CA2536482C - Penetrating pharmaceutical foam - Google Patents

Penetrating pharmaceutical foam Download PDF

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Publication number
CA2536482C
CA2536482C CA2536482A CA2536482A CA2536482C CA 2536482 C CA2536482 C CA 2536482C CA 2536482 A CA2536482 A CA 2536482A CA 2536482 A CA2536482 A CA 2536482A CA 2536482 C CA2536482 C CA 2536482C
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Prior art keywords
foamable composition
active agent
composition
acid
polyoxyethylene
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Expired - Fee Related
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CA2536482A
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French (fr)
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CA2536482A1 (en
Inventor
Dov Tamarkin
Doron Friedman
Meir Eini
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Vyne Pharmaceuticals Ltd
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Foamix Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • A61K9/122Foams; Dry foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113Multiple emulsions, e.g. oil-in-water-in-oil
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/16Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/046Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/06Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/342Alcohols having more than seven atoms in an unbroken chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39Derivatives containing from 2 to 10 oxyalkylene groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/731Cellulose; Quaternized cellulose derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Abstract

The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a surface-active agent and a gelling agent. The foam carrier further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Description

PENETRATING PHARMACEUTICAL FOAM
FIELD OF THE INVENTION
The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a surface-active agent and a gelling agent. The foam carrier further comprises active agents and excipients providing beneficial therapeutic properties.

BACKGROUND OF THE INVENTION
Foam products are used for topical applications of drugs and cosmetics.
Aerosol products and particularly foams are complicated physical-chemical structures that do not form under arbitrary circumstances. In particular, a special balance between the foam-forming components is important. Slight shifts in the composition may already result in a collapse of the foam; thus, a formulation of per se active substances may not be capable of being formulated as a foam without further provisions.
The inventors of the present invention have developed a series of novel emulsion-based foam formulations. See, for example, commonly assigned, co-pending application WO 2004/037225 (published May 6, 2004).
US Patent No. 6423323 describes a foam skin cream, which optionally contains urea and lactic acid. The skin cream formulation is limited to a very specific list of ingredients that are not contemplated in the present invention.
US Patent No. 4,145,411 describes shaving foam compositions with low levels of mineral oil (0.25-1% by weight) and urea (0.001-0.006% by weight). A
shaving foam is, by definition, not breakable and thus cannot readily facilitate topical administration of an active ingredient and especially is not well-suited for topical administration of compositions geared towards skin penetration.
US Pat. No. 6,410,036 provides examples of eutectic mixtures in non-foaming cosmetic compositions, comprising a principal acid component, such as a hydroxy acid, and a component selected from the group consisting of a carbohydrate, a polyol, an amino acid, and a carboxylic acid.

SUMMARY OF THE INVENTION
In one aspect of the present invention, an alcohol-free cosmetic or pharmaceutical foamable composition containing at least one active component, selected from the group of: (1) combination of active agents, which creates, upon admixing, a eutectic mixture; (2) urea, in a concentration of at least 2%; (3) a hydroxy acid in a concentration of at least 1%; and (4) a therapeutic enhancer is provided, which upon admixing with a liquefied gas propellant in an aerosol container releases a breakable foam that is suitable for topical administration.
The alcohol-free foam composition is suitable for inclusion of both water-soluble and oil-soluble active agents. As used herein, a foamable composition includes formulations that are capable of forming a foam when dispensed from an aerosol container.
The cosmetic or pharmaceutical foamable composition according to one or more embodiments of the present invention includes water, a hydrophobic solvent, a surface-active agent and a gelling agent and at least one active component selected from the group of (1) a combination of active agents, which creates, upon admixing, a eutectic mixture; (2) urea in a concentration of at least
2%; (3) a hydroxy acid in a concentration of at least 1 %; and (4) a therapeutic enhancer in a concentration of at least 2%; and a liquefied gas propellant in the amount of about 3-18% by weight of the total composition.
Such a composition creates an oil-in-water emulsion that is stable in its pre-dispensed state. Upon release from the aerosol container, the composition forms a breakable foam product, which is suitable for topical or mucosal administration.
In one or more embodiments of the present invention, the hydrophobic solvent is included in the foamable composition at a concentration of 5% to about 10% (Class A), or 10% to about 20% (Class B), or about 20% to about 50%
(Class C). The surface-active agent concentration is about 0.1 % to about 5%;
the concentration of the gelling agent is 0.01 % to about 5% by weight and the liquefied gas propellant is included at a concentration of about 3% to about 18%
of the total composition. Water and optional ingredients are added to complete the total mass to 100%. Yet, in other embodiments, as specified herein, foamable composition, the hydrophobic solvent content can be between 0%
and 5%.
In one or more embodiments, each of the above compositions further optionally comprises a foam adjuvant in the concentration range of 0.1 % to 5%.
The foamable composition does not contain short chain aliphatic alcohols, making it non-irritant and non-drying.
In one or more embodiments, a foamable composition is provided that includes a foamable composition as described herein and further includes at least one active agent at a therapeutically effective concentration. The foam carrier is suitable for inclusion of both water-soluble and oil-soluble active agents, as well as suspended active agents. Such a composition is suitable for topical treatment of human and animal skin and mucosal disorders or diseases.
Alternatively, the composition is suitable for cosmetic treatment, for example, for cleansing, beautifying, promoting attractiveness or altering the appearance without affecting the body structure or function.
In addition, cosmetic and medical disorders are identified that are best treated using the alcohol-free foam composition, and the advantages of such carrier and products are demonstrated.
In a preferred aspect, the invention provides a foamable composition comprising about 0.1 to 5% by weight of a surface-active agent selected from:
a polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with food fatty acids (sucrose esters), a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, Myrj 45 (Polyoxyethylene (8) Stearate), Myrj 49 (polyoxyethylene (20) stearate), Myrj 59 (polyoxyethylene (100) stearate), a polyoxyethylene cetyl ether, a polyoxyethylene palmityl ether, a polyethylene oxide hexadecyl ether, Brij 52 (polyoxyethylene (2) cetyl ether), Brij 56 (polyoxyethylene (10) cetyl
3 ether), sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, and Myrj 52 (polyoxyethylene 40 stearate). The composition also includes: about 0.1 to 5% by weight of a gelling agent; an active component selected from urea, a hydroxy acid, or both urea and a hydroxy acid; water; and a liquefied or a compressed gas propellant at a concentration of about 3% to about 18% by weight of the total composition. Such composition contains no more than 7.5%
of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, or mixtures thereof. Further, such composition forms a breakable foam upon dispensing.
In another preferred aspect, the invention provides an oil in water foamable composition comprising about 5 to about 50% by weight of composition of a liquid, non-volatile hydrophobic solvent, and about 0.1 to 5%
by weight of a surface-active agent selected from: a polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with food fatty acids (sucrose esters), a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, Myrj 45 (Polyoxyethylene (8) Stearate), Myrj 49 (polyoxyethylene (20) stearate), Myrj 59 (polyoxyethylene (100) stearate), a polyoxyethylene cetyl ether, a polyoxyethylene palmityl ether, a polyethylene oxide hexadecyl ether, Brij 52 (polyoxyethylene (2) cetyl ether), Brij 56 (polyoxyethylene (10) cetyl ether), sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, and Myrj 52 (polyoxyethylene 40 stearate). The composition further comprises about 0.1 to 5% by weight of a gelling agent, and a therapeutic enhancer selected from:
propylene glycol, butylene glycols, glycerol, pentaerythritol, sorbitol, mannitol, oligosaccharides, dimethyl isosorbide, monooleate of ethoxylated glycerides having about 8 to 10 ethylene oxide units, polyethylene glycol 200-600, transcutol, glycofurol and cyclodextrins. Further, the composition comprises a liquefied or compressed gas propellant at a concentration of about 3% to about 3a 18% by weight of the total composition. This composition contains no more than 7.5% of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, or mixtures thereof, and is a stable emulsion in its pre-dispensed state and forms a breakable foam upon dispensing.
The foam carrier or composition according to one or more embodiments of the present invention provides various advantages over current foam compostions.
1. The foam is lightweight and thus, economical.
2. The foam contains a hydrophobic solvent, in desirable concentration, which provides a refatting and skin soothing effect.
3. The foam can include water-soluble, oil-soluble active and suspended agents.
4. The foam is easily spreadable, allowing treatment of larger areas such as the arms, back, legs and the breast.
5. Due to flow properties of the foam, the foam spreads effectively into folds and wrinkles, thereby providing uniform distribution and absorption of the active agent without the need of extensive rubbing.
3b As used herein, all component percentages are reported as percent by weight of the total composition.
As used herein, the term "about" when used to refer to weight % in a composition means 10% of the reported weight %. As used herein, the term "about" when used to refer to measured characteristics of the composition means 20% of the reported value.

DETAILED DESCRIPTION OF THE INVENTION
Hydrophobic solvent The foamable composition includes a hydrophobic solvent. The hydrophobic solvent includes a material having solubility in distilled water at ambient temperature of less than about 1 gm per 100 mL, or less than about 0.5 gm per 100 mL, or less than about 0.1 gm per 100 mL. The hydrophobic solvent is a liquid at ambient (room) temperature, e.g., about 20-30 C.
The total content of hydrophobic solvent may vary from 5% to 50% (w/w).
However, different ranges (herein "composition Classes A-C") have been designated, in order to facilitate a choice of an appropriate class, according to the anticipated cosmetic or pharmaceutical need. As a rule of thumb, higher hydrophobic solvent concentrations are more appropriate for the treatment of dry skin, and/or for the treatment of a disease, which is more responsive to drugs, delivered in an oily vehicle and regulating the residence of an active ingredient in the target area. Another consideration relates to the usability and tolerability of the product, whereby very high concentration of the hydrophobic solvent (from about 25% of the composition) would leave an oily feeling subsequent to application, which is undesirable in the product. Thus, when using a foamable composition, the hydrophobic solvent concentration is selected in view of the target treated population and the specific needs of the intended treated population.
In one embodiment, the hydrophobic solvent is mineral oil. Mineral oil (Chemical Abstracts Service Registry number 8012-95-1) is a mixture of aliphatic, naphthalenic, and aromatic liquid hydrocarbons that derive from petroleum.
They are typically liquid, their viscosity is in the range of between about 35 CST
and about 100 CST (at 40 C), and their pour point (the lowest temperature at which an oil can be handled without excessive amounts of wax crystals forming so preventing flow) is below 0 C. By contrast, white petrolatum, also termed "Vaseline", is disadvantageous, due to the waxy nature of petrolatum. It is known to leave waxy and sticky feeling after application and occasionally stain cloths.
Thus, white petrolatum is not a preferred hydrophobic solvent according to the present invention.
Yet other hydrophobic solvents include, but are not limited to, liquid oils from vegetable, marine or animal sources. Preferably, the unsaturated oil is selected from the group consisting of an olive oil, a corn oil, a soybean oil, a canola oil, a cottonseed oil, a coconut oil, a sesame oil, a sunflower oil, a borage seed oil, an syzigium aromaticum oil, a hempseed oil, a herring oil, a cod-liver oil, a salmon oil, a flaxseed oil, a wheat germ oil, an evening primrose oil and any mixtures thereof, at any proportion.
A particular class of oils includes polyunsaturated oils, containing omega-3 and omega-6 fatty acids. Examples of such polyunsaturated fatty acids are linoleic and linolenic acid, gamma-linoleic acid (GLA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Thus, in a particular embodiment of the present invention the unsaturated oil contains at least 6% of an oil selected from omega-3 oil, omega-6 oil, and mixtures thereof.
Another class of oils is essential oils, which are considered "therapeutic oils" containing active biologically occurring molecules, which, upon topical application, exert a therapeutic effect. Examples of such oils are rosehip oil, which contain retinoids and is known to reduce acne and post-acne scars, tea tree oil, which possesses antibacterial, antifungal and antiviral properties.
Other examples of essential oils are basil, camphor, cardamom, carrot, citronella, clary sage, clove, cypress, frankincense, ginger, grapefruit, hyssop, jasmine, lavender, lemon, mandarin, marjoram, myrrh, neroli, nutmeg, petitgrain, sage, tangerine, vanilla, verbena, as well as any other therapeutically beneficial oil, know in the art of herbal medication.

Another class of solvents includes, but is not limited to, liquid hydrophobic plant-derived oils, which are known to possess therapeutic benefits when applied topically.
A further class of hydrophobic solvents is known as the group of "emollients". Without derogating the generality of this definition, examples of suitable emollients for use include isostearic acid derivatives, isopropyl palmitate, lanolin oil, diisopropyl dimerate, maleated soybean oil, octyl palmitate, isopropyl isostearate, cetyl lactate, cetyl ricinoleate, tocopheryl acetate, acetylated lanolin alcohol, cetyl acetate, phenyl trimethicone, glyceryl oleate, tocopheryl linoleate, wheat germ glycerides, arachidyl propionate, myristyl lactate, decyl oleate, propylene glycol ricinoleate, isopropyl lanolate, pentaerythrityl tetrastearate, neopentylglycol dicaprylate/dicaprate, hydrogenated coco-glycerides, isononyl isononanoate, isotridecyl isononanoate, myristal myristate, triisocetyl citrate, octyl dodecanol, sucrose esters of fatty acids, octyl hydroxystearate and mixtures thereof. Other examples of other suitable emollients can also be found in the Cosmetic Bench Reference, pp. 1.19-1.22 (1996).
In a particular embodiment, the hydrophobic solvent comprises a mixture of mineral oil and an emollient in a ratio between 2:8 and 8:2 on a weight basis.
Silicone oils are known for their skin protective properties and may be used as a hydrophobic solvent. The silicone oil is either a volatile silicon oil or a non-volatile silicone oil, wherein water-soluble silicones, such as dimethicone copolyol are not included in the definition of silicone oils (as hydrophobic solvents).
In a particular embodiment, the hydrophobic solvent includes at least 2%
silicone oil.
One or more hydrophobic solvents in any combination can be used.
Surface-active agents The foamable composition includes a surface-active agent. Surface-active agents (surfactants) include any agent that alters the surface properties of the oil and water components in the composition to aid in the formation of an emulsion.
A surfactant's hydrophilic/lipophilic balance (HLB) describes the emulsifier's affinity toward water or oil. The HLB scale ranges from 1 (totally lipophilic) to 20
6 (totally hydrophilic), with 10 representing an equal balance of both characteristics.
Lipophilic emulsifiers tend to form water-in-oil (w/o) emulsions; hydrophilic surfactants tend to form oil-in-water (o/w) emulsions. The HLB of a blend of two emulsifiers equals the weight fraction of emulsifier A times its HLB value plus the weight fraction of emulsifier B times its HLB value (weighted average).
Any surface-active agent, selected from anionic, cationic, non-ionic, zwitterionic, amphoteric and ampholytic surfactants, or combinations thereof may be used as surface-active agent. According to one or more embodiments of the present invention, the surface-active agent has a hydrophilic lipophilic balance (HLB) between about 9 and about 14, which is the required HLB (the HLB
required to stabilize an O/W emulsion of a given oil) of most oils and hydrophobic solvents. Thus, in one or more embodiments, the composition is a single surface active agent having an HLB value between about 9 and 14, and in one or more embodiments, the foam composition contains more than one surface active agent and the weighted average of their HLB values is between about 9 and about 14.
Non-limiting examples of surfactants include polysorbates, such as polyoxyethylene (20) sorbitan monostearate (Tween 60) and polyoxyethylene (20) sorbitan monooleate (Tween 80); Polyoxyethylene (POE) fatty acid esters, such as Myrj 45, Myrj 49 and Myrj 59; poly(oxyethylene) alkylyl ethers, such as poly(oxyethylene) cetyl ether, poly(oxyethylene) palmityl ether, polyethylene oxide hexadecyl ether, polyethylene glycol cetyl ether, brij 38, brij 52, brij 56 and brij W1; sucrose esters, partial esters of sorbitol and sorbitol anhydrides, such as sorbitan monolaurate and sorbitan monolaurate-mono or diglycerides, isoceteth-20, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate and betaines.
In some embodiments, the surface-active agent is a non-ionic surfactant.
Exemplary non-ionic surfactants include mono-, di- and tri-esters of sucrose with food fatty acids (sucrose esters), prepared from sucrose and methyl and ethyl esters of food fatty acids or by extraction from sucroglycerides. Further examples are sucrose esters with high monoester content, which have higher HLB values.
A combination of a non-ionic surfactant and an ionic surfactant (such as sodium lauryl sulphate) may be used. In one example, a non-ionic surfactant and
7 .

