V.M. & P. naphthas or fluorocarbons as solvents therefor.
- the V.M. & P. naphthas are very harsh and tend to chap and blister as well as dry out the living tissue to which they are applied.
- the liquid fluorocarbons are expensive, and also tend to chap and dry out the skin.
- the deleterious effects on the skin which are imparted by the conventional solvents result (1) from the irritating effect the chemicals have upon the skin, and (2) because the solvents actually leach essential body fats and oils from the skin and leave them dry, chapped and scaly.
- one object of this invention is to provide a solvent composition which will effectively remove conventional medical adhesives from skin, but is nondeleterious to the human body.
- a further object of this invention is to provide a novel solvent composition which will effectively remove medical adhesives from skin while simultaneously treating the skin to prevent drying and chapping.
- a further object of this invention is to provide a novel solvent composition which will effectively remove silicone resin, medical adhesives and simultaneously treat the skin to prevent drying and chapping while preparing the skin to tenaceously receive a subsequent coating of silicone resin adhesive.
- a solvent composition which is particularly suitable for removing medical adhesives from the skin, and comprises a major effective amount of a liquid aliphatic hydrocarbon fraction as solvent, and a minor effective skin conditioning amount ofa silicone fluid.
- the solvent composition preferably contains an effective proportion of a flash point suppressant for the liquid aliphatic hydro carbons.
- the medical adhesive solvent composition is pro vided which comprises a major effective amount of an aliphatic hydrocarbon fraction which includes from about 30 to about weight percent of a fraction consisting essentially of aliphatic C and Cu hydrocarbons and from about 30 to 70 weight percent of a fraction consisting essentially of aliphatic C and C H hydrocarbons; from about 15 to about 25 weight percent of flash point suppressant; and at least about 2 weight percent of a silicone fluid.
- a particularly effective combination includes equal parts of the aliphatic C -C fraction and the C -C fraction.
- composition of the subject invention can be utilized to remove conventional medical adhesives from the skin, and from other surfaces such as the skin contacting surfaces of prosthetic devices and body appliances.
- body appliance as used in the scope of this invention includes any prosthetic device or body appliance which is attached to the body by medical adhesive compositions.
- composition of the subject invention is particularly effective for both removing silicone resin medical adhesive compositions from the skin, and preparing the skin for applications of such silicone resin medical adhesive compositions.
- the liquid aliphatic hydrocarbon solvent fraction is non-toxic and is not readily absorbed through human skin but yet functions to dissolve conventional medical adhesive compositions such as silicone resin adhesive compositions.
- the silicone fluid component functions not only to replace body fats and oils which have been leached by the solvent component, but also functions to prepare the skin to tenaceously receive a subsequent application of silicone resin.
- the liquid aliphatic hydrocarbon fraction used in the solvent composition of this invention can have aliphatic components therewithin, containing from about 6 to about 15 carbon atoms.
- the liquid aliphatic hydrocarbons consist essentially of from C to C straight and/or branched chain molecules, While some unsaturation can be present in the molecules, the preferred fractions contain a majority of paraffmic components.
- the percentage of the individual components can be varied as desired within the scope of this invention.
- the aliphatic solvent fraction can comprise a majority of C s, C s, C s, or C s or various combinations thereof.
- the most preferred liquid aliphatic hydrocarbon fraction which can be used in the solvent composition of this invention includes from about 30 to 70 weight percent of a first fraction of aliphatic C,;C (C s and- /or C s) hydrocarbons combined with from about 30 to about 70 weight percent of a second fraction of aliphatic (Z -C (C s and/or C s ⁇ hydrocarbons.
- This fraction in combination with the other ingredients of the subject composition has been found to be particularly effective for removing medical adhesives, such as silicone resins and yet not impart deleterious effects to the skin.
- said first fraction will have a boiling range at 760 mm Hg within the range of from 200-260F
- said second fraction will have a boiling range at 760 mm Hg within the range of from 300 to 350 F.
- the silicone fluid which can be used in the scope of this invention includes any of the liquid organosiloxane polymers which are nondeleterious to human skin, for
- the methyl or phenyl polysiloxanes examples include the methyl or phenyl polysiloxanes.
