DE19849514A1 - Sun protection agent contains coco glyceride, isoamyl p-methoxycinnamate, 3-benzophenone, phenyl benzimidazole sulfonic acid, micronized ambiphilic titanium dioxide, tromethamine and water - Google Patents

Abstract

Sun protection agent consists of 5-10 wt. % coco glyceride, 3-6 wt. % isoamyl p-methoxycinnamate, 1-4 wt. % 3-benzophenone, 1-4 wt. % phenyl benzimidazole sulfonic acid, 2-8 wt. % micronized, ambiphilic titanium dioxide with low photocatalytic activity and 0.5-3 wt. % tromethamine, rest additives and water.

Description

The invention relates to a sunscreen. The fundamental problem is increasing stronger solar radiation on the earth's surface due to various influences and the result is an increased exposure to UVA and UVB radiation in general known. In this context, recognized dermatologists worldwide postu that protection against the two UV radiation spectra also entails the risk of acquisition malignant skin disease, such as melanoma, is minimized. On the necessary high protection factor is practically only by the combination orga nisch-chemical achievable with microfine mineral pigments, since the use of only chemical absorbers without mineral reflecting agents so high usage concentration tion would require that the risk of allergic and sensitizing effects ex increased proportionally. It should also be borne in mind that, according to recent studies, the resorp systemic stress on the body that should not be neglected conditional on the protective substances; here too the effect increases with increasing substance concentration very strongly.

A wide variety of recipe components for the formation of suns are available on the market protection means offered. The formulation components concern waxes, fats, oils, on the other hand moisturizer, also UV filter and reflecting agent, as well as emulsifier Ren, skin care substances, perfume oils and preservatives.

The invention has for its object to design a sunscreen in such a way that Achieved high UVA and UVB protection in a cost-effective and skin-friendly manner becomes.

This object is achieved by a sunscreen with the features of Claim 1 solved.

The advantages of the invention are that, despite dermatological safety and a low sun protection factor is achieved at low cost. Cocoglycerides is a knockout Kosölderivat, which has a rather slow to medium spreading ability. It owns  the property, the UV filter complex made of benzophe used to an outstanding degree to solubilize none-3 and isoamyl p-methoxycinnamate, so that compared to an their oils in addition to the higher galenic stability with decreasing tendency to crystallize also larger sun protection factors of the overall preparation with otherwise the same filter achieved in an emulsion, Cocoglycerides is an extremely finely divided fat with a small fat content Drop size and high degree of dispersion; this circumstance also supports galenically the high filter presentation on the skin and thus increases the light protection effect of the accessories riding. Isoamyl p-methoxycinnamate has good UVB protection. It also represents Isoamyl p-methoxycinnamate is an excellent solvent for the Benzophe UV filter none-3. Benzophenone-3 has both UVA and UVB protective properties. Although benzophenone-3 is not problematic galenically, since this substance in water is insoluble and at least sparingly soluble in most lipids, solubilization succeeds tion with the aforementioned components cocoglycerides and isoamyl p-methoxycinna mate as stated earlier. To the through a filter substance dissolved in the water phase Phenylbenzimidazole Sul will improve the sun protection effect of the overall preparation fonic acid used Phenylbenzimidazole sulfonic acid is a water-insoluble acid represents, which is converted with tromethamine in their salt and thus in the water-soluble form. At the same time, tromethamine has a buffering effect and can therefore be long Ensure better maintenance of the neutral pH without the formulation as a precautionary measure, it would have to be adjusted to unphysiological, ie alkaline areas to prevent the association and thus recrystallization of the sulfonic acid. In progress tromethamine has the advantage of a short production time of the water phase se, since no gaseous reaction products are formed.

To reduce the concentration of chemical UV filter substances and at the same time as the more important for the protective effect of the overall preparation seen UVA protection, a titanium oxide is used as a reflection agent, the blended or coated with simethicone and aluminum oxide. This refinement Components cause an ambiphibie of the pigment, so that a dispersion in water and oil is equally possible.  

This optimal wettability reduces the tendency to whiteness in a water-in-oil emulsion, which is already comparatively low due to the micronization. The photocatalytic The activity of the pigment used is low.

