CN103417641A - Traditional Chinese medicine essence for treating uremia and extraction process thereof - Google Patents
Traditional Chinese medicine essence for treating uremia and extraction process thereof Download PDFInfo
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- CN103417641A CN103417641A CN201310348684XA CN201310348684A CN103417641A CN 103417641 A CN103417641 A CN 103417641A CN 201310348684X A CN201310348684X A CN 201310348684XA CN 201310348684 A CN201310348684 A CN 201310348684A CN 103417641 A CN103417641 A CN 103417641A
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Abstract
The invention discloses a traditional Chinese medicine essence for treating uremia and an extraction process thereof. The traditional Chinese medicine essence is extracted from a mixture of radix dipsaci, ash bark, centella, elder and eucommia bark. The extraction process comprises the following steps: weighing in proportion, cleaning the raw materials, drying the cleaned raw materials for later use, mixing and crushing the standby traditional Chinese medicine raw materials, adding to form a slurry, warming up the slurry to 100 DEG C, decocting for 60 min, then filtering to obtain a traditional Chinese medicine liquid, cooling down the traditional Chinese medicine liquid, adding an additive, stirring for a period of time, adjusting the pH value to 5.0 with edible acetic acid, standing for 8-16 hours, and drying the standing liquid to obtain the dry powder traditional Chinese medicine essence for treating uremia. After the traditional Chinese medicine essence is applied, liver and kidney can be effectively tonified under the zero toxic or/and side effects, the hormonal readiness in vivo is promoted, the glomerulus blood stream is improved, and the adrenal cortex function is promoted, so that the renal function can be strengthened, and uremia is eliminated. Besides, the extraction process is simple in steps, convenient to implement, relatively high in extraction and suitable for large-scale production in batches.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine and method for making thereof, relate in particular to a kind of uremic Chinese medicine essence and extraction process thereof of being used for the treatment of.
Background technology
Kidney is the excretion trachea of human body Chinese medicine, clears out of much unwanted protein every day and writes product, as carbamide, creatinine, uric acid, phosphate, sulfate etc., and regulates moisture and brine drain, makes it balance in vivo.When due to various diseases, causing the kidney grievous injury, kidney can not be realized normal regulatory function, and that therefore should drain writes product with regard to retention in vivo, produces various symptoms, becomes uremia.
Cause that uremic reason has: the pathological changes of 1 kidney own, as chronic glomerulonephritis, chronic pyelonephritis, renal tuberculosis and atherosclerosis of renal glomerulus.The urinary tract that 2 calculus of urethra, prostate hyperplasia, bladder cancer etc. cause blocks, and urinates difficulty occurs, and then cause the nephrolithotomy infringement, causes secretion of urine and stops.3 minorities, by general disease (as lupus erythematosus, diabetes) pathological changes infringement kidney, cause that kidney is badly damaged and causes.
Kidney easily causes gastrointestinal tract, Neurotoxicity, cardiovascular system, blood system, respiratory system disease after damaging.Also dehydration and edema can appear.As can be seen here, the health of kidney is one particularly important in the many concerns of health of people.
Summary of the invention
In view of the demand that above-mentioned prior art exists, the objective of the invention is to propose a kind ofly to treat the uremic Chinese medicine essence achieved noticeable achievement, and propose the Chinese medicine essence extraction process that a kind of effective ingredient extraction is higher.
The uremic Chinese medicine essence of one of above-mentioned purpose of the present invention treatment, its technical scheme be achieved is: described Chinese medicine essence extracts the mixture from Radix Dipsaci, Cortex Fraxini, Herba Centellae, Ramulus Sambuci Williamsii and the Cortex Eucommiae, and described mixture component by weight is: Radix Dipsaci 15-40 part, Cortex Fraxini 15-40 part, Herba Centellae 15-40 part, Ramulus Sambuci Williamsii 15-40 part, Cortex Eucommiae 15-40 part.
Further, in described mixture, each component is 1:1:1:1:1 by weight.