- the organisiloxane polymers which can be used in the composition of this invention have a wide range of viscosities of less than 1 (about 0.65) to several thousand centistokes. It is generally preferable to utilize an organosi loxane which has a viscosity in the range of from about to about 100 centistokes.
- the silicone fluid is generally contained within the composition of the subject invention in amounts of at least about 2 weight percent thereof, and is most preferably contained in the composition of this invention within the range of about 2 to about 4 weight percent. Greater amounts (for example l0 weight percent) can be used if desired; however, it has been found that a silicone fluid content of from 2 to 4 weight percent is sufficient for most uses.
- the silicone fluid functions in cooperation with the liquid aliphatic hydrocarbon component in the solvent composition of this invention.
- the silicone fluid readily coats the living tissue and functions to immediately replace body fats and oils which are leached therefrom by the action of the solvent.
- the silicone fluid efficiently coats the skin and combines with the skin to thereby prevent chapping and irritation clue to loss of body fats and oils.
- This residue or coating of the silicone resin upon the skin which results from the application of the solvent composition of this invention thereto, tenaceously adheres to the skin and will not be removed by the application of mild soaps or detergents when removing the solvent-adhesive residue or when washing the skin after the solvent-adhesive residue has been wiped away.
- a flash point suppressant or retarder is preferably added thereto.
- Any suitable flash point suppressant which is nondeleterious to the human body can be used in the scope of this invention.
- the preferred flash point suppressants are the halogenated lower alkyl hydrocarbons (about 1 to about 5 carbon atoms), such as for example, trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, mixtures thereof and the like.
- the flash point suppressant is added to the solvent composition of this invention generally in amounts ranging from about 15 weight percent to about 25 weight percent thereof, depending upon the volatility of the particular liquid aliphatic hydrocarbon fraction used in said composition. Most preferably, the flash point suppressant is added in amounts of from about 18 to about 20 weight percent of the total composition. Generally, the flashpoint of the resulting composition then will be no less than F as detennined by ASTM D-56, and will generally be at least lOO F or more.
- the components of the solvent composition of the subject invention can be admixed in any suitable manner.
- a solvent composition of the subject invention was made by admixing 40 parts by weight of a first liquid aliphatic hydrocarbon mixture consisting essentially of C and C hydrocarbons (a mixture sold under the trademark of SOLTROL 10 by Phillips Petroleum Co.) and haVing the characteristics as set forth in Table l below, with 40 parts by weight of a second liquid aliphatic hydrocarbon fraction consisting essentially of C and C hydrocarbons (a mixture sold under the trademark of SOLTROL lOO by Phillips Petroleum Co. and having the characteristics as set forth in Table ll below.
- a first liquid aliphatic hydrocarbon mixture consisting essentially of C and C hydrocarbons (a mixture sold under the trademark of SOLTROL 10 by Phillips Petroleum Co.) and haVing the characteristics as set forth in Table l below
- a second liquid aliphatic hydrocarbon fraction consisting essentially of C and C hydrocarbons (a mixture sold under the trademark of SOLTROL lOO by Phillips Petroleum Co. and having the characteristics as set forth in Table ll below.
- This medical solvent composition was used to remove a medical adhesive (a silicone resin medical adhesive sold under the trademark of MEDICAL ADHE- SlVE B" by Dow-Corning Medical Products Division).
- the medical adhesive was used in attaching to a human male a prosthetic device for the handling of urinary incontinence.
- This prosthetic device basically comprised a knit sheath impreganted with silicone rubher and is fully disclosed in my copending patent application Ser. No. 008,819, filed Feb. 5, 197].
- the solvent was used to remove the device numerous times over a period of several months. In each instance, the solvent composition was applied during the removal operation and thereafter the skin area which was contacted by the solvent composition was washed with mild soap and water and the solvent residue containing the dissolved adhesive was flushed away.
