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Publication numberCN1353601 A
Publication typeApplication
Application numberCN 00808517
PCT numberPCT/US2000/011829
Publication date12 Jun 2002
Filing date2 May 2000
Priority date3 May 1999
Also published asCA2370939A1, CA2370939C, CN100344276C, DE60013804D1, DE60013804T2, DE60013804T3, EP1175202A1, EP1175202B1, EP1175202B3, US6451300, WO2000066081A1
Publication number00808517.X, CN 00808517, CN 1353601 A, CN 1353601A, CN-A-1353601, CN00808517, CN00808517.X, CN1353601 A, CN1353601A, PCT/2000/11829, PCT/US/0/011829, PCT/US/0/11829, PCT/US/2000/011829, PCT/US/2000/11829, PCT/US0/011829, PCT/US0/11829, PCT/US0011829, PCT/US011829, PCT/US2000/011829, PCT/US2000/11829, PCT/US2000011829, PCT/US200011829
Inventors戴维S邓洛普, 苏珊M古斯基, 维森特E利巴, 道格拉斯A罗伊斯
Applicant宝洁公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
Anti-dandruff and conditioning shampoos containing polyalkylene glycols and cationic polymers
CN 1353601 A
Abstract  translated from Chinese
本发明公开了提供出众的组合的去头屑功效和调理作用的香波组合物,而且本发明还提供了一种清洁和调理头发的方法,包括在头发和头皮上施用有效量的所述组合物。 The present invention discloses a combination provides superior anti-dandruff efficacy and conditioning shampoo compositions, but the present invention further provides a method for cleaning and conditioning hair, comprising administering an effective amount of the composition on the hair and scalp . 该去头屑和调理香波包括:(A)占组合物重量约5%至约50%的阴离子表面活性剂;(B)占组合物重量约0.01%至约10%的非挥发性调理剂;(C)占组合物重量约0.1%至约4%的去头屑颗粒;(D)占组合物重量约0.02%至约5%的至少一种阳离子聚合物;(E)占组合物重量约0.005%至约1.5%的满足式:H(OCH Go dandruff and conditioning shampoo comprising: (A) of the composition by weight of about 5% to about 50% of an anionic surfactant; (B) of the composition by weight of about 0.01% to about 10% of non-volatile conditioning agent; (C) of the composition by weight of about 0.1% to about 4% of dandruff particles; (D) of the composition by weight of about 0.02% to about 5% of at least one cationic polymer; (E) of the composition by weight of approximately 0.005% to about 1.5% satisfy the following formula: H (OCH
Claims(12)  translated from Chinese
1.一种香波组合物,特征在于其包括:a)占组合物重量5%至50%的阴离子表面活性剂;b)占组合物重量0.01%至10%的非挥发性调理剂;c)占组合物重量0.1%至4%的去头屑颗粒;d)占组合物重量0.02%至5%的至少一种阳离子聚合物;e)占组合物重量0.005%至1.5%的满足下式的聚亚烷基二醇: 1. A shampoo composition characterized in that it comprises: a) of the composition by weight of 5-50% of an anionic surfactant; b) of the composition by weight of 0.01 to 10% of non-volatile conditioning agent; c) of the composition by weight of 0.1 to 4% of anti-dandruff particulate; d) accounting for 0.02 to 5% by weight of the composition of at least one cationic polymer; e) of the composition by weight of from 0.005 to 1.5% to satisfy the following formula polyalkylene glycols: (i)其中R选自氢、甲基以及它们的混合物,(ii)其中n是平均值为1500至120000的整数;和f)水。 (I) wherein R is selected from hydrogen, methyl and mixtures thereof, (ii) where n is an integer of an average value of from 1,500 to 120,000; and f) water.
2.根据权利要求1的香波组合物,其中所述至少一种阳离子聚合物选自瓜尔衍生物,优选是瓜尔羟丙基三甲基氯化铵;纤维素衍生物,优选Polyquaternium-10;以及它们的混合物。 2. The shampoo composition according to claim 1, wherein said at least one cationic polymer selected from guar derivatives, preferably guar hydroxypropyltrimonium chloride; cellulose derivatives, preferably Polyquaternium-10 ; and mixtures thereof.
3.根据前述任一项权利要求的香波组合物,其特征在于该组合物包括占组合物重量0.1%至1%的所述至少一种阳离子聚合物。 3. The shampoo composition according to any one of the preceding claims, characterized in that the composition comprises from 0.1 to 1% by weight of the composition of at least one cationic polymer.
4.根据前述任一项权利要求的香波组合物,其中所述瓜尔衍生物的分子量为50000至700000,电荷密度为0.05meq/g至0.9meq/g;并且所述纤维素衍生物的分子量为200000至1500000,优选350000至500000,电荷密度为0.2meq/g至0.6meq/g。 4. A shampoo composition according to any one of the preceding claims, wherein the molecular weight of the guar derivative is from 50,000 to 700,000, a charge density of 0.05meq / g to 0.9meq / g; and the molecular weight of the cellulose derivative of 200,000 to 1,500,000, preferably from 350,000 to 500,000, a charge density of 0.2meq / g to 0.6meq / g.
5.根据前述任一项权利要求的香波组合物,其中所述非挥发性的调理剂是分散的聚硅氧烷。 5. A shampoo composition according to any preceding claim, wherein said non-volatile conditioning agent is dispersed silicone.
6.根据前述任一项权利要求的香波组合物,其中所述聚亚烷基二醇的平均值n为1500至50000,优选3500至15000。 6. A shampoo composition according to any preceding claim, wherein the polyalkylene glycol is the average value of n from 1,500 to 50,000, preferably 3,500 to 15,000.
7.根据前述任一项权利要求的香波组合物,其中所述去头屑颗粒是1-羟基-2-吡啶硫酮的锌盐,并且优选其中所述1-羟基-2-吡啶硫酮的锌盐为小片状颗粒形式。 7. A shampoo composition according to any preceding claim, wherein said anti-dandruff particulate is 1-hydroxy-2-pyridinethione is zinc, and preferably wherein said 1-hydroxy-2-pyridinethione small plate-like particles in the form of zinc salts.
8.根据前述任一项权利要求的香波组合物,其中所述组合物还包括占组合物重量0.1%至10%的悬浮剂,并且优选其中所述悬浮剂是乙二醇二硬脂酸酯。 8. A shampoo composition according to any preceding claim, wherein said composition further comprises of the composition by weight of 0.1 to 10% of a suspending agent, and preferably wherein said suspending agent is ethylene glycol distearate .
9.一种香波组合物,其特征在于其包括:a)占组合物重量10%至25%的阴离子表面活性剂;b)占组合物重量0.01%至10%的不溶的非挥发性聚硅氧烷调理剂;c)占组合物重量0.3%至2%的1-羟基-2-吡啶硫酮的锌盐;d)占组合物重量0.1%至0.1%的至少一种阳离子聚合物,选自瓜尔衍生物、纤维素衍生物以及它们的混合物;e)占组合物重量0.025%至1.5%的满足下式的聚亚烷基二醇: A shampoo composition characterized in that it comprises: a) of the composition by weight of 10-25% of anionic surfactant; b) of the composition by weight of 0.01 to 10% of insoluble non-volatile silicone poly oxyalkylene conditioning agent; c) accounting for from 0.3 to 2% of the composition by weight of 1-hydroxy-2-pyridinethione zinc salt; d) of the composition from 0.1 to 0.1% by weight of at least one cationic polymer selected Since guar derivatives, cellulose derivatives and mixtures thereof; e) of the composition by weight of from 0.025 to 1.5% to satisfy the following formula polyalkylene glycol: (i)其中R选自氢、甲基以及它们的混合物,(ii)其中n是平均值为3500至15000的整数;和f)水。 (I) wherein R is selected from hydrogen, methyl and mixtures thereof, (ii) where n is an integer of an average value of from 3,500 to 15,000; and f) water.
10.提供去头屑功效和调理头发的方法,其特征在于其包括:a)用水润湿所述头发;b)在所述头发上施用有效量的根据前述任一项权利要求的香波组合物;c)用水从所述头发上漂洗所述香波组合物。 10. To provide anti-dandruff efficacy and conditioning hair, characterized in that it comprises: a) wetting the hair with water; b) administering an effective amount of a shampoo composition according to any preceding claim on the hair ; c) water rinsing said shampoo composition from said hair.
11.根据前述任一项权利要求的香波组合物,其特征还在于其包括0.001%至15%的头发生长调节剂,选自:羧酸的锌盐、皂草甙、三萜、石竹素、乌索酸、桦木酸、桦木酮酸、山楂酸、南蛇藤醇、亚细亚酸、5-α-还原酶的抑制剂、孕甾酮、1,4-甲基-4-氮杂甾族化合物、17-β-N,N-二乙基氨基甲酰基-4-甲基-4-氮杂-5-α-雄甾烷-3-酮、雄激素受体拮抗剂、醋酸环丙孕酮、长压定、壬二酸及其衍生物、环孢菌素、三碘甲状腺原氨酸、氯甲苯噻嗪、钾通道开启剂、cromakalin、苯妥英、酮康唑、芬甾酮、dutasteride、煤焦油、葡糖酸锌、糖皮质激素、大环内酯类、aminexil以及它们的混合物。 11. A shampoo composition according to any preceding claim, further characterized in that it comprises from 0.001 to 15% of the hair growth regulating agent selected from: zinc salts of carboxylic acids, saponins, triterpenes, oleanolic acid, ursolic acid, betulinic acid, acid birch, hawthorn acid, Celastrus alcohol, Asia acid, 5-α- reductase inhibitors, progesterone, 1,4-dimethyl-4-aza-steroids , 17-β-N, N- diethyl-carbamoyl-4-methyl-4-aza -5-α- androstan-3-one, androgen receptor antagonists, cyproterone acetate , minoxidil, azelaic acid and its derivatives, cyclosporine, three triiodothyronine, xylazine chlorine, potassium channel opener, cromakalin, phenytoin, ketoconazole, Finland steroid ketones, dutasteride, coal tar, zinc gluconate, glucocorticoids, macrolides, aminexil, and mixtures thereof.
12.一种调节头发生长的方法,其特征在于其包括:a)用水润湿所述头发;b)在所述头发上施用有效量的根据前述任一项权利要求的香波组合物;c)用水从所述头发上漂洗所述香波组合物。 12. A method of regulating hair growth, characterized in that it comprises: a) wetting the hair with water; b) on the hair an effective amount of the shampoo composition according to any preceding claim; c) rinsing the hair with water from the shampoo composition.
Description  translated from Chinese
包含聚亚烷基二醇和阳离子聚合物的去头屑功效和调理作用的香波 Comprising polyalkylene glycol and a cationic polymer antidandruff efficacy and conditioning shampoos

技术领域 FIELD

本发明涉及提供出众的去头屑功效和调理作用的组合的香波组合物。 The present invention relates to shampoo compositions to provide superior anti-dandruff efficacy and conditioning combination. 这些组合物包含阴离子表面活性剂、调理剂、去头屑颗粒物、阳离子聚合物、聚亚烷基二醇和水。 These compositions contain anionic surfactants, conditioning agents, anti-dandruff particulates, cationic polymers, polyalkylene glycols and water.

发明背景包括各种去污表面活性剂和调理剂,特别是聚硅氧烷调理剂的组合的香波组合物是本领域公知的而且是能够买到的。 Background of the invention include various detersive surfactants and conditioning agents, especially shampoo compositions combination silicone conditioning agents are well known in the art and is able to buy. 已经发现这些组合物中的许多能够提供优异的清洁头发和调理头发的作用。 Have been found in many of these compositions can provide excellent hair cleansing and conditioning hair effect. 例如在一配方中加原-维生素调理剂的Pantene香波,其中包含阴离子表面活性剂、阳离子聚合物和聚硅氧烷调理剂,当施用于头发上时,带来了杰出的清洁、调理和发感益处。 For example, in a formulation plus the original - vitamin conditioning agents Pantene shampoo, which comprises an anionic surfactant, cationic polymer and silicone conditioning agents, when applied to the hair, brings excellent cleaning, conditioning and hair feel benefits.

去头屑香波也是本领域已知的,而且也可以买到。 Dandruff shampoos are also known in the art, but also can buy. 去头屑香波中通常引入了去头屑活性物质和去污表面活性剂。 Anti-dandruff shampoos typically introduced anti-dandruff active and detersive surfactants material. 其中,优选类型的去头屑剂是颗粒状的结晶去头屑剂,如硫、二硫化硒和吡啶硫酮(pyridinethione)的重金属盐。 Among them, the preferred type of anti-dandruff agents are particulate antidandruff agents crystallization, such as sulfur, selenium disulfide and pyridine thione (pyridinethione) of heavy metal salts. 可溶的去头屑剂如酮康唑也是本领域中已知的。 Soluble antidandruff agents such as ketoconazole are also known in the art.

类似地,还提供调理功效的去头屑香波也是本领域已知的。 Similarly, also provide conditioning effects of anti-dandruff shampoos is also known in the art. 例如,美国专利5624666例举并要求保护了包含阴离子表面活性剂、阳离子聚合物和吡啶硫酮锌作为去头屑剂的香波组合物。 For example, U.S. Patent No. 5,624,666 for example, and claimed comprising anionic surfactants, cationic polymers and zinc pyridinethione as an antidandruff agent, the shampoo composition. 美国专利5624666讲述了诸如聚硅氧烷流体的调理剂能够任选地引入到其中的组合物中。 U.S. Patent No. 5,624,666 describes a fluid such as a silicone conditioning agent which can optionally be incorporated into the composition. Head &ShouldersDandruff Shampoo Plus Conditioner是市售产品的一个实例,其在将香波应用到头发上时,同时提供了去头屑和调理功效。 Head & amp; ShouldersDandruff Shampoo Plus Conditioner is an example of commercially available products, which, when applied to the shampoo to the hair, while providing anti-dandruff efficacy and conditioning.

然而,一些消费者希望相对于目前市售的产品而言,有一种能提供出众的去头屑功效和调理性能组合作用的香波。 However, some consumers want products with respect to currently commercially available, there are capable of providing anti-dandruff efficacy and conditioning performance of the shampoo composition superior effect. 这样一种卓越的功效和调理性能的卓越组合是很难达到的。 Such a remarkable combination of superior efficacy and conditioning performance is difficult to achieve.

例如,原已确信杰出的去头屑功效能够通过使用一种凝聚相在头发和头皮上沉积去头屑活性物质而实现。 For example, the original has convinced prominent anti-dandruff efficacy relative deposited on the hair and scalp dandruff active substances is achieved through the use of an aggregation. 但是很可惜,使用凝聚相在头发和头皮上沉积去头屑活性物质能够对调理作用,特别是清洁的头发感觉产生不利影响。 But unfortunately, the use of condensed phase deposition on the hair and scalp dandruff active substances capable of conditioning, especially clean hair feel adversely affected. 为了达到良好的调理作用,希望能够降低去头屑剂的量,产生良好的调理作用,而不会降低最佳的去头屑功效。 In order to achieve good conditioning effect, hoping to reduce the amount of anti-dandruff agent, have a good conditioning effect, without reducing the preferred anti-dandruff effect.

但是,申请人现在发现,令人惊奇的是,去头屑活性物质的生物利用度和覆盖度对功效的预言性比活性物质在头发或头皮上沉积的预言性高得多。 However, the applicant now found, surprisingly, that the prophetic dandruff much higher bioavailability of the active substance and coverage of the efficacy of the active substance than predicted on the hair or scalp deposition. 事实上,申请人发现在许多情况下,即使在去头屑活性物质在头发和头皮上沉积得非常好的时候,也不能得到可接受的去头屑功效。 In fact, Applicant has found that in many cases, even in the anti-dandruff active material is deposited on the hair and scalp very good time, can not obtain an acceptable anti-dandruff efficacy. 相反,良好的去头屑功效能够在去头屑活性物质具有良好的覆盖度并且生物可利用度高、但是在头发或头皮上的沉积不突出的情况下实现。 Conversely, good anti-dandruff efficacy can be achieved in the case of anti-dandruff active material has good coverage and high bioavailable, but is deposited on the hair or scalp unobtrusive. 因此,为了提供相对于已知的香波组合物,提供去头屑功效和调理性能的卓越组合的香波组合物,必须满足生物利用度和覆盖度方面的某些标准,但是不是必须要具有将去头屑活性物质卓越地沉积在头发或头皮上的能力。 Therefore, in order to provide relative to known shampoo compositions, anti-dandruff shampoo compositions provide efficacy and conditioning performance superior combination, must meet certain criteria bioavailability and coverage areas, but it is not necessary to have to go antidandruff active material excellent ability deposited on the hair or scalp.

本发明的目的是提供香波组合物,该组合物具有出众的去头屑功效和调理性能的组合。 Object of the present invention is to provide a shampoo composition, the composition having a superior combination of anti-dandruff efficacy and conditioning performance. 本发明的另一个目的是提供一种清洁和调理的方法。 Another object of the present invention is to provide a method for cleaning and conditioning. 这些和其它的目的通过下文的详述而容易明白。 These and other objects detailed below and readily apparent.

发明概述本发明涉及具有提供去头屑功效和调理作用的卓越组合的香波组合物。 Summary of the Invention The present invention relates to shampoo compositions provide antidandruff efficacy and having opsonization excellent combination. 这些香波组合物包括:(A)占组合物重量约5%至约50%的阴离子表面活性剂;(B)占组合物重量约0.01%至约10%的非挥发性调理剂;(C)占组合物重量约0.1%至约4%的去头屑颗粒;(D)占组合物重量约0.02%至约5%的至少一种阳离子聚合物;以及(E)占组合物重量约0.005%至约1.5%的聚亚烷基二醇;以及(F)水。 These shampoo compositions comprise: (A) of the composition by weight of about 5% to about 50% of an anionic surfactant; (B) of the composition by weight of about 0.01% to about 10% of non-volatile conditioning agent; (C) of the composition by weight of about 0.1% to about 4% of the anti-dandruff particulate; (D) of the composition by weight of about 0.02% to about 5% of at least one cationic polymer; and (E) comprises from about 0.005% by weight of the composition to about 1.5% of the polyalkylene glycol; and (F) water. 聚亚烷基二醇满足式:H(OCH2-CHR)n-OH,其中R是氢、甲基或它们的混合物,并且n是平均值为约1500至约120000的整数。 Polyalkylene glycol satisfies the formula: H (OCH2-CHR) n-OH, wherein R is hydrogen, methyl or mixtures thereof, and n is an average value for an integer from about 1500 to about 120,000.

本发明还涉及提供去头屑功效和调理头发作用的方法,包括在头发和头皮上施用一定量的上述有效提供所述功效的组合物。 The present invention is further directed to providing anti-dandruff efficacy and conditioning hair effect, comprising administering an amount of the hair and scalp of the efficacy of the above-described effective to provide the composition.

发明详述本发明的香波组合物提供了去头屑功效和调理性能的卓越组合。 DESCRIPTION OF THE INVENTION The shampoo compositions of the present invention provide anti-dandruff efficacy and conditioning performance superior combination. 本发明的这样的去头屑和调理香波组合物能够包括基本组份、本发明中限定的内容以及任何附加或任选的组分或限定特征,或者由它们组成或基本由它们组成。 Such anti-dandruff and conditioning shampoo compositions of the present invention can comprise essential components, the present invention is defined in the description as well as any additional or optional ingredients or defining characteristics, or composed of them or substantially composed of them.

特别是,这些组合物包括阴离子表面活性剂、调理剂、去头屑颗粒、阳离子聚合物、聚亚烷基二醇和水。 In particular, these compositions comprise anionic surfactants, conditioning agents, anti-dandruff particulate, cationic polymers, polyalkylene glycols and water. 在稀释时,阴离子表面活性剂和阳离子聚合物形成凝聚相,并且所采用的聚亚烷基二醇的类型和用量将影响具有生物利用度的去头屑颗粒的用量。 Upon dilution, the anionic surfactants and cationic polymers are formed coacervate phase, and the type and amount of polyalkylene glycol employed will influence the amount of bioavailable antidandruff particles. 这对于去头屑功效和调理作用是重要的。 This is important for anti-dandruff efficacy and conditioning.

本发明香波组合物的组分,包括可任选加入的那些组分以及制备方法、使用方法在下文中进行了详细描述。 Component of the present invention shampoo compositions, including those components and production method, use may optionally be added are described in detail below.

I.组分本发明的去头屑和调理香波组合物包括阴离子表面活性剂、调理剂、去头屑物、至少一种阳离子聚合物聚亚烷基二醇和水。 Antidandruff I. components of the invention and conditioning shampoo compositions comprising anionic surfactants, conditioning agents, antidandruff substance, at least one cationic polymer is a polyalkylene glycol and water. 这些组分中的每一种都在下文中进行了详细描述。 Each of these components are described in detail below. A.阴离子表面活性剂本发明的去头屑和调理香波组合物包括占组合物重量约5%至约50%,优选约8%至约30%,更优选约10%至约25%,最优选约12%至约18%的适于应用到头发或皮肤上的阴离子去污表面活性剂组分。 Antidandruff A. anionic surfactants of the present invention and conditioning shampoo compositions comprising from about 5% to about 50% by weight of the composition, preferably from about 8% to about 30%, more preferably from about 10% to about 25%, most preferably from about 12% to about 18% of the active agent suitable for application to the hair, the anionic detersive surfactant component on the skin or. 相信该阴离子去污表面活性剂给组合物带来了清洁和起泡性能。 Believed that the anionic detersive surfactant to the composition to bring the cleaning and foaming properties. 此外,该阴离子去污表面活性剂在用水稀释时与本发明的阳离子聚合物组分(下文所述)形成了凝聚相。 Additionally, the anionic detersive surfactant upon dilution with water with the cationic polymer component of the invention (described below) is formed condensed phase. 据信该凝聚相对提供本发明所述的功效和调理作用具有重要作用。 It is believed that the relative cohesion effect and conditioning effect of the present invention to provide an important role.

阴离子去污表面活性剂组分能够包括阴离子去污表面活性剂、具有在组合物的pH值时为阴离子性的连接部分的两性离子或两性去污表面活性剂,或者它们的组合;优选阴离子去污表面活性剂。 An active agent component comprising an anionic detersive surfactant can be anionic detersive surfactants, having a pH when the composition is anionic connecting portion zwitterionic or amphoteric detersive surfactant, or combinations thereof; preferably anionic go dirt surfactant. 这些表面活性剂应与下文描述的基本成分在物理和化学性质上相容,并且应不过度损害产品的稳定性、美观或性能。 These basic ingredients surfactants described below should be in compatible with the physical and chemical properties, and should not unduly impair product stability, aesthetics or performance. 适用于本文所述香波组合物中的阴离子去污表面活性剂的实例包括但不限于:硫酸盐、磺酸盐、肌氨酸盐和肌氨酸衍生物。 Suitable for the shampoo compositions of anionic detersive surfactants herein include, but are not limited to: sulfates, sulfonates, sarcosinates and sarcosine derivatives.

1.硫酸盐优选用于本发明的去头屑和调理香波组合物中的阴离子去污表面活性剂为烷基和烷基醚硫酸盐。 1. sulphate present invention is preferably used in anti-dandruff and conditioning shampoo compositions of the anionic detersive surfactants are the alkyl and alkyl ether sulfates. 这些表面活性剂的通式分别为ROSO3M和R(C2H4O)xOSO3M,其中R为具有约8至18个碳原子的烷基或链烯基,x为1至10的整数,M为选自以下的阳离子:带正电的共价键合的部分(例如铵)、链烷醇胺(例如三乙醇胺)、一价金属(例如钠或钾)、多价金属阳离子(例如镁和钙)以及它们的混合物。 These formulas surfactants were ROSO3M and R (C2H4O) xOSO3M, wherein R is an alkyl or alkenyl group having from about 8 to about 18 carbon atoms, x is an integer of 1 to 10, M is selected from Cationic: positively charged covalently bonded portion (e.g. ammonium), alkanolamines (e.g. triethanolamine), monovalent metals (e.g. sodium or potassium), polyvalent metal cations (e.g. magnesium and calcium) and their mixture. 应选择阳离子M使得阴离子去污表面活性剂成分为水溶性的。 Cation M should be selected such that the active agent is an anionic detersive surfactant component is water soluble. 表面活性剂的溶解度取决于具体的阴离子去污表面活性剂和所选择的阳离子。 Solubility of the surfactant depends on the particular anionic detersive surfactants and cations chosen.

在烷基和烷基醚硫酸盐中,优选R具有约8至约18个碳原子,更优选含有约10至约16个碳原子,最优选约12至约14个碳原子。 In the alkyl and alkyl ether sulfates, preferably R has from about 8 to about 18 carbon atoms, more preferably from about 10 to about 16 carbon atoms, most preferably from about 12 to about 14 carbon atoms. 烷基醚硫酸盐通常是由环氧乙烷和具有约8至约24个碳原子的一元醇的缩合产物而制备的。 The preparation of alkyl ether sulfates are condensation products of ethylene oxide and generally having from about 8 to about 24 carbon atoms and monohydric alcohols. 醇可是合成的或者它们可由脂肪衍生得到,脂肪例如为椰子油、棕榈仁油和牛脂。 Alcohols but they may be synthetic or derived fat, fat, for example coconut oil, palm kernel oil and tallow. 优选由椰子油或棕榈仁油衍生得到的月桂醇和直链醇。 Preferably from coconut oil or palm kernel oil derived Lauryl alcohol and straight chain alcohols. 这些醇与0至约10,优选约2至约5,更优选约3摩尔的环氧乙烷反应。 These alcohols with 0 to about 10, preferably from about 2 to about 5, more preferably about 3 moles of ethylene oxide. 所得到的各种分子的混合物中例如具有平均3摩尔的氧化乙烯/1摩尔醇,再将这种混合物硫酸化并中和。 The resulting mixture of various molecules for example having an average of 3 moles of ethylene oxide / mole of the alcohol, then this mixture is sulfated and neutralized.