The extraction process of the uremic Chinese medicine essence of two treatments of above-mentioned purpose of the present invention, its technical scheme be achieved comprises operating procedure: I, by the quality proportioning: Radix Dipsaci 15-40 part, Cortex Fraxini 15-40 part, Herba Centellae 15-40 part, Ramulus Sambuci Williamsii 15-40 part, five kinds of raw material of Chinese medicine of Cortex Eucommiae 15-40 part weighing, carry out routine and clean in stainless steel tank, taking-up is dried standby; II, by standby raw material of Chinese medicine co-grinding, smashing fineness reaches 200 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and produces slip; III, slip is put into to stainless-steel pan, be heated to 100 ℃, decoct 60 minutes, then put into Filter Press and obtain the herb liquid slurry; IV, indoor at bacteria-and dust-free, the herb liquid slurry is poured in the stainless-steel pan with agitating device and stirred, be cooled to 15-18 ℃, then add a certain amount of protease, cellulase and diastase, stir 2 hours and use tablet vinegar acid for adjusting pH value 5.0, standing 24 hours; V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to 45 ℃ of electric heating aerator setting constant temperature and carry out dry 4-7 hour, obtain the uremic Chinese medicine essence for the treatment of of dry powder state, the 5-7% that the weight of this Chinese medicine essence is five kinds of raw material of Chinese medicine gross weights.
Further, the 0.2-0.4% that in the abovementioned steps IV, the protease addition is five kinds of raw material of Chinese medicine gross weights.
Further, the 0.2-0.4% that abovementioned steps IV cellulase addition is five kinds of raw material of Chinese medicine gross weights.
Further, the 0.15-0.25% that in the abovementioned steps IV, the diastase addition is five kinds of raw material of Chinese medicine gross weights.
The technical scheme of Chinese medicine essence of the present invention and extraction process thereof, its outstanding effect is: this Chinese medicine essence is effective liver and kidney tonifying under zero toxic and side effects, lifting body internal hormone level, improve the glomerule blood flow, promote adrenal cortex function, thereby strong renal function is eliminated the uremic symptom; Extraction process step of the present invention is simple in addition, and it is convenient to implement, and extraction is higher, is suitable for scale in batches and produces.
The specific embodiment
This case creator supports I am sent to gateway of a country pursuit of advanced studies thoughts on the painful and country of uremic patient, and special concentrated Study of Traditional Chinese Medicine medical knowledge, through exploring treatment uremic Chinese herbal medicine material, test, find technical solution preferably finally.
After deliberation, the present invention proposes a kind of uremic Chinese medicine essence for the treatment of, it extracts the mixture from Radix Dipsaci, Cortex Fraxini, Herba Centellae, Ramulus Sambuci Williamsii and the Cortex Eucommiae, and described mixture component by weight is: Radix Dipsaci 15-40 part, Cortex Fraxini 15-40 part, Herba Centellae 15-40 part, Ramulus Sambuci Williamsii 15-40 part, Cortex Eucommiae 15-40 part.Preferably the geometric ratio restructuring is joined.
From pharmacology: Radix Dipsaci, Herba Centellae, Ramulus Sambuci Williamsii, the Cortex Eucommiae and Cortex Fraxini, they all have liver and kidney tonifying, the strong bone of strong muscle, regulate the effects such as blood vessels, promoting blood circulation to remove obstruction in the collateral, the diuretic that dispels the wind, clearing heat for detumescence dampness, long-term taking can reduce albuminuria, improve the hormone in vivo level, improve the glomerule blood flow, promote adrenal cortex function, the nephrectasia tremulous pulse, accelerate blood flow.The patient of the special chronic renal insufficiency increased for creatinine, blood urea nitrogen, the medicines such as long-term taking Cortex Fraxini, Radix Dipsaci, Ramulus Sambuci Williamsii, the Cortex Eucommiae, Herba Centellae, can improve renal function, and creatinine, blood urea nitrogen, uric acid are descended comprehensively, makes graft function normal.