an ionic surfactant are present in the foam carrier or composition at a ratio of between 1:1 and 20:1 or between 4:1 and 10:1.
Unlike prior art foamable compositions, low total amounts of surfactant are employed to obtain a stable foam. Surprisingly, lower surfactant levels are required to obtain a stable foamable composition, which is preferred in order to reduce skin irritations. Total surfactant level is in the range of about 0.1 %
to 5%
by weight of the foamable composition, and can be less than 2% by weight or even less than 1 % by weight. Thus, according to one or more embodiments, the ratio between the surface active agent and the hydrophobic solvent is between about 1:8 and about 1:16 or between about 1:16 and about 1:32.
Foam adjuvants Foam adjuvants may optionally be included in the foam composition and include fatty alcohols having 15 or more carbons in their carbon chain, such as cetyl alcohol and stearyl alcohol (or mixtures thereof). Other examples of fatty alcohols are arachidyl alcohol (C20), behenyl alcohol (C22), 1 -triacontanol (C30), as well as alcohols with longer carbon chains (up to C50). The concentration of the fatty alcohol, required to support the foam system is inversely related to the length of its carbon chains. Fatty alcohols derived from beeswax including a mixture of alcohols, a majority of which has at least 20 carbon atoms in their carbon chain, are especially well suited as foam adjuvants.
Another class of foam adjuvants includes fatty acids having 16 or more carbons in their carbon chain, such as hexadecanoic acid (C16) stearic acid (C18), arachidic acid (C20), behenic acid (C22), octacosanoic acid (C28), as well as fatty acids with longer carbon chains (up to C50), or mixtures thereof.
Optionally, the carbon atom chain of the fatty alcohol or the fatty acid may have at least one double bond. A further class of foam adjuvant includes a long chain fatty alcohol or fatty acid, wherein the carbon atom chain is branched.
In a further class of foam adjuvants, the carbon chain of the fatty acid is substituted with a hydroxyl group, such as 12-hydroxy stearic acid.
The foam adjuvant may include a mixture of fatty alcohols, fatty acids and hydroxy fatty acids and derivatives thereof in any proportion, providing that the
8 total amount is 0.1 % to 5% (w/w) of the carrier mass. The total amount can be 0.4% - 2.5% (w/w) of the carrier mass.
Long chain saturated and mono unsaturated fatty alcohols, e.g., stearyl alcohol, erycyl alcohol, arachidyl alcohol and docosanol have been reported to possess antiviral, anti infective, anti-proliferative and anti-inflammatory properties (US Patent No. 4,874,794). Longer chain fatty alcohols, e.g., tetracosanol, hexacosanol, heptacosanol, octacosanol, triacontanol, etc. are also known for their metabolism modifying properties and tissue energizing properties. Long chain fatty acids have also been reported to possess anti-infective characteristics. Thus, the pharmaceutical or cosmetic composition containing therapeutic foam adjuvant provides an extra therapeutic benefit in comparison with currently used vehicles, which are inert and non-active.
Gelling agents Gelling agents include, but are not limited to, naturally-occurring polymeric materials such as, locust bean gum, sodium alginate, sodium caseinate, egg albumin, gelatin agar, carrageenin gum sodium alginate, xanthan gum, quince seed extract, tragacanth gum, starch, chemically modified starches and the like, semi-synthetic polymeric materials such as cellulose ethers (e.g. hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy propylmethyl cellulose), micro-crystalline cellulose and compositions (Avicel types) manufactured by FMC, polyvinylpyrrolidone, polyvinylalcohol, guar gum, hydroxypropyl guar gum, soluble starch, cationic celluloses, cationic guars and the like and synthetic polymeric materials such as carboxyvinyl polymers, polyvinylpyrrolidone, polyvinyl alcohol polyacrylic acid polymers, polymethacrylic acid polymers, polyvinyl acetate polymers, polyvinyl chloride polymers, polyvinylidene chloride polymers and the like. Optionally, mixtures of the above compounds are contemplated.
Also useful herein are gelling agents such as the acrylic acid/ethyl acrylate copolymers and the carboxyvinyl polymers sold, for example, by the B.F.
Goodrich Company under the trademark of Carbopol Registered TM resins.
These resins consist essentially of a colloidally water-soluble polyalkenyl polyether crosslinked polymer of acrylic acid crosslinked with from 0.75% to 2%
9 of a crosslinking agent such as polyallyl sucrose or polyallyl pentaerythritol.
Examples include Pemulene TR1 and TR2, Carbopol 934, Carbopol 940, Carbopol 950, Carbopol 980, Carbopol 951 and Carbopol 981. Carbopol 934 is a water-soluble polymer of acrylic acid crosslinked with about 1 % of a polyallyl ether of sucrose having an average of about 5.8 allyl groups for each sucrose molecule.
In one aspect of the invention, the gelling agent is selected from the class of amphiphilic copolymers. Amphiphilic copolymers include polymers having hydrophobic groups and hydrophilic groups or regions. These materials are referred to alternatively as "polymeric surfactants" because the hydrophilic and hydrophobic regions of the polymers serve to interact with and stabilize hydrophilic and lipophilic components, respectively, of a composition. The copolymer may be a random copolymer, a block copolymer of a graft or comb copolymer. Exemplary amphiphilic copolymers include di-, tri- or multi-block copolymer or graft copolymer of a biodegradable polymer.
The Amphiphilic copolymer may be an acrylate copolymer, in which hydrophobic moieties are chemically linked to hydrophilic polymer or hydrophilic moieties are attached to hydrophobic polymers to produce amphiphilic surface active and surface stabilizing agent. By way of example, suitable amphiphilic copolymers include cross linked copolymers of acrylic acid and a hydrophobic comonomer, such as Pemulen TR-1 and Pemulen TR-2, ETD 2020 and Carbopol 1382 (all, Acrylates/C10-30 alkyl acrylate crosspolymer), Natrosol CS Plus 330 and 430 and Polysurf 67 (all, cetyl hydroxyethyl cellulose), Aculyn 22 (acrylates /steareth-20 methacrylate copolymer), Aculyn 25 (acrylates/ laureth-25 methacrylate copolymer), Aculyn 28 (acrylates /beheneth-25 methacrylate copolymer), Aculyn 46 (PEG-150/stearyl alcohol/SMDI copolymer), Stabylen 30 (acrylates/vinyl isodecanoate), Structure 2001 (acrylates/steareth-20 itaconate copolymer), Structure 3001 (acrylates/ceteth-20 itaconate copolymer) and Structure Plus (acrylates/aminoacrylates/C10-30 alkyl PEG 20 itaconate copolymer), where PEG is polyethylene glycol, PPG is polypropylene glycol.
Other exemplary amphiphilic copolymers include silicone polymers such as amphiphilic silicone polyols or copolyol, for example cetyl dimethicone copolyol and dimethicone copolyol PPG-3 oleyl ether, acetylated starch derivatives, amphiphilic modified starches, and amphiphilic block copolymers of ethylene oxide, propylene oxide and/or propylene glycol (also known as "poloxamer").
One or more gelling agents in any combination can be used.
The gelling agent is present in the foam composition in an amount of about 0.1% to 5.0%. In one or more embodiments, the gelling agent included in the foamable composition can be less than 1 % of the foamable composition.
Active Component The active component can be a eutectic mixture of active agents. A
eutectic mixtures is a mixture of substances, which has the lowest melting point possible to obtain by the combination of the given components. Such mixtures provide an improved dermal penetration profile and enhanced therapeutic effect.
Suitable eutectic mixtures include a mixture of local anesthetic agents, for example, as are described in U.S. Patent 6,410,036. Eutectic mixtures are described, wherein (a) a local anesthetic agent in the form of its base is mixed with (b) one other local anesthetic agent in the form of its base, whereby the agent under (a) has a melting point of 30 C to 50 ; and the agent under (b) has a melting point of above 30 C, preferably above 40 C. For example a compound such as prilocaine, tetracaine, butanilicaine and trimecaine, can be combines with a compound such as bensocaine, lidocaine, bupivacaine, dibucaine, mepivacaine and etidocaine, as well as tetracaine, butanilicaine and trimecaine. Other examples of eutectic mixtures in cosmetic compositions are described in US
Pat.
No. 6,410,036, such as a mixture a principal acid component, such as a hydroxy acid, and a component selected from the group consisting of a carbohydrate, a polyol, an amino acid, and a carboxylic acid.
Yet another non-limiting example of eutectic mixtures with enhanced dermal penetration and therapeutic effect includes non-steroidal anti-inflammatory drugs (NSAIDs). As an example, a series of NSAIDs including indomethacin, naproxen, ketoprofen, phenyl salicylate, piroxicam and flurbiprofen make mixtures with another NSAID such as ibuprofen, resulting in significantly depressed melting points and better diffusion of the binary eutectic system the drug absorption was enhanced comparing to the drugs used alone.
The ratio between the substances in the eutectic mixture provides the lowest melting point and maximal dermal penetration. An exemplary mixture includes two substances in a weight ratio of 20:80 to 80:20.
In another embodiment of the invention, tetracaine and lidocaine in their base forms are mixed in a weight ratio of 30:70 to 70:30, or 45:55 to 55:45, or 50:50.
Since in many cases, local anesthetics and other therapeutic classes are intended to treat large body areas, the use of a composition including a eutectic mixture in a foam carrier is highly advantageous. Hence, a foam composition according one or more embodiments of the present invention includes a eutectic mixture of active ingredients in a therapeutically - effective concentration.
In one embodiment, the foamable composition forms an emulsion of oil and water.
Such compositions containing a eutectic mixture of active agents are more available for therapeutic treatment because of the enhanced penetration brought about by the eutectic mixture of active agents. The composition is suitable for topical application in order to treat a disease or disorder, which responds to the active agents.
According to one or more embodiments, urea is included in the foam composition as an active component.
Urea has been long recognized as a cosmetic ingredient in formulations acting as a humectant and moisturizer. There have been reports of keratolytic activity attributed to urea with the ability at high concentrations to solubilize and denature protein. High concentrations of urea are also known to have a mild, antimicrobial effect. Urea further possesses skin exfoliating properties, which are useful in the control of passage of active agents through the dermal barrier.
Urea preparations, especially those containing high urea concentration are provided in gels, creams, lotions and pastes, but not in foam. Foam is preferable in many cases where urea is needed for therapy. For example, xerosis, which is a common indication for high concentration urea preparations, is disseminated over large skin areas, and thus, the foam of the present invention, having low specific gravity and excellent spreading and absorption properties is advantageous.
In one embodiment, urea is contained in the foam composition in an amount from about 1% to about 50 % of the total composition. Preferably compositions contain from about 10% to about 20%, and from about 20% to about 50%, depending on the intended use.
Because of its keratolytic effect, urea can serve as means to induce dermal penetration of a variety of drugs or cosmetic active agents.
Furthermore, in many dermatological disorders, having urea, with its beneficial properties as mentioned above and a drug or cosmetic active agent provides a synergistic therapeutic effect. This is also the case when urea, which is known for its antibacterial and antifungal effects, is combined with another anti-infective agent.
Thus, in one or more embodiments of the present invention, the foamable composition includes urea and at least one pharmaceutical or cosmetic active agent, as defined hereinbelow. The penetration of the active agent is enhanced due to the urea present in the foam composition.
Hence, a foam according to the present invention includes a foamable composition containing urea in a therapeutically - effective concentration. In one embodiment, the foamable composition forms an emulsion of oil and water including a hydrophobic solvent at a level described herein as Class A, Class B, or Class C.
According to one or more embodiments, a hydroxy acid is included in the foam composition as an active component.
Hydroxy acids are useful in increasing the clarity of the skin surface, increasing cellular turnover, and increasing skin radiance and smoothness.
They further possess skin exfoliating properties, which are useful in the control of passage of active agents through the dermal barrier.
Suitable hydroxy acids include alpha- or beta-hydroxy acids, poly-hydroxy acids, or any combinations of any of the foregoing. The hydroxy acid can be an alpha-hydroxy acid. Non-limiting examples of alpha hydroxy acids include, but are not limited to, glycolic acid, lactic acid, malic acid, citric acid, alpha-hydroxyethanoic acid, alpha-hydroxyoctanoic acid, alpha-hydroxycaprylic acid, hydroxycaprylic acidglycolic acid, tartaric acid, pyuric acid, citric acid, as well as their corresponding salts and pharmaceutically-acceptable derivatives; or any combination of any of the foregoing.
Ascorbic acid has skin permeation and collagen synthesis activity. Beta-hydroxy acids include, but are not limited to, salicylic acid, beta hydroxybutanoic acid, tropic acid and trethocanic acid.
Because of its keratolytic effect, hydroxy acids can serve as means to induce dermal penetration of a variety of drugs or cosmetic active agents.
Furthermore, in many dermatological disorders, having urea, with its beneficial properties as mentioned above and a drug or cosmetic active agent provides a synergistic therapeutic effect.
Thus, in one or more embodiments of the present invention, the foamble composition comprises a hydroxy acid and at least one pharmaceutical or cosmetic active agent, as defined hereinbelow.
In one embodiment, the hydroxy acid is contained in the foamable composition in an amount from about 1 % to about 30 % of the total composition.
The compositions can contain from about 1 % to about 10% and from about 10%
to about 30%, depending on their designated use.
According to one or more embodiments, a therapeutic enhancer is included in the foam composition as an active component. In the context of the present invention, a therapeutic enhancer is a material that facilitates an enhanced delivery of an active agent into a target site of treatment, thus enabling an improved therapeutic effect. Suitable therapeutic enhancers include polyhydric alcohols having at least two hydroxy groups, or at least three hydroxy groups, or a derivative of a polyhydric alcohol.
Non-limiting examples are propylene glycol, butylene glycols, glycerol, pentaerythritol, sorbitol, mannitol, oligosaccharides, dimethyl isosorbide, monooleate of ethoxylated glycerides (with 8 to 10 ethylene oxide units), polyethylene glycol 200-600, transcutol (diethylene glycol monoethyl ether) and glycofurol (tetrahydrofurfuryl alcohol PEG ether). The therapeutic enhancer can further comprise at least cyclodextrins a related compounds. Cyclodextrins are structurally related cyclic oligomaltoses, which form a new group of pharmaceutical excipients. These are torus-shaped molecules with a hydrophilic outer surface and a lipophilic central cavity. Cyclodextrins are capable of forming water-soluble inclusion complexes with a wide variety of lipophilic water-insoluble drugs by taking up a whole drug molecule, or some part of it, into the cavity.
The cyclodextrin molecules are relatively large (molecular weight ranging from almost 1000 to over 1500), with a hydrated outer surface, and under normal conditions, cyclodextrin molecules will only permeate the skin barrier with considerable difficulty. It is generally believed that the cyclodextrin molecules act as true carriers by keeping lipophilic drug molecules in solution and deliver them to the skin surface where they partition from the cyclodextrin cavity into the skin.
In one embodiment, the therapeutic enhancer is contained in the foamable composition in an amount from about 2% to about 30% of the total composition.
The compositions can contain from about 2% to about 10% and from about 10%
to about 30%, depending on their designated use.
Active Agents The foam composition is useful and advantageous for the treatment of skin disorders and for skin care and cosmetic care. The addition of an oil having refatting, protective and moisture-retaining properties in a spreadable foam form can substitute for currently available dermatological and cosmetic creams, lotions, gels, etc.
In one or more embodiments of the present invention, the foam composition includes an active agent directed to the treatment of a medical disorder or a cosmetic disorder. The active agent can be categorized by the benefit it provides or by its postulated mode of action. The active agents can in some instances provide more than one benefit or operate via more than one mode of action. Therefore, classifications are made for the sake of convenience and are not intended to limit the active to that particular application or applications listed. Furthermore, foam compositions, with or without further active ingredients, are suitable for the application as "cosmeceutical"
preparations.

