CN105640926A - Itching relieving spray and preparation method thereof - Google Patents
Itching relieving spray and preparation method thereof Download PDFInfo
- Publication number
- CN105640926A CN105640926A CN201610110844.0A CN201610110844A CN105640926A CN 105640926 A CN105640926 A CN 105640926A CN 201610110844 A CN201610110844 A CN 201610110844A CN 105640926 A CN105640926 A CN 105640926A
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- CN
- China
- Prior art keywords
- parts
- hydroxybenzoate
- antipruritic
- polyacrylic acid
- preparation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Abstract
The invention discloses an itching relieving spray and a preparation method thereof. The itching relieving spray comprises raw materials in parts by weight as follows: 10-40 parts of an aqueous polyacrylic acid solution, 20-40 parts of aminomethylpropanol, 2-10 parts of phosphatidylcholine, 10-30 parts of squalene, 20-50 parts of sorbitan monolaurate, 40-90 parts of sodium hyaluronate, 10-60 parts of butanediol, 10-20 parts of glucan, 1-7 parts of phenoxyethanol, 20-30 parts of caprylyl glycol and 10-20 parts of p-hydroxy-benzoate ester. The preparation method of the itching relieving spray comprises steps as follows: aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol and p-hydroxy-benzoate ester are added to the aqueous polyacrylic acid solution under the stirring condition and are uniformly stirred, a mixture is heated to 85-90 DEG C and reacts for 1-2 h, residual components are added and uniformly stirred after the mixture is cooled to 70-75 DEG C, and a spray preparation is prepared. The itching relieving spray has a wide antibacterial range, a good antibacterial effect and an itching relieving effect.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of antipruritic spraying and preparation method thereof.
Background technology
Spraying is exactly Artificial Fog. Being exactly briefly that liquid is ejected by high-pressure system with imperceptible water particle, in atmosphere, thus forming the vaporific wonder of white, pole is as the effect of natural fog, therefore says spraying for these small artificial fog granule energy long time drifts, suspension. Spraying is the mixture of the fine particle that one is suspended in gas (such as air), and this particle is probably water or the pigment of minimum.
Spraying is carried with easily, and general spraying has an effect of moisturizing, but summer the easy growth and breeding of antibacterial, make xerosis cutis itch, and general ointment drug effect can reduce over time.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, it is provided that a kind of antipruritic spraying and preparation method thereof, it is possible to carrying with, antipruritic effect is strong.
The present invention is by the following technical solutions:
Antipruritic spraying, including the raw material of following parts by weight: polyacrylic acid aqueous solution 10��40 parts, aminomethylpropanol 20��40 parts, phosphatidylcholine 2��10 parts, squalane 10��30 parts, sorbitan mono-laurate 20��50 parts, hyaluronate sodium 40��90 parts, butanediol 10��60 parts, glucosan 10��20 parts, phenoxyethanol 1��7 part, caprylyl glycol 20��30 parts, p-Hydroxybenzoate 10��20 parts.
Antipruritic spraying, including the raw material of following parts by weight: polyacrylic acid aqueous solution 30 parts, aminomethylpropanol 30 parts, phosphatidylcholine 5 parts, squalane 20 parts, sorbitan mono-laurate 30 parts, hyaluronate sodium 50 parts, butanediol 40 parts, Dextran 15 part, phenoxyethanol 4 parts, caprylyl glycol 25 parts, p-Hydroxybenzoate 15 parts.
As to further improvement of the present invention, p-Hydroxybenzoate is methyl parahydroxybenzoate or propyl p-hydroxybenzoate.
As to further improvement of the present invention, the mass concentration of polyacrylic acid aqueous solution is 2��3%.
The preparation method of antipruritic spraying, comprise the following steps: under stirring condition, aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol, p-Hydroxybenzoate are added in polyacrylic acid aqueous solution, stir, it is heated to 85��90 DEG C, reaction 1��2h, after being cooled to 70��75 DEG C, addition squalane, sorbitan mono-laurate, hyaluronate sodium, butanediol, glucosan stir, make spray agent.
As to further improvement of the present invention, mixing speed is maintained at 300��700r/min.
Beneficial effect
The present invention can suppress the growth of staphylococcus aureus, escherichia coli and Pseudomonas aeruginosa, and scope of restraining fungi is wide, and fungistatic effect is good, thus reaching antipruritic effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described in detail.