Embodiment mono-: a kind of extraction process for the treatment of uremic Chinese medicine essence, it comprises following operating procedure.
I, by the quality proportioning: 18 jin of Radix Dipsaci, 30 jin of Cortex Fraxinis, 16 jin of Herba Centellaes, 15 jin of Ramulus Sambuci Williamsii and five kinds of raw material of Chinese medicine of 21 jin of weighings of the Cortex Eucommiae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
II, by standby raw material of Chinese medicine co-grinding, smashing fineness reaches 200 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and produces slip;
III, slip is put into to stainless-steel pan, be heated to 100 ℃, decoct 1 hour, then put into Filter Press and obtain the herb liquid slurry;
IV, indoor at bacteria-and dust-free, the herb liquid slurry is poured in the stainless-steel pan with agitating device and stirred, be cooled to 15-18 ℃, add again 0.3 jin of protease, 0.3 jin of cellulase and 0.2 jin of diastase, under the condition of 30 beats/mins of rotating speeds, stir 2 hours, and with tablet vinegar acid for adjusting pH value 5.0, standing 10 hours;
V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to the electric heating aerator and set 45 ℃ of constant temperature and carry out drying 5 hours, obtain weight and be 6 jin, the uremic Chinese medicine essence of the treatment finished product of dry powder state.
Embodiment bis-: a kind of extraction process for the treatment of uremic Chinese medicine essence, it comprises following operating procedure.
I, by the quality proportioning: 20 jin of Radix Dipsaci, 20 jin of Cortex Fraxinis, 20 jin of Herba Centellaes, 20 jin of Ramulus Sambuci Williamsii and five kinds of raw material of Chinese medicine of 20 jin of weighings of the Cortex Eucommiae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
II, by standby raw material of Chinese medicine co-grinding, smashing fineness reaches 200 orders, then adds the water of 1000 jin of raw material of Chinese medicine gross masses to mix, and produces slip;
III, slip is put into to stainless-steel pan, be heated to 100 ℃, decoct 60 minutes, then put into Filter Press and obtain the herb liquid slurry;
IV, indoor at bacteria-and dust-free, the herb liquid slurry is poured in the stainless-steel pan with agitating device and stirred, be cooled to 15-18 ℃, add again 0.4 jin of protease, 0.34 jin of cellulase and 0.25 jin of diastase, under the condition of 30 beats/mins of rotating speeds, stir 2 hours, and with tablet vinegar acid for adjusting pH value 5.0, standing 10 hours;
V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to the electric heating aerator and set 45 ℃ of constant temperature and carry out drying 6 hours, obtain weight and be 6.5 jin, the uremic Chinese medicine essence of the treatment finished product of dry powder state.
The embodiment of the present invention is intended to be convenient to understand innovation essence of the present invention; but do not limit the scope of the invention; all simple modification or equivalence are replaced, or utilize this finished product powder processing and fabricating capsule, pill, injection etc., all should be contained among the scope of the present invention.
Medical record is introduced: the present invention treats uremic Chinese medicine extraction element through development for many years, and drops into clinical trial, cures efficiency and reaches more than 98%.
13 years old boy Xia Yu, learn the trouble nephropathy at the beginning of 2008, and carbamide and creatinine are all up to a higher point of proximity at the beginning of 2013.Take the essence that Radix Dipsaci of the present invention, Herba Centellae, Ramulus Sambuci Williamsii, the Cortex Eucommiae and Cortex Fraxini extract through half a year, the interior creatinine of short body half a year has descended and has surpassed 70%, carbamide also drops to-12, and sleep urine amount, heart, blood pressure, blood test etc. are all fine, extracts as seen plain efficacy of a drug effect stronger.
