CN102485247A - Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof - Google Patents
Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition used for treating gynecologic diseases such as cervicitis, and a preparation method thereof. The composition is prepared from tree-of-heaven ailanthus bark, lightyellow sophora root, frankincense, borneol, and tree peony root-bark. The cervicitis-treating traditional Chinese medicine composition provided by the invention provides functions of heat clearing, dampness removing, morbid leucorrhea stopping, itching relieving, necrotic tissue removing, granulation promoting, astringing, and bleeding stopping. The medicine composition can be widely applied for treating gynecologic diseases caused by pathogens such as bacteria, fungi, protozoan, chlamydia, mycoplasma, and the like. Also, the medicine has an effect as a pH buffering agent. Through the regulation upon the vagina pH, a vagina self-cleaning function can be recovered.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of Chinese medicine composition of treating gynaecopathias such as cervicitis and preparation method thereof.
Background technology
Cervicitis is clinical one group of common clinical disease.Cervical erosion is the main local patholoic change in the chronic cervicitis, is commonly encountered diseases, the frequently-occurring disease of gynecological.Its sickness rate accounts for more than 50% of gynaecopathia.Show after deliberation, cervical erosion and cervical cancer important relationship arranged.The cervical cancer variability of patients of cervical ruin is 2.5%, and more non-patients of cervical ruin is high 6 times.
Doctor trained in Western medicine thinks that cervical erosion is the modal clinical manifestation of chronic cervicitis.Mostly its cause of disease is long-term chronic mechanical irritation and damage; Like childbirth, miscarriage or surgical injury etc. is the main root inducement, causes the pathogen intrusion and causes that acute infection period is active treatment not; Gradually form chronic cervicitis, make cervix uteri mainly produce rotten to the corn pathological change.Think it mainly is that the surperficial squamous epithelial cancer of cervix uteri comes off on the cervical erosion pathology, by columnar epithelium is replaced, the result that last veins beneath the skin appears.Research in recent years show again cervical erosion and whole body immunologic mechanism, great relation is arranged.The result shows that being related of the infection of HPV 16 (HPV-16), human herpesvirus 2's type (HSV-2) cytomegalovirus (CMV) and chlamydia trachomatis (CT) and cervical erosion is close.Behind the viral infection body cell, can directly exert an influence to immunity of organism, this influence comprises two aspects: the one, immunosuppressant, the 2nd, immunological enhancement, and be main with immunosuppressant.
Western medical treatment cervical erosion, secondly first-selected physiotherapy is external used medicine.The prolonged application physiotherapy can produce a lot of side effect, and treats the easy recurrence in back, and contraindication is arranged again simultaneously; Mostly the Western medicine medicine for external use is corrosive medicine, and the focus shallow to comparison sheet, that area is smaller has certain effect, but treatment is how not thorough, and long-term prescription and naturopathy can cause many side effect, and removes and stop the easy recurrence in back.
Motherland's medical science thinks that it is to invade in the noxious dampness and the damp-heat gluing each other multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels that cervical erosion forms reason, and it is not solid to cause conception vessel, and dai channel is failed to keep an appointment, and vessels of the uterus is qi-blood disharmony, the local QI and blood retardance of cervix uteri, and the evil stasis of blood causes corruption.Show that through modern Chinese medicine research the cervical erosion cause of disease is complicated, but it mainly be damp is main; Sick position is at uterus, and is dirty in close relations with spleen kidney two, and pathogenesis is mainly the damp damage and appoints, is with two arteries and veins; Vessels of the uterus is qi-blood disharmony, and with the passing of time the then damp and hot stasis of blood in cervical orifice of uterus part is long-pending, the pyretic toxicity heap soil or fertilizer over and around the roots stagnates, blood stasis causes corruption.Modern simultaneously also have the expert to think that cervical erosion and liver also have certain relation.Dampness-heat of the liver is made a bet, but coup injury is appointed the band passages through which vital energy circulates, and causes primary disease.To sum up visible, damp has important effect in the pathogenic process of cervical erosion, so the treatment of cervical erosion is engaged in damp eliminating.In recent years; Traditional Chinese medical science worker has carried out a large amount of observations to the effectiveness of Chinese medicine cervical erosion; The result shows; Chinese medicine has therapeutical effect preferably for cervical erosion, and can reduce the side effect and the palindromia rate of physiotherapy, and Chinese traditional treatment cervical erosion becomes one of method that generally adopts clinically thus.