Antibacterial agents One class of drugs comprises antibacterial agents. The term "antibacterial" as used herein shall include, but is not limited to, any substance being destructive to or inhibiting the growth of bacteria or any substance having the capacity to inhibit the growth of or to destroy bacteria and other microorganisms, and are used in the treatment of infectious diseases. It is well known that bacterial infections are involved in a variety of superficial disorders of the skin, eye, mucosal membrane, oral cavity, vagina and rectum. The antibacterial drug can be active against gram positive and gram-negative bacteria, protozoa, aerobic bacteria and unaerobic ones.
The antibacterial drug is selected from the group consisting of chloramphenicol, tetracyclines, synthetic and semi-synthetic penicillins, beta-lactams, quinolones, fluoroquinolnes, macrolide antibiotics, metronidazole and metronidazole derivatives and analogs, dicarboxylic acids, such as azelaic acid, silicylates, peptide antibiotics, cyclosporines and any combination thereof at a therapeutically effective concentration. Another group of antibacterial agents is non-specific and includes strong oxidants and free radical liberating compounds, such as hydrogen peroxide, bleaching agents (e.g., sodium, calcium or magnesium hypochlorite and the like) iodine, chlorohexidine and benzoyl peroxide.
Exemplary foamable compositions are particularly useful and beneficial in the prevention and treatment of secondary infections, accompanying skin-structure damage, such as in cuts, wounds, burns and ulcers. In all such cases, the present formulation is easy to use, being in foam state when applied and becoming liquid upon rubbing onto the skin.
While being useful in the prevention and treatment of infections, the antibacterial foam is also applicable for decontaminating areas, afflicted with bacterial warfare organisms, such as anthrax and smallpox.
Anti-fungal agents Fungal infections are another object of treatment using the foamable composition. Superficial fungal infection of the skin is one of the commonest skin diseases seen in general practice. Dermatophytosis is probably the most common superficial fungal infection of the skin. Dermatophytosis is caused by a group of fungi capable of metabolizing the keratin of human epidermis, nails or hair. There are three genera of dermatophytes causing dermatophytosis, i.e., microsporum, trichophyton and epidermophyton.
Candidiasis is an infection caused by the yeast like fungus candida albicans or occasionally other species of candida. Clinical syndromes of candidiasis include: (a) oral candidiasis (oral thrush); (b) candidiasis of the skin and genital mucous membrane; (c) candida paronychia, which inflicts the nail;
and (d) genital and vaginal candida, which inflict genitalia and the vagina.
The pharmaceutical composition can include an antifungal drug that is effective against dermatophytes and candida. The antifungal drug is selected from the group consisting of azoles, diazoles, triazoles, miconazole, fluconazole, ketoconazole, clotrimazole, itraconazole griseofulvin, ciclopirox, amorolfine, terbinafine, Amphotericin B, potassium iodide, flucytosine (5FC) and any combination thereof at a therapeutically effective concentration.
The foam composition according to one or more embodiments of the present invention is useful, for example, for the treatment of tinea corporis, tinea pedis, tinea rubrum, tinea unguium, tinea cruris, tinea barbae and tinea versicolor, as well as yeast Infections, such as candidiasis, and candidal vaginitis.
Anti-viral agents Any known antiviral drugs, in a therapeutically effective concentration, can be incorporated into the foam composition. Exemplary compositions are particularly beneficial in the case of viral infections. Cold sores are caused by the herpes simplex Type 1 virus and are sometimes referred to as facial herpes.
Mollusca are small viral growths that appear singly or in groups on the face, trunk, lower abdomen, pelvis, inner thighs, or penis. Shingles (herpes zoster) usually occurs only once in a lifetime, appears as a rash (clusters of blisters with a red base). Shingles is caused by the same virus that is responsible for chickenpox. Warts are a common, benign skin tumor caused by viral infection.
Anti-inflammatory and antiallergic agents The active agent can be an anti-inflammatory or antiallergic agent.
Exemplary anti-inflammatory or antiallergic agents include corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), anti-histamines, immunomodulators, immunosuppressants and any combination thereof at a therapeutically effective concentration.
The anti-inflammatory active agent is a corticosteroid. The corticosteroid can be selected from the group consisting of clobetasol proprionate, halobetasol proprionate, betamethasone diproprionate, betamethasone valerate, fluocinolone acetonide, halcinonide, betamethasone valerate, fluocinolone acetonide, hydrocortisone valerate, triamcinolone acetonide, hydrocortisone and any combination thereof at a therapeutically effective concentration. Since corticosteroid drugs are typically hydrophobic, suitable foam carriers include high levels of a hydrophobic solvent. The hydrophobic solvent facilitates topical distribution and enhances the rate of penetration of any of the corticosteroid drugs.
The composition may include active agents for the treatment of psoriasis.
Corticosteroid ointments, greasy preparations containing little or no water, are commonly used for treating psoriasis. Their main disadvantage is in a sticky feeling subsisting for extended periods subsequent to treatment being completed thereby creating a latent inconvenience and possible discomfort to the treatment recipient. In contrast, the foam composition according to one or more embodiments of the present invention containing high levels of an oil (hydrophobic solvent) spreads very easily throughout the afflicted area and absorbs into the skin without leaving any unpleasant sensation or look.
Examples of other inflammatory disorders that are treatable by a foamable composition including a steroid as an active agent are atopic dermatitis, seborrhea, seborrheic dermatitis of the face and trunk, seborrheic blepharitis, contact dermatitis, stasis dermatitis (gravitational eczema; varicose eczema), exfoliative dermatitis (erythroderma), lichen simplex chronicus, pityriasis rosea and pemphigus.
Topical antihistaminic preparations currently available include 1 % and 2%
diphenhydramine (Benadryl and Caladryl ), 5% doxepin (Zonalon ) cream, phrilamine maleate, chlorpheniramine and tripelennamine, phenothiazines, promethazine hydrochloride (Phenergan ) and dimethindene maleate. These drugs, as well as additional antihistamines, can also be used.
Polyunsaturated fatty acids containing omega-3 and omega-6 fatty acids (e.g., linoleic and linolenic acid, gamma-linoleic acid (GLA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also are beneficial in the treatment of psoriasis and other skin inflammation conditions and may be included in the foamable composition.
Nonsteroidal anti-inflammatory agents (NSAIDs) are useful against skin and systemic bio-abnormalities and can be added to the foam composition. The variety of compounds encompassed by NSAIDs is well-known to those skilled in the art. Specific non-steroidal anti-inflammatory agents useful in the composition include, but are not limited to oxicams, such as piroxicam, isoxicam, tenoxicam, sudoxicam; salicylates, such as salicylic acid, ethyl salicylate, methyl salycilate, aspirin, disalcid, benorylate, trilisate, safapryn, solprin, diflunisal, and fendosal;
acetic acid derivatives, such as diclofenac, fenclofenac, indomethacin, sulindac, tolmetin, isoxepac, furofenac, tiopinac, zidometacin, acematacin, fentiazac, zomepirac, clindanac, oxepinac, felbinac, and ketorolac; fenamates, such as mefenamic, meclofenamic, flufenamic, niflumic, and tolfenamic acids; propionic acid derivatives, such as ibuprofen, naproxen, benoxaprofen, flurbiprofen, ketoprofen, fenoprofen, fenbufen, indopropfen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, and tiaprofenic;
and pyrazoles, such as phenylbutazone, oxyphenbutazone, feprazone, azapropazone, and trimethazone.
Any other steroidal and nonsteroidal compounds having the capacity to prevent, alleviate the symptoms of, treat or cure inflammation processes, may be generally included as anti-inflammatory agents.
The pharmaceutical composition may include an anti-inflammatory and/or an antiallergic agent that reduces the occurrence of pro-inflammatory cytokines or inhibits the effect of pro-inflammatory cytokines.
Mixtures of any anti-inflammatory agents can be used in the composition, as well as the dermatologically acceptable salts, esters, amides, prodrugs and derivatives of these agents.

Topical application of a foam, comprising a safe and effective dose of an NSAID can be useful in the prevention and/or alleviation of the symptoms of rheumatoid arthritis, osteoarthritis and pain. Topical NSAIDs, incorporated in the foam composition can be also used in the treatment of dermatological disorders such as acne, rosacea, hair growth disorders, actinic keratosis and certain skin cancer conditions.
Local anesthetics The foam compositions may include an effective amount of a topical anesthetic. The topical anesthetic can be selected from the group consisting of benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mepivacaine, tetracaine, dyclonine, hexylcaine, procaine, cocaine, ketamine, pramoxine, phenol, any pharmaceutically acceptable salts thereof and mixtures of such anesthetic agents. Any mixture of synergistically beneficial anesthetic agents is contemplated Keratolytically active agents A keratolytic agent may be included as an active agent of a foamable composition. The term "keratolytically active agent" as used herein includes a compound that loosens and removes the stratum corneum of the skin, or alters the structure of the keratin layers of skin. Keratolytically active agents are used in the treatment of dermatological disorders that involve dry skin, hyperkeratinization (such as psoriasis), skin itching (such as xerosis), acne and rosacea.
Suitable keratolytically active agents include phenol and substituted phenolic compounds. Such compounds are known to dissolve and loosen the intracellular matrix of the hyperkeratinized tissue. As such, they are used in the treatment of dermatological disorders. Dihydroxybenzene and derivatives thereof have been recognized as potent keratolytic agents. Resorcinol (m-dihydroxybenzene) and derivatives thereof are used in anti-acne preparations.
In addition to hydroquinone (p-dihydroxybenzene) having anti-pigmentation properties, hydroquinone is also known to be keratolytic. These compounds also exhibit antiseptic properties. Cresols also possess bactericidal and keratolytic properties.

Vitamin A and vitamin A derivatives, also termed herein "retinoids", such as retinoic acid, isoretinoic acid, retinol and retinal are another class of keratolytically active agents.
Another group of keratolytically active agents include alpha-hydroxy acids, such as lactic acid and glycolic acid and their respective salts and derivatives;
and beta-hydroxy acids, such as salicylic acid (o-hydroxybenzoic acid) and salicylic acid salts and pharmaceutically acceptable derivatives.
Another class of keratolytically active agents includes urea and urea derivatives.
Retinoids Another group of active agents includes retinol, retinal, all trans retinoic acid and derivatives, isomers and analogs thereof, collectively termed "retinoids".
Etretinate, actiretin, isotretinoin, adapalene and tazarotene are further examples of said retinoid isomers and analogs. Foamable compositions containing retinoids as the active drug can be used for the treatment of acne, seborrhea, various dermatoses, inflammation of the skin, mucosal membranes, vagina and the rectum, psoriasis, actinic keratosis and skin cancers, by application onto the affected area.
Insecticide and insect repellents agents Insects such as mosquitoes, biting flies, mites, gnats, fleas, chiggers, punkies, sand flies, lice and ticks can be annoying and sometimes pose a serious risk to human and animal health. In certain areas of the United States, mosquitoes can transmit diseases like equine and St. Louis encephalitis.
Biting flies can inflict a painful bite that can persist for days, swell, and become infected.
Ticks can transmit serious diseases like Lyme disease and Rocky Mountain spotted fever.
Insect repellents may be added to the foamable composition to protect people and animals from flying or biting insects, spiders, ticks and mites.
Examples of insect repellants include, but are not limited to, DEET (N, N-diethyl -m-toluamide), dimethyl phthalate, piperonyl butoxide and permethrin.
Insect repelling terpenoids, have been reported by Hwang, et al, J. Chem.
Ecol., 11, 1297 (1985); and Ruledge, J. Am. Mosquito Control Assoc. 4, 414 (1988).