The several specific embodiments being only the application of following discloses, but the application is not limited to this, the changes that any person skilled in the art can think of, all should drop in the protection domain of the application.
Embodiment 1
Antipruritic spraying, including the raw material of following parts by weight: polyacrylic acid aqueous solution 30 parts, aminomethylpropanol 30 parts, phosphatidylcholine 5 parts, squalane 20 parts, sorbitan mono-laurate 30 parts, hyaluronate sodium 50 parts, butanediol 40 parts, Dextran 15 part, phenoxyethanol 4 parts, caprylyl glycol 25 parts, p-Hydroxybenzoate 15 parts.
P-Hydroxybenzoate is methyl parahydroxybenzoate or propyl p-hydroxybenzoate.
The mass concentration of polyacrylic acid aqueous solution is 2.5%.
The preparation method of antipruritic spraying, comprise the following steps: under stirring condition, aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol, p-Hydroxybenzoate are added in polyacrylic acid aqueous solution, stir, it is heated to 87 DEG C, reaction 1.5h, after being cooled to 72 DEG C, addition squalane, sorbitan mono-laurate, hyaluronate sodium, butanediol, glucosan stir, make spray agent.
Described mixing speed is maintained at 500r/min.
Embodiment 2
Antipruritic spraying, including the raw material of following parts by weight: polyacrylic acid aqueous solution 10 parts, aminomethylpropanol 20 parts, phosphatidylcholine 2 parts, squalane 10 parts, sorbitan mono-laurate 20 parts, hyaluronate sodium 40 parts, butanediol 10 parts, glucosan 10 parts, phenoxyethanol 1 part, caprylyl glycol 20 parts, p-Hydroxybenzoate 10 parts.
P-Hydroxybenzoate is methyl parahydroxybenzoate or propyl p-hydroxybenzoate.
The mass concentration of polyacrylic acid aqueous solution is 2%.
The preparation method of antipruritic spraying, comprise the following steps: under stirring condition, aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol, p-Hydroxybenzoate are added in polyacrylic acid aqueous solution, stir, it is heated to 85 DEG C, reaction 1h, after being cooled to 70 DEG C, addition squalane, sorbitan mono-laurate, hyaluronate sodium, butanediol, glucosan stir, make spray agent.
Described mixing speed is maintained at 300r/min.
Embodiment 3
Antipruritic spraying, including the raw material of following parts by weight: polyacrylic acid aqueous solution 40 parts, aminomethylpropanol 40 parts, phosphatidylcholine 10 parts, squalane 30 parts, sorbitan mono-laurate 50 parts, hyaluronate sodium 90 parts, butanediol 60 parts, glucosan 20 parts, phenoxyethanol 7 parts, caprylyl glycol 30 parts, p-Hydroxybenzoate 20 parts.
P-Hydroxybenzoate is methyl parahydroxybenzoate or propyl p-hydroxybenzoate.
The mass concentration of polyacrylic acid aqueous solution is 3%.
The preparation method of antipruritic spraying, comprise the following steps: under stirring condition, aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol, p-Hydroxybenzoate are added in polyacrylic acid aqueous solution, stir, it is heated to 90 DEG C, reaction 2h, after being cooled to 75 DEG C, addition squalane, sorbitan mono-laurate, hyaluronate sodium, butanediol, glucosan stir, make spray agent.
Described mixing speed is maintained at 700r/min.
Embodiment 4
Antipruritic spraying, including the raw material of following parts by weight: polyacrylic acid aqueous solution 10 parts, aminomethylpropanol 40 parts, phosphatidylcholine 6 parts, squalane 20 parts, sorbitan mono-laurate 50 parts, hyaluronate sodium 40 parts, butanediol 30 parts, glucosan 17 parts, phenoxyethanol 5 parts, caprylyl glycol 30 parts, p-Hydroxybenzoate 10 parts.
P-Hydroxybenzoate is methyl parahydroxybenzoate or propyl p-hydroxybenzoate.
The mass concentration of polyacrylic acid aqueous solution is 3%.
The preparation method of antipruritic spraying, comprise the following steps: under stirring condition, aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol, p-Hydroxybenzoate are added in polyacrylic acid aqueous solution, stir, it is heated to 85 DEG C, reaction 2h, after being cooled to 75 DEG C, addition squalane, sorbitan mono-laurate, hyaluronate sodium, butanediol, glucosan stir, make spray agent.
Described mixing speed is maintained at 500r/min.