可用于本发明香波组合物中的烷基醚硫酸盐的非限定性实例包括:椰油烷基三甘醇醚硫酸的钠和铵盐、牛油烷基三甘醇醚硫酸的钠和铵盐、牛油烷基六氧乙烯硫酸的钠和铵盐。 Can be used in the shampoo compositions of the present invention are alkyl ether sulfates of non-limiting examples include: sodium coconut alkyl triethylene glycol ether sulfate, and ammonium salts, tallow alkyl triethylene glycol ether sulfate, sodium and ammonium salts of , tallow alkyl hexaoxyethylene sodium and ammonium sulfate. 优选的烷基醚硫酸盐为包括单一化合物的混合物的那些,其中混合物中的化合物的平均烷基链长为约10至约16个碳原子,并且平均乙氧基化度为约1至约4摩尔氧化乙烯。 Preferred alkyl ether sulfates comprising a mixture of individual compounds, those wherein the average alkyl chain length of the mixture of compound is from about 10 to about 16 carbon atoms, and the average degree of ethoxylation of from about 1 to about 4 moles of ethylene oxide.

优选的烷基硫酸盐的具体实例包括,但不限于:月桂基硫酸铵、椰油基硫酸铵、月桂基硫酸钾、椰油基硫酸钾、月桂基硫酸钠、椰油基硫酸钠、月桂基硫酸单乙醇胺、椰油基硫酸单乙醇胺、月桂基硫酸二乙醇胺、月桂基硫酸三乙醇胺、月桂基硫酸三乙胺以及它们的混合物。 Specific examples of preferred alkyl sulfates include, but are not limited to: ammonium lauryl sulfate, sodium cocoyl sulfate, potassium lauryl sulfate, sodium cocoyl sulfate, sodium lauryl sulfate, sodium cocoyl sulfate, sodium lauryl sulfate, monoethanolamine cocoyl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, triethanolamine lauryl sulfate, triethylamine, and mixtures thereof. 特别优选的是月桂基硫酸铵。 Particularly preferred is ammonium lauryl sulfate.

优选的烷基醚硫酸盐的具体实例包括,但不限于:月桂基聚氧乙烯醚硫酸铵、月桂基聚氧乙烯醚硫酸钾、月桂基聚氧乙烯醚硫酸钠、月桂基聚氧乙烯醚硫酸单乙醇胺、月桂基聚氧乙烯醚硫酸二乙醇胺、月桂基聚氧乙烯醚硫酸三乙醇胺、月桂基聚氧乙烯醚硫酸三乙胺以及它们的混合物。 Specific examples of preferred alkyl ether sulfates include, but are not limited to: polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate, sodium polyoxyethylene lauryl ether sulfate monoethanolamine, polyoxyethylene lauryl ether sulfate, sodium lauryl polyoxyethylene ether sulfate, triethanolamine polyoxyethylene lauryl ether sulfate, triethylamine, and mixtures thereof. 特另优选的是月桂基聚氧乙烯醚硫酸铵。 Another particular preferred are sodium lauryl polyoxyethylene ether ammonium sulfate.

还有一类适用于本发明的去头屑和调理香波中的硫酸盐表面活性剂是硫酸盐化的甘油酯,其实例包括但不限于月桂酸单甘油酯硫酸钠。 Another type of useful in the present invention are anti-dandruff and conditioning shampoos of the sulfate surfactants are sulfated glycerides, examples of which include but are not limited to lauric monoglyceride sodium sulfate.

2.磺酸盐还适用于本发明的去头屑和调理香波组合物中的是那些称为烯烃磺酸盐的阴离子去污表面活性剂。 2. sulfonates suitable for the present invention and an anti-dandruff conditioning shampoo compositions are those anionic detersive surfactants known as olefin sulfonates. 在本文中,术语“烯烃磺酸盐”是指通过未复合的三氧化硫对α-烯烃进行磺化,中和酸性反应混合物,在使反应中形成的砜水解而形成相应的羟基-烷磺酸盐的条件下进行。 As used herein, the term "olefin sulfonates" refers uncomplexed sulfur trioxide of α- olefin sulfonation, the reaction mixture was neutralized acidic, hydrolysis sulfones formed in the reaction to form the corresponding hydroxy - alkyl sulfonamide under acid conditions. 三氧化硫可为液体或气体,通常,但不是必要的,当以液体形式使用时,用惰性稀释剂对其稀释,例如用液体二氧化硫、氯代烃等进行稀释;当以气体形式使用时,用空气、氮气、气体二氧化硫等进行稀释。 The sulfur trioxide can be liquid or gas, typically, but not necessarily, when in liquid form, it is diluted with an inert diluent, such as liquid sulfur dioxide, chlorinated hydrocarbons, etc. diluted; When used in gaseous form, diluted with air, nitrogen, gaseous sulfur dioxide and the like. 从中形成烯烃磺酸盐的α-烯烃是具有约10至约24个碳原子、优选约12至约16个碳原子的单烯烃。 Formed from α- olefins are olefin sulfonates having about 10 to about 24 carbon atoms, preferably from about 12 to about 16 carbon atoms, mono-olefins. 优选,它们是直链烯烃。 Preferably, they are straight chain olefins. 除了真正的烯烃磺酸盐和一部分羟基烷磺酸盐外,烯烃磺酸盐能够包含少量的其它物质,如烯烃二磺酸盐,这取决于反应条件、反应物的比例、原料烯烃的性质及烯烃原料中的杂质和磺化过程中的副反应等。 In addition to the true alkene sulfonates and a proportion of hydroxy-alkanesulfonates, the olefin sulfonates can contain minor amounts of other materials, such as alkene disulfonates depending upon the reaction conditions, proportion of reactants, the nature of the starting olefins and olefin feedstock impurities and sulfonation process side reactions. 这种α-烯烃磺酸盐混合物的非限定性实例在美国专利3,332,880中有述,该专利引入本文作为参考。 Such non-limiting examples of α- olefin sulfonate mixture is described in U.S. Patent No. 3,332,880, which patent is incorporated herein by reference.

另一类适用于本发明去头屑和调理香波组合物中的磺酸盐为那些称为β-烷氧基烷烃磺酸盐的阴离子去污表面活性剂。 Another class of the present invention is applicable to anti-dandruff and conditioning shampoo compositions are those known as β- sulfonate alkyloxy alkane sulphonate anionic detersive surfactant. 这些表面活性剂满足通式(I) These surfactants satisfy the formula (I) 其中,R1为具有约6至约20个碳原子的直链烷基,R2为具有约1至约3个碳原子,优选1个碳原子的低级烷基,M为如前所述的水溶性阳离子。 Wherein, R1 having from about 6 to about 20 carbon atoms, a straight-chain alkyl group, R2 having from about 1 to about 3 carbon atoms, lower alkyl is preferably a carbon atom, M is a water-soluble as previously described cation.

另一类适用于本发明去头屑和调理香波组合物中的磺酸盐为那些称为烷基芳基磺酸盐的阴离子去污表面活性剂。 Another class of the present invention is applicable to anti-dandruff and conditioning shampoo compositions are those known as alkyl sulfonates aryl sulfonate anionic detersive surfactant. 烷基芳基磺酸盐的非限定性实例包括十三烷基苯磺酸钠、十二烷基苯磺酸钠以及它们的混合物。 Alkyl aryl sulfonate thirteen non-limiting examples include benzene sulfonate, sodium dodecyl benzene sulfonate, and mixtures thereof.

其它适用于本发明去头屑和调理香波组合物中的磺酸盐为有机、硫酸反应产物的水溶性盐,通式为[R1-SO3-M],其中R1为具有约8至约24个碳原子,优选约10至约18个碳原子的直链或支链的饱和脂族烃基;M为如前所述的阳离子。 Other useful in the present invention, anti-dandruff and conditioning shampoo compositions of the sulfonate is an organic, sulfuric acid reaction products of water-soluble salts of the general formula [R1-SO3-M], wherein R1 having from about 8 to about 24 carbon atoms, saturated aliphatic hydrocarbon radical preferably from about 10 to about 18 carbon atoms, being straight or branched; M is a cation as described above. 这种阴离子去污表面活性剂的非限定性实例为按照公知的磺化方法,由甲烷系列烃与磺化剂反应所得产物的盐,所述烃包括异、新和正链烷烃,所述磺化剂例如为三氧化硫、硫酸。 Non-limiting examples of such anionic detersive surfactants is according to known sulfonation methods, salts of the methane series hydrocarbons by reaction of the resulting product with a sulfonating agent, said hydrocarbon comprises iso-new and normal paraffins, the sulfonated agent such as sulfur trioxide, sulfuric acid. 磺化方法可以包括漂白法和水解法。 Sulfonation methods may include bleaching and hydrolysis. 盐优选具有约8至约24个碳原子,更优选约12至约18个碳原子。 Salt preferably having from about 8 to about 24 carbon atoms, more preferably from about 12 to about 18 carbon atoms. 优选的是磺化的C10-C18正链烷烃的碱金属和铵盐。 Preferred are sulfonated C10-C18 n-paraffins of alkali metal and ammonium salts.

其它的适用于本发明去头屑和调理香波组合物中的磺酸盐是脂肪酸用羟乙磺酸酯化,然后用氢氧化钠中和后的反应产物。 Other useful in the present invention, anti-dandruff and conditioning shampoo compositions sulfonates of fatty acids esterified with isethionic acid and then with sodium hydroxide and the reaction product after. 优选的脂肪酸是衍生自椰子油或棕榈仁油的那些。 Preferred fatty acids are those derived from coconut oil or palm kernel oil. 合适的还有牛磺酸甲酯的脂肪酸酰胺的钠或钾盐,其中脂肪酸衍生自椰子油或棕榈仁油。 Also suitable are fatty acid amides of methyl taurine sodium or potassium salts, wherein the fatty acid derived from coconut oil or palm kernel oil. 其他类似的阴离子表面活性剂描述在美国专利2486921、美国专利2486922、美国专利2396278中,所述专利引入本文作为参考。 Other similar anionic surfactants are described in U.S. Patent No. 2,486,921, U.S. Patent No. 2,486,922, U.S. Patent No. 2,396,278, said patents being incorporated herein by reference.

其它的适用于本发明去头屑和调理香波组合物中的磺酸盐是琥珀酸盐,其实例包括,但不限于,N-十八烷基磺基琥珀酸二钠;月桂基磺基琥珀酸二钠;月桂基磺基琥珀酸二铵;N-(1,2-二羧乙基)-N-十八烷基磺基琥珀酸四钠;磺基琥珀酸钠的二戊酯;磺基琥珀酸钠的二己酯;磺基琥珀酸钠的二辛酯以及它们的混合物。 Other useful in the present invention, anti-dandruff and conditioning shampoo compositions are succinate sulfonates, examples of which include, but are not limited to, N- octadecyl sulfosuccinate; lauryl sulfosuccinate Disodium; diammonium lauryl sulfosuccinate; N- (1,2- dicarboxyethyl) -N- octadecyl sulfosuccinate, tetrasodium; sulfosuccinate sodium diamyl ester; sulfo sodium sulfosuccinate dioctyl ester and mixtures thereof; succinate sodium dihexyl ester.

3.肌氨酸和肌氨酸衍生物其它适用于本发明去头屑和调理香波组合物中的是称为肌氨酸和肌氨酸衍生物的那些阴离子去污表面活性剂。 3. sarcosine and sarcosine derivatives useful in the present invention, other anti-dandruff and conditioning shampoo compositions are those anionic detersive surfactants known as sarcosinates and sarcosine derivatives. 肌氨酸盐是肌氨酸和N-甲基甘氨酸的衍生物,用脂肪酰氯酰化。 Sarcosinates and sarcosine is N- methyl glycine derivatives, acylated with fatty acid chloride. 它们满足通式(II): They satisfy the general formula (II): 其中RCO-是脂肪酸残基,X是氢(酸形式)或阳离子类,如Na+或TEA+(盐形式)。 Wherein RCO- is a fatty acid residue, X is hydrogen (acid form) or a cationic species, such as Na + or TEA + (salt form). 肌氨酸和肌氨酸衍生物的非限定性实例包括:月桂基肌氨酸钠、月桂基肌氨酸、椰油基肌氨酸以及它们的混合物。 Non-limiting examples of sarcosinates and sarcosine derivatives include: sodium lauryl sarcosinate, lauryl sarcosine, cocoyl sarcosine and mixtures thereof. 优选的肌氨酸盐是月桂基肌氨酸钠。 A preferred sarcosinate is sodium lauryl sarcosinate. B.调理剂本发明的去头屑和调理香波组合物包括占组合物重量约0.01%至约10%,优选约0.1%至约8%,更优选约0.1%至约5%,最优选约0.2%至约3.5%的适于应用到头发或皮肤上的调理剂。 Antidandruff B. conditioners of the invention and the conditioning shampoo composition comprises from about 0.01% to about 10% by weight of the composition, preferably from about 0.1% to about 8%, more preferably from about 0.1% to about 5%, most preferably from about 0.2% to about 3.5% of the suitable application to the hair or skin conditioning agents. 相信该调理剂给头发带来了改进的调理功效,特别是清洁头发感和湿漂洗感。 I believe that hair conditioning agents to bring an improved conditioning effect, especially clean wet hair and rinse sense sense.

调理剂包括水不溶性的、水分散性的、非挥发性的形成乳化的液体颗粒或者由在阴离子去污表面活性剂组分(上文所述)中的表面活性剂胶束溶液化的液体。 Conditioning agents include water-insoluble, water dispersible, non-volatile liquid particles formed emulsified or by surfactant micelles in the anionic detersive surfactant component (described above) was of the liquid. 用于香波组合物中的合适的调理剂是特征通常为聚硅氧烷的那些调理剂(例如聚硅氧烷油、阳离子聚硅氧烷、聚硅氧烷胶、高折光指数聚硅氧烷以及聚硅氧烷树脂),有机调理油(例如烃油、聚烯烃以及脂肪酸酯)或它们的组合,或者是那些调理剂,它们在本发明的含水表面活性剂基质中形成液体、分散的颗粒。 For shampoo compositions suitable conditioning agents are typically characterized as those silicone conditioning agents (e.g., silicone oils, cationic silicones, silicone gums, high refractive index polysiloxane and silicone resins), organic conditioning oils (e.g. hydrocarbon oils, polyolefins, and fatty esters) or combinations thereof, or those conditioning agents, they form a liquid aqueous surfactant matrix of the present invention, the dispersion of particles. 这些调理剂应与组合物的基本成分在物理和化学性质上相容,并且应不过度损害产品的稳定性、美观或性能。 These conditioning agents should be physically and chemically compatible with the essential properties of components of the composition, and should not unduly impair product stability, aesthetics or performance.

调理剂在香波组合物中的浓度应足以提供所需的调理功效,这对本领域普通技术人员来说是显而易见的。 The concentration of conditioning agent in the shampoo compositions should be sufficient to provide the desired conditioning benefits, which those of ordinary skill is obvious. 这样的浓度能够随着调理剂、所需的调理性能、调理剂颗粒的平均大小、其它组分的类型和浓度以及其它的类似因素而变化。 Such concentrations can be as conditioning agent, the conditioning performance desired, the average size of the conditioning agent particles, the type and concentration of other components, and other similar factors.

1.聚硅氧烷本发明的去头屑和调理香波组合物的调理剂优选是不溶的聚硅氧烷调理剂。 Antidandruff 1. silicone conditioning agents of the present invention and preferably the conditioning shampoo compositions are insoluble silicone conditioning agent. 聚硅氧烷调理剂颗粒可以包括挥发性聚硅氧烷、非挥发性聚硅氧烷、或者它们的组合。 Silicone conditioning agent particles may comprise volatile silicone, nonvolatile silicone, or combinations thereof. 优选的是非挥发性的聚硅氧烷调理剂。 Preferred non-volatile silicone conditioning agent. 如果存在挥发性聚硅氧烷,典型地,它们还附带地用作市售形式的非挥发性聚硅氧烷材料成分如聚硅氧烷胶(silicone gum)和聚硅氧烷树脂(silicone resins)的溶剂或载体。 If the presence of volatile silicone, typically, they are also used as commercially available in the form of incidental non-volatile silicone materials ingredients, such as silicone rubber (silicone gum), and silicone resins (silicone resins ) solvent or carrier. 该聚硅氧烷调理剂颗粒可以包括聚硅氧烷流体调理剂,并且还可以包括其它成分如聚硅氧烷树脂,以改进聚硅氧烷流体沉积功效或者增加头发的光泽(特别是当使用高折光指数(例如高过约1.46)的聚硅氧烷调理剂(例如高度苯基化的聚硅氧烷)时)。 The silicone conditioning agent particles may comprise a silicone fluid conditioning agent and may also include other components such as a silicone resin to improve silicone fluid deposition efficacy or increase hair shine (particularly when using a high refractive index (e.g., higher than about 1.46) silicone conditioning agents (e.g. highly phenylated silicones) when).

聚硅氧烷调理剂的浓度通常占组合物重量的约0.01%至约10%,优选约0.1%至约8%,更优选约0.1%至约5%,最优选约0.2%至约3%。 The concentration of the silicone conditioning agents generally comprise from about 0.01% to about 10% by weight of the composition, preferably from about 0.1% to about 8%, more preferably from about 0.1% to about 5%, most preferably from about 0.2% to about 3% . 合适的聚硅氧烷调理剂以及用于所述聚硅氧烷的任选的悬浮剂的非限定性实例描述在美国再颁布专利34584、美国专利5104646和美国专利5106609中,将所述专利的说明引入本发明中作为参考。 Suitable silicone conditioning agents and non-limiting examples for the polysiloxane optionally suspending agents are described in U.S. Reissue Patent No. 34,584 enacted, U.S. Patent No. 5,104,646 and U.S. Patent No. 5,106,609, the said patent Description incorporated herein by reference. 用于本发明去头屑和调理香波组合物中的聚硅氧烷调理剂在25℃下测量的粘度优选为约20-2,000,000厘沲(csk),更优选约1,000-1,800,000厘沲,还更优选约50,000-1,500,000厘沲,最优选约100,000-1,500,000厘沲。 Viscosity used in the present invention, anti-dandruff and conditioning shampoo compositions of the silicone conditioning agent is measured at 25 ℃ preferably about 20-2,000,000 centistokes (csk), and more preferably from about 1,000-1,800,000 centistokes, still more preferably from about 50,000 to 1,500,000 centistokes, most preferably from about 100,000-1,500,000 centistokes.

分散的聚硅氧烷调理剂颗粒通常具有的数均颗粒直径为约0.01微米至约50微米。 Dispersed silicone conditioning agent particles typically have a number average particle diameter of from about 0.01 microns to about 50 microns. 对于应用于头发上的小颗粒而言,数均颗粒直径典型的范围是在约0.01微米至约4微米,优选约0.01微米至约2微米,更优选约0.01微米至约0.5微米。 For small particles is applied to the hair, the number average particle diameter is typically in the range of from about 0.01 microns to about 4 microns, preferably from about 0.01 microns to about 2 microns, more preferably from about 0.01 microns to about 0.5 microns. 对于应用于头发上的较大颗粒而言,数均颗粒直径典型的是在约4微米至约50微米,优选约6微米至约30微米,更优选约9微米至约20微米,最优选约12微米至约18微米。 For larger particles applied to the hair, the number average particle typically from about 4 microns to about 50 microns in diameter, preferably from about 6 microns to about 30 microns, more preferably from about 9 microns to about 20 microns, most preferably from about 12 microns to about 18 microns. 具有小于约5微米的平均颗粒直径的调理剂可以更有效地沉积在头发上。 Having less than about 5 microns average particle diameter of the conditioning agents can be more effectively deposited on the hair. 相信小粒径颗粒的调理剂包含在凝聚相中,凝聚相是在稀释香波时,在阴离子表面活性剂组分(如上所述)和阳离子聚合物组分(如下所述)之间形成的。 Believed that small size particles of conditioning agent is included in the condensed phase, the condensed phase is in the shampoo upon dilution, between the anionic surfactant component (described above) and the cationic polymer component (described below) is formed.

有关硅氧烷的背景材料,包括讨论聚硅氧烷流体、聚硅氧烷胶和聚硅氧烷树脂以及聚硅氧烷生产的内容可参见“Encyclopedia of Polymer Scienceand Engineering,Volume 15,第二版,pp 204-308页,John Wiley & Sons.Inc.,1989”,引入本文作为参考。 Background material on the silicone, including a discussion silicone fluids, silicone gum and silicone resins and silicone production can be found in "Encyclopedia of Polymer Scienceand Engineering, Volume 15, Second Edition , pp 204-308 pages, John Wiley & amp;. Sons.Inc, 1989 ", incorporated herein by reference.

i.聚硅氧烷油聚硅氧烷流体包括聚硅氧烷油,是一种可流动的聚硅氧烷物质,其在25℃下测得的粘度小于1,000,000厘沲,优选为约5至约1,000,000厘沲,更优选约10至约100,000厘沲。 i. silicone oil silicone fluids include silicone oils, is a flowable silicone material, which at 25 ℃ measured viscosity of less than 1,000,000 centistokes, preferably about 5 to about 1,000,000 centistokes, more preferably from about 10 to about 100,000 centistokes. 用在本发明去头屑和调理香波组合物中的适宜的聚硅氧烷油包括聚烷基硅氧烷、聚芳基硅氧烷、聚烷芳基硅氧烷、聚醚硅氧烷共聚物以及它们的组合。 Used in the present invention, anti-dandruff and conditioning shampoo compositions of suitable silicone oils include polyalkyl siloxanes, polyaryl siloxanes, poly alkylaryl siloxanes, polyether siloxane copolymer thereof and combinations thereof. 也可以使用其它的具有头发调理性能的不溶性不挥发聚硅氧烷流体。 May also be used with other insoluble hair conditioning properties of non-volatile silicone fluid.

聚硅氧烷油包括具有下式(III)的聚烷基或聚芳基硅氧烷: Silicone oils include those having the following formula (III) polyalkyl or polyaryl siloxanes: 其中,R为脂族基团,优选烷基或链烯基或芳基,R能够是取代或未取代的,x为1至约8,000的整数。 Wherein, R is an aliphatic group, preferably an alkyl or alkenyl or aryl, R can be a substituted or unsubstituted, x is an integer from 1 to about 8,000. 用在本发明去头屑和调理香波组合物中的适宜的未取代的R基包括,但不限于,烷氧基、芳氧基、烷芳基、芳烷基、芳基链烯基、烷氨基,以及醚取代的、羟基取代的及卤素取代的脂族基团和芳基。 Used in the present invention, anti-dandruff and conditioning shampoo compositions of suitable unsubstituted R groups include, but are not limited to, alkoxy, aryloxy, alkaryl, aralkyl, aryl, alkenyl, alkoxy amino, and ether-substituted, hydroxyl-substituted, and halogen-substituted aliphatic groups and aryl groups. 适宜的R基团还包括阳离子胺和季铵基团。 Suitable R groups also include cationic amines and quaternary ammonium groups.

在硅氧烷链上取代的脂族或芳基基团可具有任意结构,只要形成的聚硅氧烷仍然在室温下为流体,具有疏水性,当其涂敷于头发上时无刺激性、无毒、无害,并且与香波组合物的其它组分相容,在正常使用和贮藏条件下化学性质稳定,不溶于本发明的香波组合物中,并且能够沉积于头发上并具有调理头发的功能。 The siloxane chain substituted aliphatic or aryl group may have any structure as long as the formation of silicone remains fluid at room temperature, are hydrophobic, non-irritating when it is applied to the hair when, non-toxic, harmless, and is compatible with the other components of the shampoo composition, under normal use and storage conditions chemically stable, insoluble in the shampoo compositions of the present invention, and can be deposited on the hair and the hair with a conditioning function. 在每一单体聚硅氧烷单元的硅原子上的两个R基团可相同或不同。 On each of the monomeric units of the polysiloxane silicon atom the two R groups may be the same or different. 优选两个R基团是相同的。 Preferably two R groups are the same.

优选的烷基和链烯基取代基为C1-C5的烷基和链烯基,更优选C1-C4,最优选C1-C2。 Preferred alkyl and alkenyl substituents are C1-C5 alkyl and alkenyl groups, more preferably C1-C4, most preferably C1-C2. 其它含烷基、链烯基或链炔基的基团(如烷氧基、烷芳基和烷氨基)的脂族部分可以为直链或支链的,优选具有1-5个碳原子,更优选具有1-4个碳原子,还更优选具有1-3个碳原子,最优选具有1-2个碳原子。 Other alkyl-, alkenyl or alkynyl group (such as alkoxy, alkaryl, and alkylamino) aliphatic moiety can be straight or branched, preferably having 1-5 carbon atoms, more preferably having 1 to 4 carbon atoms, still more preferably having 1 to 3 carbon atoms, most preferably 1-2 carbon atoms. 如前所述,R取代基也能够包含氨基官能团(例如烷氨基),其能够是伯、仲或叔胺或季铵。 As described above, R substituents can also contain amino functional groups (e.g., alkylamino), which can be primary, secondary or tertiary amines or quaternary ammonium. 这些包括单-、二-和三-烷基氨基和烷氧基氨基,其中该脂族部分的链长优选如上所述。 These include single -, two - and three - alkylamino and alkoxyamino groups, wherein the aliphatic portion chain length is preferably as described above. R取代基也可被其它基团取代,如卤素(如氯、氟和溴)、卤代脂族基团或芳基、羟基(例如羟基取代的脂族基团),以及它们的混合物。 R substituents may also be substituted with other groups, such as halogen (e.g. chlorine, fluorine and bromine), halogenated aliphatic or aryl groups, hydroxy (e.g. hydroxy substituted aliphatic groups), and mixtures thereof. 例如,适宜的卤代R基团包括例如三卤代(优选三氟代)烷基,如-R1C(F)3,其中,R1为C1-C3烷基。 For example, suitable R groups include halo such as tri-halo (preferably trifluoroacetic) alkyl, such as -R1C (F) 3, wherein, R1 is C1-C3 alkyl. 这种聚硅氧烷的实例包括,但不限于,聚甲基-3,3,3-三氟丙基硅氧烷。 Examples of such polysiloxanes include, but are not limited to, poly-methyl-3,3,3-trifluoropropyl siloxane.