- silicone resin medical adhesive was applied over the skin which carried the silicone fluid coating, and the prosthetic device then applied thereto. During this several months period, no skin irritation whatsoever was observed and furthermore, the silicone resin adhesive was found to very effectively adhere to the treated area in an improved manner than when conventional solvents such as V.M. & P. naphthas are used to remove the medical adhesive.
- a skin conditioning medical adhesive solvent and skin preparation composition which consists essentially of:
- a halogenated lower alkyl hydrocarbon flashpoint suppressant selected from the group consisting of trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, and mixtures thereof;
- composition which consists essentially of a solvent of from about 30 to about weight percent ofa mixture of C C aliphatic hydrocarbons and from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons;
- said solvent not imparting deleterious results to the skin, said composition forming a more efficient seal with silicone resin medical adhesive between the skin and a prosthetic device or appliance upon reapplication thereof.
- composition of claim 1 wherein said flashpoint suppressant is trichloroethane.
- composition of claim 1 wherein said flashpoint suppressant is trichlorotrifluoroethane.
- a medical adhesive solvent and skin preparation composition which consists essentially of parts by weight of a solvent constituent which includes a liquid aliphatic hydrocarbon fraction which consists essentially of from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons and from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons, 18 parts by weight of a halogenated lower alkyl hydrocarbon selected from the group consisting of trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, and mixtures thereof; and 2 parts by weight of a liquid organosiloxane polymer.
- a solvent constituent which includes a liquid aliphatic hydrocarbon fraction which consists essentially of from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons and from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons
Abstract
A solvent composition is provided which will efficiently remove medical adhesives, particularly adhesives containing silicone resins, from skin and simultaneously replace body oils, and prepare the skin to receive subsequent applications of the adhesive. The solvent composition comprises a major effective amount of a liquid aliphatic hydrocarbon solvent fraction, preferably a C8 to C11 aliphatic hydrocarbon fraction, a minor effective skin conditioning amount (generally comprising at least about 2 weight percent) of silicone fluid, and preferably, a minor effective amount of a flash point suppressant for the liquid aliphatic hydrocarbon fraction.
Description
United States Patent [1 1 3,789,118 Broerman 1 Jan. 29, 1974 MEDICAL ADHESIVE SOLVENT Primary Examiner-Shep K. Rose COMPOSITION [76] Inventor: Arthur B. Broerman, 5901 Baylor,
Bartlesville, Okla. 74003 [22] Filed: July 16, 1971 [2]] Appl. No.: 163,498
[52] US. Cl 424/45, 252/364, 424/78, 424/184 [51] Int. Cl. B011 1/00, C23g 5/00, A6lk 9/00 [58] Field of Search 252/364; 424/184, 78, 45
[56] References Cited UNITED STATES PATENTS 2,681,878 6/1954 Kauppi 424/184 2,727,846 l2/l955 Talbot 424/l84 3,298,919 H1967 Bishop et al. 424/47 3,470,292 9/1969 Marschner 424/47 FirmRichards, Harris &
[57] ABSTRACT A solvent composition is provided which will efficiently remove medical adhesives, particularly adhesives containing silicone resins, from skin and simultaneously replace body oils, and prepare the skin to receive subsequent applications of the adhesive The solvent composition comprises a major effective amount of a liquid aliphatic hydrocarbon solvent fraction, preferably a C to C aliphatic hydrocarbon fraction, a minor efiective skin conditioning amount (generally comprising at least about 2 weight percent) of silicone fluid, and preferably, a minor effective amount of a flash point suppressant for the liquid aliphatic hydrocarbon fraction.
4 Claims, No Drawings 1 MEDICAL ADHESIVE SOLVENT COMPOSITION This invention relates to solvents. In another aspect, this invention relates to a novel medical solvent and skin preparation composition. In still another aspect, this invention relates to a novel method of applying and removing prosthetic devices and the like from the skin.
Various medical prosthetic devices and body appliances are utilized which are affixed to the human body with a medical adhesive composition. Widely utilized body appliances include cosmetic body appliances for covering scars resulting from severe injuries, for example. These appliances are generally made of silicone rubber and utilize a silicone resin medical adhesive to affix them to the body surface. Prosthetic devices in clude male urinal devices which are affixed to the body with medical adhesives.
