DE60017287D1 - Spezifische anonisten für peripherische cannabinoid-rezeptoren - Google Patents

Spezifische anonisten für peripherische cannabinoid-rezeptoren

Info

Publication number
DE60017287D1
DE60017287D1 DE60017287T DE60017287T DE60017287D1 DE 60017287 D1 DE60017287 D1 DE 60017287D1 DE 60017287 T DE60017287 T DE 60017287T DE 60017287 T DE60017287 T DE 60017287T DE 60017287 D1 DE60017287 D1 DE 60017287D1
Authority
DE
Germany
Prior art keywords
specific
compounds
activity
cannabinoid receptors
peripheral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017287T
Other languages
English (en)
Other versions
DE60017287T2 (de
Inventor
Ester Fride
Aviva Breuer
Lumir Hanus
Susanna Tchilibon
Michal Horowitz
Raphael Mechoulam
Aaron Garzon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of DE60017287D1 publication Critical patent/DE60017287D1/de
Application granted granted Critical
Publication of DE60017287T2 publication Critical patent/DE60017287T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DE60017287T 1999-10-31 2000-10-30 Spezifische Agonisten für periphere Cannabinoid-Rezeptoren Expired - Lifetime DE60017287T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL13266199 1999-10-31
IL132661A IL132661A (en) 1999-10-31 1999-10-31 Agonists specific for peripheral cannabinoid receptors
PCT/US2000/029903 WO2001032169A1 (en) 1999-10-31 2000-10-30 Agonists specific for the peripheral cannabinoid receptor

Publications (2)

Publication Number Publication Date
DE60017287D1 true DE60017287D1 (de) 2005-02-10
DE60017287T2 DE60017287T2 (de) 2005-12-08

Family

ID=11073405

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017287T Expired - Lifetime DE60017287T2 (de) 1999-10-31 2000-10-30 Spezifische Agonisten für periphere Cannabinoid-Rezeptoren

Country Status (13)

Country Link
US (3) US6864291B1 (de)
EP (1) EP1244440B1 (de)
JP (1) JP4231906B2 (de)
KR (1) KR100770695B1 (de)
AT (1) ATE286389T1 (de)
AU (1) AU778149B2 (de)
CA (1) CA2385928A1 (de)
DE (1) DE60017287T2 (de)
HU (1) HUP0203681A3 (de)
IL (2) IL132661A (de)
NZ (1) NZ518054A (de)
WO (1) WO2001032169A1 (de)
ZA (1) ZA200202181B (de)

Families Citing this family (45)