用在本发明去头屑和调理香波组合物中的适宜的R基团包括,但不限于,甲基、乙基、丙基、苯基、甲基苯基和苯基甲基。 Used in the present invention, anti-dandruff and conditioning shampoo compositions of suitable R groups include, but are not limited to, methyl, ethyl, propyl, phenyl, methylphenyl and phenylmethyl. 优选的聚硅氧烷的具体的非限定性的实例包括:聚二甲基硅氧烷、聚二乙基硅氧烷和聚甲基苯基硅氧烷。 Preferred non-limiting examples of silicones include: polydimethyl siloxane, polydiethylsiloxane, and poly (methylphenyl) siloxanes. 特别优选聚二甲基硅氧烷。 Particularly preferably polydimethylsiloxane. 其它适宜的R基团包括甲基、甲氧基、乙氧基、丙氧基和芳氧基。 Other suitable R groups include methyl, methoxy, ethoxy, propoxy, and aryloxy. 在聚硅氧烷的末端上的三个R基团也可表示相同或不同的基团。 On the end of the polysiloxane three R groups may be the same or different groups.

可使用的非挥发性聚烷基硅氧烷流体包括例如低分子量的聚二甲基硅氧烷。 May be used non-volatile polyalkylsiloxane fluids include, for example low molecular weight polydimethylsiloxane. 这些硅氧烷例如可从General Electric Company以其Viseasil R和SF 96系列购得,并且从Dow Corning以其Dow Corning200系列购得。 These siloxanes are available for example, 96 series from General Electric Company in their Viseasil R and SF, and Corning200 series commercially available from Dow Corning in their Dow. 可使用的聚烷芳基硅氧烷流体还包括例如聚甲基苯基硅氧烷。 Polyalkylaryl siloxane fluids that may be used also include for example, poly (methylphenyl) siloxanes. 这些硅氧烷可从如General Electric Company以其SF 1075甲基苯基流体购得或者从DowCorning以其556化妆品级流体购得。 These siloxanes are available, such as General Electric Company from its SF 1075 methyl phenyl fluid or its 556 Cosmetic Grade Fluid available from DowCorning. 也可使用的聚醚硅氧烷共聚物包括例如聚环氧丙烷改性的聚二甲基硅氧烷(例如Dow Corning DC-1248),但是也可使用环氧乙烷或环氧乙烷与环氧丙烷的混合物。 Polyether siloxane copolymers may also be used include, for example, polypropylene oxide modified polydimethylsiloxane (e.g., Dow Corning DC-1248), but may also be used ethylene oxide or propylene oxide with mixture of propylene oxide. 环氧乙烷和环氧丙烷的浓度必须足够低以防止其在水中和在所述的组合物中溶解。 Oxide and propylene oxide concentrations must be sufficiently low to prevent the epoxy was dissolved in water and the composition of the.

适用于本发明去头屑和调理香波组合物中的烷氨基取代的聚硅氧烷包括,但不限于:具有下述通式(IV)的那些: Useful in the present invention is substituted anti-dandruff and conditioning shampoo compositions of the alkylamino silicones include, but are not limited to: having the following general formula (IV) are those: 其中,x和y均为整数。 Where, x and y are integers. 该聚合物也被称之为“胺化聚二甲基硅氧烷(amodimethicone)”。 The polymer may also be referred to as "aminated polydimethylsiloxane (amodimethicone)".

ii.阳离子聚硅氧烷用在本发明去头屑和调理香波组合物中的阳离子聚硅氧烷流体包括但不限于满足下式(IV)的那些:(R1)aG3-a-Si-(-OSiG2)n-(-OSiGb(R1)2-b)mO-SiG3-a(R1)a其中G是氢、苯基、羟基或者C1-C8烷基,优选甲基;a为0或1-3的整数,优选0;b为0或1,优选1;n代表0-1,999的数,优选49-149,m代表1-2,000的整数,优选1-10的整数;n+m的总和为1-2,000,优选50-150;R1为一价基团,满足通式CqH2qL,其中,q为2-8的整数,L选自下述基团:-N(R2)CH2-CH2-N(R2)2-N(R2)2-N(R2)3A--N(R2)CH2-CH2-NR2H2A-其中,R2是氢、苯基、苄基或饱和烃基,优选具有约1至约20个碳原子的烷基,A-为卤素离子。 . ii cationic silicone used in the present invention, anti-dandruff and conditioning shampoo compositions of the cationic silicone fluids include, but are not limited to satisfy the following formula (IV) are those that: (R1) aG3-a-Si- ( -OSiG2) n - (- OSiGb (R1) 2-b) mO-SiG3-a (R1) a wherein G is hydrogen, phenyl, hydroxy or C1-C8 alkyl, preferably methyl; a is 0 or 1 3 is an integer, preferably 0; b is 0 or 1, preferably 1; n represents the number of 0-1,999, preferably 49-149, m represents an integer of from 1 to 2,000, preferably an integer of 1 to 10; the sum of n + m is 1-2,000, preferably 50-150; R1 is a monovalent radical, which satisfied the formula CqH2qL, wherein, q is an integer of 2-8, L is selected from the following groups: -N (R2) CH2-CH2-N ( R2) 2-N (R2) 2-N (R2) 3A - N (R2) CH2-CH2-NR2H2A- wherein, R2 is hydrogen, phenyl, benzyl or a saturated hydrocarbon, preferably having from about 1 to about 20 alkyl carbon atoms, A- is a halogen ion.

特别优选的式(IV)的阳离子聚硅氧烷为下式(VI)所示的聚合物,它也被称之为“三甲基甲硅烷基胺化聚二甲基硅氧烷(trimethylsilylamodimethicone)”, Particularly preferred compounds of formula (IV) cationic silicone polymer of the formula (VI) as shown, it is also known as "trimethylsilyl group aminated polydimethylsiloxane (trimethylsilylamodimethicone) " 可用在本发明去头屑和调理香波组合物中的其它聚硅氧烷阳离子聚合物由下式(VII)表示: Used in the present invention anti-dandruff and conditioning shampoo compositions Other silicone cationic polymers represented by the following formula (VII) represents: 其中,R3为具有1-18个碳原子的一价烃基,优选烷基或链烯基,如甲基;R4为烃基,优选C1-C18亚烷基或C1-C18亚烷氧基,更优选C1-C8亚烷氧基;Q-为卤素离子,优选氯离子;r的平均统计值为2-20,优选2-8;s的平均统计值为20-200,优选20-50。 Wherein, R3 is a monovalent hydrocarbon group having 1-18 carbon atoms, preferably an alkyl or alkenyl group, such as methyl; R4 is a hydrocarbon group, preferably C1-C18 alkylene or C1-C18 alkylene group, more preferably C1-C8 alkylene group; Q- is a halide ion, preferably chloride; r is an average statistical value of 2-20, preferably 2-8; s is an average statistical value of 20-200, preferably 20-50. 这类中的优选的聚合物可从Union Carbide以“UCARE SILICONE ALE 56TM”购得。 Preferred polymers of this type are available from Union Carbide to "UCARE SILICONE ALE 56TM" available.

iii.聚硅氧烷胶其它适用于本发明去头屑和调理香波组合物中的聚硅氧烷流体为不溶性聚硅氧烷胶。 iii. Other silicone gum useful in the present invention, anti-dandruff and conditioning shampoo compositions of the polysiloxane fluid is insoluble silicone gum. 这些胶为聚有机硅氧烷物质,在25℃下测得的粘度大于或等于1,000,000厘沲。 These polyorganosiloxane rubber material, at 25 ℃ measured viscosity of greater than or equal to 1,000,000 centistokes. 这种聚硅氧烷胶在下述文献中有述:美国专利4,152,416;Noll,Walter,Chemistry and Technology of Silicones,New York:Academic Press1968;以及General Electric Silicone Rubber Product Data Sheets SE 30、SE33、SE 54和SE 76,均引入本文作参考。 Such silicone gums have described in the following references: U.S. Patent 4,152,416; Noll, Walter, Chemistry and Technology of Silicones, New York: Academic Press1968; and General Electric Silicone Rubber Product Data Sheets SE 30, SE33, SE 54 and SE 76, which are incorporated herein by reference. 聚硅氧烷胶的重均分子量通常大于约200,000,一般约为200,000-1,000,000。 Silicone gum has a weight average molecular weight is typically greater than about 200,000, typically about 200,000 to 1,000,000. 用于本发明去头屑和调理香波组合物中的聚硅氧烷胶的具体的非限定性实例包括聚二甲基硅氧烷、(聚二甲基硅氧烷)(甲基乙烯基硅氧烷)共聚物、聚(二甲基硅氧烷)(二苯基硅氧烷)(甲基乙烯基硅氧烷)共聚物以及它们的混合物。 Used in the present invention, anti-dandruff and conditioning shampoo compositions of the silicone gum of the specific non-limiting examples include polydimethylsiloxane, (polydimethylsiloxane) (methyl vinyl silicone siloxane) copolymer, poly (dimethylsiloxane) (diphenyl siloxane) (methylvinylsiloxane) copolymer and mixtures thereof.

iv.高折光指数聚硅氧烷适用于本发明去头屑和调理香波组合物中的其它的非挥发性不溶性聚硅氧烷流体调理剂是被称为“高折光指数的聚硅氧烷”的那些调理剂,其折光指数至少为约1.46,优选至少为约1.48,更优选至少为约1.52,最优选至少为约1.55。 iv. High refractive index polysiloxanes useful in the present invention, anti-dandruff and conditioning shampoo compositions of the other non-volatile insoluble silicone fluid conditioning agents are known as "high refractive index polysiloxane" those conditioning agents, a refractive index of at least about 1.46, preferably at least about 1.48, more preferably at least about 1.52, most preferably at least about 1.55. 聚硅氧烷流体的折光指数通常小于约1.70,优选小于约1.60。 Silicone fluid is typically less than the refractive index of about 1.70, preferably less than about 1.60. 本文中,聚硅氧烷“流体”包括油和胶。 Herein, polysiloxane "fluid" includes oils and gum.

高折光指数聚硅氧烷流体包括由上文通式(III)表示的那些,以及环状聚硅氧烷,如由下式(VIII)表示的那些: High refractive index polysiloxane fluid includes those, as well as cyclic polysiloxanes by the above general formula (III) represents, as represented by the following formula (VIII) represented by those: 其中,R如上定义,n为约3至约7,优选为3至约5。 Wherein, R is as defined above, n is from about 3 to about 7, preferably from 3 to about 5.

高折光指数聚硅氧烷流体包含足以增加折光指数至所需值的一定量的含芳基的R取代基,如上文所述。 High refractive index polysiloxane fluids contain sufficient to increase the refractive index to a desired value of an amount of aryl-containing R substituents, as described above. 此外,必须选择R和n以使该物质为非挥发性物质。 In addition, R and n must be selected so that the material is non-volatile substances.

含芳基的取代基包括那些包含脂环和杂环5和6元芳环的取代基,以及包含稠合的5和6元环的那些取代基。 Aryl-containing substituents include those comprising alicyclic and heterocyclic five and six-membered aryl ring substituents containing fused five and six-membered ring and those substituents. 芳环自身可被取代或未被取代。 The aromatic ring may themselves be substituted or unsubstituted. 取代基包括脂族取代基,也可包括烷氧基取代基、酰基取代基、酮、卤素(例如氯和溴)、胺等。 Substituents include aliphatic substituents, may also include alkoxy substituents, acyl substituents, ketones, halogens (e.g., chlorine and bromine), an amine and the like. 含芳基的基团的实例包括,但不限于,取代和未取代的芳基,如苯基,和苯基衍生物,如具有C1-C5烷基或链烯基取代基的苯基。 Examples of aryl-containing groups include, but are not limited to, substituted and unsubstituted aryl groups such as phenyl, and phenyl derivatives, such as those having C1-C5 alkyl or alkenyl substituted with phenyl. 具体的非限定性实例包括烯丙基苯基、甲基苯基和乙基苯基、乙烯基苯基(例如苯乙烯基),以及苯基链炔基(例如苯基C2-C4链炔基)。 Specific non-limiting examples include allyl phenyl, methyl phenyl and ethyl phenyl, vinyl phenyl (e.g. styrene-yl), alkynyl group and phenyl (e.g. phenyl C2-C4 alkynyl ). 杂环芳基包括,但不限于,衍生自呋喃、咪唑、吡咯、吡啶等的取代基。 Heterocyclic aryl groups include, but are not limited to, derived from furan, imidazole, pyrrole, pyridine, etc. substituents. 稠合芳环取代基的实例包括,但不限于,萘、香豆素和嘌呤。 Fused aromatic ring substituents include, but are not limited to, naphthalene, coumarin, and purine.

通常,高折光指数聚硅氧烷流体具有的含芳基取代基的含量至少为约15%,优选至少约20%,更优选至少约25%,还优选至少约35%,最优选至少约50%。 Typically, the high refractive index polysiloxane fluids contain an aryl substituent group has a content of at least about 15%, preferably at least about 20%, more preferably at least about 25%, further preferably at least about 35%, most preferably at least about 50 %. 一般说来,芳基取代程度将小于约90%,更优选小于约85%,优选约55%至约80%。 In general, the degree of aryl substitution will be less than about 90%, more preferably less than about 85%, preferably from about 55% to about 80%.

高折光指数的聚硅氧烷流体的特征还有因其芳基取代而具有的相对较高的表面张力。 High refractive index polysiloxane fluid characteristics as well as its having a substituted aryl group of relatively high surface tension. 通常,聚硅氧烷流体的表面张力至少为约24达因/厘米2,通常至少为约27达因/厘米2。 Typically, the surface tension of the polysiloxane fluid of at least about 24 dynes / cm 2, usually at least about 27 dynes / cm 2. 表面张力从其目的而言,采用Nouy环状张力仪,按照Dow Corning Corporate测试法CTM 0461(1971年11月23日)进行测量。 Its surface tension purposes, using Nouy ring tensiometer according to Dow Corning Corporate Test Method CTM 0461 (1971 年 11 May 23) were measured. 表面张力的变化按照上述测量法或ASTM法1331进行测量。 Change in surface tension in accordance with the measuring method ASTM method 1331 or measured.

优选的高折光指数聚硅氧烷流体具有苯基或苯基衍生物取代基(最优选苯基)与烷基取代基,优选C1-C4烷基(最优选甲基)、羟基或C1-C4烷氨基(特别是R1NHR2NH2,其中,每一个R1和R2独立地为C1-C3烷基、链烯基和/或烷氧基)的组合。 Preferred high refractive index polysiloxane fluids having a phenyl or phenyl derivative substituents (most preferably phenyl) substituted with an alkyl group, preferably C1-C4 alkyl (most preferably methyl), hydroxy or C1-C4 alkylamino (especially R1NHR2NH2, wherein each of R1 and are independently C1-C3 alkyl, alkenyl and / or alkoxy R2) of combinations. 高折光指数聚硅氧烷可从Dow Corning,Huls America和General Electric购得。 High refractive index polysiloxanes are available from Dow Corning, Huls America, and General Electric.

当高折光指数聚硅氧烷用于本发明去头屑和调理香波组合物中时,它们优选与一种铺展剂一同用于溶液中,所述铺展剂如聚硅氧烷树脂或表面活性剂,以降低足够量的表面张力以增加铺展并由此增加由该组合物处理的头发的光泽(在干燥后)。 When the high refractive index polysiloxane used in the present invention, anti-dandruff and conditioning shampoo compositions, they are preferably used together with a spreading agent solution, the spreading agent such as a silicone resin or a surfactant , an amount sufficient to reduce the surface tension to increase thereby increasing the spreading and treated by the composition of the glossiness of hair (after drying). 通常,铺展剂的用量为足以降低高折光指数聚硅氧烷流体的表面张力的量,降低表面张力至少约5%,优选至少约10%,更优选至少约15%,还更优选至少约20%,最优选至少约25%。 Typically, the amount of the spreading agent is an amount sufficient to reduce the surface tension of the high refractive index polysiloxane fluids, reduce the surface tension of at least about 5%, preferably at least about 10%, more preferably at least about 15%, still more preferably at least about 20 %, most preferably at least about 25%. 聚硅氧烷流体/铺展剂混合物的表面张力的降低可以改进头发的光泽。 Reducing the polysiloxane fluid / spreading agent mixture may improve the surface tension of the hair sheen.

而且,铺展剂将优选降低表面张力至少约2达因/厘米2,优选至少约3达因/厘米2,更优选至少约4达因/厘米2,最优选至少约5达因/厘米2。 Further, spreading agents will preferably reduce the surface tension of at least about 2 dynes / cm 2, preferably at least about 3 dynes / cm 2, more preferably at least about 4 dynes / cm 2, most preferably at least about 5 dynes / cm 2.

聚硅氧烷流体和铺展剂的混合物(在最终组合物中以一定比例存在)的表面张力优选小于或等于约30达因/厘米2,更优选小于或等于约28达因/厘米2,最优选小于或等于约25达因/厘米2。 Surface tension of the mixture of the polysiloxane fluid and the spreading agent (in the final composition in the presence of a certain ratio) is preferably less than or equal to about 30 dynes / cm 2, more preferably less than or equal to about 28 dynes / cm 2, most preferably less than or equal to about 25 dynes / cm 2. 典型的是,表面张力的范围在约15达因/厘米2至约30达因/厘米2,更典型地为约18达因/厘米2至约28达因/厘米2,并且最通常的是约20达因/厘米2至约25达因/厘米2。 Typically, the surface tension in the range of about 15 dynes / cm 2 to about 30 dynes / cm 2, more typically from about 18 dynes / cm 2 to about 28 dynes / cm 2, and most typically is about 20 dynes / cm 2 to about 25 dynes / cm 2.

高芳基化的聚硅氧烷流体与铺展剂的重量比通常在约1000∶1至约1∶1,优选为约100∶1至约2∶1,更优选为约50∶1至约2∶1,最优选为约25∶1至约2∶1。 Highly arylated polysiloxane fluid by weight and a spreading agent than usual at about 1000 to about 1, preferably from about 100 to about 2, more preferably from about 2 to about 50:1 , most preferably from about 25 to about 2. 当使用氟化的表面活性剂时,由于这些表面活性剂的功效,特别高的聚硅氧烷流体与铺展剂的比例可以是有效的。 When fluorinated surfactants, due to the efficacy of these surfactants, particularly high polysiloxane fluid and the spreading agent can be effective. 因此设想可以使用明显高于1000∶1的比例。 Therefore, you can use the idea of significantly higher proportion 1000:1.

适用于本发明去头屑和调理香波组合物中的聚硅氧烷流体在下述文献中有述:美国专利2,826,551、美国专利3,964,500、美国专利4,364,837、英国专利849,433,以及Silicon Compounds,Petrarch Systems,Inc.(1984),均引入本文作为参考。 The present invention is applicable to anti-dandruff and conditioning shampoo compositions of the polysiloxane fluids have described in the following references: U.S. Patent No. 2,826,551, U.S. Patent No. 3,964,500, U.S. Patent 4,364,837, British Patent 849,433, and Silicon Compounds, Petrarch Systems, Inc . (1984), both incorporated herein by reference.

v.聚硅氧烷树脂本发明的去头屑和调理香波组合物中可以包含聚硅氧烷树脂。 antidandruff v. the silicone resin of the present invention and conditioning shampoo compositions can comprise a silicone resin. 这些树脂是高度交联的聚合硅氧烷体系。 These resins are highly crosslinked polymeric siloxane systems. 在聚硅氧烷树脂生产过程中,通过将三官能和四官能硅烷掺入单官能或二官能或单官能和二官能硅烷中而引入交联。 In the silicone resin during production, by the incorporation of trifunctional and tetrafunctional silanes incorporated monofunctional or difunctional or monofunctional and difunctional silane crosslinking introduced. 正如本领域普通技术人员已知的那样,为形成聚硅氧烷树脂所需的交联度可根据掺入聚硅氧烷树脂中的特定硅烷单元而变化。 As is known to those of ordinary skill in that, to form the desired degree of crosslinking polysiloxane resins can be incorporated into the silicone resin according to the specific silane units vary. 通常,可考虑采用具有足够多三官能和四官能硅氧烷单体单元(因而交联充分)以致于它们干燥能形成刚性或硬的膜的聚硅氧烷物质作为聚硅氧烷树脂。 Typically, could be considered having a sufficient number of trifunctional and tetrafunctional siloxane monomer units (and hence sufficient crosslinking) such that they dry down to a rigid material capable of forming a silicone film or a hard silicone resin. 氧原子与硅原子的比值表明在具体聚硅氧烷物质中的交联水平。 The ratio of oxygen atoms to silicon atoms suggests that the level of crosslinking in a particular silicone material. 适用于本发明去头屑和调理香波组合物中的聚硅氧烷树脂的氧原子与硅原子之比通常至少为约1.1。 Antidandruff ratio suitable for the present invention and an oxygen atom conditioning shampoo compositions of the polysiloxane resin to silicon atoms is typically at least about 1.1. 优选氧原子与硅原子之比至少为约1.2∶1.0。 Ratio of oxygen atoms to silicon atoms is preferably at least about 1.2:1.0. 用于生产聚硅氧烷树脂的硅烷包括,但不限于,一甲基-、二甲基-、三甲基-、一苯基-、二苯基-、甲基苯基-、一乙烯基-和甲基乙烯基-氯代硅烷和四氯硅烷,最常采用的是甲基取代的硅烷。 For the production of silicone resins silanes include, but are not limited to, a methyl -, dimethyl -, trimethyl -, monophenyl -, diphenyl -, methyl phenyl -, monovinyl - and methyl vinyl - chlorosilane and tetrachlorosilane, most commonly used is the methyl-substituted silanes. 优选的树脂可从General Electric得到,为GE SS4230和GE SS4267。 Preferred resins obtained from General Electric, for GE SS4230 and GE SS4267. 商购的聚硅氧烷树脂通常为溶解形式的低粘度挥发性或不挥发聚硅氧烷流体。 Commercially available silicone resins are generally dissolved in the form of a low viscosity volatile or non-volatile silicone fluid. 用于本发明的聚硅氧烷树脂应以这样的溶解形式加入和掺入本发明的组合物中,这是本领域的普通技术人员容易明白的。 Used in the present invention should be added to the silicone resin and incorporated into the compositions of the present invention in such dissolved form, which is of ordinary skill in the art readily understand.

聚硅氧烷物质,特别是聚硅氧烷树脂可方便地按照本领域技术人员公知的速记命名法系统即“MDTQ”命名法识别。 Polysiloxane materials, particularly silicone resins may conveniently be in accordance with well known to those skilled in the shorthand nomenclature system i.e. "MDTQ" nomenclature recognized. 在该系统中,聚硅氧烷是按照组成该聚硅氧烷的各种单体单元进行描述的。 In this system, the silicone is a polysiloxane according to the composition of the various monomer units has been described. 简而言之,符号M代表单官能单元(CH3)3SiO0.5;D代表二官能单元(CH3)2SiO;T代表三官能单元(CH3)SiO1.5;Q代表四官能单元SiO2。 Briefly, the symbol M denotes the monofunctional unit (CH3) 3SiO0.5; D Representative difunctional unit (CH3) 2SiO; T representative of the trifunctional unit (CH3) SiO1.5; Q representative of a tetrafunctional unit SiO2. 带上撇号的单元符号(例如M′、D′、T′、Q′)代表除甲基之外的取代基,每次出现时需具体定义。 Bring unit symbol apostrophe (eg M ', D', T ', Q') on behalf of outside except methyl substituent, need specific definitions for each occurrence. 典型的可供选择的取代基包括但不限于乙烯基、苯基、氨基、羟基等基团。 A typical choice of substituents include, but are not limited to, vinyl, phenyl, amino, hydroxy and the like groups. 在MDTQ系统中,或者以符号的下标指明聚硅氧烷中每类单元的总数目(或其平均值),或者以具体指明的比值并结合分子量的形式的各种单元的摩尔比均可完成对聚硅氧烷物质的描述。 In MDTQ system, or in symbols subscript indicates the total number of the silicone (or an average value) of each type of unit, or as specifically indicated ratios in combination with molecular weights of the various elements in the form of the molar ratio can be complete description of the silicone material. 在聚硅氧烷树脂中,T、Q、T′和/或Q′相对于D、D′、M和/或M′的较高的相对摩尔量,表明交联程度较高。 In the polysiloxane resin, T, Q, T 'and / or Q' with respect to the higher relative molar amount of D, D ', M and / or M', indicating a higher degree of crosslinking. 但是,如前讨论,交联的总水平也可通过氧与硅的比值来表示。 However, as previously discussed, the overall level of crosslinking can also be indicated by the oxygen to silicon ratio.

本发明的去头屑和调理香波组合物中优选使用的聚硅氧烷树脂包括但不限于MQ、MT、MTQ、MDT和MDTQ树脂。 Antidandruff the present invention and the silicone resin conditioning shampoo compositions preferably include, but are not limited to MQ, MT, MTQ, MDT and MDTQ resins. 因而,优选的聚硅氧烷取代基为甲基。 Thus, the preferred silicone substituent is methyl. 特别优选的聚硅氧烷树脂是MQ树脂,其中M∶Q比值为约0.5∶1.0-1.5∶1.0,聚硅氧烷树脂的平均分子量为约1000-10,000。 Especially preferred silicone resins are MQ resins, wherein the ratio is about 0.5:1.0-1.5:1.0 M:Q, silicone resin average molecular weight of about 1000-10,000.