Thus, such medical prosthetic devices and body appliances must, when in use, be securely affixed to the skin of the patient. However, for medicinal and hygienic reasons, such devices and appliances must be periodically removed from the skin and then later reapplied thereto.
Since the conventional medical adhesive compositions will tenaceously adhere to both the prosthetic device, or body appliance and the skin, it is necessary to apply a solvent for the adhesive in order to remove the device or appliance from the skin. For example, when such device or appliance is made of silicone rubber and a silicone resin is utilized as the medical adhesive, it is conventional to use V.M. & P. naphthas or fluorocarbons as solvents therefor. The V.M. & P. naphthas are very harsh and tend to chap and blister as well as dry out the living tissue to which they are applied. The liquid fluorocarbons are expensive, and also tend to chap and dry out the skin. The deleterious effects on the skin which are imparted by the conventional solvents result (1) from the irritating effect the chemicals have upon the skin, and (2) because the solvents actually leach essential body fats and oils from the skin and leave them dry, chapped and scaly.
Therefore, one object of this invention is to provide a solvent composition which will effectively remove conventional medical adhesives from skin, but is nondeleterious to the human body.
A further object of this invention is to provide a novel solvent composition which will effectively remove medical adhesives from skin while simultaneously treating the skin to prevent drying and chapping.
A further object of this invention is to provide a novel solvent composition which will effectively remove silicone resin, medical adhesives and simultaneously treat the skin to prevent drying and chapping while preparing the skin to tenaceously receive a subsequent coating of silicone resin adhesive.
According to the invention, a solvent composition is provided which is particularly suitable for removing medical adhesives from the skin, and comprises a major effective amount of a liquid aliphatic hydrocarbon fraction as solvent, and a minor effective skin conditioning amount ofa silicone fluid. In addition, the solvent composition preferably contains an effective proportion of a flash point suppressant for the liquid aliphatic hydro carbons.
According to a preferred embodiment of this invention, the medical adhesive solvent composition is pro vided which comprises a major effective amount of an aliphatic hydrocarbon fraction which includes from about 30 to about weight percent of a fraction consisting essentially of aliphatic C and Cu hydrocarbons and from about 30 to 70 weight percent of a fraction consisting essentially of aliphatic C and C H hydrocarbons; from about 15 to about 25 weight percent of flash point suppressant; and at least about 2 weight percent of a silicone fluid. A particularly effective combination includes equal parts of the aliphatic C -C fraction and the C -C fraction.
The composition of the subject invention can be utilized to remove conventional medical adhesives from the skin, and from other surfaces such as the skin contacting surfaces of prosthetic devices and body appliances. It is herein noted that the term body appliance as used in the scope of this invention includes any prosthetic device or body appliance which is attached to the body by medical adhesive compositions.
Furthermore, the composition of the subject invention is particularly effective for both removing silicone resin medical adhesive compositions from the skin, and preparing the skin for applications of such silicone resin medical adhesive compositions. The liquid aliphatic hydrocarbon solvent fraction is non-toxic and is not readily absorbed through human skin but yet functions to dissolve conventional medical adhesive compositions such as silicone resin adhesive compositions. In addition, the silicone fluid component functions not only to replace body fats and oils which have been leached by the solvent component, but also functions to prepare the skin to tenaceously receive a subsequent application of silicone resin.
The liquid aliphatic hydrocarbon fraction used in the solvent composition of this invention can have aliphatic components therewithin, containing from about 6 to about 15 carbon atoms. To avoid volatility extremes and yet utilize extremely effective solvent components for a medical adhesive, it is generaliy preferred that the liquid aliphatic hydrocarbons consist essentially of from C to C straight and/or branched chain molecules, While some unsaturation can be present in the molecules, the preferred fractions contain a majority of paraffmic components. The percentage of the individual components can be varied as desired within the scope of this invention. For example, the aliphatic solvent fraction can comprise a majority of C s, C s, C s, or C s or various combinations thereof.
