CN105646222A - Method for producing polyglycerol fatty acid ester iodine complex - Google Patents
Method for producing polyglycerol fatty acid ester iodine complex Download PDFInfo
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- CN105646222A CN105646222A CN201410676044.6A CN201410676044A CN105646222A CN 105646222 A CN105646222 A CN 105646222A CN 201410676044 A CN201410676044 A CN 201410676044A CN 105646222 A CN105646222 A CN 105646222A
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- fatty acid
- acid ester
- iodine
- complexes
- iodo
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Abstract
The invention relates to a method for producing a polyglycerol fatty acid ester iodine complex; with polyglycerol fatty acid ester as a complex carrier is complexed with iodine (I) to generate the polyglycerol fatty acid ester iodine complex. The appearance body is a deep purple sticky liquid and is soluble in water, the pH value is 5-6, and the iodine content is 5-15%.
Description
[technical field]
The present invention is a kind of manufacture method of polyglyceryl fatty acid ester iodo-complexes.
[background technology]
Iodo-complexes is a kind of taking surfactant as carrier with the indefinite form chelated iodine of solubilizer. About the chemical constitution between iodine and surfactant, a lot of people are in research. Generally believe that I is gathered among surfactant micella, this iodine is surrounded by micella and forms complexing phenomenon. When iodo-complexes micella is diluted by water, alcohol equal solvent, micellar concentration reduces, the adhesion between iodine and surfactant micella or say complexing power and weaken, and iodine is dissociated out, now iodine produces strong oxidation to microorganism surface, and the mercapto hydrogen that destroys protein reaches sterilizing object. " sterilization clinical trial and the performance study of surfactant-iodo-complexes " delivered in China's " Surfactant Industry " second phase in 1992, propose for the first time at home the concept of surfactant iodo-complexes, confirm that polytype surfactant can do the carrier of iodo-complexes; The object of the research and development of surfactant iodo-complexes and research, after having proved that iodine is by surfactant complexing, has changed the water-fast physical property of iodine. That is to say: the simple substance of iodine is slightly soluble in water, but just can be absolutely water-soluble after becoming iodo-complexes by the complexing of surfactant, but bactericidal properties and the antibacterial row performance of iodine to microorganism do not change. The important change of the physical property of this iodine, makes iodine have using value widely, especially medicine, medical aspect; A lot of non-ionic surface active agents can be cooked carrier and iodine complexing, generate iodo-complexes. Chinese patent [201110029189.3] proposes to do carrier and iodine complexing by cocoyl dimethyl oxidation ammonium, manufactures iodo-complexes; Chinese patent [201110166871.7] proposes to do carrier and iodine complexing by lauryl glucoside, manufactures iodo-complexes; Chinese patent [201110166891.4] proposes to do carrier and iodine complexing by laurate polyethylene glycol (400) ester, manufactures iodo-complexes; Chinese patent [201110278315.9] proposes to do carrier and iodine complexing by lauryl sorbitan ester APEO, manufactures iodo-complexes; Chinese patent [201210107430.4] proposes to do carrier and iodine complexing by PPG, manufactures iodo-complexes; Chinese patent [201210107551.9] proposes to do carrier and iodine complexing by laruyl alcohol acid amides APEO, manufactures iodo-complexes; Chinese patent [201210107552.3] proposes to do carrier and iodine complexing by bay alkyl dimethyl betaine, manufactures iodo-complexes.
The present invention proposes to do carrier and iodine complexing by polyglyceryl fatty acid ester by experiment first, produces polyglyceryl fatty acid ester iodo-complexes.
[summary of the invention]
The present invention is a kind of preparation method of polyglyceryl fatty acid ester iodo-complexes.
Structural formula of the present invention:
。
The present invention does complexing carrier and iodine (I) complexing with polyglyceryl fatty acid ester, generates polyglyceryl fatty acid ester iodo-complexes.
Its concrete thing of polyglyceryl fatty acid ester of the present invention is six polyglycereol monolaurates (HLB values: 13) or eight polyglycereol monolaurates (HLB value: 15) or ten polyglycereol monolaurates (HLB value: 15.5) or eight polyglycereol monoleates (HLB value: 13) or ten polyglycereol monoleate (HLB values: 14.5).