当使用聚硅氧烷树脂成分时,折光指数低于1.46的不挥发性聚硅氧烷流体与聚硅氧烷树脂成分的重量比优选为约4∶1-400∶1,更优选约9∶1-200∶1,最优选约19∶1-100∶1,特别是当聚硅氧烷流体成分为如前所述的聚二甲基硅氧烷流体或聚二甲基硅氧烷流体与聚二甲基硅氧烷胶的混合物时更是如此。 By weight of non-volatile silicone fluid and a silicone resin component, when using the silicone resin component, a refractive index of less than 1.46 is preferably from about 4:1-400:1, more preferably from about 9: 1-200:1, most preferably about 19:1-100:1, particularly when the silicone fluid component is a polydimethylsiloxane described above polydimethylsiloxane fluid or a fluid with a mixture of polydimethylsiloxane gum especially when. 目前,由于聚硅氧烷树脂在组合物中与聚硅氧烷流体,即调理活性物质形成一部分相同的相,因而,在确定组合物中聚硅氧烷调理剂的水平时,应当包括流体与树脂的总和。 At present, due to the silicone resin in the composition with the silicone fluid, i.e. the conditioning active material forming part of the same phase, therefore, the level of silicone conditioning agent is polyethylene in determining the composition, and should include a fluid the sum of the resin.

2.有机调理油本发明的去头屑和调理香波组合物的调理组分还可以包括占组合物重量约0.05%至约3%,优选约0.08%至约1.5%,更优选约0.1%至约1%的至少一种有机调理油作为调理剂,其可以单独使用,也可以与其它调理剂如聚硅氧烷(如上所述)组合使用。 2. Organic conditioning oils anti-dandruff and conditioning components of the present invention, the conditioning shampoo compositions may further comprise about 0.05% to about 3% by weight of the composition, preferably from about 0.08% to about 1.5%, more preferably from about 0.1% to about 1% of at least one organic conditioning oil as the conditioning agent, which may be used alone, may be such as polysiloxane (as described above) in combination with other conditioning agents.

相信当这些有机调理油与组合物的基本组分组合使用,特别是与阳离子聚合物(如下所述)组合使用时,给香波组合物带来了改进的调理性能。 Believed that when these organic conditioning oil in combination with the essential components of the composition to use, especially with a cationic polymer (described below) in combination, to the shampoo composition brings improved conditioning performance. 这些调理油可以增加头发的光泽。 These can increase hair conditioning oil sheen. 此外,它们可以增强干梳理和干头发感。 In addition, they can enhance dry combing and dry hair feel. 相信这些有机调理油中的大多数或所有这些有机调理油可溶解在香波组合物的表面活性剂胶束中。 I believe these organic conditioning oils most or all of these organic conditioning oil soluble surfactant micelles in shampoo compositions. 而且还相信这种溶解在表面活性剂胶束中的作用有益于本发明香波组合物的改进的头发调理性能。 But also believe in surfactant micelles dissolved in this beneficial shampoo compositions of the present invention is an improved hair conditioning properties.

适于用作本发明的调理剂的有机调理油优选是低粘度、水不溶性的液体,选自烃油、聚烯烃、脂肪酯以及它们的混合物。 The organic conditioning oils suitable for use as the conditioning agent of the present invention are preferably low viscosity, water-insoluble liquid selected from hydrocarbon oils, polyolefins, fatty esters and mixtures thereof. 这样的有机调理油在40C测得的粘度优选为约1厘泊至约200厘泊,更优选约1厘泊至约100厘泊,最优选约2厘泊至约50厘泊。 Such organic conditioning oil viscosity measured at 40C is preferably from about 1 cps to about 200 cps, more preferably from about 1 cps to about 100 cps, and most preferably about 2 cps to about 50 cps.

i.烃油适于在本发明的去头屑和调理香波组合物中用作调理剂的有机调理油包括但不限于具有至少10个碳原子的烃油,如环状烃、直链脂族烃(饱和的或不饱和的)、支链脂族烃(饱和的或不饱和的),包括聚合物和它们的混合物。 i. a hydrocarbon oil suitable for the present invention in an anti-dandruff and conditioning shampoo compositions used as conditioning agents in the organic conditioning oils include, but are not limited to, hydrocarbon oils having at least 10 carbon atoms, such as cyclic hydrocarbons, straight chain aliphatic hydrocarbons (saturated or unsaturated), and branched chain aliphatic hydrocarbons (saturated or unsaturated), including polymers and mixtures thereof. 直链烃油优选为约C12至约C19。 Straight-chain hydrocarbon oils preferably from about C12 to about C19. 包括烃聚合物的支链烃油通常将含有超过19个碳原子。 Include hydrocarbon polymers Branched chain hydrocarbon oils will typically contain more than 19 carbon atoms.

这些烃油的具体的非限定性的实例包括链烷烃油、矿物油、饱和和不饱和的十二烷、饱和和不饱和的十三烷、饱和和不饱和的十四烷、饱和和不饱和的十五烷、饱和和不饱和的十六烷、聚丁烯、聚癸烯以及它们的混合物。 These particular non-limiting examples of hydrocarbon oils include paraffin oil, mineral oil, saturated and unsaturated dodecane, saturated and unsaturated tridecane, saturated and unsaturated tetradecane, saturated and unsaturated pentadecane, saturated and unsaturated hexadecane, polybutene, polydecene, and mixtures thereof. 这些化合物以及较高链长烃的支链异构体也能够使用,其实例包括高支链的、饱和的或不饱和的烷烃,如全甲基取代的异构体,例如十六烷和二十烷的全甲基取代的异构体,如2,2,4,4,6,6,8,8-二甲基-10-甲基十一烷和2,2,4,4,6,6-二甲基-8-甲基壬烷,从Permethyl Corporation购得。 These compounds as well as branched isomers higher chain length hydrocarbons, can also be used, examples of which include highly branched, saturated or unsaturated alkanes, such as full-methyl substituted isomers, e.g., hexadecane and eicosane full-methyl substituted isomers, e.g. 2,2,4,4,6,6,8,8- dimethyl-10-methyl-undecanoic and 2,2,4,4,6,6 - dimethyl-8-methyl-nonane, available from Permethyl Corporation. 烃聚合物如聚丁烯和聚癸烯。 Hydrocarbon polymers such as polybutene and polydecene. 优选的烃聚合物是聚丁烯,如异丁烯和丁烯的共聚物。 Preferred hydrocarbon polymer is polybutene, such as a copolymer of isobutylene and butene. 市售的这类物质为L-14聚丁烯,从Amoco Chemical Corporation购得。 Such material is commercially available L-14 polybutene from Amoco Chemical Corporation purchased.

ii.聚烯烃用于本发明的去头屑和调理香波组合物中的有机调理油还能包括液体聚烯烃,更优选液体聚-α-烯烃,最优选氢化的液体聚-α-烯烃。 ii. The polyolefin used in the present invention, anti-dandruff and conditioning shampoo compositions of the organic conditioning oils can also include liquid polyolefins, more preferably liquid polyethylene -α- olefins, most preferably hydrogenated liquid poly -α- olefin. 用于本发明的聚烯烃是通过聚合C4至约C14烯烃单体,优选C6至约C12烯烃单体而制备的。 Is obtained by polymerizing olefin monomers C4 to about C14, preferably C6 to about C12 olefin monomer used to prepare the polyolefins of the present invention.

用于制备本发明聚烯烃液体的烯烃单体的非限定性实例包括乙烯、丙烯、1-丁烯、1-戊烯、1-己烯、1-辛烯、1-癸烯、1-十二烯、1-十四烯、支链异构体如4-甲基-1-戊烯以及它们的混合物。 Non-limiting examples of the present invention for the preparation of polyolefins liquid olefin monomers include ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 1-octene, 1-decene, 1-ten diene, 1-tetradecene, branched chain isomers such as 4-methyl-1-pentene and mixtures thereof. 适于制备聚烯烃液体的还有含烯烃的精炼原料或流出物。 Also suitable for preparing the polyolefin liquids refinery feedstock or an olefin-containing effluent. 优选的氢化的聚-α-烯烃单体包括但不限于:1-己烯至1-十六烯,1-辛烯至1-十四烯以及它们的混合物。 Preferred poly -α- hydrogenated olefin monomers include, but are not limited to: 1-hexene to 1-hexadecene hexene, 1-octene to 1-tetradecene, and mixtures thereof.

iii.脂肪酯适于在本发明的去头屑和调理香波组合物中用作调理剂的其它有机调理油包括但不限于具有至少10个碳原子的脂肪酯。 iii. Other fatty esters suitable organic conditioning oils for use in the present invention, anti-dandruff and conditioning shampoo compositions used as conditioning agents include, but are not limited to, fatty esters having at least 10 carbon atoms. 这些脂肪酯包括衍生自脂肪酸或醇的带有烃基链的酯(例如单酯,多元醇酯,以及二-和三-羧酸酯)。 These fatty esters include those derived from fatty acids or alcohols with a hydrocarbon chain (e.g. monoesters, polyhydric alcohol esters, and di - and tri - carboxylate). 本发明的脂肪酯的烃基残基可以包括或具有共价连接在其上的其它相容的官能团,如酰胺和烃氧基部分(例如乙氧基或醚键等)。 Hydrocarbyl residue of the fatty ester of the present invention may include or have covalently attached to other compatible functional groups thereon, such as an amide, and a hydrocarbon moieties (e.g., ethoxy or ether linkages, etc.).

适用于本发明的去头屑和调理香波组合物中的是具有约C10至约C22脂族链的脂肪酸的烷基和烯基酯,具有约C10至约C22烷基和/或链烯基醇衍生的脂族链的烷基和链烯基脂肪醇羧酸酯,以及它们的混合物。 Suitable for the present invention are anti-dandruff and conditioning shampoo compositions having from about C10 to about C22 aliphatic chains of the fatty acid esters of alkyl and alkenyl groups having from about C10 to about C22 alkyl and / or alkenyl alcohol derived alkyl and alkenyl fatty alcohol carboxylic acid esters of the aliphatic chain, and mixtures thereof. 优选的脂肪酯的具体实例包括但不限于:异硬脂酸异丙酯、月桂酸己酯、月桂酸异己酯、棕榈酸异己酯、棕榈酸异丙酯、油酸癸酯、油酸异癸酯、硬脂酸十六酯、硬脂酸癸酯、异硬脂酸异丙酯、己二酸二己基癸(dihexyldecyl adipate)酯、乳酸月桂酯、乳酸肉豆蔻酯、乳酸十六酯、硬脂酸油酯、油酸油酯、肉豆蔻酸油酯、乙酸月桂酯、丙酸鲸蜡酯和己二酸油酯。 Specific examples of preferred fatty esters include, but are not limited to: isopropyl isostearate, hexyl laurate, lauric alien palmitate ester dissidents, isopropyl palmitate, decyl oleate, oleic acid isodecyl stearate, cetyl stearate, decyl oleate, isopropyl isostearate, dihexyl decyl adipate (dihexyldecyl adipate) ester, lauryl lactate, myristyl lactate, cetyl lactate esters, hard oil fatty acid ester, oleyl oleate, oleyl myristate, lauryl acetate, cetyl propionate, and oleyl adipate.

其它适用于本发明去头屑和调理香波组合物中的脂肪酯是通式为R′COOR的单羧酸酯,其中R′和R是烷基或链烯基残基,并且R′和R中碳原子的总和至少是10,优选至少为20。 Other useful in the present invention, anti-dandruff and conditioning shampoo compositions of the fatty ester of the general formula R'COOR monocarboxylic acid ester, wherein R 'and R is an alkyl or alkenyl residue, and R' and R the sum of carbon atoms is at least 10, preferably at least 20. 单羧酸酯不必须含有至少一个具有至少10个碳原子的链,而是脂族链碳原子数的总数必须至少为10。 Monocarboxylic acid ester does not have to contain at least one chain having at least 10 carbon atoms, but the total number of aliphatic chain carbon atoms must be at least the number 10. 单羧酸酯的具体的非限定性的实例包括:肉豆蔻酸异丙酯、硬脂酸甘醇酯和月桂酸异丙酯。 Specific non-limiting examples of monocarboxylic acid esters include: isopropyl myristate, glycol stearate, and isopropyl laurate.

适用在本发明去头屑和调理香波组合物中的其它脂肪酯是羧酸的二-和三-烷基和链烯基酯,如C4-C8二羧酸的酯(例如琥珀酸、戊二酸、己二酸、己酸、庚酸和辛酸的C1-C22酯,优选C1-C6酯)。 In the present invention, suitable anti-dandruff and conditioning shampoo compositions of other fatty acid ester is di - and tri - alkyl and alkenyl esters, such as C4-C8 esters of dicarboxylic acids (e.g., succinic acid, glutaric acid, adipic acid, hexanoic acid, heptanoic acid and octanoic acid esters of C1-C22, preferably C1-C6 ester). 羧酸的二-和三-烷基和链烯基酯的具体的非限定性的实例包括硬脂酰基硬脂酸异鲸蜡酯、己二酸二异丙酯和柠檬酸三硬脂酯。 Dicarboxylic acids - and tris - Specific non-limiting examples of alkyl and alkenyl esters include isocetyl stearoyl stearate ester, diisopropyl adipate, and tristearyl citrate esters.

适用在本发明去头屑和调理香波组合物中的其它的脂肪酯是被称作多元醇酯的那些。 In the present invention, suitable anti-dandruff and conditioning shampoo compositions of other fatty esters are those known as polyhydric alcohol esters. 这样的多元醇酯包括亚烷基二醇酯,如乙二醇单和双脂肪酸酯,双甘醇单和双脂肪酸酯,聚乙二醇单和双脂肪酸酯,丙二醇单和双脂肪酸酯,聚丙二醇单油酸酯,聚丙二醇2000单硬脂酸酯,乙氧基化的丙二醇单硬脂酸酯,甘油基单-和二-脂肪酸酯,多甘油多脂肪酸酯,乙氧基化的甘油基单硬脂酸酯,1,3-丁二醇单硬脂酸酯,1,3-丁二醇二硬脂酸酯,聚氧乙烯多元醇脂肪酸酯,脱水山梨(糖)醇脂肪酸酯,以及聚氧乙烯脱水山梨(糖)醇脂肪酸酯。 Such polyhydric alcohol esters include alkylene glycol esters, such as ethylene glycol mono- and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol mono- and di-fatty acid esters, propylene glycol mono- and di-fatty esters, polypropylene glycol monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl single - and di - fatty acid esters, polyglycerol fatty acid esters and more, B ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid esters, sorbitan ( sugar) alcohol fatty acid esters, and polyoxyethylene sorbitan (sugar) alcohol fatty acid esters.

适用在本发明去头屑和调理香波组合物中的其它的脂肪酯是甘油酯,包括,但不限于,单-、二-、三-甘油酯,优选二或三甘油酯,最优选三甘油酯。 In the present invention, suitable anti-dandruff and conditioning shampoo compositions of other fatty esters are glycerides, including, but not limited to, single -, two -, three - glycerides, preferably di- or tri-glycerides, most preferably triglycerol esters. 对于用在本发明香波组合物中而言,甘油酯优选是甘油和长链羧酸如C10-C22羧酸的单-、二-、三-酯。 For use in the shampoo compositions of the present invention, the glycerides are preferably glycerol and long chain carboxylic acids such as C10-C22 mono -, di -, tri - ester. 这类物质中的许多种能够由动物和植物中的脂肪和油得到,如蓖麻油,红花油,棉籽油,玉米油,橄榄油,鳕鱼肝油,杏仁油,鳄梨油,棕榈油,芝麻油,羊毛脂和大豆油。 Many kinds of such materials can be obtained from animal and vegetable fats and oils, such as castor oil, safflower oil, cottonseed oil, corn oil, olive oil, cod liver oil, almond oil, avocado oil, palm oil, sesame oil , lanolin and soybean oil. 合成油包括但不限于三油精和三硬脂精甘油基二月桂酸酯。 Synthetic oils include, but are not limited to, triolein and tristearin glyceryl dilaurate.

适用在本发明去头屑和调理香波组合物中的其它的脂肪酯是水不溶性的合成脂肪酯。 In the present invention, suitable anti-dandruff and conditioning shampoo compositions of other fatty esters are water insoluble synthetic fatty esters. 某些优选的合成酯满足通式(IX): Some preferred synthetic esters which satisfied the formula (IX):

其中R1是C7-C9烷基,链烯基,羟基烷基或羟基链烯基,优选饱和的烷基,更优选饱和的直链烷基;n是2-4的正整数,优选为3;Y是具有约2至约20个碳原子,优选具有约3至约14个碳原子的烷基,链烯基,羟基或羧基取代的烷基或链烯基。 Wherein R1 is a C7-C9 alkyl, alkenyl, hydroxy alkyl or hydroxy alkenyl group, preferably a saturated alkyl group, more preferably a saturated straight chain alkyl group; n is a positive integer of 2 to 4, preferably 3; Y is having from about 2 to about 20 carbon atoms, preferably an alkyl group having from about 3 to about 14 carbon atoms, alkenyl, hydroxy or carboxy substituted alkyl or alkenyl group. 其它优选的合成的酯满足通式(X): Other preferred synthetic esters which satisfied the formula (X): 其中R2是C8-C10烷基,链烯基,羟基烷基或羟基链烯基,优选饱和的烷基,更优选饱和的直链烷基;n和Y的定义如上式(X)中的定义。 Wherein R2 is a C8-C10 alkyl, alkenyl, hydroxy alkyl or hydroxy alkenyl group, preferably a saturated alkyl group, more preferably a saturated straight chain alkyl group; n and Y are defined as above defined formula (X) in .

相信当优选的合成酯和本发明香波组合物的基本组分组合使用时,特别是与阳离子聚合物组分(如下文所述)组合使用时,带来了改进的湿头发感。 Believe that a combination of essential components when the preferred synthetic esters and shampoo compositions of the present invention is used, especially when the cationic polymer component (described below) used in combination brings improved wet hair feel. 这些合成酯通过降低已用阳离子聚合物调理过的湿头发的粘糊或过度调理感而改进湿头发感。 These synthetic esters by reducing conditioning cationic polymer has been used over the wet slimy or excessive hair conditioner to improve wet hair feel a sense.

适用于本发明去头屑和调理香波组合物中的合成脂肪酯的具体的非限定性的实例包括P-43(三羟甲基丙烷的C8-C10三酯),MCP-684(3,3-二乙醇-1,5-戊二醇的四酯),MCP121(己二酸的C8-C10二酯),均购自Mobil ChemicalCompany。 The present invention is applicable to anti-dandruff and conditioning shampoo compositions of the synthesis of fatty esters of non-limiting specific examples include P-43 (trimethylolpropane triesters of C8-C10), MCP-684 (3,3 - diethanol-1,5-pentanediol tetraester), MCP121 (adipic acid C8-C10 diesters), were purchased from Mobil ChemicalCompany.

3.其它调理剂适用于本发明组合物中的还有由Procter & Gamble Company在其美国专利5674478和5750122中描述的调理剂,上述专利引入本文作为参考。 3. Other conditioning agents useful in the compositions of the present invention as well as by the Procter & amp; Gamble Company conditioning agents described in U.S. Patent No. 5,674,478 and 5,750,122 which, the aforementioned patents incorporated herein by reference. 适用于本发明中还有描述于下述专利中的那些:USP 4529586(Clairol),4507280(Clairol),4663158(Clairol),4197865(L'Oreal),4217914(L'Oreal),4381919(L'Oreal)和4422853(L'Oreal),所有这些专利文献都引入本文作为参考。 Useful in the present invention, there is described in the following patents that: USP 4529586 (Clairol), 4507280 (Clairol), 4663158 (Clairol), 4197865 (L'Oreal), 4217914 (L'Oreal), 4381919 (L ' Oreal) and 4422853 (L'Oreal), all of these patent documents are incorporated herein by reference.

用于本发明的组合物中的一些其它优选的聚硅氧烷调理剂包括:AbilS 201(聚二甲基硅氧烷/PG-丙基聚二甲基硅氧烷硫代硫酸钠共聚物),从Goldschmidt购得;DC Q2-8220(三甲基甲硅烷基胺化聚二甲基硅氧烷),从道康宁公司购得;DC 949(胺化聚二甲基硅氧烷,鲸蜡基三甲基氯化铵,以及Trideceth-12),从道康宁公司购得;DC 749(环状聚(二)甲基硅氧烷和三甲基甲硅烷氧基硅酸盐),从道康宁公司购得;DC 2502(鲸蜡基聚二甲基硅氧烷),从道康宁公司购得;BC 97/004和BC 99/088(氨基官能化的聚硅氧烷微乳液),从Basildon Chemicals购得;GE SME253和SM2115-D2和SM2658和SF1708(氨基官能化的聚硅氧烷微乳液),从General Electric购得;聚硅氧烷化的道氏池花籽油,从Croda购得;以及下面所述的那些聚硅氧烷调理剂:GAP Corp.的美国专利4834767(季化氨基内酰胺),BiosilTechnologies的美国专利5854319(含有氨基酸的活性聚硅氧烷乳液)以及道康宁的美国专利4898585(聚硅氧烷),所有这些引入本发明作为参考。 Used in the compositions of the present invention some other preferred silicone conditioning agents include: AbilS 201 (dimethicone / PG- propyl polydimethylsiloxane copolymer sodium thiosulfate thereof), commercially available from Goldschmidt; DC Q2-8220 (trimethylsilyl group aminated polydimethylsiloxane), commercially available from Dow Corning Corporation; DC 949 (aminated polydimethylsiloxane, whale wax trimethyl ammonium chloride, and Trideceth-12), commercially available from Dow Corning Corporation; DC 749 (cyclic poly (dimethylsiloxane) methyl siloxane and trimethyl siloxy silicate), from Dow Corning The company purchased; DC 2502 (cetyl dimethicone), available from Dow Corning Corporation; BC 97/004 and BC 99/088 (amino functionalized polysiloxane microemulsion), from Basildon Chemicals available; GE SME253 and SM2658 and SM2115-D2 and SF1708 (amino functional silicone microemulsion), purchased from General Electric; polysiloxane of meadowfoam seed oil, available from Croda; and those described below silicone conditioning agent: GAP Corp. U.S. Patent No. 4,834,767 (the quaternized aminoamide), BiosilTechnologies U.S. Patent No. 5,854,319 (containing the amino acid reactive silicone emulsions), and Dow Corning's U.S. Patent No. 4,898,585 (polysiloxanes), all of which are incorporated herein by reference. C.去头屑剂本发明的去头屑和调理香波组合物包括占组合物重量约0.1%至约4%,优选约0.1至约3%,最优选约0.3%至约2%的适于用在头发或皮肤上的去头屑颗粒。 C. antidandruff agent of the present invention, anti-dandruff and conditioning shampoo compositions comprising from about 0.1% to about 4% by weight of the composition, preferably from about 0.1 to about 3%, most preferably from about 0.3% to about 2% of suitable with the hair or skin dandruff particles. 去头屑颗粒给香波组合物带来了抗微生物活性。 Anti-dandruff shampoo compositions of the particles to bring the anti-microbial activity. 去头屑颗粒的合适的非限定性的实例包括:吡啶硫酮盐,硫化硒,微粒化硫以及它们的混合物。 Antidandruff particles Suitable non-limiting examples include: pyridinethione salts, selenium sulfide, particulate sulfur, and mixtures thereof. 优选的是吡啶硫酮盐。 Preferred are pyridinethione salts. 这些去头屑颗粒应与组合物的基本组分在化学性质和物理性质上相容,而且不过分损害产品的稳定性、美观或性能。 These anti-dandruff particulate should be chemically and physically compatible with the essential components of the composition, and not overly damage stability, aesthetics or performance.

1.吡啶硫酮盐吡啶硫酮去头屑微粒,特别是1-羟基-2-吡啶硫酮盐,是用于本发明去头屑和调理香波组合物中的特别优选的微粒状去头屑剂。 1. Pyridinethione salts Pyridinethione anti-dandruff particulates, especially 1-hydroxy-2-pyridinethione salts, are used in the present invention, anti-dandruff and conditioning shampoo compositions of particularly preferred particulate antidandruff agent. 吡啶硫酮去头屑微粒的浓度通常占组合物重量的约0.1%至约4%,优选约0.1%至约3%,最优选约0.3%至约2%。 Pyridinethione anti-dandruff particulate concentration is usually from about 0.1% by weight of the composition to about 4%, preferably from about 0.1% to about 3%, most preferably from about 0.3% to about 2%. 优选的吡啶硫酮盐包括由重金属盐形成的那些,重金属如锌,锡,镉,镁,铝和锆,优选锌,更优选1-羟基-2-吡啶硫酮的锌盐(称为“吡啶硫酮锌”或“ZPT”),最优选1-羟基-2-吡啶硫酮盐,为小片状颗粒形式,其中这些颗粒的平均粒径为至多约20μ,优选至多约5μ,最优选至多2.5μ。 Preferred pyridinethione salts include those of heavy metals such as zinc, tin, cadmium, magnesium, aluminum and zirconium, preferably zinc salts formed by the heavy metal, and more preferably 1-hydroxy-2-pyridinethione zinc salt (referred to as "pyridine zinc pyrithione "or" ZPT "), most preferably 1-hydroxy-2-pyridinethione salts, in the form of small plate-like particles, wherein the average particle size of these particles is up to about 20μ, preferably up to about 5μ, most preferably at most 2.5μ. 由其他阳离子形成的盐,如钠,也是合适的。 Salts formed from other cations, such as sodium, are also suitable. 吡啶硫酮去头屑剂描述于下述文献中:例如美国专利2809971,美国专利3236733,美国专利3753196,美国专利3761418,美国专利4345080,美国专利4323683,美国专利4379753,和美国专利4470982,本发明引入这些专利作为参考。 Pyridinethione antidandruff agents are described in the following references: U.S. Patent No. 2,809,971, for example, U.S. Patent No. 3,236,733, U.S. Patent No. 3,753,196, U.S. Patent No. 3,761,418, U.S. Patent No. 4,345,080, U.S. Patent No. 4,323,683, U.S. Patent 4,379,753, and U.S. Patent No. 4,470,982, the present invention These patents are incorporated herein by reference. 设想当ZPT在本发明的香波组合物中用作去头屑颗粒时,可以刺激或/和调节头发的生长或再生,或两者,或者可以降低或抑制头发损失,或者可以使头发显得更厚或饱满。 Contemplated when ZPT is used as anti-dandruff particulate in the shampoo compositions of the present invention, can stimulate and / or regulating hair growth or regeneration, or both, or may decrease or inhibit hair loss, or may make the hair appear thicker or full.