Because its sick bit comparison is special, the endo-medicine effect is slower, is not easy to through sick position, so mostly the traditional Chinese medical science in recent years is external treatment to the treatment of cervical erosion.Conclude bibliographical information in recent years, the Chinese medicine of external treatment cervical erosion commonly used roughly is divided into following several types: 1. removing dampness, subside a swelling, hold back skin ulcer, putrefaction removing, granulation promoting medicine; 2. heat clearing away, detoxifcation, dampness, blood-cooling drugs; 3. invigorate blood circulation, blood stasis dispelling, swollen medicine looses.Mostly dosage form is powder, suppository, pill, tablet, unguentum, paste etc.This shows that the medication of treatment cervical erosion will be main with dampness or damp eliminating medicine, and is aided with promoting blood circulation and cooling blood, the promoting tissue regeneration and ulcer healing medicine is main.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition of treating gynaecopathias such as vaginitis, cervicitis, cervical erosion and preparation method thereof.
In order to realize the object of the invention, a kind of Chinese medicine composition of treating gynaecopathia of the present invention comprises following raw materials by weight proportions: Cortex Ailanthi 35～45, Radix Sophorae Flavescentis 23～35, Olibanum 25～35, Borneolum Syntheticum 0.8～1.2, Cortex Moutan 25～35.
Preferably, a kind of Chinese medicine composition of treating gynaecopathia of the present invention comprises following raw materials by weight proportions: Cortex Ailanthi 40, Radix Sophorae Flavescentis 30, Olibanum 30, Borneolum Syntheticum 1, Cortex Moutan 30.
Aforesaid Chinese medicine composition, it is effervescent tablet, effervescent capsule, effervescent granule, washing liquid, suppository or gel.Wherein, used carrier is conventional carrier in the preparation, disintegrating agent commonly used such as sodium bicarbonate and citric acid, polyethylene glycol 6000 etc., excipient such as dextrin, micropowder silica gel mixture, microcrystalline Cellulose, greasing base etc.
Prepare the method for aforementioned Chinese medicine composition effervescent tablet, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, it is an amount of with sodium bicarbonate and mannitol to add adipic acid, mixing, granulation, tabletting promptly gets.
Prepare the method for aforementioned Chinese medicine composition effervescent capsule, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, it is an amount of with sodium bicarbonate and mannitol to add adipic acid, mixing, granulation, encapsulated, promptly get.
Prepare the method for aforementioned Chinese medicine composition effervescent granule, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, it is an amount of with sodium bicarbonate and mannitol to add adipic acid, mixing, granulation, packing promptly gets.
Prepare the method for aforementioned Chinese medicine composition washing liquid, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after; The volatile oil that adds the Olibanum that obtains in the step 3) is with step 2) Cortex Ailanthi, the Radix Sophorae Flavescentis clear paste mix homogeneously that make, add polyoxyethylene sorbitan monoleate again and sodium benzoate is an amount of; Add water and be settled to 1000ml, promptly get.
Prepare the method for aforementioned Chinese medicine composition suppository, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, add gelatin: glycerol: mannitol is processed suppository by the substrate that 2: 5: 6 weight ratio is mixed with, and promptly gets.
Chinese medicine composition of the present invention is the compound Chinese medicinal preparation with the theory of Chinese medical science prescription; Many deficiencies of chemical medicine both can have been overcome; The incomparable many-sided therapeutical effect of chemical medicine (, putrefaction-removing granulation-promoting antipruritic, astringing to arrest bleeding etc.) can be brought into play again, the former caused gynecological inflammation that causes a disease such as antibacterial, fungus, protozoon, chlamydia, mycoplasma can be widely used in, simultaneously like removing damp-heat, leukorrhagia stopping; This Chinese traditional compound medicine also has the effect of pH buffer agent; Through regulating vagina pH, make the vagina self-cleaning function be able to recover, suppress pathogenic microorganism or protozoacide growth and breeding through self-cleaning system; In addition, Chinese medicine composition provided by the invention is better than Western medicine far away to the comprehensive inhibitory action of virus.Therefore, aspect the treatment gynecological inflammation, the exploitation determined curative effect, the pure Chinese medicinal preparation that dosage form is novel has vast market prospect.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1 Chinese medicine composition effervescent tablet of the present invention
The I method for preparing
The following raw material medicaments of weighing: Cortex Ailanthi 1750g, Radix Sophorae Flavescentis 1750g, Olibanum 1250g, Borneolum Syntheticum 60g, Cortex Moutan 1250g.