Comparative example 1
Identical with embodiment 1, difference is in that: be not added with squalane.
Performance test
The each 5mL of product of Example 1��4 and comparative example 1 adds culture medium, inoculate respectively and cultivate through 20h, cultivate 24h, measure the least concentration and the minimal inhibitory concentration MIC(unit mg/mL that have no bacterial growth for bacterium solution 0.01moL37 DEG C that concentration is 105CFU/mL), result is in Table 1.
Table 1
Conclusion: the present invention can suppress the growth of staphylococcus aureus, escherichia coli and Pseudomonas aeruginosa, scope of restraining fungi is wide, fungistatic effect is good, and the addition of squalane significantly improves the antibacterial intensity of the present invention, makes the present invention can kill antibacterial when low concentration.
Claims (6)
1. antipruritic spraying, it is characterized in that, including the raw material of following parts by weight: polyacrylic acid aqueous solution 10��40 parts, aminomethylpropanol 20��40 parts, phosphatidylcholine 2��10 parts, squalane 10��30 parts, sorbitan mono-laurate 20��50 parts, hyaluronate sodium 40��90 parts, butanediol 10��60 parts, glucosan 10��20 parts, phenoxyethanol 1��7 part, caprylyl glycol 20��30 parts, p-Hydroxybenzoate 10��20 parts.
2. antipruritic spraying according to claim 1, it is characterized in that, including the raw material of following parts by weight: polyacrylic acid aqueous solution 30 parts, aminomethylpropanol 30 parts, phosphatidylcholine 5 parts, squalane 20 parts, sorbitan mono-laurate 30 parts, hyaluronate sodium 50 parts, butanediol 40 parts, Dextran 15 part, phenoxyethanol 4 parts, caprylyl glycol 25 parts, p-Hydroxybenzoate 15 parts.
3. antipruritic spraying according to claim 1, it is characterised in that p-Hydroxybenzoate is methyl parahydroxybenzoate or propyl p-hydroxybenzoate.
4. antipruritic spraying according to claim 1, it is characterised in that the mass concentration of polyacrylic acid aqueous solution is 2��3%.
5. based on the preparation method of the antipruritic spraying described in claim 1, it is characterized in that, comprise the following steps: under stirring condition, aminomethylpropanol, phosphatidylcholine, phenoxyethanol, caprylyl glycol, p-Hydroxybenzoate are added in polyacrylic acid aqueous solution, stir, be heated to 85��90 DEG C, react 1��2h, after being cooled to 70��75 DEG C, addition squalane, sorbitan mono-laurate, hyaluronate sodium, butanediol, glucosan stir, and make spray agent.
6. the preparation method of antipruritic spraying according to claim 5, it is characterised in that mixing speed is maintained at 300��700r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610110844.0A CN105640926B (en) | 2016-02-29 | 2016-02-29 | Antipruritic spraying and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610110844.0A CN105640926B (en) | 2016-02-29 | 2016-02-29 | Antipruritic spraying and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105640926A true CN105640926A (en) | 2016-06-08 |
| CN105640926B CN105640926B (en) | 2018-10-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610110844.0A Expired - Fee Related CN105640926B (en) | 2016-02-29 | 2016-02-29 | Antipruritic spraying and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060013785A1 (en) * | 2004-07-15 | 2006-01-19 | Dirk Lauscher | Hairstyling gels with light protective action for skin and hair |
| CN104887544A (en) * | 2015-05-29 | 2015-09-09 | 苏州市贝克生物科技有限公司 | Collagen wetting paste and preparation method thereof |
| CN104940041A (en) * | 2015-05-29 | 2015-09-30 | 苏州市贝克生物科技有限公司 | Oil-in-water cream and preparation method thereof |
-
2016
- 2016-02-29 CN CN201610110844.0A patent/CN105640926B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060013785A1 (en) * | 2004-07-15 | 2006-01-19 | Dirk Lauscher | Hairstyling gels with light protective action for skin and hair |
| CN104887544A (en) * | 2015-05-29 | 2015-09-09 | 苏州市贝克生物科技有限公司 | Collagen wetting paste and preparation method thereof |
| CN104940041A (en) * | 2015-05-29 | 2015-09-30 | 苏州市贝克生物科技有限公司 | Oil-in-water cream and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王慧琴: "《实用消毒剂生产技术与使用方法》", 31 October 2006 * |
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| Publication number | Publication date |
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| CN105640926B (en) | 2018-10-16 |
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