2.硫化硒硫化硒是本发明去头屑和调理香波组合物中适用的微粒状去头屑剂,其有效浓度占组合物重量的约0.1%至约4%,优选约0.3%至约2.5%,最优选约0.5%至约1.5%。 2. Selenium sulfide Selenium sulfide is the present invention anti-dandruff and conditioning shampoo compositions suitable for use in a particulate antidandruff agent in an effective concentration from about 0.1% to about 4% by weight of the composition, preferably from about 0.3% to about 2.5 %, most preferably from about 0.5% to about 1.5%. 硫化硒通常被认为是具有一摩尔硒和两摩尔硫的化合物,但是它也可以是满足通式SexSy的环状结构,其中x+y=8。 Selenium sulfide is generally considered to be one mole of the compound of selenium and two moles of sulfur with, but it may also be a cyclic structure satisfies the general formula SexSy, wherein x + y = 8. 硫化硒的平均粒径通常小于15μm,这可以通过向前激光散射仪器(例如Malvern 3600设备),优选小于10μm。 The average particle size of the selenium sulfide are typically less than 15μm, which can forward laser light scattering instrument (e.g., Malvern 3600 apparatus), preferably less than 10μm. 硫化硒化合物描述在例如美国专利2694668,美国专利3152046,美国专利4089945,和美国专利4885107中,本发明引入这些专利作为参考。 Selenium sulfide compounds are described in, e.g., U.S. Patent No. 2,694,668, U.S. Patent No. 3,152,046, U.S. Patent 4,089,945, and U.S. Patent No. 4,885,107, the present invention is the introduction of these patents are incorporated by reference.

3.硫硫也可以用作本发明去头屑和调理香波组合物中的微粒状去头屑剂。 3. Sulfur Sulfur may also be used in the present invention, anti-dandruff and conditioning shampoo compositions of the particulate antidandruff agent. 颗粒状硫的有效浓度通常占组合物重量的约1%至约4%,优选约2%至约4%。 Effective concentration of the particulate sulfur are generally from about 1% to about 4% by weight of the composition, preferably from about 2% to about 4%. D.阳离子聚合物本发明的去头屑和调理香波组合物包括占组合物重量的约0.02%至约5%,更优选约0.05%至约3%,还更优选约0.1%至约2%,最优选约0.5%至约1%的至少一种适于用在头发或皮肤上的有机阳离子沉积和调理聚合物。 D. Cationic polymer The anti-dandruff and conditioning shampoo of the present invention the composition comprises from about 0.02% to about 5% by weight of the composition, more preferably from about 0.05% to about 3%, still more preferably from about 0.1% to about 2% organic cationic deposition and conditioning polymer, most preferably from about 0.5% to about 1% of at least one suitable for use on the hair or skin. 相信阳离子聚合物给本发明所述的香波组合物带来了增加的去头屑功效和增加的调理作用。 Believed that the cationic polymer to the shampoo composition according to the present invention resulted in increased anti-dandruff efficacy and increased conditioning. 这些阳离子聚合物应与组合物的基本组分在化学性质和物理性质上相容,而且不过分损害产品的稳定性、美观或性能。 These cationic polymers should be chemically and physically compatible with the essential components of the composition, and not overly damage stability, aesthetics or performance.

1.阳离子聚合物的特征用在本发明中的阳离子聚合物的选择和存在量必须要使得阳离子聚合物溶解在香波组合物中,并且优选在稀释时,溶解在香波组合物中的复合凝聚相中。 1. The cationic polymer used in the present invention is characterized in the presence of selection and amount of the cationic polymer must be such that the cationic polymer is dissolved in the shampoo composition, and preferably upon dilution, was dissolved in the shampoo composition of complex coacervate phase in. 下文中详细描述了这样的凝聚相。 Described in detail hereinafter such a condensed phase. 而且还详述了阳离子聚合物的物理特性和合适的反离子。 But also details the physical properties of a cationic polymer and a suitable counterion.

i.由阳离子聚合物形成的凝聚相在稀释香波组合物时,在本发明的阳离子聚合物和阴离子去污表面活性剂组分之间(如上文所述)形成凝聚相。 i. a polymer formed by cationic coacervate phase upon dilution of the shampoo compositions, in (as described above) between the cationic polymers of the present invention and the anionic detersive surfactant component forms the condensed phase. 相信聚合物的阳离子部分和表面活性剂的阴离子部分结合而形成不溶性的复合物,它们在稀释时沉淀(凝聚相)。 Believe that the anionic portion of the polymer and the cationic surfactant portion combine to form insoluble complexes, which precipitate (aggregated phase) upon dilution. 阳离子聚合物的复合凝聚相还能够与香波组合物中的其它任选阴离子组分(如下文所述)一起形成。 Complex cationic polymers can also be condensed phase with the shampoo composition other optional anionic components (described below) together form. 凝聚相的形成依赖于多种标准,如分子量,组分浓度,相互作用的离子组分的比例,离子强度(包括例如通过加入盐而带来的离子强度的改变),阳离子和阴离子组分的电荷密度,pH和温度。 Condensed phase formation is dependent on a variety of criteria, such as molecular weight, component concentration, the ratio of interacting ionic components, ionic strength (including, for example changes caused by the addition of salt and ionic strength), cationic and anionic components charge density, pH, and temperature. 凝聚相体系和这些参数的效果描述在如下述文献中:J.Caelles等人,“混合体系中的阴离子和阳离子化合物”(Cosmetics&Toiletries,Vol.106,1991年4月,49-54页);CJvan Oss,“凝聚作用,复合-凝聚作用和絮凝”(J.DispersionScience and Tech.,Vol.9(5,6),1988-89,561-73页);和DJBurgess,“复合凝聚相体系的实用分析”(J.of Colloid and Interface Science,Vol.140,No.1,(1990年11月),227-38页);所有这些引入本发明作为参考。 Condensed phase systems and the effect of these parameters as described in the following references: J.Caelles et al., "Mixed system of anionic and cationic compounds" (Cosmetics & amp; Toiletries, Vol.106,1991 April, p. 49-54) ; CJvan Oss, "unifying role, composite - unifying role and flocculation" (J.DispersionScience and Tech, Vol.9 (5,6), 1988-89,561-73 page.); and DJBurgess, "complex condensed phase systems Practical analysis "(J.of Colloid and Interface Science, Vol.140, No.1, (1990 November 2005), p. 227-38); all of which are incorporated herein by reference. 本发明所述的香波组合物通常具有的阴离子去污表面活性剂组分和阳离子聚合物组分的比例为约25∶0.02至约1∶5,优选约20∶0.1至约12∶1。 The proportion of the shampoo compositions of the invention generally has anionic detersive surfactant component and a cationic polymer component is from about 25:0.02 to about 5, preferably about 12 to about 20:0.1.

相信凝聚相提供了调理功效,特别是当头发是润湿的时候而使用产品时,通过帮助将调理剂沉积在头发和头皮上而提供了调理功效。 Believe condensed phase provides conditioning benefits, especially when the hair is wet and when using the product, by helping to deposit conditioning agents onto the hair and scalp to provide a conditioning effect. 而且本领域中还知道凝聚相也帮助沉积其它类型的颗粒物。 And is also known in the art also helps the condensed phase deposition of other types of particulate matter. 认为这是在稀释时,通过在凝聚相的边缘浓缩颗粒物而出现的。 It is believed at the time of dilution, by the edge of the condensed phase and concentrate particles appear.

现已发现,在这样的组合物中的聚合物的特征能够影响去头屑颗粒的生物利用度/覆盖度,这样的特征包括阳离子瓜尔聚合物分子量和电荷密度。 It has been found, characteristics of the polymer in such compositions can affect the anti-dandruff particle bioavailability / coverage, such characteristics include cationic guar polymer molecular weight and charge density. 优选低分子量的瓜尔,优选低电荷密度的瓜尔。 Preferably a low molecular weight of guar, preferably a low charge density of guar. 特别优选低分子量和低电荷密度的瓜尔。 Particularly preferred low molecular weight and low charge density of the guar. 相信这些选定的瓜尔赋予了所形成的凝聚相改善的物理性能(即流变性)。 Believe these selected guar gives the formed coacervate phase improved physical properties (i.e. rheology).

用来分析复合凝聚相的形成的技术是本领域公知的技术。 Used to analyze complex coacervate phase is formed by techniques known in the art techniques. 例如可以在任意选定的稀释阶段,采用显微分析香波组合物来鉴别是否形成凝聚相。 For example, at any chosen stage of dilution, using microscopic analysis of the shampoo composition to identify whether the formation of the condensed phase. 这种凝聚相可识别为组合物中附加的乳化相。 Such coacervate phase in the composition can be identified as additional emulsified phase. 使用染料有助于区分凝聚相和分散在香波组合物中的其它不溶相。 Helps to distinguish using dyes aggregation phase dispersed in the shampoo composition other insoluble phases.

ii.阳离子聚合物的物理特性适用于本发明的阳离子调理聚合物的平均分子量为约5,000至约10,000,000,优选约100,000至约2,000,000,更优选约200,000至约1,500,000,更优选约250,000至约850,000,更优选约350,000至约500,000。 Physical Characteristics ii. cationic polymers suitable cationic conditioning polymers of the present invention the average molecular weight of from about 5,000 to about 10,000,000, preferably from about 100,000 to about 2,000,000, more preferably from about 200,000 to about 1,500,000, more preferably from about 250,000 to about 850,000, more preferably from about 350,000 to about 500,000. 在香波组合物的预期使用时的pH值下,测得的聚合物的阳离子电荷密度约为0.2meq/g至约7meq/g,优选约0.4meq/g至约5meq/g,更优选约0.6meq/g至约2meq/g,更优选约0.5meq/g至约1meq/g,更优选约0.5meq/g至约0.9meq/g。 At a pH value of the expected use of the shampoo composition, measured cationic charge density of the polymer was about 0.2meq / g to about 7meq / g, preferably from about 0.4meq / g to about 5meq / g, more preferably from about 0.6 meq / g to about 2meq / g, more preferably from about 0.5meq / g to about 1meq / g, more preferably from about 0.5meq / g to about 0.9meq / g. 香波组合物的预期使用时的pH值通常为约3至约9,优选约4至约7。 PH value of the expected use of the shampoo composition is generally from about 3 to about 9, preferably from about 4 to about 7.

iii.形成阳离子聚合物时使用的反离子任何阴离子反离子都可以与阳离子聚合物结合使用,只要在香波组合物中的或在香波组合物的凝聚相中的阳离子聚合物仍能保持溶解在水中,并且还要求该反离子与香波组合物的基本组分在化学和物理性质上相容,或者不过分损害产品的性能、稳定性或美观即可。 iii. Any anionic counterion counterion forming cationic polymers may be used in combination with cationic polymers, as long as in the shampoo compositions or condensed phase in the shampoo composition of a cationic polymer is dissolved in the water can maintain and also requires that the basic component of counter-ions with shampoo composition on the chemical and physical properties compatible with, or unduly damage the product performance, stability or aesthetics can be. 这种反离子的非限制性的实例包括卤素(例如氯、氟、溴和碘)、硫酸根和甲酯硫酸根以及它们的混合物。 Non-limiting examples of counter ions include halogen (e.g. chlorine, fluorine, bromine and iodine), sulfate and methosulfate, and mixtures thereof.

2.阳离子聚合物的类型可适用于本发明香波组合物中的阳离子聚合物的实例包括但不限于阳离子多糖(例如阳离子纤维素衍生物和阳离子瓜尔),乙烯基单体的共聚物,乙烯基吡咯烷酮共聚物,阳离子改性的蛋白质,以及某些聚合物季盐。 2. Types cationic polymers may be applied in the shampoo compositions of the present invention Examples of cationic polymers include, but are not limited to cationic polysaccharides (e.g. cationic cellulose derivatives and cationic guar), copolymers of vinyl monomers, ethylene pyrrolidone copolymers, cationic modified proteins, and certain polymeric quaternary salts. 这些阳离子聚合物详细描述于下文中。 These cationic polymers are described in detail below.

i.阳离子多糖本发明去头屑和调理香波组合物中优选的阳离子聚合物是被称为阳离子多糖的那些。 i. The present invention is a cationic polysaccharide anti-dandruff and conditioning shampoo compositions preferred cationic polymers are those known as cationic polysaccharides. 阳离子多糖是基于C5-C6糖的那些聚合物和在多糖主链上接枝阳离子部分而具有阳离子性的衍生物,包括季铵或阳离子胺取代的单体单元以及任选与非阳离子单体结合形成的均聚物、共聚物、三元共聚物等。 Cationic polysaccharides are those polymers based cation portion and grafted C5-C6 sugars in the polysaccharide backbone having cationic derivatives include quaternary ammonium or cationic amine-substituted monomer units and optionally in combination with non-cationic monomers formation of homopolymers, copolymers, terpolymers and the like. 多糖可以由一种类型的糖或一种以上的糖构成。 Polysaccharides may be composed of one type of sugar or of more than one sugar. 阳离子胺可为伯胺、仲胺或叔胺(优选仲胺或叔胺),这取决于香波组合物的特定种类及其所选定的pH值。 The cationic amines can be primary amines, secondary or tertiary amines (preferably secondary or tertiary amine), depending on the particular kind of the shampoo composition and the pH selected. 单体可以是直链或支链几何构形。 Monomers may be straight-chain or branched-chain geometry. 所有的单体单元可以具有连接于其上的含阳离子氮的部分,优选一些单体单元不具有这样的连接部分。 All fractions containing the monomer units may have cationic nitrogen attached thereto, preferably some of the monomer units having no such connecting portion. 阳离子多糖的非限定性实例在下述文献中有述:CTFA Cosmetic IngredientDictionary,第3版,由Estrin、Crosley和Haynes编辑,(美国化妆品、盥洗用品和香料协会(The Cosmitic,Toiletry,and Fragrance Association,Inc.,即CTFA,Washington,DC1982),该文献引入本文作为参考。 Non-limiting examples of cationic polysaccharides are described in the following references: CTFA Cosmetic IngredientDictionary, 3rd edition, edited by Estrin, Crosley, and Haynes, (US cosmetics, toiletries, and Fragrance Association (The Cosmitic, Toiletry, and Fragrance Association, Inc ., i.e., CTFA, Washington, DC1982), which is incorporated herein by reference.

阳离子多糖聚合物包括下列物质:阳离子纤维素和羟乙基纤维素;阳离子淀粉和羟基烷基淀粉;基于从瓜尔豆的胚乳得到的称为瓜尔胶的半乳甘露聚糖的阳离子聚合物;基于树胶醛醣植物胶的阳离子聚合物;衍生自木糖聚合物的阳离子聚合物(如见于树木、稻草、棉籽壳、玉米穗轴中的那些);衍生自海藻糖聚合物的阳离子聚合物(如见于海藻中的细胞壁的组分的那些);衍生自果糖聚合物的阳离子聚合物(如Inulin,见于某些植物);基于含酸的糖的阳离子聚合物(如半乳糖醛酸和葡糖醛酸);基于胺糖的阳离子聚合物(如半乳糖胺和葡糖胺);基于5和6元环的多元醇的阳离子聚合物;基于半乳糖单体的阳离子聚合物(如见于植物胶中和mucilate中的那些);以及基于甘露糖单元的阳离子聚合物(如见于植物、酵母和红藻中的那些)。 Cationic polysaccharide polymers include the following materials: cationic cellulose and hydroxyethyl cellulose; cationic starches and hydroxyalkyl starches; based on the guar endosperm obtained galactomannan guar gum known as cationic polymers ;-based arabinose vegetable gum cationic polymer; cationic polymers derived from xylose polymers (such as found in trees, straw, cottonseed hulls, corn cobs those); cationic polymers derived from trehalose polymer (such as those found in the cell walls of algae component); cationic polymers derived from fructose polymers (such as Inulin, found in certain plants); a sugar-based acid-containing cationic polymers (such as galacturonic acid and glucosamine uronic acid); cationic polymers based on amine sugars (such as galactosamine and glucosamine); based 5- and 6- membered rings of polyhydric alcohols cationic polymers; cationic polymers based on galactose monomers (such as found in a plant gum and mucilate those); and a cationic polymer (e.g. found in plants, yeasts, and red algae those) based on mannose units. 优选的是阳离子纤维素和羟乙基纤维素;阳离子淀粉和羟烷基淀粉;基于瓜尔胶的阳离子聚合物,以及它们的混合物。 Preferred are cationic cellulose and hydroxyethyl cellulose; cationic starches and hydroxyalkyl starches; cationic guar gum based polymers, and mixtures thereof.

a.阳离子纤维素衍生物适用于本发明的去头屑和调理香波组合物中的多糖阳离子聚合物是阳离子纤维素衍生物和阳离子淀粉衍生物。 a. cationic cellulose derivatives of the present invention is applicable to anti-dandruff and conditioning shampoo compositions of the cationic polysaccharide polymer is a cationic cellulose derivatives and cationic starch derivatives. 合适的阳离子聚合物包括满足通式(XI)的那些: Suitable cationic polymers include satisfy the formula (XI) are those: 其中A是葡糖酐残基(例如淀粉或纤维素葡糖酐残基);R是亚烷基氧亚烷基、多氧亚烷基或羟基亚烷基,或者它们的组合;R1、R2和R3独立地是烷基、芳基、烷基芳基、芳基烷基、烷氧基烷基或烷氧基芳基,每一个基团含有多达约18个碳原子,每个阳离子部分的碳原子总数(即R1、R2和R3中碳原子的总和)优选约20或低于20;X是如上所述的阴离子反离子。 Wherein A is an anhydroglucose residual group (e.g., starch or cellulose anhydroglucose residual); R is an alkylene oxyalkylene, polyoxyalkylene, or hydroxyalkylene group, or combinations thereof; R1, R2 and R3 are independently alkyl, aryl, alkylaryl, arylalkyl, alkoxyalkyl or alkoxyaryl groups, each group containing up to about 18 carbon atoms, each cationic moiety The total number of carbon atoms (i.e., R1, R2 and R3 is the sum of carbon atoms) is preferably about 20 or less than 20; X is an anionic counterion as described above.

优选的阳离子纤维素聚合物包括但不限于,可从Amerchol公司以其聚合物系列Polymer JR和LR中得到的那些,为与三甲基铵取代的环氧化物反应的羟乙基纤维素的盐,工业中(CTFA)称为Polyquaternium 10(例如从Amerchol公司得到的JR 30M)。 Preferred cationic cellulose polymers include, but are not limited to, those for with trimethyl ammonium substituted epoxide of hydroxyethyl cellulose obtainable from Amerchol Corp. in their Polymer Series in Polymer JR and LR salt, the industry (CTFA) referred Polyquaternium 10 (e.g., obtained from Amerchol Corp. JR 30M). 优选用在本发明中的Polyquaternium 10聚合物的电荷密度通常为约0.3meq/g至约3meq/g,且分子量为约200000至约1500000。 Preferred for use in the present invention, the charge density of the polymer is Polyquaternium 10 is typically from about 0.3meq / g to about 3meq / g, and a molecular weight of from about 200,000 to about 1,500,000. 另一种优选类型的阳离子纤维素的非限定性实例包括与月桂基二甲基铵取代的环氧化物反应的羟乙基纤维素的聚合季铵盐,工业中(CTFA)称为Polyquaternium 24(例如从Amerchol公司得到的Polymer LM-200)。 Another non-limiting examples of preferred types of cationic cellulose include hydroxyethyl cellulose reacted with lauryl dimethyl ammonium-substituted epoxide of the polymeric quaternary ammonium salts, the industry (CTFA) known as Polyquaternium 24 ( for example, the company obtained from Amerchol Polymer LM-200).

适用于本发明的还有那些与二烯丙基二甲基氯化铵反应的羟乙基纤维素的含季氮的纤维素共聚物,工业中(CTFA)称为Polyquaternium 4(例如从National Starch公司得到的CelquatH-100)。 There are those suitable for hydroxyethyl cellulose and diallyl dimethyl ammonium chloride the reaction of the present invention is a copolymer of quaternary nitrogen-containing cellulose, the industry (CTFA) referred Polyquaternium 4 (e.g., from National Starch The company was CelquatH-100). 适用于本发明的含季氮的纤维素醚描述于美国专利3962418中,并且适用于本发明的其它的醚化的纤维素和淀粉的共聚物描述于美国专利3958581中,本发明引入上述专利作为参考。 Useful in the present invention are quaternary nitrogen-containing cellulose ethers described in U.S. Patent No. 3,962,418, and applicable to other etherified cellulose and starch copolymer of the present invention are described in U.S. Patent No. 3,958,581, the present invention introduces the above-mentioned patents as reference.

b.阳离子瓜尔适用于本发明的去头屑和调理香波组合物中的其它合适的多糖阳离子聚合物是阳离子瓜尔聚合物。 b. cationic guar applicable to the present invention, anti-dandruff and conditioning shampoo compositions of Other suitable polysaccharide cationic polymers are cationic guar polymers. 瓜尔是带正电的取代的半乳甘露聚糖(瓜尔)胶衍生物。 Guar is positively charged substituted galactomannan (guar) gum derivatives. 这些衍生物的分子量通常为约50,000至约2,500,000,优选约50,000至约1,000,000,更优选约50,000至约700,000。 Molecular weight of these derivatives is generally from about 50,000 to about 2,500,000, preferably from about 50,000 to about 1,000,000, more preferably from about 50,000 to about 700,000.

用于制备这些瓜尔胶衍生物的瓜尔胶通常是从瓜尔植物的种子中得到的天然物质。 Guar gum is used in preparing these guar gum derivatives is typically obtained from natural substances guar seed plants. 瓜尔分子本身是直链甘露聚糖,在该分子中在交替的甘露糖单元上由单节的半乳糖单元以规则的间隔成为该分子的支链。 Guar molecule itself is a straight chain mannan, in the molecule on alternate mannose units from a single section of the galactose units at regular intervals become branched chain of the molecule. 甘露糖单元通过β(1-4)糖苷键互相连接。 Mannose unit through a β (1-4) glycosidic linkages connected to each other. 半乳糖通过α(1-6)键而形成支链。 Galactose formed by branched α (1-6) bond. 瓜尔胶的阳离子衍生物是通过将聚半乳甘露聚糖的羟基和活性季铵化合物反应而得到。 Cationic guar gum derivative is prepared by polymerization of hydroxy galactomannan and the active quaternary ammonium compound is obtained. 阳离子基团在瓜尔结构上的取代度必须足以提供上文所述的所需的阳离子电荷密度。 Cationic groups on the guar structure must be sufficient to provide a degree of substitution of the above desired cationic charge density.

用于形成阳离子瓜尔聚合物的合适的季铵化合物包括满足通式(XII)的那些: Suitable quaternary ammonium compounds for use in forming the cationic guar polymers include satisfy the formula (XII) are those: 其中R1、R2和R3是甲基或乙基;R4或者是为通式(XIII)的环氧基烷基: Wherein R1, R2 and R3 are methyl or ethyl; R4, or the general formula (XIII) of the epoxy group: 或者R4是满足通式(XIV)的表卤醇: Or R4 is satisfied the formula (XIV) of epihalohydrin: 其中R5是C1-C3亚烷基;X是氯或溴;Z是阴离子,如Cl-、Br-、I-或HSO4-。 Wherein R5 is C1-C3 alkylene; X is chlorine or bromine; Z is an anion, such as Cl-, Br-, I- or HSO4-.

由上述试剂形成的阳离子瓜尔聚合物(瓜尔胶的阳离子衍生物)由下列通式(XV)表示: Reagent formed from the above cationic guar polymers (cationic derivatives of guar gum) represented by the following general formula (XV) represents:

其中R是瓜尔胶。 Where R is guar gum. 优选,阳离子瓜尔聚合物是瓜尔羟基丙基三甲基氯化铵,具体的,由下列通式(XVI)表示: Preferably, the cationic guar polymer is guar hydroxypropyl trimethyl ammonium chloride, specifically, is represented by the following general formula (XVI): 满足通式(XVI)的阳离子瓜尔聚合物的具体的非限定性的实例包括:JaguarC 13S,阳离子电荷密度为0.8meq/g(从Rhodia Company得到),JaguarC 17,阳离子电荷密度为1.6meq/g(从Rhodia Company得到)。 Satisfy the formula (XVI) Specific non-limiting examples of cationic guar polymers include: JaguarC 13S, a cationic charge density of 0.8meq / g (available from Rhodia Company), JaguarC 17, cationic charge density of 1.6meq / g (available from Rhodia Company). 其它合适的阳离子瓜尔聚合物包括羟基丙基化的阳离子瓜尔衍生物。 Other suitable cationic guar polymers include hydroxypropylated cationic guar derivatives. 还有的其它合适的阳离子聚合物包括醚化的瓜尔的共聚物,其中的一些实例描述于美国专利3958581中,本发明引入该专利作为参考。 Still other suitable cationic polymers include guar ether copolymers, some examples of which are described in US Patent 3,958,581, the present invention which patent is incorporated by reference.

ii.乙烯基单体的共聚物适用于本发明的去头屑和调理香波组合物中的其它合适的阳离子聚合物是乙烯基单体与水溶性的单体反应的共聚物,乙烯基单体具有阳离子质子化的胺或季铵官能团。 ii. a copolymer of vinyl monomers suitable for the present invention are anti-dandruff and conditioning shampoo compositions of Other suitable cationic polymers are copolymers of monomer reacted with water-soluble vinyl monomer, the vinyl monomer having cationic protonated amine or quaternary ammonium functional groups. 这种单体的非限定性的实例包括:丙烯酰胺、甲基丙烯酰胺、烷基和二烷基丙烯酰胺、烷基和二烷基甲基丙烯酰胺、丙烯酸烷基酯、甲基丙烯酸烷基酯、乙烯基己内酰胺、乙烯基吡咯烷酮以及它们的混合物。 Non-limiting examples of such monomers include: acrylamide, methacrylamide, alkyl and dialkyl acrylamides, alkyl and dialkyl methacrylamides, alkyl acrylate, alkyl methacrylate ester, vinyl caprolactam, vinyl pyrrolidone, and mixtures thereof. 烷基和二烷基取代的单体优选具有C1-C7烷基,更优选C1-C3烷基。 The alkyl and dialkyl substituted monomers preferably have C1-C7 alkyl, more preferably C1-C3 alkyl. 其它合适的单体包括乙烯基酯、乙烯基醇(由聚乙酸乙烯酯水解制得)、马来酸酐、丙二醇、乙二醇以及它们的混合物。 Other suitable monomers include vinyl esters, vinyl alcohol (made by hydrolysis of polyvinyl acetate prepared), maleic anhydride, propylene glycol, ethylene glycol and mixtures thereof.