Preparation process comprises:
1) the Cortex Ailanthi decocte with water is 3 times, adds the water of 9 times of Cortex Ailanthi weight altogether, decocts 2.5 hours at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1.5 hours with the Radix Sophorae Flavescentis decocte with water after soaking 3 times, adds the water of 12 times of Radix Sophorae Flavescentis weight altogether, decocts collecting decoction 3 hours at every turn; Filter, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 70wt%; Left standstill 24 hours, and filtered, filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor; Be concentrated into the clear paste of relative density 1.05～1.10, drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 10 times of weight, distills 9 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, add adipic acid 260g and sodium bicarbonate 200g and mannitol 20g, mixing, granulation, tabletting promptly gets.
Embodiment 2 Chinese medicine composition effervescent capsules of the present invention
The I method for preparing
The following raw material medicaments of weighing: Cortex Ailanthi 2250g, Radix Sophorae Flavescentis 1150g, Olibanum 1750g, Borneolum Syntheticum 40g, Cortex Moutan 1750g.
Preparation process comprises:
1) decocting that adds 2 times of Cortex Ailanthi weight boiled 1 hour, filtered decocting liquid, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5 hour, the decocting that the Radix Sophorae Flavescentis after soaking is added 6 times of Radix Sophorae Flavescentis weight boiled 0.5 hour, filtered decocting liquid, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15; Put coldly, add ethanol and make and contain alcohol amount and reach 60wt%, left standstill 8 hours, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6 times of weight, distills 5 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, add adipic acid 220g and sodium bicarbonate 180g and mannitol 20g, mixing, granulation, encapsulated, promptly get.
Embodiment 3 Chinese medicine composition effervescent granules of the present invention
The I method for preparing
The following raw material medicaments of weighing: Cortex Ailanthi 2000g, Radix Sophorae Flavescentis 1500g, Olibanum 1500g, Borneolum Syntheticum 50g, Cortex Moutan 1500g.
Preparation process comprises:
1) the Cortex Ailanthi decocte with water is 2 times, adds the water of 6 times of Cortex Ailanthi weight altogether, decocts 1.5 hours at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1 hour with the Radix Sophorae Flavescentis decocte with water after soaking 2 times, adds the water of 9 times of Radix Sophorae Flavescentis weight altogether, decocts collecting decoction 2 hours at every turn; Filter, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 65wt%; Left standstill 16 hours, and filtered, filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor; Be concentrated into the clear paste of relative density 1.05～1.10, drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 8 times of weight, distills 7 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 6 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 3 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, add adipic acid 240g and sodium bicarbonate 200g and mannitol 20g, mixing, granulation, packing promptly gets.
Embodiment 4 Chinese medicine composition washing liquids of the present invention
The I method for preparing
The following raw material medicaments of weighing: Cortex Ailanthi 1750g, Radix Sophorae Flavescentis 1150g, Olibanum 1250g, Borneolum Syntheticum 40g, Cortex Moutan 1250g.
Preparation process comprises:
1) decocting that adds 2 times of Cortex Ailanthi weight boiled 1 hour, filtered decocting liquid, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5 hour, the decocting that the Radix Sophorae Flavescentis after soaking is added 6 times of Radix Sophorae Flavescentis weight boiled 0.5 hour, filtered decocting liquid, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15; Put coldly, add ethanol and make and contain alcohol amount and reach 60wt%, left standstill 8 hours, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6 times of weight, distills 5 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after; The volatile oil that adds the Olibanum that obtains in the step 3) is with step 2) Cortex Ailanthi, the Radix Sophorae Flavescentis clear paste mix homogeneously that make, add polyoxyethylene sorbitan monoleate 120g and sodium benzoate 60g again; Add water and be settled to 1000ml, promptly get.