Used carrier polyglyceryl fatty acid ester of the present invention belongs to non-ionic surface active agent, has good water-soluble, solubilising, dispersiveness, thickening property and biological degradability. Be widely used in the various fields such as daily chemical industry, food industry, pharmacy industry. Polyglyceryl fatty acid ester is to human body skin and human body mucous membrane nonirritant, nontoxic.
Organic acid acid of the present invention is citric acid, oxalic acid, tartaric acid etc., and Main Function is complex system pH regulating action.
Material composition of the present invention: polyglyceryl fatty acid ester 80-90 part, iodine (I) 5-10 part, organic acid 1-3 part, iodide 2-4 part.
The synthetic of polyglyceryl fatty acid ester iodo-complexes of the present invention is to complete in particular device, temperature, time response process; Device therefor is stainless steel (or enamel or glass) material, and reactor need be air-tight state, need to have material circulation equipment and firing equipment. Reaction temperature is controlled between 50-70 DEG C, and the material synthetic system pH value in building-up process is faintly acid.
The present invention, in temperature controlled chuck stainless steel cauldron, is warming up to 50 ± 2 DEG C, stirs, and adds successively polyglyceryl fatty acid ester, organic acid acid, iodide; Be warming up to 60 ± 2 DEG C and add iodine, reactor complex reaction is after 2 hours, and reaction mass carries out system circulation 1 hour, and temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing. Finished product need be placed in lucifuge, nonmetallic container and preserve.
Polyglyceryl fatty acid ester iodo-complexes outward appearance body shape of the present invention is darkviolet thick liquid, and pH value (25 DEG C, 1% aqueous solution) 5-6 is water-soluble, content of iodine (%) 5-15, moisture content (%)≤0.5.
Finished product of the present invention need be placed in lucifuge, nonmetallic container and preserve.
The present invention manufactures that raw material is easy to get, pollution-free in production process, without discarded object, meet the requirement of environmental protective chemical industry production technology.
[detailed description of the invention]
Embodiment mono-:
Throwing raw materials ratio: eight 85 parts of polyglycereol monolaurates, 10 parts of iodine (I), 3 parts of organic acids, 2 parts, iodide.
Synthesis route: in temperature controlled airtight stainless steel cauldron, be warming up to 50 ± 2 DEG C, stir, add successively 85 kilograms of eight polyglycereol monolaurates, 3 kilograms of organic acids, 2 kilograms, iodide; Heat up 60 ± 2 DEG C and add 10 kilograms of iodine; Reactor complex reaction time 2 h, then carries out Matter Transfer reaction 1 hour. Temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing. Material need be placed in lucifuge, nonmetallic container.
Embodiment bis-:
Press following part by weight throwing raw materials: ten 89 parts of polyglycereol monolaurates, 7 parts of iodine (I), 2 parts of organic acids, 2 parts, iodide.
Synthesis route: in temperature controlled airtight stainless steel cauldron, be warming up to 50 ± 2 DEG C, stir, add successively 89 kilograms of ten polyglycereol monolaurates, 2 kilograms of organic acids, 2 kilograms, iodide; Heat up 60 ± 2 DEG C and add 7 kilograms of iodine; Reactor complex reaction time 2 h, then carries out Matter Transfer reaction 1 hour. Temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing. Material need be placed in lucifuge, nonmetallic container.
Embodiment tri-:
Press following part by weight throwing raw materials: ten 92 parts of polyglycereol monoleates, 5 parts of iodine (I), 1 part of organic acid, 2 parts, iodide.
Synthesis route: in temperature controlled airtight stainless steel cauldron, be warming up to 50 ± 2 DEG C, stir, add successively 92 kilograms of ten polyglycereol monoleates, add 1 kilogram of organic acid, 2 kilograms, iodide; Heat up 60 ± 2 DEG C and add 5 kilograms of iodine; Reactor reaction complexing time 2 h, then carries out Matter Transfer reaction 1 hour. Temperature is down to 35 ± 2 DEG C of qualified rear dischargings after testing. Material need be placed in lucifuge, nonmetallic container.
Claims (3)
1. a manufacture method for polyglyceryl fatty acid ester iodo-complexes, is characterized in that: polyglyceryl fatty acid ester is done carrier and iodine (I) complexing, and complexing goes out polyglyceryl fatty acid ester iodo-complexes.