合适的阳离子质子化的氨基和季铵单体,包含在本发明的香波组合物的阳离子聚合物中,包括被下列物质取代的乙烯基化合物:二烷基氨基烷基丙烯酸酯、二烷基氨基烷基(甲基)丙烯酸酯、单烷基氨基烷基丙烯酸酯、单烷基氨基烷基(甲基)丙烯酸酯、三烷基甲基丙烯酰氧基烷基铵盐、三烷基丙烯酰氧基烷基铵盐、二烯丙基季铵盐;具有含环状阳离子氮环如吡啶鎓、咪唑鎓和季化的吡咯烷酮的乙烯基季铵单体,如烷基乙烯基咪唑鎓、烷基乙烯基吡啶鎓和烷基乙烯基吡咯烷酮盐。 Suitable cationic protonated amino and quaternary ammonium monomers, contained in the shampoo composition of the cationic polymers of the present invention, the following materials including substituted vinyl compound: dialkylaminoalkyl acrylate, dialkylamino alkyl (meth) acrylate, monoalkylamino alkyl acrylate, monoalkyl aminoalkyl (meth) acrylate, trialkyl methacryloxy alkylammonium salts, trialkyl acryloxy oxy alkyl ammonium salt, diallyl quaternary ammonium salt; vinyl quaternary ammonium monomers having cyclic cationic nitrogen-containing rings such as pyridinium, imidazolium, and quaternized pyrrolidone, e.g., alkyl vinyl imidazolium, alkyl alkyl vinyl pyridinium, and alkyl vinyl pyrrolidone salts. 这些单体的烷基部分优选低级烷基,如C1-C3烷基。 Alkyl portions of these monomers preferably lower alkyl, such as C1-C3 alkyl.

用于本发明的合适的胺取代的乙烯基单体包括二烷基氨基烷基丙烯酰胺和二烷基氨基烷基(甲基)丙烯酰胺,其中烷基优选C1-C7烃基,更优选C1-C3烷基。 Suitable amines for the present invention is substituted vinyl monomers include dialkylaminoalkyl acrylamide and dialkylaminoalkyl (meth) acrylamide, wherein the alkyl groups are preferably C1-C7 hydrocarbon group, and more preferably C1- C3 alkyl.

iii.乙烯基吡咯烷酮共聚物适用于本发明的去头屑和调理香波组合物中的其它合适的阳离子聚合物包括:1-乙烯基-2-吡咯烷酮和1-乙烯基-3-甲基咪唑鎓盐(例如氯盐)的共聚物,工业中(CTFA)称为Polyquaternium 16(例如LuviquatFC 370,可从BASF Wyandotte Corporation得到);1-乙烯基-2-吡咯烷酮和二甲基氨基乙基(甲基)丙烯酸酯的共聚物,工业中(CTFA)称为Polyquaternium 11(例如Gafquat755N,可从ISP Corporation得到);阳离子二烯丙基含季铵的聚合物,包括例如二甲基二烯丙基氯化铵均聚物,工业中(CTFA)称为Polyquaternium 6;丙烯酰胺和二甲基二烯丙基氯化铵的共聚物,工业中(CTEA)称为Polyquaternium 7;以及不饱和C3-C5羧酸的均聚物和共聚物的氨基烷基酯的无机酸盐,如描述于美国专利4009256中的那些,本发明引入该专利作为参考。 . iii vinylpyrrolidone copolymers of the present invention is applicable to anti-dandruff and conditioning shampoo compositions Other suitable cationic polymers include: 1-vinyl-2-pyrrolidone and 1-vinyl-3-methylimidazolium salts (e.g., chloride) copolymer, the industry (CTFA) referred Polyquaternium 16 (e.g. LuviquatFC 370, available from BASF Wyandotte Corporation); 1- vinyl-2-pyrrolidone and dimethylaminoethyl ( meth) acrylate copolymer, the industry (CTFA) referred Polyquaternium 11 (e.g. Gafquat755N, available from ISP Corporation); cationic diallyl quaternary ammonium-containing polymers including, for example dimethyl-diene propyl chloride homopolymer, the industry (CTFA) known as Polyquaternium 6; acrylamide and dimethyl diallyl ammonium chloride copolymers, industry (CTEA) known as Polyquaternium 7; and unsaturated C3 -C5 carboxylic acid homopolymers and copolymers of inorganic acid salts of amino-alkyl esters, such as described in U.S. Patent No. 4,009,256 in those, the present invention which patent is incorporated herein by reference.

iv.阳离子改性的蛋白质和聚合四价盐适用于本发明的去头屑和调理香波组合物中的其它合适的阳离子聚合物是阳离子改性的蛋白质,如月桂基二甲基铵羟基丙基胶原蛋白(例如CroquatL,从Croda Corporation得到),或椰油基二甲基铵羟丙基水解头发角蛋白(例如CroquatHH,从Croda Corporation得到)。 iv. cationically modified proteins and polymeric quaternary salts of the present invention is applicable to anti-dandruff and conditioning shampoo compositions Other suitable cationic polymers are cationic modified proteins, such as lauryl dimethyl ammonium hydroxypropyl collagen (e.g. CroquatL, obtained from Croda Corporation), or a coco dimethyl ammonium hydroxypropyl hydrolyzed hair keratin (e.g. CroquatHH, obtained from Croda Corporation). 其它阳离子聚合物包括聚合四价盐,由己二酸和二甲基氨基丙基胺与二氯乙醚反应得到,工业中(CTFA)称为Polyquaternium 2(例如MirapolAD-1,可从Rhodia得到);以及壬二酸和二甲基氨基丙基醚反应得到的聚合四价盐,工业中(CTFA)称为Polyquaternium 18(例如MirapolAZ-1,可从Rhodia公司得到)。 Other cationic polymers include polymeric quaternary salt, obtained from adipic acid and dimethylaminopropyl amine reaction with dichloromethyl ethyl ether, the industry (CTFA) known as Polyquaternium 2 (e.g. MirapolAD-1, available from Rhodia) ; and polymeric quaternary salt of azelaic acid and dimethylamino-propyl ether obtained by the reaction, the industry (CTFA) known as Polyquaternium 18 (e.g. MirapolAZ-1, available from Rhodia Corporation).

v.其它阳离子聚合物适用于本发明的其它阳离子聚合物是Arquad系列的季铵盐,从AkzoNobel得到。 v. Other cationic polymers useful in the present invention are other cationic polymers are Arquad series of quaternary ammonium salts, available from AkzoNobel. 其它优选用于本发明的阳离子聚合物包括:聚合物KG30M(Polyquaternium 10和季化纤维素),Incroquat二十二烷基三甲基甲酯硫酸铵(鲸蜡/硬脂醇(ceteary alcohol)和二十二烷基三甲基甲酯硫酸铵),从Croda得到;Merquat5(季铵树脂),从Calgon得到;Gafquat系列440(阳离子季化的共聚物),从ISP得到;Akypoquat131,从Kao得到;SalcareSC60(季铵树脂),或者SalcareSC 95或SC96(阳离子液体分散体增稠剂),均购自Ciba;MeadowquatHG(PEG2-二道氏池花酰氨基-乙基甲基甲酯硫酸铵),购自Fanning。 Other preferred cationic polymers useful in the present invention include: Polymer KG30M (Polyquaternium 10 and quaternized cellulose), Incroquat behenyl trimethylammonium methosulfate (cetyl / stearyl alcohol (ceteary alcohol) and behenyl trimethylammonium methosulfate), obtained from Croda; Merquat5 (quaternary ammonium resin), available from Calgon; Gafquat series 440 (cationic quaternized copolymers), available from ISP; Akypoquat 131, obtained from Kao; SalcareSC60 (quaternary ammonium resin), or SalcareSC 95 or SC96 (cationic liquid dispersion thickeners), were purchased from Ciba; MeadowquatHG (PEG2- two meadowfoam acid amino - ethyl methosulfate), available from Fanning. E.聚亚烷基二醇本发明的去头屑和调理香波组合物包含占组合物重量的约0.005%至约1.5%,优选约0.025%至约0.1%,更优选约0.05%至约1%,更优选约0.1%至约0.5%,最优选约0.1%至约0.3%的选定的适用于头发或皮肤上的聚亚烷基二醇。 E. polyalkylene glycols of the present invention and an anti-dandruff conditioning shampoo composition comprises from about 0.005% to about 1.5% by weight of the composition, preferably from about 0.025% to about 0.1%, more preferably from about 0.05% to about 1 %, more preferably from about 0.1% to about 0.5%, most preferably from about 0.1% to about 0.3% of the selected application to the hair or skin of the polyalkylene glycol. 相信选定的聚亚烷基二醇给本发明所述的组合物带来了增强的起泡性能,改进的香波铺展性,并且重要的是,增加了去头屑颗粒的功效。 Believed selected polyalkylene glycol to the composition of the present invention brings enhanced foaming performance, improved shampoo spreadability, and importantly, increased anti-dandruff particulate efficacy. 这样的聚亚烷基二醇应该与本文描述的基本成分在物理和化学性质上相容,并且应不过度损害产品的稳定性、美观或性能。 The basic components of such a polyalkylene glycol should be described herein in the physical and chemical properties compatible with, and should not unduly impair product stability, aesthetics or performance.

现已发现,这些聚亚烷基二醇当加入到本发明所述的香波组合物中时,通过带来与头发调理性的消费者感觉性相关的更多、更稠密的泡沫,而增强了起泡性能。 When it has been found that these polyalkylene glycols when added to the shampoo compositions of the present invention is described, by bringing the hair conditioning properties related consumers feel more and more dense foam, and enhance the blistering performance. 现已发现,在那些包括聚硅氧烷调理剂的实施方案中,选定的聚亚烷基二醇能够降低清洁头发所需的阴离子去污表面活性剂的浓度。 It has been found, in those embodiments comprising silicone conditioning agents, the selected polyalkylene glycols can reduce the concentration required to clean the hair anionic detersive surfactant. 在这样降低了表面活性剂的组合物中,头发清洁性和调理性仍保持良好,但是整体起泡性能得到了改善。 In this way reduces the surfactant composition, hair cleansing and conditioning is still good, but the overall performance is improved foaming. 聚亚烷基二醇例如已知可用于改善清洁组合物的起泡性能,如美国专利5837661所述,本发明引入该专利作为参考。 Polyalkylene glycols such as known for use in cleaning compositions to improve foaming performance, as described in U.S. Patent 5,837,661, which patent is incorporated the present invention by reference.

现已发现,这些选定的聚亚烷基二醇当加入到含聚硅氧烷的香波组合物中时,增加了香波组合物在头发中的铺展性。 It has been found that these selected polyalkylene glycols When added to shampoo compositions containing polysiloxane, the increase in the shampoo compositions in hair spreadability. 在使用期间,香波组合物的增加的铺展性也给消费者带来了可感觉到的增强的调理性。 During use, the shampoo composition of the increased spreading also give consumers perceived enhanced conditioning. 该性能由这些作为已知的增稠剂的选定的聚亚烷基二醇得到是特别令人惊奇的,因为增稠剂预期将会损害而不是增强香波组合物在头发中的铺展性。 The performance obtained by such a known thickener selected polyalkylene glycols is particularly surprising, because the thickener is expected to enhance the damage rather than in the hair shampoo composition spreadability.

适用于本发明香波组合物中的聚亚烷基二醇的特征在于如下的通式(XVII): Suitable for use in the shampoo compositions of the present invention the polyalkylene glycol is characterized by the following general formula (XVII): 其中R是氢、甲基或者它们的混合物,优选为氢,n为约1,500至约120,000的整数,优选约1,500至约50,000,更优选约2,500至约25,000,最优选约3,500至约15,000。 Wherein R is hydrogen, methyl or mixtures thereof, preferably hydrogen, n is an integer of from about 1,500 to about 120,000, preferably from about 1,500 to about 50,000, more preferably from about 2,500 to about 25,000, most preferably from about 3,500 to about 15,000. 当R是氢时,这些物质为氧化乙烯的聚合物,也称作聚乙二醇。 When R is hydrogen, these materials are polymers of ethylene oxide, also known as polyethylene glycols. 当R为甲基时,这些物质为氧化丙烯的聚合物,也称作聚丙二醇。 When R is methyl, these materials are polymers of propylene oxide, also known as polypropylene glycol. 另外应当知道,当R为甲基时,所得到的聚合物可能存在多种位置异构体。 Further to be understood that, when R is methyl, the resulting polymer may be multiple positional isomers. 优选用于本发明的是聚乙二醇和聚丙二醇以及它们的混合物。 Preferred for use herein is polyethylene glycol and polypropylene glycol and mixtures thereof.

本发明的去头屑和调理香波组合物中所使用的聚乙二醇聚合物的具体非限定性的实例包括:PEG-2M,其中的R是氢且n的平均值约2000(例如Polyox WSRN-10,得自Union Carbide);PEG-5M,其中的R是氢且n的平均值约5000(例如Polyox WSRN-35和Polyox WSRN-80,二者都得自Union Carbide);PEG-7M,其中的R是氢且n的平均值约7000(例如PolyoxWSRN-750,得自Union Carbide);PEG-9M,其中的R是氢且n的平均值约9000(例如Polyox WSRN-3333,得自Union Carbide);PEG-14M,其中的R是氢且n的平均值约14000(例如Polyox WSRN-3000,得自UnionCarbide);PEG-23M,其中的R是氢且n的平均值约23000(例如Polyox WSRN-12k,得自Union Carbide);PEG-90M,其中的R是氢且n的平均值约90000(例如Polyox WSR301,得自Union Carbide);以及PEG 100M,其中的R是氢且n的平均值约100000(例如Carbowax PEG 4600TM,得自UnionCarbide)。 Specific non-limiting examples of the present invention and antidandruff polyethylene glycol polymer conditioning shampoo compositions used include: PEG-2M, wherein R is hydrogen and n is an average value of about 2,000 (e.g. Polyox WSR N-10, available from Union Carbide); PEG-5M, wherein R is hydrogen and n is an average value of about 5,000 (e.g. Polyox WSRN-35 and Polyox WSRN-80, both from Union Carbide had ); PEG-7M, wherein R is hydrogen and n is an average value of about 7,000 (e.g. PolyoxWSRN-750, available from Union Carbide); PEG-9M, wherein R is hydrogen and n is an average value of about 9,000 (e.g. Polyox WSRN-3333, available from Union Carbide); PEG-14M, wherein R is hydrogen and n is an average value of about 14,000 (e.g. Polyox WSRN-3000, available from UnionCarbide); PEG-23M, wherein R is hydrogen and n is an average value of about 23,000 (e.g. Polyox WSRN-12k, available from Union Carbide); PEG-90M, wherein R is hydrogen and n is an average value of about 90,000 (e.g. Polyox WSR301, available from Union Carbide); and PEG 100M, wherein R is hydrogen and n is an average value of about 100,000 (e.g. Carbowax PEG 4600TM, available from UnionCarbide). 优选的聚乙二醇包括PEG 7M,PEG 14M,PEG 25M,PEG90M以及它们的混合物。 Preferred polyethylene glycols include PEG 7M, PEG 14M, PEG 25M, PEG90M, and mixtures thereof. F.水本发明的去头屑和调理香波组合物包括占组合物重量的约20%至约94.75%,优选约50%至约94.75%,更优选约60%至约85%的水。 F. Water The anti-dandruff and conditioning shampoo compositions of the invention comprises about 20% to about 94.75% by weight of the composition, preferably from about 50% to about 94.75%, more preferably from about 60% to about 85% water.

II.任选组分本发明的去头屑和调理香波组合物在一些实施方案中,还包括已知或有效用于头发护理或个人护理产品的附加的任选组分。 II. Antidandruff optional component of the present invention and conditioning shampoo compositions in some embodiments, further comprising a known or effective for use in hair care or additional optional components of personal care products. 附加的表面活性剂、悬浮剂、头发生长调节剂以及其它任选组分在下文中详细描述。 Additional surfactants, suspending agents, hair growth regulators, and other optional components described in detail hereinafter. A.其它表面活性剂本发明的去头屑和调理香波组合物在一些实施方案中还可以包括占组合物重量的约0.5%至约25%,优选约1%至约20%,更优选约1%至约10%的不是上述阴离子表面活性剂的表面活性剂,它们适于应用到头发或皮肤上。 A. Other antidandruff surfactants of the present invention and conditioning shampoo compositions in some embodiments may also include from about 0.5% to about 25% by weight of the composition, preferably from about 1% to about 20%, more preferably from about Surfactant 1% to about 10% of anionic surfactant other than the above, which are suitable for application to the hair or skin. 这样的任选的其它表面活性剂应该与香波组合物的基本成分在物理和化学性质上相容,并且应不过度损害产品的稳定性、美观或性能。 Such optional other surfactants should be physically and chemically compatible with the essential components of properties of the shampoo composition, and should not unduly impair product stability, aesthetics or performance. 合适的其它表面活性剂包括但不限于:两性表面活性剂、两性离子表面活性剂、阳离子表面活性剂、非离子表面活性剂以及它们的混合物。 Suitable other surfactants include, but are not limited to: amphoteric surfactants, zwitterionic surfactants, cationic surfactants, nonionic surfactants and mixtures thereof.

适用于本发明的两性去污表面活性剂包括但不限于:那些通常被描述为脂族仲胺和叔胺的衍生物的表面活性剂,其中脂族基团可为直链或支链基团,并且,脂族取代基之一包含约8至约18个碳原子,而另一个包含一种阴离子水溶性基团如羧基、磺酸根、硫酸根、磷酸根或膦酸根。 Useful in the present invention are amphoteric detersive surfactants include, but are not limited to: those generally described as aliphatic derivatives of secondary and tertiary amines surfactant, in which the aliphatic radical can be straight or branched chain group and, one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic water-solubilizing group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate.

适用于本发明的两性离子去污表面活性剂包括但不限于那些通常被描述为脂族季铵、季磷和季锍化合物的衍生物的表面活性剂,其中脂族基团可为直链或支链基团,并且,脂族取代基之一包含约8至约18个碳原子,而另一个包含一种阴离子基团如羧基、磺酸根、硫酸根、磷酸根或膦酸根。 Useful in the present invention are zwitterionic detersive surfactants include, but are not limited to those generally described as aliphatic quaternary ammonium, quaternary phosphonium and quaternary sulfonium compounds surfactant, in which the aliphatic radical can be straight chain or branched chain group, and the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic group such as carboxy, sulfonate, sulfate, phosphate, or phosphonate. 优选的两性离子去污表面活性剂是甜菜碱。 Preferred zwitterionic detersive surfactants are betaine.

用于本发明的阳离子去污表面活性剂包括但不限于含有季氮部分的表面活性剂。 Used in the present invention are cationic detersive surfactants include, but are not limited to quaternary nitrogen-containing portion of the surfactant. 合适的阳离子表面活性剂的实例是满足于通式(XVIII)的那些: Examples of suitable cationic surfactants are those that meet the general formula (XVIII) are: 其中R1,R2,R3,R4独立地选自C1-C22脂族基或芳族,烷氧基,聚氧亚烷基,烷基酰氨基,羟基烷基,芳基或烷基芳基,具有至多约22个碳原子,优选是C1-C22烷基;X是成盐阴离子,如选自卤素(例如氯,溴),乙酸根,柠檬酸根,乳酸根,羟乙酸根,磷酸根,硝酸根,硫酸根以及烷基硫酸根。 Wherein R1, R2, R3, R4 are independently selected from C1-C22 aliphatic group or an aromatic, alkoxy, polyoxyalkylene, alkylamido, hydroxyalkyl, aryl or alkylaryl group, having up to about 22 carbon atoms, preferably a C1-C22 alkyl; X is a salt-forming anion, such as selected from halogen (e.g. chlorine, bromine), acetate, citrate, lactate, glycolate, phosphate, nitrate , sulfate and alkyl sulfate. 脂族基团除含碳和氢原子外还能够包含醚键以及其它如氨基的基团。 Aliphatic groups in addition to carbon and hydrogen atoms can also contain ether linkages, and other groups such as amino groups. 较长链(例如C12以及更大)的脂族基团能够是饱和的或不饱和的。 The longer chain (e.g. C12 and higher) aliphatic groups can be saturated or unsaturated.

优选的阳离子去污表面活性剂是含有两个长烷基链和两个短烷基链的那些或者含有一个长烷基链和三个短烷基链的那些。 Preferred cationic detersive surfactants are those containing two long alkyl chains and those two short alkyl chains or contain a long alkyl chain and three short alkyl chains. 这些长烷基链优选是C12-C22,更优选C16-C22。 The long alkyl chains are preferably C12-C22, more preferably C16-C22. 这些短烷基链优选是C1-C3,更优选C1-C2。 These short alkyl chain is preferably C1-C3, more preferably C1-C2.

适用于本发明的非离子去污表面活性剂包括但不限于由氧化烯基团(亲水性)和有机疏水化合物(可以是脂族或烷基芳族性的)缩合而制得的那些化合物。 The present invention is applicable to non-ionic detersive surfactants include, but are not limited to the alkylene oxide groups (hydrophilic) and an organic hydrophobic compound (which may be aliphatic or alkyl aromatic in nature) are those compounds prepared by condensation of .

其它适用于本发明去头屑和调理香波组合物中的两性、两性离子、阳离子和非离子去污表面活性剂的非限定性实例描述于McCutcheon's,Emulsifiers and Detergents(1989)(MCPub.Co.出版),以及美国专利2438091,美国专利2528378,美国专利2658072,美国专利3155591,美国专利3929678,美国专利3959461,美国专利4387090,美国专利5104646,美国专利5106609,美国专利5837661中,本发明引入这些专利作为参考。 Other non-limiting examples of the present invention is applicable to anti-dandruff and conditioning shampoo compositions of amphoteric, zwitterionic, cationic and nonionic detersive surfactants are described in McCutcheon's, Emulsifiers and Detergents (1989) (MCPub.Co. Publishing ), and U.S. Patent No. 2,438,091, U.S. Patent No. 2,528,378, U.S. Patent No. 2,658,072, U.S. Patent No. 3,155,591, U.S. Patent No. 3,929,678, U.S. Patent No. 3,959,461, U.S. Patent No. 4,387,090, U.S. Patent No. 5,104,646, U.S. Patent No. 5,106,609, U.S. Patent No. 5,837,661, the present invention is the introduction of these patents are incorporated reference. B.悬浮剂本发明的去头屑和调理香波组合物可以在一些实施方案中包括占组合物重量的约0.1%至约10%,优选约0.3%至约5.0%,更优选约0.3%至约2.5%的适于用在头发或皮肤上的悬浮剂。 B. antidandruff suspending agent of the invention and conditioning shampoo compositions may in some embodiments comprise from about 0.1% to about 10% by weight of the composition, preferably from about 0.3% to about 5.0%, more preferably from about 0.3% to about 2.5% is suitable for use on the hair or skin of suspending agents. 相信该悬浮剂将水不溶性的分散的物质悬浮在香波组合物中。 Believed that the suspending agent be dispersed water insoluble materials suspended in the shampoo compositions. 这样的悬浮剂应该与组合物的基本成分在物理和化学性质上相容,并且应不过度损害产品的稳定性、美观或性能。 Such suspending agent should be physically and chemically compatible with the essential properties of components of the composition, and should not unduly impair product stability, aesthetics or performance. 可以适用在本发明香波组合物中的悬浮剂的实例包括但不限于:酰基衍生物、长链氧化胺、黄原胶以及它们的混合物。 Can be applied in the shampoo compositions of the present invention Examples of suspending agents include, but are not limited to: acyl derivatives, long chain amine oxides, xanthan gum and mixtures thereof. 这些和其它合适的悬浮剂进一步详述于下文中。 These and other suitable suspending detailed further below.

1.酰基衍生物和长链氧化胺酰基衍生物悬浮剂包括但不限于:甘油酯、长链烃、长链脂肪酸的长链酯、长链烷醇酰胺的长链酯。 1. acyl derivatives and long chain amine oxides acyl derivative suspending agents include, but are not limited to: glycerol esters, long chain hydrocarbons, long chain esters of long chain fatty acids, long chain esters of long chain alkanol amides. 其它的合适的悬浮剂包括长链氧化胺。 Other suitable suspending agents include long chain amine oxides. 酰基衍生物和长链氧化胺悬浮剂描述于美国专利4741855中,本发明引入该专利作为参考。 Acyl derivatives and long chain amine oxide suspending agents are described in U.S. Patent No. 4,741,855, the present invention which patent is incorporated herein by reference.

用于本发明的优选的酰基衍生物悬浮剂是甘油酯,包括具有16-22个碳原子的脂肪酸的乙二醇酯。 Preferred acyl derivative suspending agents used in the present invention are glycerides, including glycol esters of fatty acids having 16 to 22 carbon atoms. 更优选硬脂酸乙二醇酯,包括单酯和二酯,最优选的是包含少于约7%的单硬脂酸酯的二硬脂酸乙二醇酯。 More preferably ethylene glycol monostearate, including mono- and diesters, and most preferably contains less than about 7% of the mono stearate ester ethylene glycol distearate.