A particular group of insect repellents includes the terpenoid compounds, described in U.S. Patent No. 5,411,992, including:
(1) Terpenoid-alcohol or terpene-ols are terpenoids which have at least one hydroxyl group. Examples of terpene-ols include: C1oH160 compounds, perillyl alcohol, carveol, myrtenol, and cis-verbenol; C1oH180 compounds, myrtanol, iso-pinocampheol, dihydrocarveol, isopulegol, terpineol, terpinen-4-ol, nerol, geraniol, and linalool, and C1oH200 compounds, menthol, beta-citronellol, and dihydro-myrcenol.
(2) Terpenoid-esters are terpenoids, which have at least one ester group which is the product of the bonding of the hydroxyl group of a terpene-ol with an aliphatic carboxylic acid that can contain functional groups such as the hydroxyl or amine on the aliphatic chain. Examples of suitable aliphatic carboxylic acids include acetic acid, propionic acid, lactic acid, and various amino acids.
Examples of terpenoid-esters include: carvyl acetate, carvyl propionate, and menthyl lactate.
(3) Essential oils which contain terpenoids and perfumes which contain terpenoids. Non-limiting examples of essential oils having a high content of terpene-ols and esters include bergamot (62% terpenoids); sage (>50%
terpenoids); styrax (>50% terpenoids); peppermint (>50% terpenoids); and pine Siberian (75% terpenoids %). Terpenes, aldehydes and ketones vary in their usefulness but as a general group have potential as insect-repellent.
The foamable composition is particularly suitable for the effective uniform spreading of an insect repellent agent onto large areas of the skin of humans and animals. The hydrophobic solvent present in the foam composition helps retain the insect repellent on the skin surface for an extended period of time.
The foamable composition is suitable for delivery of insect-killing agents (insecticides) to an afflicted external surface area of humans and animals.
Thus, the pharmaceutical or cosmetic composition includes an insecticide selected from the group consisting of permethrin, hexachlorobenzene, carbamate, naturally occurring pyrethroids, permethrin, allethrin, malathion, piperonyl butoxide and any combination thereof at a therapeutically effective concentration. The application of the composition is very convenient and it spreads easily, even over hairy areas. The hydrophobic solvent present in the foam composition helps retain the insecticide on the treated area for an extended period of time.
Furthermore, the presence of a hydrophobic solvent in the foam eases mechanical removal of lice and nits with a comb.
Anti-cancer drugs Anti-cancer drugs can also be used as the drug of choice for the treatment of skin malignant tumors such as basal cell carcinoma, squamous sell carcinoma, melanoma and Kaposi's sarcoma, as well as the pre-cancerous condition actinic keratosis. In certain cases, topical cytotoxic and anti proliferative drugs are used to treat or prevent such cancers, including 5-fluorouracil, also called 5-FU.
5-FU, as well as any other anti-cancer agents, know in the art of cancer medicine, can be incorporated in the foam at therapeutically effective levels. An exemplary family of anticancer drugs, suitable for usage in the foam of the present formulation comprises antiestrogens, such as tamoxifen.
Photodynamic therapy agents The foam composition is also useful to deliver photo-sensitizing agents. A
photosensitizer can be selected from the group consisting of poephyrins, modified porphyrins, psoralen, 8-methoxypsoralen, 5-methoxypsoralen, psoralen derivatives, chlorins, bacteriochlorins, phthalocyanines, naphthalocyanines, pheophorbides, purpurins, m-THPC, mono-L-aspartyl chlorin e6, bacteriochlorins, phthalocyanines, benzoporphyrin derivatives and photosensitizer precursors, such as aminolevulinic acid (ALA).
Active agents for burns, wounds, cuts and ulcers The treatment of burns, wounds, cuts and ulcers using a foamable composition is particularly advantageous. The foam can include both anti-infective agents (against bacteria, fungi and/or viruses), antiinflammatory agents (steroidal and/or NSAIDs) and pain relieving components. Upon application, the foam spreads easily, covering the surface of the affected area, and without causing pain.
Skin Care Active Agents The foam composition is useful and advantageous for skin care and cosmetic care. The combination of oil and water having moisture-retaining properties in a spreadable foam form can be used to substitute currently used cosmetic skin care creams, lotions, gels, etc. The cosmetic foam compositions are suitable for the further application as "cosmeceutical" preparation (cosmetic products with therapeutic benefit), to treat "cosmetic" skin disorders, such as aging skin, wrinkles, hyperpigmentation (melasma, chloasma, freckles, etc.), scaly skin and other skin undesirable properties.
The CTFA Cosmetic Ingredient Handbook describes a wide variety of nonlimiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for use in the compositions of the present invention. Examples of these ingredient classes include: abrasives, absorbents, aesthetic components such as fragrances, pigments, colorings/colorants, essential oils, astringents, etc. (e.g., clove oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate), anti-acne agents, anti-caking agents, antifoaming agents, antimicrobial agents (e.g., iodopropyl butylcarbamate), antioxidants, binders, biological additives, buffering agents, bulking agents, chelating agents, chemical additives, colorants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, external analgesics, film formers or materials, e.g., polymers, for aiding the film-forming properties and substantivity of the composition (e.g., copolymer of eicosene and vinyl pyrrolidone), opacifying agents, pH adjusters, propellants, reducing agents, sequestrants, skin bleaching and lightening agents (e.g., hydroquinone, kojic acid, ascorbic acid, magnesium ascorbyl phosphate, ascorbyl glucosamine), skin-conditioning agents (e.g., humectants, including miscellaneous and humectants facilitating regulating the residence of an active agent in the skin), skin soothing and/or healing agents (e.g., panthenol and derivatives (e.g., ethyl panthenol), aloe vera, pantothenic acid and pantothenic acid derivatives, allantoin, bisabolol, and dipotassium glycyrrhizinate), skin treating agents, thickeners, and vitamins and derivatives thereof.
Anti-acne active agents An anti-acne agent can be included in the foamable composition. The anti-acne agent can be selected from the group consisting of resorcinol, sulfur, salicylic acid and salicylates, alpha-hydroxy acids, nonsteroidal anti-inflammatory agents, benzoyl peroxide, retinoic acid, isoretinoic acid and other retinoid compounds, adapalene, tazarotene, azelaic acid and azelaic acid derivatives, antibiotic agents, such as erythromycin and clyndamycin, zinc salts and complexes, and combinations thereof, in a therapeutically effective concentration.
Anti-wrinkle active agents/anti-atrophy active agents and agents to treat dry and scaly skin (xerosis and ichthyosis) The foamable composition may also include an effective amount of an anti-wrinkle active and/or at least one anti-atrophy active. Exemplary anti-wrinkle/anti-atrophy active agents suitable for use in the foamable compositions include sulfur-containing D and L amino acids and their derivatives and salts, particularly the N-acetyl derivatives; thiols; hydroxy acids (e.g., alpha-hydroxy acids such as lactic acid and glycolic acid and their derivatives and salts;
or beta-hydroxy acids such as salicylic acid and salicylic acid salts and derivatives), urea, hyaluronic acid, phytic acid, lipoic acid; lysophosphatidic acid, skin peel agents (e.g., phenol, resorcinol and the like), vitamin B3 compounds (e.g., niacinamide, nicotinic acid and nicotinic acid salts and esters, including non-vasodilating esters of nicotinic acid (such as tocopheryl nicotinate), nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide), vitamin B5 and retinoids (e.g., retinol, retinal, retinoic acid, retinyl acetate, retinyl palmitate, retinyl ascorbate). In the case of dry, scaly skin (xerosis) and ichthyosis such agents can alleviate the symptoms by temporary relief of itching associated with these conditions.
Anti-oxidants/radical scavengers An effective amount of an anti-oxidant/radical scavenger can be added to the foamable compositions, for example, in an amount from about 0.1 % to about
10% (w/w), or from about 1 % to about 5% (w/w).
Anti-oxidants/radical scavengers such as ascorbic acid (vitamin C) and ascorbic acid salts, ascorbyl esters of fatty acids, ascorbic acid derivatives (e.g., magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl sorbate), tocopherol (vitamin E), tocopherol sorbate, tocopherol acetate, other esters of tocopherol, butylated hydroxy benzoic acids and their salts, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (commercially available under the tradename Trolox. ), gallic acid and gallic acid alkyl esters, especially propyl gallate, uric acid and uric acid salts and alkyl esters, sorbic acid and sorbic acid salts, lipoic acid, amines (e.g., N,N-diethylhydroxylamine, amino-guanidine), sulfhydryl compounds (e.g., glutathione), dihydroxy fumaric acid and dihydroxy fumaric acid salts, lycine pidolate, arginine pilolate, nordihydroguaiaretic acid, bioflavonoids, curcumin, lysine, methionine, proline, superoxide dismutase, silymarin, tea extracts, grape skin/seed extracts, melanin, and rosemary extracts can be used.
The foam is suitable for delivering skin protecting and revitalizing anti-oxidants/radical scavengers. Polyunsaturated fatty acids containing omega-3 and omega-6 fatty acids (e.g., linoleic and linolenic acid, gamma-linoleic acid (GLA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are beneficial in the treatment of psoriasis and other skin inflammation conditions.
Likewise, emollients and silicone oils exert moisture-retaining and skin protective effects on the skin. Thus, a skin protective foam is provided, wherein the hydrophobic solvent comprises in full or in part, a solvent, selected from the group of emollients, silicone oil and oils, rich in unsaturated fatty acids, thus, affording a synergistic therapeutic effect of the anti-oxidants/radical scavenger agent and the vehicle components.
Self-tanning active agents The foam composition is particularly suitable for the uniform delivery of a tanning active agent onto large areas of the skin. The compositions contain from about 0.1 % to about 20%, or from about 2% to about 7%, or even from about 3%
to about 6% of dihydroxyacetone or any other compound know in the art as an artificial tanning active agent.
Skin lightening and whitening agents The foam composition may be formulated to provide a composition for the uniform delivery of a skin lightening agent. When used, the composition contains from about 0.1 % to about 10%, or from about 0.2% to about 5% of a skin-lightening agent. Suitable skin lightening or whitening agents include those known in the art, including hydroquinone, azelaic acid and other related dicarboxylic acids, and salts and derivatives thereof, retinoids, kojic acid, arbutin, nicotinic acid and nicotinic acid precursors, salts and derivatives, ascorbic acid and salts and derivatives thereof (e.g., magnesium ascorbyl phosphate or sodium ascorbyl phosphate), and herbal extracts (e.g., mulberry extract, placental extract).
In one or more embodiments of the present invention, the foam composition includes a combination of at least one skin-whitening agent and at least one additional active agent selected from retinoids, keratolytically active agents and anti-inflammatory agents.
In one or more embodiments, the composition includes a combination of at least one skin-whitening agent and at least one keratolytically active agent selected from a alpha-hydroxy acids, beta hydroxy acids, and retinoids.
In one or more embodiments of the present invention, the foam composition includes a combination of a skin-whitening agent and an inorganic sunscreen agent. When inorganic sunscreen agents, e.g. titanium dioxide and zinc oxide, are rubbed onto the skin, they leave a white coating, which provides an instant (although transient) whitening effect, which is highly desirable by the consumer, who wishes to see instant change in his/her appearance. The whitening agent, in combination with the inorganic sunscreen agent in the foam carrier can be easily and uniformly distributed on the skin surface, thereby affording an even instant whitening effect, unlike creams that are difficult to spread evenly on skin areas.
Agents for Hair Growth Disorders Agents that affect the pattern of hair growth can be suitably incorporated in the foam composition. Male pattern baldness (MPB), the commonest cause of balding, is induced by the activity of the male hormone dihydrotestosterone (DHT), which is converted from the hormone testosterone by the enzymes 5-alpha reductase. Current treatments of MPB include minoxidil and agents, which inhibit 5-alpha reductase, such as finasteride, spironolactone, azelaic acid and azelaic acid derivatives and salts. Such agents, as well as other agents known in the art, can be incorporated in the foam composition.
Polyunsaturated fatty acids, i.e., such which include any of the essential fatty acids (EFA's), such as linoleic and linolenic acid, gamma-linoleic acid (GLA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are also known to contribute to hair growth. Thus, a hair growth foam composition is provided, in which the hydrophobic solvent comprises in full or in part, an oil, rich in such unsaturated fatty acids.
Figure-forming Agents; Agents to Treat Cellulite / Slimming Figure forming agents such as used in the treatment of cellulite and in slimming products can be suitably incorporated in the foam composition. A non-limiting exemplary list of active agents known in the treatment of cellulite and in the induction of a slimming effect include:
- Herbal extracts: baldderwack extract, butcher's, broom, cayenne, dandelion, red clover, ginkgo biloba, horse chestnut, witch hazel and borage oil - Omega 3 and omega 6 oils - Caffeic acid and salts and derivatives thereof - Xanthine agents, such as theophiline and pentoxyphilline - Nicotinic acid and salts and derivatives thereof Agents to Treat Sunburn, Heat Burn, Radiation Burn, Rash and Itch Cosmetic and pharmaceutical ingredients which are known in the art of pharmacology and cosmetology to treat dermatitis, minor skin irritations, sunburn, heat burn, radiation burn, and inhibit inflammation can be beneficially incorporated in the foam composition.
Examples of such active agents include chamomile extract (matricaria recutitia), cucumber distillate (cucumis sativus), lavender water (lavendula angustifolia), rose water (rosa damascena), witch hazel (hamamelis virginiana), allantoin, bisabolol, rosehip oil, calendula oil, azulaene, menthol and camphor.
Other skin care active agents The active agent can be selected from the group of sulfur-containing amino acids, thiol compounds, alpha hydroxy acids, lactic acid and lactic acid derivatives and salts, glycolic acid, glycolic acid derivatives and glycolic acid salts, beta-hydroxy acids, salicylic acid and salicylic acid salts and derivatives, phytic acid, lipoic acid, lysophosphatidic acid, skin peel agents, phenol, resorcinol, vitamin B3 compounds, niacinamide, nicotinic acid and nicotinic acid salts and esters, tocopheryl nicotinate, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide, retinoids, retinol, retinal, retinoic acid, retinyl acetate, retinyl palmitate and retinyl ascorbate, caffeine, theophilline, pentoxyphilline, dihydroxy acetone kojic acid, arbutin, nicotinic acid and nicotinic acid precursors, nicotinic acid salts, nicotinic acid derivatives, ascorbic acid, ascorbic acid salts and ascorbic acid derivatives "Alcohol free"
The foam carrier or foam composition is essentially free of short chain aliphatic alcohols (i.e., methyl, ethyl, isopropyl and butyl alcohol), unlike the composition disclosed in US Patents No. 6,126,920 and 6,358,541, which contains an aliphatic alcohol, preferably in amounts of 40-90% aliphatic alcohol.
For the purpose of the present application, the term "alcohol free" refers to compositions that contain no more than 7.5% by weight of any aliphatic alcohol, having one to six carbon atoms in their carbon backbone, or no more than 7.5%
by weight of any mixture of such aliphatic alcohols.
Optional Ingredients The pharmaceutical or cosmetic foam carrier optionally includes a variety of pharmaceutical or cosmetic ingredients, which are added in order to fine-tune the consistency of the formulation, protect the formulation components from degradation and oxidation and bestow their cosmetic acceptability. Such an excipient is prefereably selected from the group consisting of: a diglyceride, a triglyceride, a stabilizing agent, an antioxidant, glycerol, a flavoring, a colorant, an odorant agent and any other formulation component known in the art of pharmaceutical and cosmetic formulary. A pharmaceutical or cosmetic composition manufactured using the foam carrier according to the present invention is very easy to use. When applied onto the afflicted body surface of humans or animals, it is in a foam state, allowing free application without spillage.
Upon further application of a mechanical force, e.g., by rubbing the composition onto the body surface, it freely spreads on the surface and is rapidly absorbed.
Composition and Foam Physical Characteristics A pharmaceutical or cosmetic composition manufactured using the foam carrier according to one or more embodiments of the present invention is very easy to use. When applied onto the afflicted body surface of mammals, i.e., humans or animals, it is in a foam state, allowing free application without spillage.
Upon further application of a mechanical force, e.g., by rubbing the composition onto the body surface, it freely spreads on the surface and is rapidly absorbed.
The foam composition or carrier includes water, hydrophobic solvents, surfactant, gelling agent and propellant, thereby creating a stable emulsion having an acceptable shelf-life of at least one year, or at least two years at ambient temperature. A feature of a product for cosmetic or medical use is long term stability. Propellants, which are a mixture of low molecular weight hydrocarbons, tend to impair the stability of emulsions. It has been observed, however, that foam compositions including amphiphilic copolymers as gelling agents are surprisingly stable. Following accelerated stability studies, they demonstrate desirable texture; they form fine bubble structures that do not break immediately upon contact with a surface, spread easily on the treated area and absorb quickly.
The composition should also be free flowing, to allow it to flow through the aperture of the container, e.g., and aerosol container, and create an acceptable foam. Compositions containing semi-solid hydrophobic solvents, e.g., white petrolatum, as the main ingredients of the oil phase of the emulsion, exhibit high viscosity and poor flowability and are inappropriate candidates for a foamable composition.
Foam quality can be graded as follows:
Grade E (excellent): very rich and creamy in appearance, does not show any bubble structure or shows a very fine (small) bubble structure; does not rapidly become dull; upon spreading on the skin, the foam retains the creaminess property and does not appear watery.
Grade G (good): rich and creamy in appearance, very small bubble size, "dulls" more rapidly than an excellent foam, retains creaminess upon spreading on the skin, and does not become watery.
Grade FG (fairly good): a moderate amount of creaminess noticeable, bubble structure is noticeable; upon spreading on the skin the product dulls rapidly and becomes somewhat lower in apparent viscosity.