As can be seen here, the present invention treats development and the application of uremic Chinese medicine essence and extraction process thereof, compare to existing other Chinese medicine semi-finished product or Chinese medicine eating method, this Chinese medicine essence is effective liver and kidney tonifying under zero toxic and side effects, lifting body internal hormone level, improve the glomerule blood flow, promotes adrenal cortex function, thereby strong renal function, eliminate the uremic symptom; Extraction process step of the present invention is simple in addition, and it is convenient to implement, and extraction is higher, is suitable for scale in batches and produces.
Claims (6)
1. treat uremic Chinese medicine essence for one kind, it is characterized in that: described Chinese medicine essence extracts the mixture from Radix Dipsaci, Cortex Fraxini, Herba Centellae, Ramulus Sambuci Williamsii and the Cortex Eucommiae, and described mixture component by weight is: Radix Dipsaci 15-40 part, Cortex Fraxini 15-40 part, Herba Centellae 15-40 part, Ramulus Sambuci Williamsii 15-40 part, Cortex Eucommiae 15-40 part.
2. treat according to claim 1 uremic Chinese medicine essence, it is characterized in that: in described mixture, each component is by weight being 1:1:1:1:1.
3. an extraction process for the treatment of uremic Chinese medicine essence, its feature comprises operating procedure:
I, by the quality proportioning: Radix Dipsaci 15-40 part, Cortex Fraxini 15-40 part, Herba Centellae 15-40 part, Ramulus Sambuci Williamsii 15-40 part, five kinds of raw material of Chinese medicine of Cortex Eucommiae 15-40 part weighing, carry out routine and clean in stainless steel tank, taking-up is dried standby;
II, by standby raw material of Chinese medicine co-grinding, smashing fineness reaches 200 orders, then adds the water of 10 times of raw material of Chinese medicine gross masses to mix, and produces slip;
III, slip is put into to stainless-steel pan, be heated to 100 ℃, decoct 60 minutes, then put into Filter Press and obtain the herb liquid slurry;
IV, indoor at bacteria-and dust-free, the herb liquid slurry is poured in the stainless-steel pan with agitating device and stirred, be cooled to 15-18 ℃, then add a certain amount of protease, cellulase and diastase, stir 2 hours and use tablet vinegar acid for adjusting pH value 5.0, standing 24 hours;
V, standing liquid is put into to centrifuge dehydration in aseptic temperature control workshop after, produced precipitate is put into to 45 ℃ of electric heating aerator setting constant temperature and carry out dry 4-7 hour, obtain the uremic Chinese medicine essence for the treatment of of dry powder state, the 5-7% that the weight of this Chinese medicine essence is five kinds of raw material of Chinese medicine gross weights.
4. treat according to claim 3 the extraction process of uremic Chinese medicine essence, it is characterized in that: the 0.2-0.4% that described protease addition is five kinds of raw material of Chinese medicine gross weights.
5. treat according to claim 3 the extraction process of uremic Chinese medicine essence, it is characterized in that: the 0.2-0.4% that described cellulase addition is five kinds of raw material of Chinese medicine gross weights.
6. treat according to claim 3 the extraction process of uremic Chinese medicine essence, it is characterized in that: the 0.15-0.25% that described diastase addition is five kinds of raw material of Chinese medicine gross weights.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306759A (en) * | 2014-09-29 | 2015-01-28 | 匡玉华 | Chinese herbal preparation for treating uremia and preparation method of Chinese herbal preparation |
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| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN102091107A (en) * | 2011-03-09 | 2011-06-15 | 桂林普兰德生物科技有限公司 | Method for extracting total triterpene of centella asiatica by enzymic process |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101129394A (en) * | 2006-08-21 | 2008-02-27 | 中国医学科学院药物研究所 | New use of aesculin in preventing and/or treating cardiovascular disease |
| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN102091107A (en) * | 2011-03-09 | 2011-06-15 | 桂林普兰德生物科技有限公司 | Method for extracting total triterpene of centella asiatica by enzymic process |
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| CN104306759A (en) * | 2014-09-29 | 2015-01-28 | 匡玉华 | Chinese herbal preparation for treating uremia and preparation method of Chinese herbal preparation |
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Application publication date: 20131204 |