其它适用于本发明的香波组合物中的是长链(即C8-C22)烃,包括N,N-二烃基酰氨基苯甲酸和其可溶性盐(例如钠盐和钾盐),特别是这一族的N,N-二(氢化)C16,C18和牛脂酰氨基苯甲酸物质,其可从Stepan Company商购。 Other useful in the present invention are shampoo compositions are long chain (i.e. C8-C22) hydrocarbons, including N, N- dihydrocarbyl amido benzoic acid and soluble salts thereof (e.g., sodium and potassium), especially this family of N, N- di (hydrogenated) C16, C18 and tallow amido benzoic acid substance, which is commercially available from Stepan Company provider. 长链脂肪酸的长链酯的非限定性实例包括硬脂酸硬脂基酯和棕榈酸鲸蜡基酯。 Non-limiting examples of long-chain fatty acids, long chain esters include stearyl stearate and cetyl palmitate ester. 长链烷醇酰胺的长链酯的非限定性实例包括硬脂酰胺二乙醇酰胺二硬脂酸酯和硬脂酰胺单乙醇酰胺硬脂酸酯。 Non-limiting examples of long chain esters of long chain alkanol amides include stearamide diethanolamide distearate and stearamide monoethanolamide stearate. 用作本发明悬浮剂的合适的长链氧化胺的非限定性的实例包括烷基(C16-C22)二甲基氧化胺(例如硬脂基二甲基氧化胺)。 Suitable suspending agents used for the present invention, non-limiting examples of long chain amine oxides include alkyl (C16-C22) dimethyl amine oxides (e.g. stearyl dimethyl amine oxide).

2.黄原胶适于用作本发明悬浮剂的还有黄原胶。 2. xanthan gum suitable for use as suspending the invention there is xanthan gum. 黄原胶的浓度通常为组合物重量的约0.1%至约3%,优选约0.4%至约1.2%。 The concentration of xanthan gum by weight of the composition is typically about 0.1% to about 3%, preferably from about 0.4% to about 1.2%. 在含聚硅氧烷的香波组合物中使用黄原胶作为悬浮剂在美国专利4,788,006中有述,该文献引入本文作为参考。 Used in silicone-containing shampoo compositions of xanthan gum as a suspending agent are described in U.S. Patent No. 4,788,006, which is incorporated herein by reference. 长链酰基衍生物与黄原胶也可组合在香波组合物中用作悬浮剂,正如美国专利4,704,272所述,该文献引入本文作为参考。 Long chain acyl derivatives and xanthan gum may also be used in combination as the suspending agent in the shampoo composition, as described in U.S. Patent 4,704,272, which is incorporated herein by reference.

3.其它悬浮剂适于用在本发明的去头屑和调理香波组合物中的其它合适的悬浮剂包括羧乙烯基聚合物。 3. Other suspending agents suitable for use in the present invention, anti-dandruff and conditioning shampoo compositions of Other suitable suspending agents include carboxyvinyl polymers. 在这些聚合物中优选的是与聚烯丙基蔗糖交联的丙烯酸的共聚物,其描述于美国专利2798053中,本发明引入该专利作为参考。 Preferred among these polymers are crosslinked with polyallyl sucrose copolymers of acrylic acid, which is described in U.S. Patent No. 2,798,053, the present invention which patent is incorporated herein by reference. 这些聚合物的实例包括Carbopol 934,940,941和956,来自BFGoodrichCompany。 Examples of these polymers include Carbopol 934,940,941, and 956, from BFGoodrichCompany.

适用于本发明的其它的悬浮剂包括具有至少约16个碳原子的脂肪烷基部分的伯胺(例如棕榈胺和硬脂胺),每个具有至少约12个碳原子的两个脂肪烷基部分的仲胺(例如二棕榈酰基胺和二-(氢化牛脂)-胺)。 Other useful in the present invention suspending agents include fatty alkyl moiety having at least about 16 carbon atoms, a primary amine (e.g., palm and stearylamine), each of the two fatty alkyl groups having at least about 12 carbon atoms, secondary amine moiety (e.g. dipalmitoyl amine and di - (hydrogenated tallow) - amine). 合适的还有二-(氢化牛脂)-邻苯二甲酸酰胺,以及交联的马来酸酐-甲基乙烯基醚共聚物。 Also suitable are di - (hydrogenated tallow) - phthalic acid amide, and crosslinked maleic anhydride - methyl vinyl ether copolymer.

可以用在香波组合物中的其它合适的悬浮剂包括能够赋予组合物胶状粘度的那些,如水溶性或胶体水溶性聚合物状纤维素醚(例如甲基纤维素,羟基丁基甲基纤维素,羟基丙基纤维素,羟基丙基甲基纤维素,羟乙基乙基纤维素和羟乙基纤维素),瓜尔胶,聚乙烯基醇,聚乙烯基吡咯烷酮,羟丙基瓜尔胶,淀粉和淀粉衍生物,以及其它的增稠剂,粘度调节剂,胶凝剂以及它们的混合物。 Can be used in the shampoo compositions Other suitable suspending agents include gum composition capable of imparting viscosity to those, such as water-soluble or water-soluble colloidal polymer cellulose ethers (e.g. methyl cellulose, hydroxybutyl methyl cellulose, hydroxypropyl propyl cellulose, hydroxypropyl methyl cellulose, hydroxyethyl ethylcellulose and hydroxyethylcellulose), guar gum, polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, starch and starch derivatives, and other thickeners, viscosity modifiers, gelling agents and mixtures thereof. 用作悬浮剂的优选的粘度调节剂是三羟基硬脂精(例如Thixin RTM,从Rheox Company得到)。 Used as a suspending agent is preferred viscosity modifiers trihydroxystearin (e.g. Thixin RTM, obtained from Rheox Company). C.头发生长调节剂本发明的组合物除吡啶硫酮锌之外,还可以任选地包括其它头发生长调节剂。 C. hair growth regulating composition of the present invention, in addition to zinc pyrithione, also can optionally include other hair growth regulating agents. 这样的调节剂能够选自各种能够以不同方式起增强本发明化合物的头发生长效果的分子。 Such modifiers can be selected from a variety of different ways can enhance hair growth effects of the compounds of the present invention is a molecule. 这些任选的调节剂在存在时,在本发明组合物中的用量通常为组合物重量的约0.001%至约15%,优选约0.1%至约10%,更优选约0.5%至约5%。 These optional modifier in the presence of an amount of the composition of the present invention generally comprises from about 0.001% to about 15%, by weight, preferably from about 0.1% to about 10%, more preferably from about 0.5% to about 5% .

在本发明中所使用的术语“头发生长调节”指的是包括:刺激头发生长和/或头发增稠;预防,减少,阻止和/或延迟头发损失和/或头发变少;增加头发的生长速度;诱发更多的发簇的形成;增加发簇直径;使发簇变长;改变从毫毛到末端的毛囊;将毛囊从毛发生长终期转化成毛发生长初期相(由此增加了毛发生长初期相毛囊相对于毛发生长终期相毛囊的整体比例);治疗脱发,以及它们的组合。 In the present invention, the term "hair growth regulating" is meant to include: stimulating hair growth and / or hair thickening; prevent, reduce, prevent and / or delay hair loss and / or hair becomes small; increase hair growth speed; induce the formation of more hair switches; diameter increase hair switch; make longer hair switch; change from vellus hair to terminal hair follicles; the hair follicles from telogen to anagen phase transformation (thereby increasing hair growth the early follicular phase relative to the overall proportion of telogen phase of the hair follicle); treatment of hair loss, and combinations thereof.

血管扩张剂如钾通道激动剂包括,例如长压定(minoxidil)和长压定衍生物,如aminexil以及如在下述美国专利中的那些:3382247,5756092(1998年5月26日授权),5772990(1998年6月30日授权),5760043(1998年6月2日授权),5328914(1994年7月12日授权),5466694(1995年11月14日授权),5438058(1995年8月1日授权),4973474(1990年11月27日授权)(所述这些专利引入本发明作为参考),并且cromakalin和氯甲苯噻嗪能够用作本发明组合物中任选的头发生长调节剂。 Vasodilators such as potassium channel agonist, including, for example, minoxidil (minoxidil) and minoxidil derivatives such aminexil well as those in the following US patents: 3382247,5756092 (May 26, 1998 authorized), 5,772,990 (June 30, 1998 authorized), 5,760,043 (June 2, 1998 authorization), 5,328,914 (July 12, 1994 authorization), 5,466,694 (November 14, 1995 authorization), 5,438,058 (1995 August 1 Day authorization), 4,973,474 (November 27, 1990 authorization) (described in these patents are incorporated herein by reference), and xylazine cromakalin and chlorine can be used in the compositions of the present invention, optionally, hair growth regulators.

其它适用于本发明的一类合适的任选的活性增强剂是抗雄激素。 Other useful in the present invention is a class of suitable optional activity enhancer is an anti-androgen. 合适的抗雄激素的实例可以包括但不限于5-α-还原酶抑制剂如芬甾酮(finesteride)和描述于美国专利5516779(1996年5月14日授权)(本发明引入该专利作为参考)以及在Nnane等人的Cancer Research 58“C17,20-裂解酶和5α-还原酶的一些新抑制剂在体内和体外的效果以及它们在治疗前列腺癌中的潜在作用”,以及去醋酸环丙孕酮、壬二酸及其衍生物,以及在美国专利5480913(1996年1月2日授权)中描述的那些,氟他米特(flutamide),以及在美国专利5411981(1995年5月2日授权)、美国专利5565467(1996年10月15日授权)、美国专利4910226(1990年3月20日授权)中描述的那些,本发明引入所有这些文献作为参考。 Suitable examples of anti-androgens may include, but are not limited to 5-α- reductase inhibitors such as Fen-steroidal ketone (finesteride) and described in US Patent 5,516,779 (May 14, 1996 authorization) (introduced by the invention of the patent as a reference ) and Nnane et al. Cancer Research 58 "C17,20- lyase inhibitors and some new effects in vivo and in vitro, and their potential role in the treatment of prostate cancer in 5α- reductase," and went on cyproterone Progesterone, azelaic acid and its derivatives, as well as those of fluorine in the United States Patent 5,480,913 (January 2, 1996 authorization), he described Mitt (flutamide), as well as in the United States Patent 5,411,981 (May 2, 1995 Those present invention is authorized), US Patent 5,565,467 (October 15, 1996 authorization), US Patent 4,910,226 (March 20, 1990 authorization) as described in the introduction of all these documents as a reference.

其它合适类别的任选的头发生长调节剂是免疫抑制剂如1)环孢菌素(cyclosporin)和环孢菌素类似物,包括在美国临时专利申请60/122,925中描述的那些,Fulmer等人,“使用非免疫抑制化合物治疗头发损失的方法”,1995年3月5日申请,本发明引入作为参考,和2)FK506类似物,如在美国临时专利申请60/102,449中描述的那些,McIver等人,“杂环2-取代的酮酰胺”,1998年9月30日申请;在美国临时专利申请60/102,448中描述的那些,McIver等人,“2-取代的酮酰胺”,1998年9月30日申请;在美国临时专利申请60/102,539中描述的那些,McIver等人,“2-取代的杂环磺酰胺”,1998年9月30日申请;在美国临时专利申请60/102,458中描述的那些,Tiesman等人,“使用酮酰胺治疗头发损失的方法”,1998年9月30日申请;在美国临时专利申请60/102,437中描述的那些,McIver等人,“使用磺酰胺治疗头发损失的方法”,1998年9月30日申请;本发明引入上述内容作为参考。 Other suitable classes of optional hair growth regulating agents are immunosuppressants such as 1) cyclosporin (cyclosporin) and cyclosporin analogs, including application 60 / 122,925 as those described in, Fulmer et al., In U.S. Provisional Patent "Using a non-immunosuppressive compound for treating hair loss method", March 5, 1995 application, incorporated herein by reference, and 2) FK506 analogs, such as in U.S. Provisional Patent Application 60 / 102,449 as those described in, McIver et al., "2-substituted heterocyclic ketoamide", September 30, 1998 application; in U.S. Provisional Patent Application 60 / 102,448 as those described in, McIver et al., "2-substituted ketoamide", 1998 September 30 application; those in U.S. Provisional Patent Application, McIver like described human 60 / 102,539, "a 2-substituted heterocyclic sulfonamide", September 30, 1998 application; in U.S. Provisional Patent Application 60 / 102,458 those described in, Tiesman et al., "hair loss treatment using ketoamide method", September 30, 1998 application; those in U.S. Provisional Patent Application, McIver like who described 60 / 102,437, "Using sulfonamide treatment Methods "hair loss, September 30, 1998 to apply; The present invention introduces the above reference.

其它合适类别的任选的头发生长调节剂是抗微生物剂如硫化硒、酮康唑、三氯卡班、三氯生、吡啶硫酮锌、伊曲康唑(itraconazole)、亚细亚酸、扁柏酚、mipirocin以及描述在EPA 0,680,745(本发明引入上述内容作为参考)、clinacycin盐酸盐、苯甲酰基过氧化物、苯甲基过氧化物以及甲胺四环素(minocyclin)。 Other suitable types of optional hair growth regulating agents are anti-microbial agents such as selenium sulfide, ketoconazole, triclocarban, triclosan, zinc pyrithione, itraconazole (itraconazole), Asia acid, Hinokitiol , mipirocin and described in EPA 0,680,745 (the contents of the present invention is introduced into the above reference), clinacycin hydrochloride, benzoyl peroxide, benzyl peroxide and minocycline (minocyclin).

消炎剂也能够引入本发明的组合物中作为任选的活性增强剂。 Anti-inflammatory agents can also be incorporated into the composition of the present invention as an optional activity enhancer. 合适的消炎剂的实例可以包括糖皮质激素如氢化可的松、糠酸毛他松(mometasonefuroate)和脱氢皮质(prednisolone)、非甾族消炎剂包括环加氧酶(cyclooxygenase)或脂氧合酶抑制剂如描述在美国专利5756092中的那些,以及苄基胺(benzydamine),水杨酸,以及描述于EPA 0770399(1997年5月2日出版)中的那些化合物,WO 94/06434(1994年3月31日出版),以及FR2268523(1975年11月21日出版),本发明引入上述内容作为参考。 Suitable examples of anti-inflammatory agents may include corticosteroids such as hydrocortisone, mometasone his hair loose (mometasonefuroate) and prednisolone (prednisolone), non-steroidal anti-inflammatory agents, including cyclooxygenase (cyclooxygenase) or lipoxygenase enzyme inhibitors such as described in U.S. Patent No. 5,756,092 in those, and benzylamine (benzydamine), salicylic acid, and are described in EPA 0770399 (1997 年 5 published May 2) those compounds, WO 94/06434 (1994 On March 31 publication), and FR2268523 (1975 年 11 月 21 issue), the present invention introduces the above reference.

其它合适类别的任选的头发生长调节剂是甲状腺激素及其衍生物和类似物。 Optionally, other suitable types of hair growth regulating agents are thyroid hormone and its derivatives and the like. 用于本发明的合适的甲状腺激素的实例可以包括三碘甲状腺原氨酸(triiodothyrionine)。 Examples of suitable thyroid hormone used in the present invention may include three-triiodothyronine (triiodothyrionine). 可适用于本发明中的甲状腺激素类似物的实例包括描述于美国临时专利申请60/136996,Zhang等人,“治疗头发损失的方法”,1999年6月1日申请;在美国临时专利申请60/137024,Zhang等人,“使用联苯化合物治疗头发损失的方法”,1999年6月1日申请;在美国临时专利申请60/137022,Zhang等人,“使用羧基衍生物治疗头发损失的方法”,1999年6月1日申请;在美国临时专利申请60/137023,Zhang等人,“使用磺酰基拟甲状腺化合物治疗头发损失的方法”,1999年6月1日申请;在美国临时专利申请60/137052,Youngquist等人,“联芳基化合物”,1999年6月1日申请;在美国临时专利申请60/137063,Youngquist等人,“硫桥接的化合物”,1999年6月1日申请;在美国临时专利申请60/136958,Youngquist等人,“取代的联芳基醚化合物”,1999年6月1日申请。 Examples applicable to the present invention, the thyroid hormone analogs include those described in U.S. Provisional Patent Application 60/136996, Zhang et al., "A method of treating hair loss", June 1, 1999 an application; in U.S. Provisional Patent Application 60 / 137024, Zhang et al., "How to Use biphenyl compounds for the treatment of hair loss", June 1, 1999 an application; in U.S. Provisional Patent Application 60/137022, Zhang et al., "carboxyl derivatives for the treatment of hair loss method "June 1, 1999 to apply; in US Provisional Patent Application 60/137023, Zhang et al.," Use sulfonyl compounds for the treatment of hair loss thyroid proposed method, "June 1, 1999 to apply; in US Provisional Patent Application 60/137052, Youngquist et al., "biaryl compounds," June 1, 1999 to apply; in US Provisional Patent Application 60/137063, Youngquist et al., "bridging sulfur compounds," June 1, 1999 to apply ; in US Provisional Patent Application 60/136958, Youngquist et al., "substituted biaryl ether compounds," June 1, 1999 to apply.

前列腺素激动剂或拮抗剂也能够在本发明的组合物中用作任选的头发生长调节剂。 Prostaglandin agonists or antagonists can also be used as optional hair in the compositions of the present invention growth regulators. 合适的前列腺素激动剂或拮抗剂的实例包括latanoprost和描述于WO 98/33497(Johnstone,1998年8月6日公开);WO95/11003(Stjernschantz,1995年4月27日公开),JP 97-100091(Ueno)和JP96-134242(Nakamura)中的那些。 Suitable prostaglandin agonists or antagonists include latanoprost and described in WO 98/33497 (Johnstone, 1998 年 8 月 6 Publication Date); WO95 / 11003 (Stjernschantz, 1995 年 4 月 27 Publication Date), JP 97- 100091 (Ueno) and JP96-134242 (Nakamura) those.

适用于本发明的另一类任选的头发生长调节剂是类视黄素(retinoids)。 Another class of the present invention is applicable to the optional hair growth regulating agents are retinoids (retinoids). 合适的类视黄素可以包括异维甲酸(isotretinoin)、阿昔曲丁(acitretin)、tazarotene 。 Suitable retinoids may include isotretinoin (isotretinoin), acitretin (acitretin), tazarotene.

可以用作本发明的任选的头发生长调节剂的渗透增强剂(penetrationenhancer)的非限定性实例包括例如:2-甲基丙-2-醇、丙-2-醇、乙基-2-羟基丙酸酯、己-2,5-二醇、POE(2)乙醚、二(2-羟基丙基)醚、戊-2,4-二醇、丙酮、POE(2)甲醚、2-羟基丙酸、2-羟基辛酸、丙-1-醇、1,4-二氧杂环己烷、四氢呋喃、丁-1,4-二醇、丙二醇二壬酸酯、聚氧丙烯15硬脂基醚、辛醇、油醇的POE醚、油醇、月桂醇、己二酸二辛酯(dioctyl adipate)、己二酸二辛酯(dicapryl adipate)、己二酸二异丙酯、癸二酸二异丙酯、癸二酸二丁酯、癸二酸二乙酯、癸二酸二甲酯、癸二酸二辛酯、辛二酸二丁酯、壬二酸二辛酯、癸二酸二苄酯、邻苯二甲酸二丁酯、壬二酸二丁酯、肉豆蔻酸乙酯、壬二酸二甲酯、肉豆蔻酸丁酯、丁二酸二丁酯、邻苯二甲酸二癸酯、油酸癸酯、辛酸乙酯、水杨酸乙酯、棕榈酸异丙酯、月桂酸乙酯、2-乙基己基壬酸酯、异硬脂酸异丙酯、月桂酸丁酯、苯甲酸苄酯、苯甲酸丁酯、月桂酸己酯、癸酸己酯、癸酸乙酯、辛酸乙酯、硬脂酸丁酯、水杨酸苄酯、2-羟基丙酸、2-羟基辛酸、甲基亚砜、N,N-二甲基乙酰胺、N,N-二甲基甲酰胺、2-吡咯烷酮、1-甲基-2-吡咯烷酮、5-甲基-2-吡咯烷酮、1,5-二甲基-2-吡咯烷酮、1-乙基-2-吡咯烷酮、氧化膦、糖酯、四氢糠醛醇、脲、二乙基-间-甲苯酰胺、1-十二烷基氮杂环庚-2-酮,以及描述于下述美国专利中的那些:5015470(1991年5月14日颁布)和5496827(1994年7月15日颁布)(本发明引入上述专利作为参考)。 The present invention may be used as optional hair growth regulating agent permeation enhancer (penetrationenhancer) Non-limiting examples include, for example: 2-methyl propan-2-ol, propan-2-ol, ethyl-2-hydroxy propionate, hexyl-2,5-diol, POE (2) ethyl ether, di (2-hydroxypropyl) ether, pentane-2,4-diol, acetone, POE (2) methyl ether, 2-hydroxy- propionic acid, 2-hydroxy octanoic acid, propan-1-ol, 1,4-dioxane, tetrahydrofuran, butane-1,4-diol, propylene glycol dipelargonate, polyoxypropylene 15 stearyl ether , octanol, oleyl alcohol ether POE, oleyl alcohol, lauryl alcohol, dioctyladipate (dioctyl adipate), dioctyladipate (dicapryl adipate), diisopropyladipate sebacate isopropyl sebacate, diethyl sebacate, dimethyl sebacate, dioctyl sebacate, dibutyl suberate, azelaic dioctyl sebacate benzyl ester, dibutyl phthalate, dibutyl azelate, ethyl myristate, dimethyl azelate, butyl myristate, dibutyl succinate, didecyl phthalate esters, decyl oleate, ethyl caprylate, ethyl salicylate, isopropyl palmitate, ethyl laurate, 2-ethylhexyl isononanoate, isopropyl isostearate, butyl laurate, benzyl benzoate, butyl benzoate, hexyl laurate, capric acid hexyl ester, ethyl decanoate, ethyl caprylate, butyl stearate, benzyl salicylate, 2-hydroxy propionic acid, 2-hydroxy octanoic acid, methyl sulfoxide, N, N- dimethylacetamide, N, N- dimethylformamide, 2-pyrrolidone, 1-methyl-2-pyrrolidone, 5-methyl-2-pyrrolidone, 1 , 5-dimethyl-2-pyrrolidone, 1-ethyl-2-pyrrolidone, phosphine oxides, sugar esters, tetrahydro furfural alcohol, urea, diethyl - inter - toluamide, 1-dodecylazacycloheptan- -2-one, and is described in the following US patents that: 5,015,470 (May 14, 1991 issued) and 5,496,827 (July 15, 1994 issued) (The present invention introduces the aforementioned patent reference).

用于本发明中的其它类别的任选的头发生长调节剂包括类黄素(flavinoid)、子囊霉素(ascomycin)衍生物和类似物,组胺拮抗剂如二苯羟基胺盐酸盐(diphenhydramine hydrochloride),其它三萜类如石竹素、乌索酸和描述于下列文献中的那些:美国专利5529769、JP 10017431、WO95/35103、USP 5468888、JP 09067253、WO 92/09262、JP 62093215、USP 5631282、USP5679705、JP 08193094,皂角苷,如描述于下述中的那些:EP0558509(Bonte等人,1993年9月8日公开)和WO 97/01346(Bonte等人,1997年1月16日公开)(本发明引入上述专利作为参考);proeoglycanase或葡糖胺葡聚糖酶抑制剂如在下述专利中描述的那些:美国专利5015470(1991年5月14日颁布)、美国专利5300284(1994年4月5日颁布)、美国专利5185325(1993年2月9日颁布)(本发明引入上述专利作为参考);雌激素激动剂和拮抗剂,pseudoterins,细胞因子和生长因子促进剂、类似物或抑制剂如白介素1抑制剂、白介素6抑制剂、白介素10促进剂、肿瘤坏死因子抑制剂、维生素如维生素D类似物和甲状旁腺激素拮抗剂、维生素B12类似物和泛醇(panthenol)、干扰素(interfuron)激动剂和拮抗剂、羟基酸如描述于美国专利5550158中的那些、二苯酮和乙内酰脲抗惊厥药如苯妥英。 The hair of the present invention is used optionally in the other classes include a class of growth regulators flavin (flavinoid), ascomycin (ascomycin) derivatives and analogs, histamine antagonists such as diphenyl hydroxylamine hydrochloride (diphenhydramine hydrochloride), other triterpenes such as oleanolic acid, ursolic acid is described in the following documents and those: U.S. Patent No. 5529769, JP 10017431, WO95 / 35103, USP 5468888, JP 09067253, WO 92/09262, JP 62093215, USP 5631282 , USP5679705, JP 08193094, saponins, such as those described in the following: EP0558509 (Bonte et al., September 8, 1993 open) and WO 97/01346 (Bonte et al., January 16, 1997 open ) (the present invention incorporates the above patents are incorporated by reference); or those proeoglycanase glucosamine glucanase enzyme inhibitors as described in the following patents: U.S. Patent 5,015,470 (May 14, 1991 issued), U.S. Patent No. 5,300,284 (1994, April 5 promulgated), US Patent 5,185,325 (February 9, 1993 enacted) (the present invention introduces the aforementioned patent reference); estrogen agonists and antagonists, pseudoterins, cytokines and growth factor promoters, analogs or inhibitors such as interleukin-1 inhibitors, interleukin-6 inhibitor, interleukin-10 accelerator, tumor necrosis factor inhibitors, vitamins such as vitamin D analogs and parathyroid hormone antagonists, vitamin B12 analogs and panthenol (panthenol), interference hormone (interfuron) agonists and antagonists, within those, hydroxy benzophenone and acetic acid as described in U.S. Patent No. 5,550,158 in ureide anticonvulsants such as phenytoin.