The most preferred liquid aliphatic hydrocarbon fraction which can be used in the solvent composition of this invention includes from about 30 to 70 weight percent of a first fraction of aliphatic C,;C (C s and- /or C s) hydrocarbons combined with from about 30 to about 70 weight percent of a second fraction of aliphatic (Z -C (C s and/or C s} hydrocarbons. This fraction in combination with the other ingredients of the subject composition has been found to be particularly effective for removing medical adhesives, such as silicone resins and yet not impart deleterious effects to the skin. Generally, said first fraction will have a boiling range at 760 mm Hg within the range of from 200-260F, and said second fraction will have a boiling range at 760 mm Hg within the range of from 300 to 350 F.
The silicone fluid which can be used in the scope of this invention includes any of the liquid organosiloxane polymers which are nondeleterious to human skin, for
example, the methyl or phenyl polysiloxanes. The organisiloxane polymers which can be used in the composition of this invention have a wide range of viscosities of less than 1 (about 0.65) to several thousand centistokes. It is generally preferable to utilize an organosi loxane which has a viscosity in the range of from about to about 100 centistokes. The silicone fluid is generally contained within the composition of the subject invention in amounts of at least about 2 weight percent thereof, and is most preferably contained in the composition of this invention within the range of about 2 to about 4 weight percent. Greater amounts (for example l0 weight percent) can be used if desired; however, it has been found that a silicone fluid content of from 2 to 4 weight percent is sufficient for most uses.
As described above, the silicone fluid functions in cooperation with the liquid aliphatic hydrocarbon component in the solvent composition of this invention. When the solvent composition of the subject invention is applied to an adhesive coating on animal skin, and particularly human skin, the silicone fluid readily coats the living tissue and functions to immediately replace body fats and oils which are leached therefrom by the action of the solvent. Thus, the silicone fluid efficiently coats the skin and combines with the skin to thereby prevent chapping and irritation clue to loss of body fats and oils. This residue or coating of the silicone resin upon the skin which results from the application of the solvent composition of this invention thereto, tenaceously adheres to the skin and will not be removed by the application of mild soaps or detergents when removing the solvent-adhesive residue or when washing the skin after the solvent-adhesive residue has been wiped away.
The residue or coating which remains on the skin after application of the solvent composition of this invention imparts a special affinity to the skin for subsequent amounts of the silicone resin. Thus, it has been found that when the solvent composition of the subject invention is used to remove the silicone resin, subsequent applications of the silicone resin when reapplying the prosthetic device or body applicance will be received more uniformly on the skin and form a more efficient seal between the skin and the device or appliance than when conventional solvents are initially utilized.
In addition to the liquid aliphatic hydrocarbons and the silicone fluid components of the subject invention, a flash point suppressant or retarder is preferably added thereto. Any suitable flash point suppressant which is nondeleterious to the human body can be used in the scope of this invention. The preferred flash point suppressants are the halogenated lower alkyl hydrocarbons (about 1 to about 5 carbon atoms), such as for example, trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, mixtures thereof and the like. The flash point suppressant is added to the solvent composition of this invention generally in amounts ranging from about 15 weight percent to about 25 weight percent thereof, depending upon the volatility of the particular liquid aliphatic hydrocarbon fraction used in said composition. Most preferably, the flash point suppressant is added in amounts of from about 18 to about 20 weight percent of the total composition. Generally, the flashpoint of the resulting composition then will be no less than F as detennined by ASTM D-56, and will generally be at least lOO F or more.
The components of the solvent composition of the subject invention can be admixed in any suitable manner. For example, it is convenient to add the silicone fluid and the flash point suppressant to the liquid aliphatic hydrocarbon and mix until a generally uniform composition is obtained.
The following example is given to further illustrate the scope of this invention and is not intended to limit the scope thereof:
EXAMPLE A solvent composition of the subject invention was made by admixing 40 parts by weight of a first liquid aliphatic hydrocarbon mixture consisting essentially of C and C hydrocarbons (a mixture sold under the trademark of SOLTROL 10 by Phillips Petroleum Co.) and haVing the characteristics as set forth in Table l below, with 40 parts by weight of a second liquid aliphatic hydrocarbon fraction consisting essentially of C and C hydrocarbons (a mixture sold under the trademark of SOLTROL lOO by Phillips Petroleum Co. and having the characteristics as set forth in Table ll below.