Grade F (fair): very little creaminess noticeable, larger bubble structure than a "fairly good" foam, upon spreading on the skin it becomes thin in appearance and watery.
Grade P (poor): no creaminess noticeable, large bubble structure, and when spread on the skin it becomes very thin and watery in appearance.
Grade VP (very poor): dry foam, large very dull bubbles, difficult to spread on the skin.
Topically administratable foams are typically of quality grade E or G, when released from the aerosol container. Smaller bubbles are indicative of more stable foam, which does not collapse spontaneously immediately upon discharge from the container. The finer foam structure looks and feels smoother, thus increasing its usability and appeal.
A further aspect of the foam is breakability. The breakable foam is thermally stable, yet breaks under sheer force. Sheer-force breakability of the foam is clearly advantageous over thermally-induced breakability. Thermally sensitive foams immediately collapse upon exposure to skin temperature and, therefore, cannot be applied on the hand and afterwards delivered to the afflicted area.
Another property of the foam is specific gravity, as measured upon release from the aerosol can. Typically, foams have specific gravity of between about 0.01 g/mL and about 0.1 g/mL.
Further Technical Parameters The composition of the present invention can be contained in and dispensed from a container capable of withstanding the pressure of the propellant gas and having an appropriate valve/nozzle for dispensing the composition as foam under pressure. A customary liquefied propellant can be added, in the amount of about 3-18% of the total composition. Liquefied propellants are gases that exist as liquids under pressure, including high purity hydrocarbons such as propane, isobutane and n-butane, dimethyl ether and chlorofluorocarbons (CFCs).
A specific embodiment according to the present invention comprises placing the composition of the present invention on a patch, regulating residence of an active ingredient in the skin tape or the skin-contact compartment of a transdermal delivery apparatus and applying such object onto the skin, in order to attain effective superficial treatment or enhanced penetration of the drug into the skin or through the skin.
Utilizing such strategy, one can apply drugs, which are currently administered systemically or that require transdermal delivery, in the preferred therapeutic system of the present invention. Examples for such drugs are nicotine, testosterone and other male hormones and male hormone precursors, estrogen and other female hormones and hormone precursors, growth hormone, insulin, caffeine, steroidal and non-steroidal antiinflammatory agents and thyroid hormone substitutes.
The general process, as typically exemplified in Example 1 can be applied in order to produce the composition of the present invention.
The pharmaceutical carrier according to the present invention can also be used to prepare cosmetics for beauty purpose by adding into skin care agents and perfume.
Fields Of Pharmaceutical Applications By including an appropriate active component and optionally an appropriate at least one active agent, the foam composition of the present invention is useful in the therapy of a variety of disorders, such as classified, in a non-limiting exemplary manner, according to the following groups:
Dermatitis including contact dermatitis, atopic dermatitis, seborrheic dermatitis, nummular dermatitis, chronic dermatitis of the hands and feet, generalized exfoliative dermatitis, stasis dermatitis; lichen simplex chronicus;
diaper rash; bacterial infections including cellulitis, acute lymphangitis, lymphadenitis, erysipelas, cutaneous abscesses, necrotizing subcutaneous infections, staphylococcal scalded skin syndrome, folliculitis, furuncles, hidradenitis suppurativa, carbuncles, paronychial infections, erythrasma;
fungal infections including dermatophyte infections, yeast infections; parasitic infections including scabies, pediculosis, creeping eruption; viral infections; disorders of hair follicles and sebaceous glands including acne, rosacea, perioral dermatitis, hypertrichosis (hirsutism), alopecia, including male pattern baldness, alopecia areata, alopecia universalis and alopecia totalis; pseudofolliculitis barbae, keratinous cyst; scaling papular diseases including psoriasis, pityriasis rosea, lichen planus, pityriasis rubra pilaris; benign tumors including moles, dysplastic nevi, skin tags, lipomas, angiomas, pyogenic granuloma, seborrheic keratoses, dermatofibroma, keratoacanthoma, keloid; malignant tumors including basal cell carcinoma, squamous cell carcinoma, malignant melanoma, paget's disease of the nipples, Kaposi's sarcoma; reactions to sunlight including sunburn, chronic effects of sunlight, photosensitivity; bullous diseases including pemphigus, bullous pemphigoid, dermatitis herpetiformis, linear immunoglobulin A disease;
pigmentation disorders including hypopigmentation such as vitiligo, albinism and postinflammatory hypopigmentation and hyperpigmentation such as melasma (chloasma), drug-induced hyperpigmentation, postinflammatory hyperpigmentation; disorders of cornification including ichthyosis, keratosis pilaris, calluses and corns, actinic keratosis; pressure sores; disorders of sweating; inflammatory reactions including drug eruptions, toxic epidermal necrolysis; erythema multiforme, erythema nodosum, granuloma annulare.
The foam composition is useful in the therapy of non-dermatological disorders, which respond to topical / transdermal delivery of an active agent.
By way of example, such disorders include localized pain in general, as well as joint pain, muscle pain, back pain, rheumatic pain, arthritis, ostheoarthritis and acute soft tissue injuries and sports injuries. Other disorders of this class include conditions, which respond to hormone therapy, such as hormone replacement therapy, transdermal nicotine administration, and other respective disorders, known in the art of drug delivery.
The foam compositions are further useful for the treatment and prevention of disorders and diseases of other body cavities including the rectum, vagina, penile urethra and ear canal.
Thus, the foam compositions are useful in treating a patient having any one of a variety of gynecological disorders, such as classified, in a non-limiting exemplary manner, according to the following groups: pelvic pain, including premenstrual syndrome (PMS), mittelschmerz (severe midcycle pain due to ovulation), dysmenorrhea (pain related to the menstrual cycle), endometriosis, ectopic pregnancy, ovarian cysts and masses, acute pelvic inflammatory disease, pelvic congestion syndrome and vulvodynia; vulvovaginal infections, including bacterial vaginosis, candidal vaginitis, trichomonas vaginalis, herpes simplex genital ulcers and warts, pelvic inflammatory disease (PID), cervicitis, acute and chronic salpingitis; endometriosis; gynecological neoplasms, including endometrial Cancer, ovarian cancer, cervical cancer, vulvar cancer, vaginal cancer, fallopian tube cancer and gestational trophoblastic disease; benign tumors; sexually transmitted diseases; sexual dysfunction disorders that respond to pharmacological therapy, including sexual arousal disorder, female orgasmic disorder, dyspareunia and vaginismus; and various gynecological disorders that respond to hormonal therapy.
Rectal applications include, for example, anal abscess/fistula, anal cancer, anal warts, Crohn's disease, haemorrhoids, anal and perianal pruritus, soreness, and excoriation, perianal thrush, anal fissures, fecal incontinence, constipation, polyps of the colon and rectum.
The foam compositions are further useful for intra-vaginal and rectal treatment of sexually-transmitted and non-sexually-transmitted infectious disease (STDs).
In one or more embodiments, the invention provides a method of treatment of a disorder of the skin, mucosal membrane, ear channel, vaginal, rectal and penile urethra disorders, comprising topical application of the foam composition, whereby one or more active agents, in a therapeutically effective concentration to the afflicted area.
In a further embodiment, the invention provides a method of treatment of a non-dermatological disorder, which responds to topical delivery of an active agent, comprising topical application of the foam composition of the present invention, whereby one or more active agents, in a therapeutically effective concentration to the skin.

Treatment / Therapy The terms "therapy" and "treatment" as used herein interchangeably, cover any treatment of a disease or disorder, and includes, for example:
(i) Curing the disease or disorder;
(ii) preventing the disease or disorder from occurring in a subject which may be predisposed to the disease but has not yet been diagnosed as having it;
(iii) inhibiting the disease or disorder;
(iv) relieving the disease or disorder;
(iv) causing regression of the disease;
(v) providing a beneficial immunological effect;
(vi) improving the quality of life of a subject afflicted by a disease or disorder; and, in the case of cosmetic treatment (vii) cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions EXAMPLES
In the following, we are going to describe some examples and experiments in detail. This invention is not limited to these examples and experiments.
Many variations will suggest themselves are within the full intended scope of the appended claims.
Example 1 - Production of Pharmaceutical or Cosmetic Foam Carrier and composition - General Method The method for preparing of a pharmaceutical foam carrier generally comprised following steps.
Step 1 - Aqueous Phase: Gelling agent and surface-active agent are dissolved in water, with agitation. The solution is warmed to 50-70 C. Water soluble cosmetic or pharmaceutical active Ingredients* and optional water soluble ingredients are added with agitation to the Aqueous Phase mixture.
Step 2 - Hydrophobic Phase: The hydrophobic solvent is heated to same temperature. Oil soluble cosmetic or pharmaceutical active agents* and optional oil soluble formulation ingredients are added with agitation to the Hydrophobic Phase mixture.

Step 3 - The warm Hydrophobic Phase is gradually poured into the warm Aqueous Phase, with agitation, followed by Ultraturax homogenization. The mixture is allowed to cool down to ambient temperature.
Step 4 - The mixture, at ambient temperature, is added to an aerosol container, the container is sealed and appropriate amount of propellant (about 10% of the composition mass) is compressed into the container.
* In case of heat sensitive active ingredients, add the active ingredient with agitation to the mixture, after Step 3.
In the following examples, foam compositions were prepared as described above and tested for foam quality Example 2 - Diclofenac foam composition with transcutol Component % w/w Mineral oil (hydrophobic solvent) 6.00 Isopropyl myristate (hydrophobic solvent) 6.00 Stearyl alcohol (foam adjuvant) 1.00 Xanthan gum (gelling agent) 0.30 Methocel K1 00M (gelling agent) 0.30 TWEEN 80 (surfactant) 1.00 MYRJ 49p (surfactant) 3.00 Cocamidopropyl betaine (surfactant) 0.50 Transcutol p (therapeutic enhancer) 20.00 Glyceryl monostearate (co-emulsifier) 0.50 Diclofenac sodium (active agent) 1.00 Phenonip (preservative) 0.30 Butane/propane (propellant) 8.00 Water to 100.0 Foam Quality E
Density 0.028 Example 3 - Local anesthetic Lidocaine foam compositions with either urea, lactic acid or a therapeutic enhancer Component % w/w Mineral oil 6.00 6.00 6.00 6.00 12.00 Isopropyl myristate 6.00 6.00 6.00 6.00 12.00 Glyceryl monostearate 0.50 0.50 0.50 0.50 1.00 Stearyl alcohol 1.00 1.00 1.00 1.00 1.00 Xanthan gum 0.30 0.30 0.30 0.30 0.30 Methocel K100M 0.30 0.30 0.30 0.30 0.30 TWEEN 60 1.00 TWEEN 80 1.00 1.00 1.00 2.00 MYRJ 49p 3.00 3.00 3.00 3.00 4.00 Lactic acid 10.00 5.00 Glycofurol 1.00 10.00 Urea 10.00 Cocamidopropyl betaine - 0.50 - 0.50 -Lidocaine base 4.00 4.00 4.00 4.00 4.00 Phenonip 0.30 0.30 0.30 0.30 0.30 Butane/propane 8 8 6 10 10 Water to 100 to 100 to 100 to 100 to 100 Foam Quality E E E E E
Density 0.028 0.038 0.044 0.028 0.028 Component % w/w Mineral oil 6.00 6.00 6.00 22.00 6.00 Isopropyl myristate 6.00 6.00 6.00 22.00 6.00 Glyceryl monostearate 0.50 0.50 0.50 1.00 0.50 Stearyl alcohol 1.00 1.00 1.00 1.00 1.00 Xanthan gum 0.30 0.30 0.30 0.40 0.30 Methocel K100M 0.30 0.30 0.30 0.40 0.30 TWEEN 80 1.00 1.00 2.00 1.00 MYRJ 49p 1.00 3.00 3.00 4.00 3.00 Propylene glycol 3.00 Transcutol p 10.00 1.00 2.00 10.00 Cocamidopropyl betaine 0.50 0.50 0.50 0.50 0.50 Lidocaine base 4.00 4.00 4.00 4.00 4.00 Phenonip 0.30 0.30 0.30 0.30 0.30 Butane/propane 8 8 6 8 10 Water to 100 to 100 to 100 to 100 to 100 Foam Quality E E E E E
Density 0.032 0.035 0.048 0.075 0.025 Example 4 - Foam Compositions with Urea Component . % w/w Mineral oil 6.00 6.00 6.00 6.00 Isopropyl myristate 6.00 6.00 6.00 6.00 Glyceryl monostearate 0.50 0.50 0.50 0.50 Stearyl alcohol 0.20 0.20 0.20 1.00 Urea 10.00 10.00 10.00 10.00 Xanthan gum 0.30 0.30 0.30 0.30 Methocel K100M 0.30 0.30 0.30 0.30 Myrj 52 3.00 TWEEN 80 1.00 Myrj 49p 3.00 TWEEN 60 1.00 1.00 1.00 Cocamidopropyl betaine 0.50 0.50 0.50 Phenonip 0.30 0.30 0.30 0.30 Butane/propane 8.00 8.00 8.00 6.00 Water to 100 to 100 to 100 to 100 Foam Quality E E E E
Density n/a 0.023 n/a 0.044 omponent % w/w Mineral oil 6.00 6.00 Isopropyl myristate 6.00 6.00 Glyceryl monostearate 0.50 0.50 Stearyl alcohol 1.00 1.00 Urea 40.00 40.00 20.00 20.00 Xanthan gum 0.30 0.30 0.30 0.30 Methocel K100M 0.30 0.30 0.30 0.30 Myrj 52 3.00 3.00 3.00 3.00 TWEEN 80 1.00 1.00 1.00 1.00 Cocamidopropyl betaine 0.50 0.50 0.50 Phenonip 0.30 0.30 0.30 0.30 Butane/propane 8.00 6.00 8.00 8.00 Water to 100 to 100 to 100 to 100 Foam Quality E E E E
Density 0.022 0.029 0.032 0.024 Component % W/w Capric/caprylic triglycerides 12.00 Glyceryl monostearate 0.50 Tween 80 3.0 Pemulene TR1 0.50 Hydrophilic Drug 1.0 Urea 10.0 Phenonip 0.30 Butane/propane 8.00 Water to 100 Foam Quality E
Density 0.030 Component % w/w Capric/caprylic triglycerides 12.00 Glyceryl monostearate 0.50 Tween 80 3.0 Pemulene TR1 0.50 Hydrophobic Drug 1.0 Urea 10.0 Phenonip 0.30 Butane/propane 8.00 Water to 100 Foam Quality E
Density 0.030 Component % w/w Capric/caprylic triglycerides 25.00 Glyceryl monostearate 0.50 Stearyl alcohol 1.00 Xanthan gum 0.30 Methocel K1 00M 0.30 TW EEN 80 1.00 MYRJ 52P 3.00 Urea 10.00 Cocamidopropyl betaine 0.50 Hydrophilic Drug 0.1-2.0 Phenonip 0.30 Butane/propane 6.00 Water to 100 Foam Quality E
Density 0.034 Component % w/w Capric/caprylic triglycerides 25.00 Glyceryl monostearate 0.50 Stearyl alcohol 1.00 Xanthan gum 0.30 Methocel K100M 0.30 TWEEN 80 1.00 MYRJ 52P 3.00 Urea 10.00 Cocamidopropyl betaine 0.50 Lipophilic Drug 2.0 Phenonip 0.30 Butane/propane 8.00 Water to 100 Foam Quality E
Density 0.020 Component % w/w Capric/caprylic triglycerides 12.00 Glyceryl monostearate 0.50 Pemulene TR1 0.50 Methocel K1 00M 0.30 Xanthan gum 0.30 Urea 10.00 Ketoconazole 1.0 Phenonip 0.30 Butane/propane 8.00 Water to 100 Foam Quality E
Density 0.020 Example 5 - Local anesthetic foam composition comprising eutectic mixture Component % w/w Mineral oil 6.00 Isopropyl myristate 6.00 Glyceryl monostearate 0.50 Stearyl alcohol 1.00 Xanthan gum 0.30 Methocel K100M 0.30 TWEEN 80 1.00 MYRJ 49p 3.00 Cocamidopropyl betaine 0.50 Transcutol p 20.00 Lidocaine base 2.50 Prilocaine base 2.50 Phenonip 0.30 Water to 100 Butane/propane 8.00 Foam Quality E
Density 0.030 Example 6 - Further foam composition with either transcutol or glycofurol Component % w/w Isopropyl myristate 30.00 Glyceryl monostearate 0.50 Xanthan gum 0.30 Methocel K100M 0.30 TWEEN 80 1.00 MYRJ 49p 3.00 Cocamidopropyl betaine 0.50 Transcutol p 20.00 Hyrdophylic drug 1.0 Phenonip 0.30 Butane/propane 8.00 Water to 100 Foam Quality E
Density 0.028 Component % w/w Isopropyl myristate 30.00 Glyceryl monostearate 0.50 Xanthan gum 0.30 Methocel K100M 0.30 TWEEN 80 1.00 MYRJ 49p 3.00 Cocamidopropyl betaine 0.50 Transcutol p 20.00 Hyrdophobic drug 1.0 Phenonip 0.30 Water to 100 Butane/propane 8.00 Foam Quality E
Density 0.030 Component % w/w Capric/caprylic triglycerides 12.00 Glyceryl monostearate 0.50 Pemulene TR1 0.50 Methocel K100M 0.30 Xanthan gum 0.30 Transcutol 10.00 Ketoconazole 1.0 Phenonip 0.30 Water to 100 Butane/propane 8.00 Foam Quality E
Density 0.038 Component % w/w Capric/caprylic triglycerides 12.00 Glyceryl monostearate 0.50 Pemulene TR1 0.50 Methocel K100M 0.30 Xanthan gum 0.30 Glycofurol 10.00 Ketoconazole 1.0 Phenonip 0.30 Water to 100 Butane/propane 8.00 Foam Quality E
Density 0.034 Example 7 - Foam Compositions with Hydroxy Acids Component % w/w Capric/caprylic triglycerides 18.00 Glyceryl monostearate 0.50 Pemulene TR1 0.50 Methocel K100M 0.30 Xanthan gum 0.30 Hydrophilic Drug 1.0 Lactic acid 6.0 Phenonip 0.30 Butane/propane 8.00 Water to 100 Foam Quality E
Density 0.030 Component % w/w Capric/caprylic triglycerides 18.00 Glyceryl monostearate 0.50 Pemulene TR1 0.50 Methocel K100M 0.30 Xanthan gum 0.30 Hydrophobic Drug 1.0 Lactic acid 6.0 Phenonip 0.30 Butane/propane 6.00 Water to 100 Foam Quality E
Density 0.038 Component % w/w Capric/caprylic triglycerides 25.00 Glyceryl monostearate 0.50 Stearyl alcohol 1.00 Xanthan gum 0.30 Methocel K100M 0.30 TWEEN 80 1.00 MYRJ 52P 3.00 Glycolic acid 4.00 Cocamidopropylbetaine 0.50 Hydrophylic Drug 2.0 Phenonip 0.30 Butane/propane 6.00 Water to 100 Foam Quality E
Density 0.044 Component % w/w Capric/caprylic triglycerides 25.00 Glyceryl monostearate 0.50 Stearyl alcohol 1.00 Xanthan gum 0.30 Methocel K100M 0.30 TWEEN 80 1.00 MYRJ 52P 3.00 Glycolic acid 4.00 Cocamidopropylbetaine 0.50 Hydrohobic Drug 2.0 Phenonip 0.30 Butane/propane 12.00 Water to 100 Foam Quality E
Density 0.020 Although various embodiments that incorporate the teachings of the present invention have been shown and described in detail herein, those skilled in the art can readily devise many other varied embodiments that incorporate these teachings.