其它头发生长剂详细描述于例如JP 09-157139(Tsuji等人,1997年6月17日公开);EP 0277455 Al(Mirabeau,1998年8月10日公开);WO97/05887(Cabo Soler等人,1997年2月20日公开);WO 92/16186(Bonte等人,1992年3月13日公开);JP 62-93215(Okazaki等人,1987年4月28日公开);USP 4987150(Kurono等人,1991年1月22日颁布);JP 290811(Ohba等人,1992年10月15日公开);JP 05-286835(Tanaka等人,1993年11月2日公开);FR 2723313(Greff,1994年8月2日公开);USP 5015470(Gibson,1991年5月14日颁布);USP 5559092(1996年9月24日颁布);USP5536751(1996年7月16日颁布);USP 5714515(1998年2月3日颁布);EPA0319991(1989年6月14日公开);EPA 0357630(1988年10月6日公开);EPA0573253(1993年12月8日公开);JP 61-260010(1986年11月18日公开);USP 5772990(1998年6月30日颁布);USP 5053410(1991年10月1日颁布);USP 4761401(1988年8月2日颁布);本发明引入上述文献作为参考。 Other hair growth agent described in detail, for example, JP 09-157139 (Tsuji et al., June 17, 1997 public); EP 0277455 Al (Mirabeau, 1998 年 8 月 10 Publication Date); WO97 / 05887 (Cabo Soler et al. February 20, 1997 public); WO 92/16186 (Bonte et al., March 13, 1992 public); JP 62-93215 (Okazaki et al, April 28, 1987 open); USP 4987150 (Kurono, etc. People, January 22, 1991 promulgation); JP 290811 (Ohba et al., October 15, 1992 open); JP 05-286835 (Tanaka et al., November 2, 1993 public); FR 2723313 (Greff, August 2, 1994 public); USP 5015470 (Gibson, 1991 年 5, issued May 14); USP 5559092 (1996 年 9 月 24 issued); USP5536751 (1996 年 7 issued on 16 May); USP 5714515 (1998 On February 3 promulgated); EPA0319991 (1989 年 6 月 14 Publication Date); EPA 0357630 (1988 年 10 月 6 Publication Date); EPA0573253 (1993 年 12 月 8 Publication Date); JP 61-260010 (1986 November February 18 open); USP 5772990 (1998 年 6 Promulgated); USP 5053410 (1991 年 10 Promulgated); USP 4761401 (1988 年 8 Promulgated); The present invention introduces the above literature reference.

用于本发明的一些优选的头发生长调节剂是羧酸的锌盐、皂草苷、三萜、石竹素、乌索酸、桦木酸、桦木酮酸、山楂酸、南蛇藤醇(celastrol)、亚细亚酸、5-α-还原酶的抑制剂、孕酮、1,4-甲基-4-氮杂类固醇(azasteroids)、17-β-N,N-二乙基氨基甲酰基-4-甲基-4-氮杂-5-α-雄甾-3-酮、雄激素受体拮抗剂、醋酸环丙孕酮、长压定、壬二酸及其衍生物、环孢菌素、三碘甲状腺原氨酸、氯甲苯噻嗪、钾通道开启剂、cromakalin、苯妥英、酮康唑、芬甾酮、dutasteride、煤焦油、葡糖酸锌、糖皮质激素、大环内酯类、aminexil以及它们的混合物。 The invention is preferably used in some hair growth regulator is a carboxylic acid zinc salts, saponins, triterpenoids, oleanolic acid, ursolic acid, betulinic acid, acid birch, hawthorn acid, Celastrus alcohol (celastrol) Asiatic acid, 5-α- reductase inhibitor, progesterone, 1,4-methyl-4-aza-steroids (azasteroids), 17-β-N, N- diethyl-carbamoyl-4- -5-α- methyl-4-aza-androst-3-one, androgen receptor antagonists, cyproterone acetate, minoxidil, azelaic acid and derivatives thereof, cyclosporin, three triiodothyronine, xylazine chlorine, potassium channel opener, cromakalin, phenytoin, ketoconazole, Finland steroid ketones, dutasteride, coal tar, zinc gluconate, glucocorticoids, macrolides, aminexil and mixtures thereof. D.其它任选成分本发明的去头屑和调理香波组合物在一些实施方案中还可以包括其它已知或有效用于头发护理或个人护理产品中的附加任选组分。 D. Other optional ingredients anti-dandruff and conditioning shampoo compositions of the present invention in some embodiments may also include other known or effective for use in hair care or personal care products additional optional components. 这种任选成分的浓度通常为组合物重量的0至约25%,更典型的是约0.05%至约25%,更典型的是约0.1%至约15%。 0 to about 25% concentration of such optional ingredients generally weight of the composition, more typically from about 0.05% to about 25%, more typically from about 0.1% to about 15%. 这种任选的组分应与本发明所述的基本组分在物理和化学上相容且不应当过度损害产品的稳定性、美观或性能。 Such optional components should be physically and chemically compatible with the essential components according to the present invention and should not be excessive damage stability, aesthetics or performance.

用于香波组合物中的任选的组分的非限定性的实例包括抗静电剂、泡沫促进剂、可溶的去头屑剂、粘度调节剂和增稠剂、pH调节剂(例如柠檬酸钠、柠檬酸、琥珀酸、磷酸、氢氧化钠和碳酸钠)、防腐剂(例如DMDM乙内酰脲)、抗微生物剂(例如三氯生或三氯卡班)、染料、有机溶剂或稀释剂、珠光助剂、香料、脂肪醇、蛋白质、皮肤活性剂、防晒剂、维生素和灭虱剂。 Non-limiting examples of shampoo compositions of the optional components used include antistatic agents, foam boosters, soluble anti-dandruff agents, viscosity modifiers and thickeners, pH adjusting agents (e.g. citric acid sodium, citric acid, succinic acid, phosphoric acid, sodium hydroxide and sodium carbonate), preservatives (e.g. DMDM hydantoin), anti-microbial agents (e.g. triclosan or triclocarban), a dye, an organic solvent or diluent agents, pearlescent aids, perfumes, fatty alcohols, proteins, skin active agents, sunscreens, vitamins, and anti-lice agent.

可以使用任选的抗静电剂如水不溶性的阳离子表面活性剂,浓度通常为组合物重量的约0.1%至约5%。 You can use an optional antistatic agent such as water-insoluble cationic surfactant concentration is usually from about 0.1% by weight of the composition to about 5%. 这样的抗静电剂应不过分干扰香波组合物的使用性能和最终益处;特别地,抗静电剂应不干扰阴离子表面活性剂。 Such antistatic agent should not unduly interfere with the use and performance of the final shampoo composition benefits; in particular, the antistatic agent should not interfere with the anionic surfactant. 合适的抗静电剂的具体的非限定性的实例是三鲸蜡基甲基氯化铵。 Specific non-limiting examples of suitable antistatic agents are three-cetyl dimethyl ammonium chloride.

用于本发明所述香波组合物中的任选的泡沫促进剂包括脂肪酯(例如C8-C22)单-和二-(C1-C5,特别是C1-C3)烷醇酰胺。 Used in the shampoo compositions of the present invention, the optional foam boosters include fatty ester (e.g. C8-C22) Single - and di - (C1-C5, especially C1-C3) alkanol amides. 这样的泡沫促进剂的具体非限定性的实例包括椰油单乙醇酰胺、椰油二乙醇酰胺以及它们的混合物。 Such a specific non-limiting examples of foam boosters include cocamide, coconut diethanolamide, and mixtures thereof monoethanol.

除本发明的颗粒状的去头屑活性物质外,还可以使用任选的去头屑剂,通常其浓度是组合物重量的约0.1%至约4%,优选为约0.2%至约2%。 In addition to the present invention, the particulate antidandruff active substances, but also can use an optional antidandruff agents, typically at a concentration from about 0.1% to about 4% by weight of the composition, preferably from about 0.2% to about 2% . 这样的任选的去头屑剂包括水溶性的去头屑剂,其具体的非限定性的实例包括:羟甲辛吡酮乙醇胺(piroctone olamine),酮康唑(ketoconazol)以及它们的混合物。 Such optional anti-dandruff agents include soluble anti-dandruff agents, specific non-limiting examples include: ethanolamine octopirox (piroctone olamine), ketoconazole (ketoconazol), and mixtures thereof.

可以使用任选的粘度改性剂和增稠剂,通常以有效量用于本发明去头屑和调理香波组合物中使得通常的整体粘度为约1,000厘沲至约20,000厘沲,优选约3,000厘沲至约10,000厘沲。 Can be optionally used viscosity modifiers and thickeners, generally used in the present invention in an effective amount anti-dandruff and conditioning shampoo compositions such that generally the overall viscosity of about 1,000 centistokes to about 20,000 centistokes, preferably from about 3,000 centistokes to about 10,000 centistokes. 这种粘度改性剂和增稠剂的具体的非限定性的实例包括:氯化钠、硫酸钠以及它们的混合物。 Specific non-limiting examples of such viscosity modifiers and thickeners include: sodium chloride, sodium sulfate and mixtures thereof.

III.生产方法本发明的去头屑和调理香波组合物可以通过任何已知或其它的有效的适于提供香波组合物的技术制备,条件是所得的组合物提供了杰出的本文所述的头发感功效。 III. Antidandruff producing method of the present invention and conditioning shampoo compositions can provide excellent hair described herein by any known or otherwise effective adapted to provide shampoo compositions were prepared, provided that the resultant composition sense of efficacy. 制备本发明的去头屑和调理香波组合物的方法包括常规的配制和混合技术。 The method of the present invention for preparing anti-dandruff and conditioning shampoo compositions include conventional formulation and mixing techniques. 能够使用如在美国专利5837661中所述的方法(本发明引入上述文献作为参考),其中本发明的去头屑剂将通常以在'661说明书中加入聚硅氧烷预混物的相同步骤加入。 The method can be used as described in U.S. Patent No. 5,837,661 (the present invention incorporates by reference supra), wherein the antidandruff agent of the present invention will be generally the same as the step of adding a premix of the silicone in the '661 specification is added .

IV.使用方法本发明的去头屑和调理香波组合物以清洁和调理头发或皮肤的常规方式使用。 IV. The method of the present invention is the use of anti-dandruff and conditioning shampoo compositions of cleansing and conditioning to the hair or skin using conventional means. 特别地,它们以常规方式治疗通常称为头屑的症状。 In particular, they are often referred to in a conventional manner of treatment of the symptoms of dandruff. 用于清洁和调理头发或皮肤的有效量的组合物涂覆于优选已预先润湿(通常是水)的头发或者身体的其它部位,然后将组合物漂洗掉。 Composition is applied to clean and condition the hair or skin an effective amount is preferably used in a pre-wetted (typically water) hair or other parts of the body, and then the composition is rinsed off. 有效量的范围通常为约1克至约50克,优选约1克至约20克。 Effective amounts generally range from about 1 g to about 50 g, preferably from about 1 g to about 20 g. 应用于头发上通常包括将组合物在头发中揉抹,从而使得大部分或全部头发均与组合物接触。 Is applied to the hair typically includes the composition in the hair rub wipe, such that most or all of the hair are in contact with the composition.

用于提供去头屑功效和调理头发作用的方法包括下列步骤:(a)将头发用水润湿,(b)将有效量的香波组合物施用到头发上,和(c)用水从头发上漂洗香波组合物。 The method for providing anti-dandruff efficacy and conditioning hair comprises the steps of action: (a) wetting the hair with water, (b) an effective amount of the shampoo composition to the hair, and (c) from the hair is rinsed with water shampoo compositions. 这些步骤可以根据需要重复许多次,以达到所寻求的清洁、调理和去头屑功效。 These steps can be repeated as many times as necessary to achieve the sought cleaning, conditioning and antidandruff efficacy.

还设想当所使用的去头屑微粒是吡啶硫酮锌,和/或如果使用其它任选的头发生长调节剂时,本发明的香波组合物可以提供调节头发的生长。 It is also contemplated antidandruff particles when used is zinc pyrithione, and / or if other optional hair growth when adjusting agent, the shampoo compositions of the invention may be adjusted to provide hair growth. 使用这样的香波组合物的常规方法包括上述步骤a、b和c。 Using such a conventional shampoo composition comprising the above steps a, b and c.

实施例下列是本发明去头屑和调理香波组合物的非限定性的实例。 EXAMPLES The following are anti-dandruff and conditioning shampoo compositions of non-limiting examples of the present invention. 这些实施例的给出仅是为了说明的目的,并不能被理解为对本发明的限定,因为在不脱离本发明的精神和范围的基础上,可以对本发明进行许多改变,这是本领域普通技术人员能够认识到的。 These examples are given solely for the purpose of illustration and are not to be construed as limiting the present invention because without departing from the basic spirit and scope of the present invention may be many variations of the present invention, which is one of ordinary skill were able to recognize. 在这些实施例中,除非特别说明,所有的浓度都是重量百分比。 In these examples, unless otherwise stated, all concentrations are weight percent. 本发明所用的术语“少量物质”指的是任选的那些物质,如防腐剂、粘度调节剂、pH调节剂、香料、泡沫促进剂等。 As used herein, the term "small amounts of substances" refers to those optional substances, such as preservatives, viscosity modifiers, pH adjusting agents, perfumes, foam boosters and the like. 本领域普通技术人员很清楚的是,这些少量物质的选择将随着选定的用以制备本发明的特定成分的物理和化学特性而改变。 Those of ordinary skill in very clear that the choice of a small amount of these substances will vary with the selected physical and chemical properties of the present invention for the preparation of a specific component is changed.

合适的制备下列实施例(I-IX)中所述的去头屑和调理香波组合物的方法如下:将大约1/3至全部的月桂基聚氧乙烯醚硫酸铵(25%wt溶液)加入到带夹套的混合罐中,在缓慢搅拌下加热到约60℃至约80℃,形成表面活性剂溶液。 Suitable antidandruff prepared as described in the following examples (I-IX) and methods for conditioning shampoo composition is as follows: Approximately 1/3 to all of the polyoxyethylene lauryl ether sulfate (25% wt solution) was added to the mixing tank with a jacket, and heated under slow stirring to about 60 ℃ to about 80 ℃, forming a surfactant solution. 在该罐中加入椰油单乙醇酰胺和脂肪醇(如果使用这些物质的情况下),进行分散。 Add coconut monoethanolamide, and fatty alcohols (in the case of these materials, if used under) in the tank, to be dispersed. 在该罐中加入盐(例如氯化钠)和pH调节剂(例如柠檬酸、柠檬酸钠),使其进行分散。 Adding salt (e.g. sodium chloride) and pH modifiers (e.g. citric acid, sodium citrate) in the tank, so that to be dispersed. 在该混合容器中加入乙二醇二硬脂酸酯(EGDS),进行熔融。 Ethylene glycol distearate (EGDS) in the mixing vessel, and melt. 在EGDS熔化和分散后,在该表面活性剂溶液中加入防腐剂。 After the EGDS is melted and dispersed, preservative is added in the surfactant solution. 将所得的混合物冷却到约25℃至约40℃,收集在成品罐中。 The resulting mixture was cooled to about 25 ℃ to about 40 ℃, collected in a finishing tank. 冷却步骤的结果是EGDS结晶而在产品中形成结晶网。 The results and the cooling step is to form a crystalline network in the product EGDS crystals. 在成品罐中,在搅拌下,加入剩余的月桂基聚氧乙烯醚硫酸铵和其它组分,包括聚硅氧烷和去头屑颗粒,以确保得到均匀混合物。 In the finishing tank, with stirring, add the remaining lauryl polyoxyethylene ether ammonium sulfate and other components, including the silicone and anti-dandruff particles, to ensure a homogeneous mixture. 将阳离子聚合物分散在水中,为约0.1%至约10%的水溶液,然后加入最终混合物中。 The cationic polymer dispersed in water, about 0.1% to about 10% aqueous solution, and then added to the final mixture. 在加入所有的组分后,可以根据需要在混合物中加入附加的粘度和pH调节剂,以调节产品粘度和pH至所需的程度。 After addition of all the components, may also add to the mixture an additional viscosity and pH adjusting agent to adjust product viscosity and pH to the extent desired. 实施例号 I II III IV V月桂基聚氧乙烯醚硫酸铵 12 12 11 10 12月桂基硫酸铵 8 8 7 6 6瓜尔羟丙基三甲基氯化铵 0.4 0.4 0.25 0.6 0.6PEG 23M2--- --- --- --- 0.1PEG 90M30.1 0.05 0.025 0.01 ---吡啶硫酮锌41 1 1 1 11-癸烯均聚物50.2 0.3 0.3 0.5 0.4辛酸三甲基丙烷辛酯60.2 0.1 0.1 0.0 0.1聚二甲基硅氧烷71.0 2.0 0.8 0.5 1.25乙二醇二硬脂酸酯 1.0 2.0 1.5 2.0 1.5椰油单乙醇酰胺 0.6 0.8 0.6 0.8 1.0鲸蜡醇 0.9 0.9 0.9 0.9 1.0水和少量物质 足量1.分子量为约200,000、电荷密度为约0.71meq/g的瓜尔,来自Aqualon。 Example No. I II III IV V lauryl polyoxyethylene ether ammonium sulfate 1212111012 lauryl sulfate 88,766 guar hydroxypropyl trimethyl ammonium chloride 0.4 0.4 0.25 0.6 0.6PEG 23M2-- - --- --- --- 0.1PEG 90M30.1 0.05 0.025 0.01 --- Zinc Pyrithione 4111111- decene homopolymer 50.2 0.3 0.3 0.5 0.4 octyl octanoate trimethylpropane 60.2 0.1 0.1 0.0 0.1 Polydimethylsiloxane 2.0 0.8 0.5 71.0 1.25 Ethylene glycol distearate 1.0 2.0 1.5 2.0 1.5 Coconut monoethanolamide 0.6 0.8 0.6 0.8 1.0 Cetyl alcohol 0.9 0.9 0.9 0.9 1.0 Water and a small amount of material 1. The full amount of a molecular weight of about 200,000, the charge density of about 0.71meq / g of guar, from Aqualon.

2.Polyox WSR N-12k,来自Union Carbide。 2.Polyox WSR N-12k, from Union Carbide.

3.Polyox WSR 301,来自Union Carbide。 3.Polyox WSR 301, from Union Carbide.

4.ZPT,平均粒径为约2.5μm,来自Arch/Olin。 4.ZPT, an average particle size of about 2.5μm, from Arch / Olin.

5.Puresyn 6,来自Mobil。 5.Puresyn 6, from Mobil.

6.Mobil P43,来自Mobil。 6.Mobil P43, from Mobil.

7.Visasil 330,000厘沲,来自General Electric Silicones。 7.Visasil 330,000 centistokes, from General Electric Silicones. 实施例号 VI VII VIII IX X月桂基聚氧乙烯醚硫酸铵 12 12 10 10 12月桂基硫酸铵 8 6 6 5 6Polyquaternium-101--- --- 0.25 0.25 0.1瓜尔羟丙基三甲基氯化铵2--- 0.25 --- --- ---瓜尔羟丙基三甲基氯化铵30.5 --- 0.25 0.35 0.4PEG 7M40.1 --- 0.1 0.1 0.2PEG 90M5--- 0.1 --- --- ---吡啶硫酮锌61 1 1 1 11-癸烯均聚物70.2 0.4 0.4 0.5 0.5辛酸三甲基丙烷辛酯80.1 --- 0.1 0.2 ---聚二甲基硅氧烷90.55 1.15 1.35 3.25 3.35乙二醇二硬脂酸酯 1.5 1.0 1.5 2.0 2.0椰油单乙醇酰胺 0.6 1.1 0.8 1.1 1.3鲸蜡醇 0.9 0.6 0.9 1.0 1.0水和少量物质 足量1.UCARE Polymer LR 400,来自Amerchol。 Example No. VI VII VIII IX X Sodium lauryl polyoxyethylene ether ammonium sulfate 1212101012 lauryl sulfate 8 6 6 5 6Polyquaternium-101 --- --- 0.25 0.25 0.1 Guar Hydroxypropyl trimethyl chloro ammonium 2 --- --- --- --- 0.25 guar hydroxypropyl trimethyl ammonium chloride 30.5 --- 0.25 0.35 0.4PEG 7M40.1 --- 0.1 0.1 0.2PEG 90M5 --- 0.1 --- --- --- Zinc Pyrithione 6111111- decene homopolymer 70.2 0.4 0.4 0.5 0.5 octyl octanoate trimethylpropane 80.1 0.1 0.2 --- --- polydimethylsiloxane Siloxane 90.55 1.15 1.35 3.25 3.35 Ethylene glycol distearate 1.5 1.0 1.5 2.0 2.0 Coconut monoethanolamide 0.8 1.1 0.6 1.1 0.9 0.6 1.3 Cetyl alcohol 0.9 1.0 1.0 Water and a small amount of material sufficient 1.UCARE Polymer LR 400 from Amerchol.

2.Jaguar C17,来自Rhodia。 2.Jaguar C17, from Rhodia.

3.分子量为约200000、电荷密度为约0.71meq/g的瓜尔,来自Aqualon。 3. The molecular weight of about 200,000, the charge density of about 0.71meq / g of guar, from Aqualon.

4.Polyox WSR N-750,来自Union Carbide。 4.Polyox WSR N-750, from Union Carbide.

5.Polyox WSR 301,来自Union Carbide。 5.Polyox WSR 301, from Union Carbide.

6.ZPT,平均粒径为约2.5μm,来自Arch/Olin。 6.ZPT, an average particle size of about 2.5μm, from Arch / Olin.

7.Puresyn 6,来自Mobil。 7.Puresyn 6, from Mobil.

8.Mobil P43,来自Mobil。 8.Mobil P43, from Mobil.

9.Visasil 330000厘沲,来自General Electric Silicones。 9.Visasil 330000 centistokes, from General Electric Silicones. 实施例号 XI XII XIII XIV XV月桂基聚氧乙烯醚硫酸铵 10 11 12 13 12月桂基硫酸铵 6 7 7 5 5Polyquaternium-1010.15 --- --- --- ---瓜尔羟丙基三甲基氯化铵2--- --- 0.1 --- ---瓜尔羟丙基三甲基氯化铵3--- 0.4 --- 0.1 ---瓜尔羟丙基三甲基氯化铵4--- --- --- --- 0.5瓜尔羟丙基三甲基氯化铵50.25 --- --- --- ---PEG 90M60.025 0.1 0.15 0.15 0.2吡啶硫酮锌71 1 1 1 11-癸烯均聚物80.6 0.2 0.4 --- 0.1辛酸三甲基丙烷辛酯9--- --- 0.3 0.2 0.1聚二甲基硅氧烷101.35 1.45 0.75 1.1 0.85乙二醇二硬脂酸酯 1.0 1.2 1.5 2.0 2.0椰油单乙醇酰胺 0.6 1.0 0.6 0.6 1.1鲸蜡醇 0.9 1.0 0.6 0.6 1.1水和少量物质 足量1.UCARE Polymer LR 400,来自Amerchol。 Example No. XI XII XIII XIV XV Sodium lauryl polyoxyethylene ether ammonium sulfate 1011121312 lauryl sulfate 6 7 7 5 5Polyquaternium-1010.15 --- --- --- --- Guar hydroxypropyltrimonium methyl chloride 2 --- --- --- --- 0.1 guar hydroxypropyl trimethyl ammonium chloride 3 --- 0.4 --- 0.1 --- guar hydroxypropyl trimethyl ammonium chloride 4 --- --- --- --- 0.5 guar hydroxypropyl trimethyl ammonium chloride 50.25 --- --- --- --- PEG 90M60.025 0.1 0.15 0.15 0.2 pyridine thione zinc 7111111- decene homopolymer 80.6 0.2 0.4 --- 0.1 caprylic trimethylpropane octyl 9 --- --- 0.3 0.2 0.1 Dimethicone 1.45 0.75 1.1 0.85 101.35 Ethylene glycol distearate 1.0 1.2 1.5 2.0 2.0 Coconut monoethanolamide 0.6 1.0 0.6 0.6 0.9 1.0 1.1 Cetyl alcohol 0.6 0.6 1.1 water and a small amount of material sufficient 1.UCARE Polymer LR 400, from Amerchol.

2.Jaguar C17,来自Rhodia。 2.Jaguar C17, from Rhodia.

3.Jaguar C14S,来自Rhodia。 3.Jaguar C14S, from Rhodia.

4.分子量为约900,000、电荷密度为约0.71meq/g的瓜尔,来自Aqualon。 The molecular weight of about 900,000, the charge density of about 0.71meq / g of guar, from Aqualon.

5.分子量为约200,000、电荷密度为约0.71meq/g的瓜尔,来自Aqualon。 5. The molecular weight of about 200,000, the charge density of about 0.71meq / g of guar, from Aqualon.

6.Polyox WSR 301,来自Union Carbide。 6.Polyox WSR 301, from Union Carbide.

7.ZPT,平均粒径为约2.5μm,来自Arch/Olin。 7.ZPT, an average particle size of about 2.5μm, from Arch / Olin.

8.Puresyn 6,来自Mobil。 8.Puresyn 6, from Mobil.

9.Mobil P43,来自Mobil。 9.Mobil P43, from Mobil.

10.Visasil 330,000厘沲,来自General Electric Silicones。 10.Visasil 330,000 centistokes, from General Electric Silicones.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
CN101365779B11 Mar 200514 Aug 2013荷兰联合利华有限公司Beauty wash product composition
Classifications
International ClassificationA61K8/46, A61Q5/12, A61K8/86, A61K8/89, A61K8/04, A61K8/58, A61Q5/02, A61K8/27, A61K8/73, A61K8/891, A61K8/37, A61K8/64, A61Q7/00, A61K8/00, A61K8/43, C11D3/20, A61K8/49, A61Q5/00
Cooperative ClassificationA61K8/4933, A61K8/463, A61Q5/12, A61K8/731, A61K8/891, A61K8/0254, A61K2800/412, A61Q5/02, A61K2800/5426, A61K8/737, A61K8/375, A61K8/27, A61Q5/006, A61K8/86
European ClassificationA61K8/02N3, A61K8/891, A61Q5/02, A61Q5/12, A61K8/86, A61K8/37C, A61K8/49C6, A61K8/46C, A61Q5/00F, A61K8/73R, A61K8/73C, A61K8/27
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DateCodeEventDescription
29 May 2002C10Request of examination as to substance
12 Jun 2002C06Publication
24 Oct 2007C14Granted