In summary, it works through the synergism of the four filter substances, at niedi substance concentrations and thus lower resorptive load on the user, maintain a high degree of protection in the entire UVA and UVB spectral range; the kos metallic product properties are nevertheless very good and there is no whitening.

According to one embodiment of the invention, the emulsifier system is based on two dodecyl Glycol copolymers, one as a real emulsifier, the other as an emulsion stabilizer and co-emulsifier. Both dodecyl glycol copolymers belong to the group of the polyalkylene glycols and are water-in-oil emulsifiers or stabilizers of such Emulsions. The water-in-oil emulsion obtained favors in contrast to an oil in water emulsion the whiteness of the cream does not come into contact with water because suppressed by the reduced wettability of the pigment with water Water-in-oil preparation easier to formulate permanently waterproof. By the received Hydrophobicity reduces the wash off of the formulation and the skin adhesion elevated. This also means that there is less need for repeat application Exposure to water and sweat.

According to a further embodiment of the invention, there is provision regarding the fat phase oleyl erucate, dicaprylyl ether and cyclomethicone to use. With the pre called components you achieve that the fat phase slow, medium and fast-spreading oils. This blend creates a long lasting, from the start noticeable feeling of smoothness. With an unbalanced composition of the fat phase, the Preparation leaves a greasy, sticky or non-nourishing impression that has a negative impact on compliance Oleyl Erucate provides a synthetic jojoba wax and has a slow spreading ability. Nevertheless, it is quickly absorbed very affinity for the skin and leaves a high impression of care. Dicaprylyl ether is a quick spreading ether and classified as a so-called dry oil. The viscosity is water  same and it leaves no noticeable fat film on the skin. Cyclomethicone shows similar surface sensory properties such as dicaprylyl ether. It leaves no feeling of fat the skin and serves to increase the water resistance of the overall preparation.

An embodiment of the invention is described in more detail below.

Composition of a sunscreen, whereby the weight percentages given may be slightly below or exceeded:
8.0% by weight cocoglycerides,
6.0 percent by weight oleyl erucate,
4.0 weight percent dicaprylyl ether,
3.0 weight percent hydrogenated castor oil,
2.0 percent by weight of methyl palmitate,
1.0% by weight cyclomethicone,
3.0 weight percent glycerols,
4.0 weight percent isoamyl p-methoxycinnamate,
2.0 percent by weight benzophenone-3,
2.0 percent by weight of phenylbenzimidazole sulfonic acid,
4.0% by weight of titanium dioxide with alumina and with Simethicone as a solid mixed product or blend,
3.0 weight percent PEG 45- / dodecyl glycol copolymer,
3.0 weight percent methoxy PEG-22 / dodecyl glycol copolymer,
0.2% by weight of allantoin,
1.0% by weight of tromethamine,
0.2% by weight of perfume,
0.5 weight percent phenoxyethanol,
Rest of water.

The above sunscreen can be made as follows:
The production process is described for a batch of approx. 100-130 kg of finished product in a FRYMA® ointment machine with a heatable kettle and a paddle stirrer with a scraper and a gap homogenizer.

• 1. The pre-weighed substances of the fat phase are raised together to approx. 80 ° C melted and heated (Cocoglycerides, Oleyl Erucate, Dicaprylyl Ether, Hydrogenated Castor Oil, Cetyl Palmitate, Cyclomethicone, both Dodecyl Glycol Copolymers).
• 2. Benzophenone-3 and isoamyl p-methoxycinnamate are added to the clear melt, short phase homogenization.
• 3. Apply a vacuum to the kettle, activate the stirrer and homogenizer. Suck in the titanium oxide compound powder while stirring / homogenizing at the same time moderate dispersion.  
• 4. Establish the water phase in a second boiler. Aqua, glycerol, allantoin, Phenylbenzimidazole Sulfonic Acid, Tromethamine are combined until total clarity of the solution stirred; may need more tromethamines for neutralization be added to the sulfonic acid.
• 5. The approx. 75-80 ° C warm water phase is analog 3. in the boiler to the fat phase sucks; Stirrer and homogenizer remain activated at the highest level until the entire Water phase is incorporated and then 2 min.
• 6. Active cooling of the batch to room temperature (homogenizer off (only switched on at the highest level if phenoxyethanol and perfume are sucked in at approx. 40 ° C [analogous to 3. via addition funnel]).
  Stirrer at slow speed, same as scraper, during the entire cooling process.
• 7. Filling into tubes, the closure (threaded piece and closure cap) is not sufficient Metal exists because of the pigment content of sanding and abrasion effects Tube metal appear when opening and closing the tube (black abrasion in the ge winch).