Claims (51)

CLAIMS:
1. A foamable composition comprising:
(i) about 0.1 to 5% by weight of a surface-active agent selected from the group consisting of a polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with food fatty acids (sucrose esters), a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, Myrj 45 (Polyoxyethylene (8) Stearate), Myrj 49 (polyoxyethylene (20) stearate), Myrj 59 (polyoxyethylene (100) stearate), a polyoxyethylene cetyl ether, a polyoxyethylene palmityl ether, a polyethylene oxide hexadecyl ether, Brij 52 (polyoxyethylene (2) cetyl ether), Brij 56 (polyoxyethylene (10) cetyl ether), sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, and Myrj 52 (polyoxyethylene 40 stearate);
(ii) about 0.1 to 5% by weight of a gelling agent;
(iii) an active component selected from the group consisting of one or more of urea and a hydroxy acid;
(iv) water; and (v) a liquefied or a compressed gas propellant at a concentration of about 3% to about 18% by weight of the total composition;
wherein the composition contains no more than 7.5% of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, or mixtures thereof; and wherein the composition forms a breakable foam upon dispensing.
2. The foamable composition of claim 1, further comprising about 5 to about 50% by weight of composition of a liquid, non-volatile hydrophobic solvent, wherein said composition is an oil in water emulsion.
3. The foamable emulsion of claim 2, wherein said emulsion is stable in its pre-dispensed state.
4. The foamable composition of claim 1, wherein said active component consists of about 1% to about 50% urea.
5. The foamable composition of claim 4, wherein said active component consists of about 10% to about 20% urea.
6. The foamable composition of claim 4, wherein said active component consists of about 20% to about 50% urea.
7. The foamable composition of claim 1, wherein said active component consists of about 1% to about 30% hydroxy acid.
8. The foamable composition of claim 7, wherein said active component consists of about 1% to about 10% hydroxy acid.
9. The foamable composition of claim 7, wherein said active component consists of about 10% to about 30% hydroxy acid.
10. The foamable composition of claim 1, wherein said active component consists of a combination of about 1% to about 50% urea and about 1% to about 30% hydroxy acid.
11. An oil in water foamable composition comprising:
(i) about 5 to about 50% by weight of composition of a liquid, non-volatile hydrophobic solvent;
(ii) about 0.1 to 5% by weight of a surface-active agent selected from the group consisting of a polysorbate, a polyoxyethylene fatty acid ester, a polyoxyethylene alkyl ether, a sucrose ester, a partial ester of sorbitol, a partial ester of sorbitol anhydride, sodium methyl cocoyl taurate, sodium methyl oleoyl taurate, sodium lauryl sulfate, triethanolamine lauryl sulfate, a betaine, a mono-, di- or tri-ester of sucrose with food fatty acids (sucrose esters), a monoglyceride, a diglyceride, polyoxyethylene (20) sorbitan monostearate, polyoxyethylene (20) sorbitan monooleate, Myrj 45 (Polyoxyethylene (8) Stearate), Myrj 49 (polyoxyethylene (20) stearate), Myrj 59 (polyoxyethylene (100) stearate), a polyoxyethylene cetyl ether, a polyoxyethylene palmityl ether, a polyethylene oxide hexadecyl ether, Brij 52 (polyoxyethylene (2) cetyl ether), Brij 56 (polyoxyethylene (10) cetyl ether), sorbitan monolaurate, isoceteth-20, cocamidopropyl betaine, and Myri 52 (polyoxyethylene 40 stearate);
(iii) about 0.1 to 5% by weight of a gelling agent;
(iv) a therapeutic enhancer selected from the group consisting of propylene glycol, butylene glycols, glycerol, pentaerythritol, sorbitol, mannitol, oligosaccharides, dimethyl isosorbide, monooleate of ethoxylated glycerides having about 8 to 10 ethylene oxide units, polyethylene glycol 200-600, transcutol, glycofurol and cyclodextrins; and a liquefied or compressed gas propellant at a concentration of about 3% to about 18% by weight of the total composition;
wherein the composition contains no more than 7.5% of methyl alcohol, ethyl alcohol, isopropyl alcohol, butyl alcohol, or mixtures thereof; and wherein said composition is a stable emulsion in its pre-dispensed state and forms a breakable foam upon dispensing.
12. The foamable composition of claim 11, wherein the composition comprises about 1% to about 10% of the therapeutic enhancer.
13. The foamable composition of claim 11, wherein the composition comprises about 10% to about 30% of the therapeutic enhancer.
14. The foamable composition of claim 1, 2, 4, 7 or 11, further comprising a therapeutically effective concentration of at least one active agent.
15. The foamable composition of claim 2 or 11, wherein said hydrophobic solvent comprises about 5-10% by weight of the composition.
16. The foamable composition of claim 2 or 11, wherein said hydrophobic solvent comprises about 10-20% by weight of the composition.
17. The foamable composition of claim 2 or 11, wherein said hydrophobic solvent comprises about 20-50% by weight of the composition.
18. The foamable composition of claim 2 or 11, wherein said hydrophobic solvent comprises a mixture of mineral oil and an emollient in a ratio between 2:8 and 8:2 on a weight basis.
19. The foamable composition of claim 1 or 11, wherein said surface-active agent is selected from the group consisting of a non ionic surface active agent, a cationic surface active agent, an amphoteric surface active agent and a zwitterionic surface active agent.
20. The foamable composition of claim 1 or 11, wherein said surface-active agent is a mixture of a non ionic surface active agent and an ionic surface active agent in a 1:1 to 20:1 ratio.
21. The foamable composition of claim 1 or 11, wherein said surface-active agent is a non ionic surface-active agent.
22. The foamable composition of claim 1 or 11, wherein the surface-active agent has HLB value of more than 9.
23. The foamable composition of claim 1 or 11, wherein the gelling agent comprises an amphiphilic copolymer.
24. The foamable composition of claim 2 or 11, wherein the hydrophobic solvent is selected from the group consisting of vegetable oil, marine oil, mineral oil, emollient, silicone oil, plant-derived therapeutic oil and mixture thereof at any proportion
25. The foamable composition of claim 2 or 11, wherein the ratio between the surface active agent and the hydrophobic solvent is between about 1:8 and about 1:16.
26. The foamable composition of claim 2 or 11, wherein the ratio between the surface active agent and the hydrophobic solvent is between about 1:16 and about 1:32.
27. The foamable composition of claim 14, wherein said active agent is antibacterial.
28. The foamable composition of claim 27, wherein said active agent is selected from the group consisting of chloramphenicol, tetracyclines, synthetic and semi-synthetic penicillins, beta-lactams, quinolones, fluoroquinolnes, macrolide antibiotics, peptide antibiotics, cyclosporines, Metronidazole, free radical generating agents, iodine, chlorohexidine, benzoyl peroxide, hydrogen peroxide and any combination thereof at a therapeutically effective concentration.
29. The foamable composition of claim 14, wherein said active agent is antifungal.
30. The foamable composition of claim 29, wherein said active agent is selected from the group of azoles, diazoles, triazoles, miconazole, fluconazole, ketoconazole, clotrimazole, itraconazole griseofulvin, ciclopirox, amorolfine, terbinafine, amphotericin B, potassium iodide, flucytosine (5FC) and any combination thereof at a therapeutically effective concentration.
31. The foamable composition of claim 14, wherein said active agent is antiviral.
32. The foamable composition of claim 31, wherein said active agent is selected from the group consisting of vidarabine, acyclovir, gancyclovir, nucleoside-analog reverse transcriptase inhibitors, AZT (zidovudine), ddl (didanosine), ddC (zalcitabine), d4T (stavudine), 3TC (lamivudine), non-nucleoside reverse transcriptase inhibitors, nevirapine, delavirdine, protease Inhibitors, saquinavir, ritonavir, indinavir, nelfinavir, ribavirin, amantadine, rimantadine and interferon.
33. The foamable composition of claim 14, wherein said active agent is selected from the group consisting of an anti-inflammatory agent and an anti-allergic agent.
34. The foamable composition of claim 33, wherein said active agent is selected from the group comprising corticosteroids, non-steroidal antiinflammatory drugs, anti- histamines, immunomodulating agents, immunosuppressants and any combination thereof at a therapeutically effective concentration.
35. The foamable composition of claim 33 wherein the anti-inflammatory agent is selected from the group comprising clobetasol proprionate, halobetasol proprionate, betamethasone diproprionate, betamethasone valerate, fluocinolone acetonide, halcinonide, betamethasone valerate, fluocinolone acetonide, hydrocortisone valerate, triamcinolone acetonide, hydrocortisone, oxicams, piroxicam, isoxicam, tenoxicam, sudoxicam, salicylates, aspirin, disalcid, benorylate, trilisate, safapryn, solprin, diflunisal, fendosal, diclofenac, fenclofenac, indomethacin, sulindac, tolmetin, isoxepac, furofenac, tiopinac, zidometacin, acematacin, fentiazac, zomepirac, clindanac, oxepinac, felbinac, ketorolac, fenamates, mefenamic, meclofenamic, flufenamic, niflumic, tolfenamic acids, propionic acid derivatives, ibuprofen, naproxen, benoxaprofen, flurbiprofen, ketoprofen, fenoprofen, fenbufen, indopropfen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic, pyrazoles, phenylbutazone, oxyphenbutazone, feprazone, azapropazone and trimethazone, and any combinations thereof.
36. The foamable composition of claim 33 wherein the antiallergic agent is selected from the group comprising diphenhydramine, doxepin, phrilamine maleate, chlorpheniramine and tripelennamine, phenothiazines, promethazine hydrochloride, dimethindene maleate and any combination thereof at a therapeutically effective concentration.
37. The foamable composition of claim 14, wherein said active agent is an anticancer agent.
38. The foamable composition of claim 14, wherein the active agent is a photodynamic therapy agent.
39. The foamable composition of claim 14, wherein said active agent is a local anesthetic.
40. The foamable composition of claim 39, wherein said local anesthetic is selected from the group comprising benzocaine, lidocaine, bupivacaine, chlorprocaine, dibucaine, etidocaine, mepivacaine, tetracaine, dyclonine, hexylcaine, procaine, cocaine, ketamine, pramoxine, phenol
41. The foamable composition of claim 14, wherein the active agent is a retinoid.
42. The foamable composition of claim 41, wherein said retinoid is selected from the group comprising retinol, retinal, all trans retinoic acid, etretinate, actiretin, isotretinoin, adapalene and tazarotene.
43. The foamable composition of claim 14, wherein said active agent is an anti-wrinkle agent.
44. The foamable composition of claim 14, wherein said active agent is selected from the group comprising ascorbic acid and its salts, ascorbyl esters of fatty acids, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl sorbate, tocopherol, tocopherol sorbate, tocopherol acetate, other esters of tocopherol, butylated hydroxy benzoic acids and their salts, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, gallic acid and its alkyl esters, propyl gallate, uric acid and its salts and alkyl esters, sorbic acid and its salts, lipoic acid, N,N-diethylhydroxylamine, amino-guanidine, sulfhydryl compounds, glutathione, dihydroxy fumaric acid and its salts, lycine pidolate, arginine pilolate, nordihydroguaiaretic acid, bioflavonoids, curcumin, lysine, methionine, proline, superoxide dismutase, silymarin, tea extract, grape skin/seed extract, melanin, and rosemary extract.
45. The foamable composition of claim 14, wherein said active agent is a self-tanning agent.
46. The foamable composition of claim 14, wherein said active agent is an anti-acne active agent.
47. The foamable composition of claim 46, wherein said active agent is selected from the group comprising resorcinol, sulfur, salicylic acid, salicylate salts, benzoyl peroxide, retinoic acid, isotretinoin, adapalene, tazarotene, azelaic acid and azelaic acid derivatives, antibiotic agents, erythromycin and clindamycin and zinc salts and complexes.
48. The foamable composition of claim 14, wherein said active agent is a skin whitening agents.
49. The foamable composition of claim 14, wherein said active agent is intended for transdermal delivery.
50. The foamable composition of claim 1 or 11, further comprising a foam adjuvant.
51. The foamable composition of claim 14, wherein, upon foaming of the foamable composition, an alcohol-free foam is obtained having a specific gravity of between about 0.01 g/mL and about 0.1 g/mL.
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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams
US8865139B1 (en) 2009-10-02 2014-10-21 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US8900553B2 (en) 2007-12-07 2014-12-02 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9050253B2 (en) 2003-08-04 2015-06-09 Foamix Pharmaceuticals Ltd. Oleaginous pharmaceutical and cosmetic foam
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US20070292461A1 (en) * 2003-08-04 2007-12-20 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8119150B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Non-flammable insecticide composition and uses thereof
US8119109B2 (en) 2002-10-25 2012-02-21 Foamix Ltd. Foamable compositions, kits and methods for hyperhidrosis
US20050186142A1 (en) * 2002-10-25 2005-08-25 Foamix Ltd. Kit and composition of imidazole with enhanced bioavailability
US20050205086A1 (en) * 2002-10-25 2005-09-22 Foamix Ltd. Retinoid immunomodulating kit and composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9668972B2 (en) * 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
US20060233721A1 (en) * 2002-10-25 2006-10-19 Foamix Ltd. Foam containing unique oil globules
EA009031B1 (en) 2003-01-24 2007-10-26 Стифел Рисерч Оустрэйлиа Пти Лтд. Clindamycin phosphate based foam
US7575739B2 (en) 2003-04-28 2009-08-18 Foamix Ltd. Foamable iodine composition
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
GB0323908D0 (en) * 2003-10-11 2003-11-12 Nupharm Lab Ltd Pharmaceutical foam formulation
CA2565754A1 (en) * 2004-04-28 2005-10-28 Foamix Ltd. Body cavity foams
RU2006146985A (en) 2004-05-28 2008-07-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) MUSCARINE RECEPTOR MODULATORS
WO2006010589A2 (en) * 2004-07-29 2006-02-02 Mipharm S.P.A. Post foaming gel mousse
PL1700597T3 (en) * 2005-03-04 2010-07-30 Tecnimede Sociedade Tecnico Medicinal S Pharmaceutical composition containing in association ubidecarenone, dexpanthenol and chlorhexidine or a pharmaceutically acceptable salt thereof for cutaneous application
WO2007054818A2 (en) 2005-05-09 2007-05-18 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
PL2526930T3 (en) 2005-06-01 2014-05-30 Glaxosmithkline Ip Dev Ltd Vitamin formulation
CA2611577A1 (en) * 2005-06-07 2007-09-07 Foamix Ltd. Antibiotic kit and composition and uses thereof
WO2007085902A2 (en) * 2005-07-19 2007-08-02 Foamix Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
DE202005011885U1 (en) * 2005-07-28 2006-08-31 Schwan-Stabilo Cosmetics Gmbh & Co. Kg Foamed preparation from particle shaped material, useful e.g. in cosmetic preparation, comprises a composition containing a surfactant and a thickening agent in liquid medium
FR2890559B1 (en) * 2005-09-13 2011-06-24 Galderma Sa DERMATOLOGICAL FOAMS BASED ON METRONIDAZOLE AND EMULSIONS FOR PREPARATION
FR2890560B1 (en) * 2005-09-13 2011-06-24 Galderma Sa METRONIDAZOLE DERMATOLOGICAL FOAMS AND EMULSIONS FOR THEIR PREPARATION
EP2100601B1 (en) * 2005-10-24 2012-06-27 Precision Dermatology, Inc. Topical pharmaceutical foam composition
US9642912B2 (en) 2006-03-06 2017-05-09 Crescita Therapeutics Inc. Topical formulations for treating skin conditions
US9308181B2 (en) 2006-03-06 2016-04-12 Nuvo Research Inc. Topical formulations, systems and methods
AU2007273935B2 (en) 2006-03-31 2011-08-18 Stiefel Research Australia Pty Ltd Foamable suspension gel
WO2008075207A2 (en) * 2006-04-04 2008-06-26 Foamix Ltd. Anti-infection augmentation foamable compositions and kit and uses thereof
WO2008110872A2 (en) * 2006-06-23 2008-09-18 Foamix Ltd. Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
FR2911781B1 (en) * 2007-01-26 2009-03-20 Fabre Pierre Dermo Cosmetique DERMATOLOGICAL EMULSION AND PREPARATION METHOD
PL1986473T3 (en) * 2007-04-03 2017-07-31 Tsinghua University Organic electroluminescent device
EP2393301A1 (en) 2007-06-11 2011-12-07 Samsung Electronics Co., Ltd. Method and apparatus for generating header information of stereoscopic image
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009060629A1 (en) 2007-11-11 2009-05-14 Medrx Co., Ltd. Lidocaine tape preparation
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
EA201070690A1 (en) 2007-12-06 2010-10-29 Унилевер Н.В. COMPOSITION FOR PERSONAL CARE
KR20100095436A (en) 2007-12-06 2010-08-30 유니레버 엔.브이. Personal care composition
WO2010041141A2 (en) 2008-10-07 2010-04-15 Foamix Ltd. Oil-based foamable carriers and formulations
US9314524B2 (en) * 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
AU2009205314A1 (en) 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
EP2143421A1 (en) * 2008-07-07 2010-01-13 Almirall Hermal GmbH Topical composition for the treatment of actinic keratosis
EP2246034A2 (en) * 2008-10-10 2010-11-03 Unilever PLC Use of personal care composition
RU2011119503A (en) * 2008-10-15 2012-11-27 Киннова Фармасьютикалс, Инк. SALICYLIC ACID COMPOSITION
ATE500817T1 (en) * 2008-12-23 2011-03-15 Intendis Gmbh FOAMABLE COMPOSITION SUBSTANTIALLY FREE OF PHARMACEUTICALLY ACTIVE INGREDIENTS FOR THE TREATMENT OF HUMAN SKIN
US9012477B2 (en) * 2009-01-06 2015-04-21 Nuvo Research Inc. Method of treating neuropathic pain
WO2010085589A2 (en) 2009-01-22 2010-07-29 G&H Brands Llc Desensitizing drug product
US9676696B2 (en) 2009-01-29 2017-06-13 The Procter & Gamble Company Regulation of mammalian keratinous tissue using skin and/or hair care actives
BRPI1008037B1 (en) * 2009-02-25 2019-08-06 Stiefel Research Australia Pty Ltd. Oil-in-water emulsion aerosol foam composition, use of said composition for treating a skin condition, disorder or condition and process for preparing said composition
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
WO2011014850A2 (en) * 2009-07-31 2011-02-03 Nuvo Research Inc. Topical eutectic-based formulations
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
CA2785643A1 (en) 2009-12-23 2011-06-30 Nuvo Research Inc. Highly permeating terbinafine formulation
US9693976B2 (en) 2010-01-14 2017-07-04 Crescita Therapeutics Inc. Solid-forming local anesthetic formulations for pain control
JP5816636B2 (en) 2010-03-17 2015-11-18 ノバリック ゲーエムベーハー Pharmaceutical composition for the treatment of elevated intraocular pressure
WO2011133177A1 (en) 2010-04-21 2011-10-27 Teikoku Pharma Usa, Inc. Local anesthetic emulsion compositions and methods of making and using the same
EP2409683A1 (en) * 2010-07-06 2012-01-25 KRKA, D.D., Novo Mesto Stable aqueous formulations comprising poorly water soluble active ingredients
US8978936B2 (en) 2010-07-12 2015-03-17 Foamix Pharmaceuticals Ltd. Apparatus and method for releasing a unit dose of content from a container
WO2012010942A2 (en) * 2010-07-22 2012-01-26 Lupin Limited Novel pharmaceutical composition(s) of hiv protease inhibitor(s)
US20130165880A1 (en) 2010-09-17 2013-06-27 David T. Amos Antimicrobial disposable absorbent articles
EP2462921A1 (en) 2010-11-11 2012-06-13 Novaliq GmbH Liquid pharmaceutical compositions for the treatment of a posterior eye disease
WO2012160179A2 (en) 2011-05-25 2012-11-29 Novaliq Gmbh Topical pharmaceutical composition based on semifluorinated alkanes
US9089129B2 (en) * 2011-10-07 2015-07-28 American Sterilizer Company Non-aerosol foaming alcohol hand sanitizer
CN102416018A (en) * 2011-10-13 2012-04-18 嘉兴富特吉生物科技有限公司 Method for treating cervical erosion by using preparation containing triamcinolone acetonide
FR2983731B1 (en) * 2011-12-07 2014-04-25 Univ Paris Descartes TOPICAL EMULSIONS BASED ON EUTECTIC MIXTURES OF LOCAL ANESTHETICS AND FATTY ACID
ES2625538T3 (en) 2012-01-23 2017-07-19 Novaliq Gmbh Stabilized protein compositions based on semi-fluorinated alkanes
CN102579276B (en) * 2012-03-28 2013-04-10 湖北美林药业有限公司 Permeation-promoting combination for cosmetic
EP2830602B1 (en) 2012-03-30 2020-10-21 Micelle BioPharma, Inc. Omega-3 fatty acid ester compositions
US10898458B2 (en) 2012-03-30 2021-01-26 Micelle Biopharma, Inc. Self-micellizing fatty acids and fatty acid ester compositions and their use in the treatment of disease states
US9480651B2 (en) 2012-03-30 2016-11-01 Sancilio & Company, Inc. Omega-3 fatty acid ester compositions unitary pharmaceutical dosage forms
US20160228397A1 (en) 2012-03-30 2016-08-11 Sancilio & Company, Inc. Omega-3 fatty acid ester compositions
PT2895144T (en) 2012-09-12 2017-02-22 Novaliq Gmbh Semifluorinated alkane compositions
WO2014095289A2 (en) * 2012-12-20 2014-06-26 Unilever Plc Method of treating hair ageing
EP2964196A1 (en) * 2013-03-08 2016-01-13 Cipla Limited Pharmaceutical compositions for rectal administration
DK3024484T3 (en) 2013-07-23 2018-10-08 Novaliq Gmbh STABILIZED ANTIBODY COMPOSITIONS
JP5671118B1 (en) * 2013-10-09 2015-02-18 近代化学株式会社 Foamable composition for repelling harmful animals
US9895311B2 (en) * 2014-09-25 2018-02-20 Pharmiva Ab Foam-forming compositions and methods for delivering an active to a body cavity
CN104324039A (en) * 2014-10-20 2015-02-04 付茜 Medicine for treating lipomyoma on surface of human body and using method
CN105497601A (en) * 2014-11-27 2016-04-20 印文敏 Traditional Chinese medicine for treating odontogenic keratocysts
ES2803248T3 (en) 2015-09-30 2021-01-25 Novaliq Gmbh 2-perfluorohexyl octane for ophthalmic administration
PL3355990T3 (en) 2015-09-30 2019-11-29 Novaliq Gmbh Semifluorinated compounds and their compositions
RU2018119510A (en) 2015-10-30 2019-12-05 Тимбер Фармасьютикалз ЭлЭлСи COMPOSITIONS OF ISOTRETINOIN AND THEIR APPLICATION AND METHODS
CN105497340A (en) * 2015-12-31 2016-04-20 张光勤 Hemorrhoid ointment, as well as preparation method and hemorrhoid ointment set thereof
CN105557752A (en) * 2016-03-03 2016-05-11 佛山市正典生物技术有限公司 Iodine salicylate foam-type disinfectant and preparation method thereof
EP3442480B1 (en) 2016-06-23 2019-10-02 Novaliq GmbH Topical administration method
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
JP7012075B2 (en) 2016-09-22 2022-01-27 ノバリック ゲーエムベーハー Pharmaceutical composition for use in the treatment of blepharitis
CA3036306A1 (en) 2016-09-23 2018-03-29 Novaliq Gmbh Ophthalmic compositions comprising ciclosporin
WO2018109717A1 (en) * 2016-12-16 2018-06-21 Ferring B.V. Rectal foam formulations
US11273174B2 (en) 2017-04-21 2022-03-15 Novaliq Gmbh Iodine compositions
CN110650734A (en) 2017-05-12 2020-01-03 诺瓦利克有限责任公司 Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of conditions associated with contact lenses
PL3628002T3 (en) * 2017-05-23 2023-07-31 Pharmiva Ab Foam-forming compositions for delivering an active to a body cavity
KR102002283B1 (en) * 2017-09-05 2019-07-23 코스맥스 주식회사 Composition comprising eutectic mixture of extract of centella asiatica
WO2019063551A1 (en) 2017-09-27 2019-04-04 Novaliq Gmbh Ophthalmic compositions comprising latanoprost for use in the treatment of ocular diseases
US11896559B2 (en) 2017-10-04 2024-02-13 Novaliq Gmbh Opthalmic compositions comprising F6H8
CN107823178B (en) * 2017-11-13 2021-02-26 福建卫生职业技术学院 Niflumic acid colon targeted preparation for treating irritable bowel syndrome and preparation method thereof
RS64869B1 (en) * 2017-11-14 2023-12-29 Profem Gmbh Emulsions for the treatment of vaginal infections
WO2019166631A1 (en) 2018-03-02 2019-09-06 Novaliq Gmbh Pharmaceutical compositions comprising nebivolol
GB201813876D0 (en) 2018-08-24 2018-10-10 Antibiotx As Treatment
EP3856128B1 (en) 2018-09-27 2023-06-07 Dermaliq Therapeutics, Inc. Topical sunscreen formulation
CN112823020A (en) 2018-10-12 2021-05-18 诺瓦利克有限责任公司 Ophthalmic compositions for treating dry eye
WO2020089470A1 (en) 2018-11-02 2020-05-07 UNION therapeutics A/S Halogenated salicylanilides for treating the symptoms of dermatitis
WO2020089467A1 (en) 2018-11-02 2020-05-07 UNION therapeutics A/S Dosage regimen
CN115335025A (en) * 2020-03-02 2022-11-11 Elc管理有限责任公司 Delivery of cosmetic agents, compositions and uses thereof
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections
CN112405939A (en) * 2020-11-07 2021-02-26 江苏特伟尔斯新材料有限公司 Waste foamed plastic recycling process
CN115869209A (en) * 2021-09-29 2023-03-31 株式会社Lg生活健康 Cosmetic composition comprising eutectic mixture of vitamin C
CN115463044B (en) * 2021-10-19 2023-12-08 广州花出见生物科技有限公司 Brightening composition containing supermolecule azelaic acid and preparation method thereof