Embodiment 5 Chinese medicine composition suppositorys of the present invention
The I method for preparing
The following raw material medicaments of weighing: Cortex Ailanthi 2250g, Radix Sophorae Flavescentis 1750g, Olibanum 1750g, Borneolum Syntheticum 60g, Cortex Moutan 1750g.
Preparation process comprises:
1) the Cortex Ailanthi decocte with water is 3 times, adds the water of 9 times of Cortex Ailanthi weight altogether, decocts 2.5 hours at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1.5 hours with the Radix Sophorae Flavescentis decocte with water after soaking 3 times, adds the water of 12 times of Radix Sophorae Flavescentis weight altogether, decocts collecting decoction 3 hours at every turn; Filter, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts coldly, adds ethanol and makes and contain the alcohol amount and reach 70wt%; Left standstill 24 hours, and filtered, filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor; Be concentrated into the clear paste of relative density 1.05～1.10, drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 10 times of weight, distills 9 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, add the substrate that is mixed with by 20g gelatin, 50g glycerol, 60g mannitol, process suppository, promptly get.
II investigates the effect of Chinese medicine composition suppository treatment gynaecopathia of the present invention.
1, case is selected
Prescription on individual diagnosis female gynecological disease patient 120 examples of 2008-2009 institute of traditional Chinese medicine, age 18-50 year.
2, group technology
120 routine prescription on individual diagnosis patients are divided into 5 treatment groups and 1 matched group, every group 20 example at random.
3, Therapeutic Method
3.1 treatment group
According to the description of embodiment 1, process Chinese medicine composition effervescent tablet of the present invention, each 3,2 externals every day, using for 4 weeks continuously is a course of treatment, observe the curative effect after 2 courses of treatment.
According to the description of embodiment 2, process Chinese medicine composition effervescent capsule of the present invention, each 3,2 externals every day, using for 4 weeks continuously is a course of treatment, observe the curative effect after 2 courses of treatment.
According to the description of embodiment 3, process Chinese medicine composition effervescent granule of the present invention, each 15g, 2 externals every day, using for 4 weeks continuously is a course of treatment, observe the curative effect after 2 courses of treatment.
According to the description of embodiment 4, process Chinese medicine composition washing liquid of the present invention, each 15ml, 2 externals every day, using for 4 weeks continuously is a course of treatment, observe the curative effect after 2 courses of treatment.
According to the description of embodiment 5, process Chinese medicine composition suppository of the present invention, each 1 piece, 2 externals every day, using for 4 weeks continuously is a course of treatment, observe the curative effect after 2 courses of treatment.
3.2 matched group
The Chinese medicine composition suppository of commercially available common treatment gynaecopathia.Each 1 piece, 2 externals every day, using for 4 weeks continuously is a course of treatment, observe the curative effect after 2 courses of treatment.
4, experimental result
Clinical efficacy: two groups of patient's curative effects compare, and the result is as shown in table 1.
Curative effect relatively before and after the table 1 liang group patient treatment
*Compare P＜0.01 with matched group, have significant difference
Comparative result shows between group, and the improvement of treatment group gynaecopathia symptom obviously is superior to matched group.
Though, the present invention has been done detailed description in the preceding text with general explanation and specific embodiments, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (8)
1. a Chinese medicine composition of treating gynaecopathia is characterized in that, comprises following raw materials by weight proportions: Cortex Ailanthi 35～45, Radix Sophorae Flavescentis 23～35, Olibanum 25～35, Borneolum Syntheticum 0.8～1.2, Cortex Moutan 25-35.
2. Chinese medicine composition as claimed in claim 1 is characterized in that, comprises following raw materials by weight proportions: Cortex Ailanthi 40, Radix Sophorae Flavescentis 30, Olibanum 30, Borneolum Syntheticum 1, Cortex Moutan 30.
3. according to claim 1 or claim 2 Chinese medicine composition, it is effervescent tablet, effervescent capsule, effervescent granule, washing liquid or suppository.
4. prepare the method for the said Chinese medicine composition effervescent tablet of claim 3, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, it is an amount of with sodium bicarbonate and mannitol to add adipic acid, mixing, granulation, tabletting promptly gets.