In summary, the aforementioned sunscreen has the following properties:

• - Machine capability is guaranteed with the above recipe.
• - A sunscreen manufactured according to the recipe is extremely stable. The galenical stability with heat (45 ° C over 6 months) as well as with cold covering stung (10 thaw freeze cycles) by the emulsifier complex (dodecylglycol copolymers + glycerol and cetyl palmitate as stabilizers or co-emulsifiers), the solubilization and prevention of recrystallization of benzophenone-3 garan the synergism of cocoglycerides and isoamyl p-methoxycinnamate. The Mikroni sation and ambiphibia effectively prevent pigment sedimentation. The pigmen te or filter substances are photocatalytically practically inactive and to a high degree pho tolysis stable.
• - The sunscreen fulfills the sensory requirements such as pleasant application and easy to remove from the tube, even at low temperatures and on wet Skin without sticking or creating a visible whitening effect. This will be in the front recipe due to the emulsion type, the high content of dissolved substances in the water phase and the addition of glycerin. The preparation is therefore in the Universally applicable in both winter and summer.
• - The preparation is due to the type of emulsion and the addition of cyclomethicone (here a short chain) defies a water content of <50% absolutely water and sweatproof
• - The recipe comes largely without the known potential allergens and without Petroleum products such as petroleum jelly etc.  
• - The factor combination works perfectly with each other and with the fat phase synergistic, so that UVA and UVB protection with a protection factor of more than 20 is achieved at very low filter substance concentrations.
• - The cream is due to its application properties such as high spreading tendency and good distribution Availability economical in order and therefore very economical.
• - The production proves to be inexpensive, since both the otherwise not unproblematic pigment to be processed matically without producing a predispersion di can be added directly to the batch, on the other hand the water phase by simple Mixture of components can be produced.

The individual components of the aforementioned recipe are defined according to the INCI nomenclature. With regard to the feasibility of the invention, particularly good results are achieved with the following products available on the market in order to produce the aforementioned sunscreen:

• - "MYRITOL 331®" from Henkel-Cospha was used as cocoglycerides.
• - "CETIOL J 600®" from Henkel-Cospha is suitable as the oleyl erucate.
• - "BELSIL CM 040®" from Wacker-Chemie is suitable as cyclomethicone.
• - "EUSOLEX T-2000®" was the Titanium Dioxide / Alumina / Simethicone blend Merck used.
• - As PEG 45- / Dodecyl Glycol Copolymer "ELFACOS ST 9®" is particularly suitable as Methoxy PEG-22 / dodecyl glycol copolymer "ELFACOS E 200®, both from AKZO.

Claims (3)

1. Sunscreen consisting of:

• - 5-10% by weight cocoglycerides,
• 3-6% by weight of isoamyl p-methoxycinnamate,
• 1-4 percent by weight of benzophenone-3,
• 1-4% by weight of phenylbenzimidazole sulfonic acid,
• - 2-8% by weight micronized, ambiphilic titanium dioxide with low photocatalytic activity
• 0.5-3% by weight of tromethamine,
• - rest of additives and water.

2. Sunscreen according to claim 1, with the following additives:

• - 2-5% by weight PEG 45- / dodecyl glycol copolymer,
• - 2-5% by weight methoxy PEG 22 / dodecyl glycol copolymer.

3. Sunscreen according to claim 1 or 2, with the following additives:

• 4-8% by weight oleyl erucate,
• - 2-8 weight percent dicaprylyl ether,
• - 0.5-5 weight percent cyclomethicone.