Family Cites Families (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144386A (en) * 1958-05-09 1964-08-11 Merck & Co Inc Mastitis aerosol foam
GB922930A (en) * 1959-09-21 1963-04-03 Sunnen Joseph Spermicidal composition and method of making same
US3298919A (en) * 1962-12-26 1967-01-17 Dow Corning Shaving cream containing polysiloxanes
US3236457A (en) * 1963-08-21 1966-02-22 John R Kennedy Composite spray container assembly
US3303970A (en) * 1964-07-14 1967-02-14 Jerome Marrow Device for simultaneously dispensing from plural sources
GB1121358A (en) * 1965-10-21 1968-07-24 Bristol Myers Co Aerosol manufacture
US3563098A (en) * 1968-06-28 1971-02-16 Rex Chainbelt Inc Automatic quick release mechanism
US3559890A (en) * 1968-09-03 1971-02-02 William R Brooks Foam dispenser
US3866800A (en) * 1969-02-12 1975-02-18 Alberto Culver Co Non-pressurized package containing self-heating products
US4001391A (en) * 1969-04-18 1977-01-04 Plough, Inc. Means for depositing aerosol sprays in buttery form
JPS5715147B2 (en) * 1972-03-09 1982-03-29
US4439416A (en) * 1973-03-23 1984-03-27 Colgate-Palmolive Company Self-heating shaving composition
US3865275A (en) * 1973-07-30 1975-02-11 Raymond Lee Organization Inc Apparatus for operating an aerosol can
US4145411A (en) * 1974-09-05 1979-03-20 Colgate-Palmolive Company Pressurized foaming shaving composition
US4310510A (en) * 1976-12-27 1982-01-12 Sherman Kenneth N Self administrable anti-fertility composition
JPS5569682A (en) * 1978-11-20 1980-05-26 Toyo Aerosol Kogyo Kk Foam shrinkable composition
US4439441A (en) * 1979-01-11 1984-03-27 Syntex (U.S.A.) Inc. Contraceptive compositions and methods employing 1-substituted imidazole derivatives
US4309995A (en) * 1980-01-28 1982-01-12 Sacco Susan M Vaginal irrigation apparatus
JPS56135416A (en) * 1980-03-27 1981-10-22 Mitsubishi Chem Ind Ltd Pharmaceutical preparation for skin
LU83876A1 (en) * 1982-01-15 1983-09-02 Oreal COSMETIC COMPOSITION FOR TREATMENT OF KERATINIC FIBERS AND METHOD FOR TREATING THE SAME
GB8330969D0 (en) * 1983-11-21 1983-12-29 Wellcome Found Promoting healing
US4985459A (en) * 1984-02-08 1991-01-15 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US5002680A (en) * 1985-03-01 1991-03-26 The Procter & Gamble Company Mild skin cleansing aerosol mousse with skin feel and moisturization benefits
DE3670569D1 (en) * 1985-03-01 1990-05-31 Procter & Gamble Mild cleaning foam.
DE3521713A1 (en) * 1985-06-18 1986-12-18 Henkel KGaA, 4000 Düsseldorf OIL-IN-WATER EMULSIONS WITH IMPROVED VISCOSITY BEHAVIOR
US4806262A (en) * 1985-08-14 1989-02-21 The Procter & Gamble Company Nonlathering cleansing mousse with skin conditioning benefits
US4906453A (en) * 1986-08-12 1990-03-06 Jumpeer Nails, Inc. Mousse product
DE3628531A1 (en) * 1986-08-22 1988-02-25 Merz & Co Gmbh & Co FOAMABLE CREAMS
JPH0778019B2 (en) * 1986-11-08 1995-08-23 久光製薬株式会社 Foamed anti-inflammatory analgesic preparation
US4898246A (en) * 1987-07-06 1990-02-06 Total Walther Feuerschutz Gmbh Quick release valve for sprinkler head
US4847068A (en) * 1987-08-06 1989-07-11 Johnson & Johnson Consumer Products, Inc. Skin care compositions
US4981677A (en) * 1987-09-23 1991-01-01 L'oreal Petrolatum-containing aerosol foam concentrate
EP0309353B1 (en) * 1987-09-23 1994-07-27 L'oreal Aerosol foam skin-treating composition containing petrolatum
US5143717A (en) * 1987-12-30 1992-09-01 Code Blue Medical Corporation Burn foam and delivery system
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
US4902281A (en) * 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US5204093A (en) * 1989-04-06 1993-04-20 Victor Steven A Shaving cream composition for the treatment of acne vulgaris and pseudofolliculitis barbae and method of producing and using same
GB8909559D0 (en) * 1989-04-26 1989-06-14 Smith Kline French Lab Pharmaceutical compositions
US4874794A (en) 1989-04-28 1989-10-17 Lidak Biopharmaceuticals Inflammatory disease treatment
US5002540A (en) * 1989-05-22 1991-03-26 Warren Kirschbaum Intravaginal device and method for delivering a medicament
US4981367A (en) * 1989-07-28 1991-01-01 Stranco, Inc. Portable mixing apparatus
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5091111A (en) * 1990-09-19 1992-02-25 S. C. Johnson & Son, Inc. Aqueous emulsion and aersol delivery system using same
FR2668927B1 (en) * 1990-11-09 1993-01-08 Oreal COSMETIC ANHYDROUS COMPOSITION IN AEROSOL FORM FOR THE FORMATION OF A FOAM.
US5227163A (en) 1991-01-18 1993-07-13 Clilco, Ltd. Lice-repellant compositions
JPH04282311A (en) * 1991-03-08 1992-10-07 Koike Kagaku Kk Aerosol-type foamable wound-disinfectant
US5389676A (en) * 1991-03-22 1995-02-14 E. B. Michaels Research Associates, Inc. Viscous surfactant emulsion compositions
DE4210165A1 (en) * 1991-07-30 1993-02-04 Schering Ag TRANSDERMAL THERAPEUTIC SYSTEMS
GB9118028D0 (en) * 1991-08-21 1991-10-09 Secr Defence Brit Improved transdrmal formulations
ZA933133B (en) * 1992-05-15 1994-10-05 Akzo Nv Application for introducing a cream-type substance into a woman's vagina
KR950702436A (en) * 1992-07-28 1995-07-29 자코부스 코르넬리스 라세르 PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER
JP3328344B2 (en) * 1992-12-22 2002-09-24 タイホー工業株式会社 Method of controlling foaming state retention time of foaming type cleaning polishes
EP0698393B1 (en) * 1993-05-19 2002-07-03 Hisamitsu Pharmaceutical Co., Inc. 3-l-MENTHOXY-PROPANE-1, 2-DIOL AS SOLUBILIZING AGENT AND EXTERNAL PREPARATION CONTAINING THE SAME
US5398846A (en) * 1993-08-20 1995-03-21 S. C. Johnson & Son, Inc. Assembly for simultaneous dispensing of multiple fluids
JP2978043B2 (en) * 1993-09-16 1999-11-15 高砂香料工業株式会社 (2S) -3-{(1R, 2S, 5R)-[5-methyl-2- (1-methylethyl) cyclohexyl] oxy} -1,2-propanediol, its production method and use
FR2713486B1 (en) * 1993-12-14 1996-02-09 Scophysa New compositions for foams, in particular rectal foams, and foams thus obtained.
ES2079320B1 (en) * 1994-05-17 1996-10-16 Cusi Lab OPHTHALMIC DISSOLUTION BASED ON A DICLOFENACO AND TOBRAMYCIN AND ITS APPLICATIONS.
US5902574A (en) * 1994-05-23 1999-05-11 The Gillette Company Shaving preparation for improved shaving comfort
FR2722431B1 (en) * 1994-07-12 1996-09-13 Lir France Sa DOUBLE DISPENSER FOR FLUID PRODUCTS
JP3173330B2 (en) * 1994-07-20 2001-06-04 トヨタ自動車株式会社 Slip control device for vehicle lock-up clutch
US5869529A (en) * 1994-07-20 1999-02-09 Agis Industries (1983) Ltd. Topical preparation for the prevention and treatment of lesions and sores associated with a herpes virus
GB9414699D0 (en) * 1994-07-21 1994-09-07 Slagel David Aqueous foamable composition
US5512555A (en) * 1994-07-21 1996-04-30 Merck & Co., Inc. Method of treating sweat-related conditions using finasteride, epristeride and a cholestan-3-one
DE4428096A1 (en) * 1994-08-09 1996-02-15 Wella Ag Two-chamber container
GB9424562D0 (en) * 1994-12-06 1995-01-25 Giltech Ltd Product
US5616136A (en) * 1995-01-09 1997-04-01 Med-Safe Systems, Inc. Quick release needle removal apparatus
GB9504265D0 (en) 1995-03-03 1995-04-19 Medeva Plc Corticosteroid-containing pharmaceutical composition
EP0738510A3 (en) * 1995-04-20 2005-12-21 L'oreal Use of a HMG-CoA reductase inhibitor as an anti-ageing agent and as an anti-acne agent. Composition comprising at least one HMG-CoA reductase inhibitor and at least one active substance with scaling properties.
FR2742986B1 (en) * 1995-12-29 1998-01-30 Rhone Poulenc Chimie COSMETIC COMPOSITIONS FOR THE HAIR OR THE SKIN BASED ON SULPHONATED COPOLYESTERS WITH POLYORGANOSILOXANE MOTIFS
US5716611A (en) * 1996-01-02 1998-02-10 Euro-Celtique, S.A. Emollient antimicrobial formulations containing povidone iodine
US5759524A (en) * 1996-02-09 1998-06-02 The Procter & Gamble Company Photoprotective compositions
US5716621A (en) * 1996-07-03 1998-02-10 Pharmadyn, Inc. Nonocclusive drug delivery device and process for its manufacture
FR2754451B1 (en) * 1996-10-14 1998-11-06 Oreal SELF-FOAMING CREAM
EP0889719B1 (en) * 1996-11-16 2003-04-02 Wella Aktiengesellschaft Agents for dying and decolorizing fibers
US5856452A (en) * 1996-12-16 1999-01-05 Sembiosys Genetics Inc. Oil bodies and associated proteins as affinity matrices
US6582711B1 (en) * 1997-01-09 2003-06-24 3M Innovative Properties Company Hydroalcoholic compositions thickened using polymers
IN186803B (en) * 1997-02-05 2001-11-10 Panacea Biotec Ltd
US6183762B1 (en) * 1997-05-27 2001-02-06 Sembiosys Genetics Inc. Oil body based personal care products
CA2300054C (en) 1997-08-18 2003-09-30 Neubourg, Stephanie Foam skin cream, uses of the foam skin protection cream and a process for its preparation
US6024285A (en) * 1997-08-19 2000-02-15 Micron Technology, Inc. Wireless communication devices and methods of forming wireless communication devices
US5865347A (en) * 1997-10-27 1999-02-02 William T. Wilkinson Multi-chamber dispenser for flowable materials
US6110966A (en) * 1998-02-20 2000-08-29 Medi-Cell Laboratories, Inc. Triple action complex
DE19807774A1 (en) * 1998-02-24 1999-08-26 Beiersdorf Ag Use of flavone, flavanone or flavonoid compound for protection of ascorbic acid or ascorbyl compound against oxidation, especially in cosmetic and dermatological preparations,
AUPP583198A0 (en) * 1998-09-11 1998-10-01 Soltec Research Pty Ltd Mousse composition
RU2134052C1 (en) * 1998-10-07 1999-08-10 Нерушай Сергей Алексеевич Method and apparatus for aerosol application of perfumery liquids
US6344218B1 (en) * 1998-11-23 2002-02-05 The Procter & Gamble Company Skin deodorizing and santizing compositions
FR2787325B1 (en) * 1998-12-17 2001-01-26 Oreal NANOEMULSION BASED ON OXYETHYLENE OR NON-OXYETHYLENE SORBITAN FATTY ESTERS, AND ITS USES IN THE COSMETIC, DERMATOLOGICAL AND / OR OPHTHALMOLOGICAL FIELDS
FR2788007B1 (en) * 1999-01-05 2001-02-09 Oreal NANOEMULSION BASED ON BLOCK COPOLYMERS OF ETHYLENE OXIDE AND PROPYLENE OXIDE, AND ITS USES IN THE COSMETIC, DERMATOLOGICAL AND / OR OPHTHALMOLOGICAL FIELDS
FR2789371B1 (en) * 1999-02-05 2001-04-27 Sofab DISTRIBUTOR OF CHEMICALLY UNSTABLE PRODUCTS
US6168576B1 (en) * 1999-05-24 2001-01-02 Irene N. Reynolds Device for dispensing vaginal medication
US6190365B1 (en) * 1999-06-21 2001-02-20 Chun Lim Abbott Vaginal douche applicator and method of vaginal deodorization using the same
US6524594B1 (en) * 1999-06-23 2003-02-25 Johnson & Johnson Consumer Companies, Inc. Foaming oil gel compositions
AU5764800A (en) * 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
DE19938757A1 (en) * 1999-08-16 2001-02-22 Beiersdorf Ag Cosmetic or dermatological preparations of the oil-in-water type
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US6186367B1 (en) * 1999-10-19 2001-02-13 Valley Design Inc. Metered liquid squeeze dispenser
US20030077301A1 (en) * 1999-12-16 2003-04-24 Maibach Howard I. Topical pharmaceutical composition for the treatment of inflammatory dermatoses
US6967023B1 (en) * 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
IL133969A0 (en) * 2000-01-10 2001-04-30 Thixo Ltd Thixotropic compositions containing unsaturated oils and food products containing the same
DE20006099U1 (en) * 2000-04-01 2000-07-06 Megaplast Gmbh & Co Kg Dosing pump dispenser with at least two dosing pumps
JP2002012513A (en) * 2000-04-24 2002-01-15 Kanebo Ltd Urea-containing whipped cosmetic
US6358541B1 (en) 2000-05-03 2002-03-19 David S. Goodman Topical preparation for the treatment of hair loss
US6410036B1 (en) * 2000-05-04 2002-06-25 E-L Management Corp. Eutectic mixtures in cosmetic compositions
JP4653282B2 (en) * 2000-05-23 2011-03-16 昭和薬品化工株式会社 Minocycline-containing composition
US6514487B1 (en) * 2000-08-08 2003-02-04 Teresa Leigh Barr Foam and gel oat protein complex and method of use
DE10058384B4 (en) * 2000-11-24 2004-12-16 Wella Aktiengesellschaft Cosmetic or dermatological agent in the form of a creamy permanent foam or a stably foamed cream, its use and method for producing the agent
US20050013853A1 (en) * 2000-11-29 2005-01-20 Irit Gil-Ad Anti-proliferative drugs
US6682726B2 (en) * 2001-04-30 2004-01-27 The Gillette Company Self-foaming shaving lotion
JP2003012511A (en) * 2001-06-27 2003-01-15 Rohto Pharmaceut Co Ltd Aerosol composition
US7002483B2 (en) * 2001-07-11 2006-02-21 Trw Inc. Configurable arrangement of multiple transmitters and multiple receivers for the performance of remote convenience functions
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US6691898B2 (en) * 2002-02-27 2004-02-17 Fomo Products, Inc. Push button foam dispensing device
BR0308530B1 (en) * 2002-03-19 2014-02-18 COMBINATION OF A FIRST CONTAINER AND A SECOND CONTAINER TO FORM A MINISTRY UNIT, MINISTRY UNIT, AND A CONTAINER FOR A NET SUBSTANCE
MXPA05004278A (en) * 2002-10-25 2005-10-05 Foamix Ltd Cosmetic and pharmaceutical foam.
US20060018937A1 (en) * 2002-10-25 2006-01-26 Foamix Ltd. Steroid kit and foamable composition and uses thereof
US7820145B2 (en) * 2003-08-04 2010-10-26 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US20040151756A1 (en) * 2003-02-04 2004-08-05 Richards Anthony P. Edible low density high surface area drug vehicle, method of manufacturing low density high surface area drug vehicle
US6843390B1 (en) * 2003-03-17 2005-01-18 Joe G. Bristor Multiple fluid closed system dispensing device
US20050042182A1 (en) * 2003-08-13 2005-02-24 Moshe Arkin Topical compositions of urea
US7735914B2 (en) * 2003-07-29 2010-06-15 L & P Property Management Company Ottoman recliner
EA200600666A1 (en) * 2003-09-29 2006-10-27 Этена Хелткеа Инк. GEL AND WOODY COMPOSITIONS WITH HIGH ALCOHOL CONTENT
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
US7288692B2 (en) * 2004-07-14 2007-10-30 Exxonmobil Chemcial Patents Inc. Process for producing olefins
WO2007054818A2 (en) * 2005-05-09 2007-05-18 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20070009607A1 (en) * 2005-07-11 2007-01-11 George Jones Antibacterial/anti-infalmmatory composition and method
CN100531515C (en) * 2005-07-22 2009-08-19 鸿富锦精密工业(深圳)有限公司 Printing circuit board with modified power zone block
CA2618974C (en) * 2005-08-09 2014-01-28 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
US7826675B2 (en) * 2006-07-04 2010-11-02 Hewlett-Packard Development Company, L.P. Feature-aware image defect removal
MX2009000507A (en) * 2006-07-14 2009-06-12 Stiefel Res Australia Pty Ltd Fatty acid pharmaceutical foam.
ES2330291B1 (en) * 2008-02-29 2010-10-18 Lipotec Sa USEFUL PEPTIDES IN THE TREATMENT OF SKIN, MUCOSAS AND / OR LEATHER HAIR AND ITS USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS.