2. the manufacture method of a kind of polyglyceryl fatty acid ester iodo-complexes according to claim 1, is characterized in that: the structural formula of polyglyceryl fatty acid ester iodo-complexes is
In formula: n=5-9; R=fatty acid alkyl.
3. the manufacture method of a kind of polyglyceryl fatty acid ester iodo-complexes according to claim 1, is characterized in that: polyglyceryl fatty acid ester is six polyglycereol monolaurates (HLB value: 13) or eight polyglycereol monolaurates (HLB value: 15) or ten polyglycereol monolaurates (HLB value: 15.5) or eight polyglycereol monoleates (HLB value: 13) or ten polyglycereol monoleate (HLB values: 14.5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410676044.6A CN105646222A (en) | 2014-11-24 | 2014-11-24 | Method for producing polyglycerol fatty acid ester iodine complex |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410676044.6A CN105646222A (en) | 2014-11-24 | 2014-11-24 | Method for producing polyglycerol fatty acid ester iodine complex |
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| Publication Number | Publication Date |
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| CN105646222A true CN105646222A (en) | 2016-06-08 |
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| CN201410676044.6A Pending CN105646222A (en) | 2014-11-24 | 2014-11-24 | Method for producing polyglycerol fatty acid ester iodine complex |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3438907A (en) * | 1965-07-26 | 1969-04-15 | Wyandotte Chemicals Corp | Iodine-containing nonionic surfactant compositions |
| CN102335128A (en) * | 2011-06-29 | 2012-02-01 | 杨灵杰 | Formula and preparation method of iodine complex solution |
| CN102838484A (en) * | 2011-06-21 | 2012-12-26 | 天津博莱恩科技发展有限公司 | Polyoxyethylene laurate (400) ester-iodine complex |
| CN103012767A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Lauryl sorbitan ester polyoxyethylene ether iodine complex |
| CN103006453A (en) * | 2011-09-22 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing sterilizing shampoo |
| CN103373933A (en) * | 2012-04-13 | 2013-10-30 | 天津博克尼科技发展有限公司 | Lauryl dimethyl betaine and iodine complex |
| CN103374127A (en) * | 2012-04-13 | 2013-10-30 | 天津博克尼科技发展有限公司 | Polyether polyol and iodine complex |
| CN103374123A (en) * | 2012-04-13 | 2013-10-30 | 天津博克尼科技发展有限公司 | Laurinol amide polyoxyethylene ether iodo-complex |
| CN103651567A (en) * | 2012-09-24 | 2014-03-26 | 天津博克尼科技发展有限公司 | Special washing disinfectant for food utensil and equipment |
-
2014
- 2014-11-24 CN CN201410676044.6A patent/CN105646222A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3438907A (en) * | 1965-07-26 | 1969-04-15 | Wyandotte Chemicals Corp | Iodine-containing nonionic surfactant compositions |
| CN102838484A (en) * | 2011-06-21 | 2012-12-26 | 天津博莱恩科技发展有限公司 | Polyoxyethylene laurate (400) ester-iodine complex |
| CN102335128A (en) * | 2011-06-29 | 2012-02-01 | 杨灵杰 | Formula and preparation method of iodine complex solution |
| CN103012767A (en) * | 2011-09-20 | 2013-04-03 | 天津博克尼科技发展有限公司 | Lauryl sorbitan ester polyoxyethylene ether iodine complex |
| CN103006453A (en) * | 2011-09-22 | 2013-04-03 | 天津博克尼科技发展有限公司 | Iodine-containing sterilizing shampoo |
| CN103373933A (en) * | 2012-04-13 | 2013-10-30 | 天津博克尼科技发展有限公司 | Lauryl dimethyl betaine and iodine complex |
| CN103374127A (en) * | 2012-04-13 | 2013-10-30 | 天津博克尼科技发展有限公司 | Polyether polyol and iodine complex |
| CN103374123A (en) * | 2012-04-13 | 2013-10-30 | 天津博克尼科技发展有限公司 | Laurinol amide polyoxyethylene ether iodo-complex |
| CN103651567A (en) * | 2012-09-24 | 2014-03-26 | 天津博克尼科技发展有限公司 | Special washing disinfectant for food utensil and equipment |
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Application publication date: 20160608 |
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