5. prepare the method for the said Chinese medicine composition effervescent of claim 3 capsule, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, it is an amount of with sodium bicarbonate and mannitol to add adipic acid, mixing, granulation, encapsulated, promptly get.
6. prepare the method for the said Chinese medicine composition effervescent granule of claim 3, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, it is an amount of with sodium bicarbonate and mannitol to add adipic acid, mixing, granulation, packing promptly gets.
7. prepare the method for the said Chinese medicine composition washing liquid of claim 3, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after; The volatile oil that adds the Olibanum that obtains in the step 3) is with step 2) Cortex Ailanthi, the Radix Sophorae Flavescentis clear paste mix homogeneously that make, add polyoxyethylene sorbitan monoleate again and sodium benzoate is an amount of; Add water and be settled to 1000ml, promptly get.
8. prepare the method for the said Chinese medicine composition suppository of claim 3, it is characterized in that, comprise the steps:
1) the Cortex Ailanthi decocte with water is 1-3 time, adds the water of 2-9 times of Cortex Ailanthi weight altogether, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5-1.5 hour,, add the water of 6-12 times of Radix Sophorae Flavescentis weight altogether, decocted 0.5-3 hour at every turn the Radix Sophorae Flavescentis decocte with water after soaking 1-3 time; Collecting decoction filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, puts cold; Add ethanol and make and contain alcohol amount and reach 60-70wt%, left standstill 8-24 hour, filter; Filtrate recycling ethanol merges with the Cortex Ailanthi clear paste that obtains in the step 1) to there not being the alcohol flavor, is concentrated into the clear paste of relative density 1.05～1.10; Drying is ground into fine powder, and is subsequent use;
3) Olibanum adds the water of 6-10 times of weight, distills 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization that obtains is put in addition; The aqueous solution redistillation is collected the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges the paeonol crystallization;
5) get the paeonol crystallization that obtains in Borneolum Syntheticum, the step 4) with the small amount of ethanol dissolving after, add the volatile oil of the Olibanum that obtains in the step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: water is 1: 8: 80 weight ratio; Carried out inclusion in 1 hour 60 ℃ of stirrings; Cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying; Be ground into fine powder, subsequent use;
6) with step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, mix with the inclusion complex fine powder that step 5) makes, add gelatin: glycerol: mannitol is processed suppository by the substrate that 2: 5: 6 weight ratio is mixed with, and promptly gets.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784131A (en) * | 2012-08-16 | 2012-11-21 | 湖北天圣康迪制药有限公司 | Paeonol inclusion compound and preparation method thereof |
| CN107267288A (en) * | 2017-06-17 | 2017-10-20 | 安徽仁之堂药业有限公司 | A kind of highly effective extraction method of Olibanum volatile oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422652A (en) * | 2002-12-05 | 2003-06-11 | 株洲千金药业股份有限公司 | Chinese medicinal preparation for treating gynaecology disease of cervicitis |
| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN102085248A (en) * | 2009-12-07 | 2011-06-08 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition for treating cervix diseases, method for preparing same and method for detecting same |
-
2010
- 2010-12-06 CN CN201010580133.2A patent/CN102485247B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422652A (en) * | 2002-12-05 | 2003-06-11 | 株洲千金药业股份有限公司 | Chinese medicinal preparation for treating gynaecology disease of cervicitis |
| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN102085248A (en) * | 2009-12-07 | 2011-06-08 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition for treating cervix diseases, method for preparing same and method for detecting same |
Non-Patent Citations (2)
| Title |
|---|
| 向大雄等: "椿乳凝胶成型工艺研究", 《中成药》, vol. 28, no. 8, 31 August 2006 (2006-08-31) * |
| 张杰等: "椿乳凝胶中苦参、椿皮提取条件的研究", 《中成药》, vol. 28, no. 6, 30 June 2006 (2006-06-30) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102784131A (en) * | 2012-08-16 | 2012-11-21 | 湖北天圣康迪制药有限公司 | Paeonol inclusion compound and preparation method thereof |
| CN107267288A (en) * | 2017-06-17 | 2017-10-20 | 安徽仁之堂药业有限公司 | A kind of highly effective extraction method of Olibanum volatile oil |
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