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US6342611B1 (en) * 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
WO1999057106A1 (en) 1998-05-04 1999-11-11 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US6995187B1 (en) 1999-10-18 2006-02-07 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
IL132661A (en) * 1999-10-31 2008-11-26 Raphael Mechoulam Agonists specific for peripheral cannabinoid receptors
EP1361876A4 (de) * 2001-01-26 2004-03-31 Univ Connecticut Neue cannabimimetische liganden
US7173027B2 (en) * 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
EP1414775B1 (de) * 2001-07-13 2012-12-19 The University of Connecticut Bicyclisches cannabinoid
CN1589269A (zh) 2001-10-26 2005-03-02 康涅狄格大学 杂1,2－二氢化茚:一类新型有效的大麻配体
TW200407110A (en) * 2001-11-23 2004-05-16 Astrazeneca Ab New use for the treatment of gastroesophageal reflux disease
WO2003061699A1 (fr) * 2001-12-27 2003-07-31 Japan Tobacco, Inc. Remedes pour affections allergiques
IL150302A (en) * 2002-01-31 2008-07-08 Naim Menashe Bicyclic cb2 cannabinoid receptor ligands
JP2005523259A (ja) * 2002-01-31 2005-08-04 ファーモス コーポレイション 二環式ｃｂ２カンナビノイド受容体リガンド
WO2004017922A2 (en) 2002-08-23 2004-03-04 University Of Connecticut Keto cannabinoids with therapeutic indications
WO2004078261A1 (en) * 2003-03-07 2004-09-16 The University Court Of The University Of Aberdeen Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
TW200505902A (en) * 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
AU2004249669B2 (en) * 2003-05-20 2008-05-22 The University Of Tennessee Research Foundation Cannabinoid derivatives, methods of making, and use thereof
EP1758566A2 (de) * 2004-06-22 2007-03-07 Pharmos Limited Verwendung von agonisten des cb-2-rezeptors zur behandlung von chorea huntington
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US20070060638A1 (en) * 2005-08-26 2007-03-15 Olmstead Mary C Methods and therapies for potentiating therapeutic activities of a cannabinoid receptor agonist via administration of a cannabinoid receptor antagonist
US7763607B2 (en) 2006-04-27 2010-07-27 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators
MX2008013678A (es) * 2006-04-27 2008-11-04 Solvay Pharm Gmbh Compuestos farmaceuticos que comprenden moduladores de receptores de canabinoide cbx y moduladores de canal de potasio.
WO2008001369A1 (en) * 2006-06-27 2008-01-03 Pharmos Corporation Use of cb2 receptor agonists for promoting neurogenesis
US9763894B2 (en) * 2006-12-05 2017-09-19 Virginia Commonwealth University Inflammation therapy
GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
WO2008107879A1 (en) * 2007-03-05 2008-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Novel cannabidiol derivatives and their use as anti-inflammatory agents
JP2010540618A (ja) 2007-10-02 2010-12-24 アリエル−ユニバーシティー リサーチ アンド デベロップメント カンパニー リミテッド 幼児の成長および発達を増大するための内在性カンナビノイド
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
WO2010041253A1 (en) 2008-10-06 2010-04-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Compositions comprising cb receptor agonists, uses thereof and methods for their preparation
WO2011009883A1 (en) 2009-07-23 2011-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Selective cb2 receptor agonists for use in the prevention or treatment of alcoholic liver disease
ITMI20122221A1 (it) 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende
WO2014170902A1 (en) 2013-04-17 2014-10-23 Ariel - University Research And Development Company, Ltd. Cb2 receptor ligands for the treatment of psychiatric disorders
EP2992880A1 (de) * 2014-09-04 2016-03-09 Fundació Institut de Recerca de l'Hospital de la Santa Creu l Sant Pau Verwendung von Hämoxygenase-1-Induktoren und Cannabinoid-2-Rezeptor oder Delta-Opiod-Rezeptoragonisten bei Entzündungsschmerz
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
EP3664795A4 (de) 2017-08-09 2021-04-28 Cannibite BVBA Cannabis und derivate davon zur behandlung von schmerzen und entzündungen im zusammenhang mit zahnmark und knochenregeneration im zusammenhang mit kieferknochendefekten
EP3836894A1 (de) * 2019-10-25 2021-06-23 Gelest Technologies, Inc. Auf silizium basierende cannabiolderivate und zusammensetzungen davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL55274A (en) 1978-08-02 1982-08-31 Yissum Res Dev Co 4-(2,6-dihydroxy-4-(dimethylheptyl)phenyl)substituted 2-pinen-10-ol and pinane derivatives,their preparation and pharmaceutical compositions comprising them
US5434295A (en) 1994-02-07 1995-07-18 Yissum Research Development Company Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds
FR2735774B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
IL132661A (en) * 1999-10-31 2008-11-26 Raphael Mechoulam Agonists specific for peripheral cannabinoid receptors

Also Published As

Publication number Publication date
WO2001032169A1 (en) 2001-05-10
IL148796A (en) 2008-11-26
AU1245801A (en) 2001-05-14
NZ518054A (en) 2003-10-31
US20020173528A1 (en) 2002-11-21
EP1244440A4 (de) 2003-05-14
US7214716B2 (en) 2007-05-08
US6903137B2 (en) 2005-06-07
KR20030008208A (ko) 2003-01-24
EP1244440A1 (de) 2002-10-02
JP2004505006A (ja) 2004-02-19
HUP0203681A2 (hu) 2003-04-28
HUP0203681A3 (en) 2003-05-28
IL132661A0 (en) 2001-03-19
EP1244440B1 (de) 2005-01-05
JP4231906B2 (ja) 2009-03-04
ATE286389T1 (de) 2005-01-15
ZA200202181B (en) 2003-05-28
AU778149B2 (en) 2004-11-18
US20050165118A1 (en) 2005-07-28
US6864291B1 (en) 2005-03-08
KR100770695B1 (ko) 2007-10-29
IL132661A (en) 2008-11-26
CA2385928A1 (en) 2001-05-10
DE60017287T2 (de) 2005-12-08

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Legal Events

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8364 No opposition during term of opposition