TABLE I Property Typicnt Test Mcthutl Distillation, rec, "F at 760 mm ASI'M D-Xh 202 209 2 l 7 227 245 0.01133 neutral l negative 28 2 none AS'IM AS'IM ASTM ASTM ASTM AST M ASTM AS I'M ASTM AS'lM ASTM ASTM TABLE ll Property Typical Test Method Distillation, evap, "F at 760 mm ASTM D-R DP 343 API Gravity at 60F 58.7 ASTM D487 Specific Gravity, fvtlfbtPF 0.744 ASTM D-l298 20MC 0.740 Wcstphal Balance Density at 60F, lb/gul 619 ASTM D-l 250 Flash Point, TCT, Fv I ASTM D-56 Color Sayholt +30 ASTM D-l56 Corrosion. Copper Strip, 3 hrs at 2l2F l ASTM D-l30 Acidity of Distillation Residue neutral ASTM D4093 Aniline Point, "F 179 ASTM D-l0l2 Next. 18 parts by weight by trichloroethane and 2 parts by weight of silicone fluid (a silicone fluid sold under the trademark of DC 200, by Dow-Corning and having from to I00 centistokes viscosity) was added to the 80 parts by weight of the liquid aliphatic hydrocarbons to form the medical solvent composition of the subject invention.
This medical solvent composition was used to remove a medical adhesive (a silicone resin medical adhesive sold under the trademark of MEDICAL ADHE- SlVE B" by Dow-Corning Medical Products Division). The medical adhesive was used in attaching to a human male a prosthetic device for the handling of urinary incontinence. This prosthetic device basically comprised a knit sheath impreganted with silicone rubher and is fully disclosed in my copending patent application Ser. No. 008,819, filed Feb. 5, 197]. The solvent was used to remove the device numerous times over a period of several months. In each instance, the solvent composition was applied during the removal operation and thereafter the skin area which was contacted by the solvent composition was washed with mild soap and water and the solvent residue containing the dissolved adhesive was flushed away. A layer of silicone fluid remained on the skin. When it was desired to reapply the prosthetic device, the silicone resin medical adhesive was applied over the skin which carried the silicone fluid coating, and the prosthetic device then applied thereto. During this several months period, no skin irritation whatsoever was observed and furthermore, the silicone resin adhesive was found to very effectively adhere to the treated area in an improved manner than when conventional solvents such as V.M. & P. naphthas are used to remove the medical adhesive.
While this invention has been described in relation to its preferred embodiments, it is to be understood that various modifications will be apparent to one skilled in the art from a reading of this specification, and it is intended to cover such modifications as fall within the scope of the appended claims.
I claim:
1. A skin conditioning medical adhesive solvent and skin preparation composition which consists essentially of:
a. about 2 to about l0 weight percent of liquid or ganosiloxane polymer effective to replace body fats and oils leached from the skin by solvent action;
b. about 5 to about 25 weight percent of a halogenated lower alkyl hydrocarbon flashpoint suppressant selected from the group consisting of trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, and mixtures thereof; and
c. the balance of said composition which consists essentially of a solvent of from about 30 to about weight percent ofa mixture of C C aliphatic hydrocarbons and from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons;
said solvent not imparting deleterious results to the skin, said composition forming a more efficient seal with silicone resin medical adhesive between the skin and a prosthetic device or appliance upon reapplication thereof.
2. The composition of claim 1 wherein said flashpoint suppressant is trichloroethane.
3. The composition of claim 1 wherein said flashpoint suppressant is trichlorotrifluoroethane.
4. A medical adhesive solvent and skin preparation composition which consists essentially of parts by weight of a solvent constituent which includes a liquid aliphatic hydrocarbon fraction which consists essentially of from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons and from about 30 to about 70 weight percent of a mixture of C C aliphatic hydrocarbons, 18 parts by weight of a halogenated lower alkyl hydrocarbon selected from the group consisting of trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, and mixtures thereof; and 2 parts by weight of a liquid organosiloxane polymer.