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8840869B2 (en) 2002-10-25 2014-09-23 Foamix Ltd. Body cavity foams
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US9492412B2 (en) 2002-10-25 2016-11-15 Foamix Pharmaceuticals Ltd. Penetrating pharmaceutical foam
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US9050253B2 (en) 2003-08-04 2015-06-09 Foamix Pharmaceuticals Ltd. Oleaginous pharmaceutical and cosmetic foam
US9101662B2 (en) 2003-08-04 2015-08-11 Foamix Pharmaceuticals Ltd. Compositions with modulating agents
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8900553B2 (en) 2007-12-07 2014-12-02 Foamix Pharmaceuticals Ltd. Oil and liquid silicone foamable carriers and formulations
US9161916B2 (en) 2007-12-07 2015-10-20 Foamix Pharmaceuticals Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US8871184B2 (en) 2009-10-02 2014-10-28 Foamix Ltd. Topical tetracycline compositions
US10029013B2 (en) 2009-10-02 2018-07-24 Foamix Pharmaceuticals Ltd. Surfactant-free, water-free formable composition and breakable foams and their uses
US8865139B1 (en) 2009-10-02 2014-10-21 Foamix Pharmaceuticals Ltd. Topical tetracycline compositions
US10265404B2 (en) 2009-10-02 2019-04-23 Foamix Pharmaceuticals Ltd. Compositions, gels and foams with rheology modulators and uses thereof

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