Claims (3)
- 2. The composition of claim 1 wherein said flashpoint suppressant is trichloroethane.
- 3. The composition of claim 1 wherein said flashpoint suppressant is trichlorotrifluoroethane.
- 4. A medical adhesive solvent and skin preparation composition which consists essentially of 80 parts by weight of a solvent constituent which includes a liquid aliphatic hydrocarbon fraction which consists essentially of from about 30 to about 70 weight percent of a mixture of C8 - C9 aliphatic hydrocarbons and from about 30 to about 70 weight percent of a mixture of C10 -C11 aliphatic hydrocarbons; 18 parts by weight of a halogenated lower alkyl hydrocarbon selected from the group consisting of trichloroethane, tetrachlorodifluoroethane, trichloromonofluoromethane, trichlorotrifluoroethane, and mixtures thereof; and 2 parts by weight of a liquid organosiloxane polymer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16349871A | 1971-07-16 | 1971-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3789118A true US3789118A (en) | 1974-01-29 |
Family
ID=22590267
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00163498A Expired - Lifetime US3789118A (en) | 1971-07-16 | 1971-07-16 | Medical adhesive solvent composition |
Country Status (1)
Country | Link |
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US (1) | US3789118A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996153A (en) * | 1973-05-26 | 1976-12-07 | Hans Schwarzkopf Gmbh | Aerosol propellant |
US4306989A (en) * | 1979-10-09 | 1981-12-22 | Lift-Off, Inc. | Composition for releasing adhesives from a surface |
US4324595A (en) * | 1979-08-31 | 1982-04-13 | Dow Corning Corporation | Method for removing tacky adhesives and articles adhered therewith |
US5190595A (en) * | 1991-09-03 | 1993-03-02 | International Business Machines Corporation | Ozone safe stripping solution for thermal grease |
WO1997020910A1 (en) * | 1995-12-07 | 1997-06-12 | Draxis Health Inc. | Gypsum removal composition and method of removing gypsum from skin |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2681878A (en) * | 1951-09-04 | 1954-06-22 | Dow Corning | Insect repellent compositions |
US2727846A (en) * | 1951-08-22 | 1955-12-20 | Silicote Corp | Siloxane-containing dressing |
US3298919A (en) * | 1962-12-26 | 1967-01-17 | Dow Corning | Shaving cream containing polysiloxanes |
US3470292A (en) * | 1965-06-01 | 1969-09-30 | Colgate Palmolive Co | Film-forming composition containing a phosphatide and a siloxane |
-
1971
- 1971-07-16 US US00163498A patent/US3789118A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2727846A (en) * | 1951-08-22 | 1955-12-20 | Silicote Corp | Siloxane-containing dressing |
US2681878A (en) * | 1951-09-04 | 1954-06-22 | Dow Corning | Insect repellent compositions |
US3298919A (en) * | 1962-12-26 | 1967-01-17 | Dow Corning | Shaving cream containing polysiloxanes |
US3470292A (en) * | 1965-06-01 | 1969-09-30 | Colgate Palmolive Co | Film-forming composition containing a phosphatide and a siloxane |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996153A (en) * | 1973-05-26 | 1976-12-07 | Hans Schwarzkopf Gmbh | Aerosol propellant |
US4324595A (en) * | 1979-08-31 | 1982-04-13 | Dow Corning Corporation | Method for removing tacky adhesives and articles adhered therewith |
US4306989A (en) * | 1979-10-09 | 1981-12-22 | Lift-Off, Inc. | Composition for releasing adhesives from a surface |
US5190595A (en) * | 1991-09-03 | 1993-03-02 | International Business Machines Corporation | Ozone safe stripping solution for thermal grease |
WO1997020910A1 (en) * | 1995-12-07 | 1997-06-12 | Draxis Health Inc. | Gypsum removal composition and method of removing gypsum from skin |
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