CA2502986A1 - Cosmetic and pharmaceutical foam - Google Patents
Cosmetic and pharmaceutical foam Download PDFInfo
- Publication number
- CA2502986A1 CA2502986A1 CA002502986A CA2502986A CA2502986A1 CA 2502986 A1 CA2502986 A1 CA 2502986A1 CA 002502986 A CA002502986 A CA 002502986A CA 2502986 A CA2502986 A CA 2502986A CA 2502986 A1 CA2502986 A1 CA 2502986A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- agent
- active agent
- weight
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008260 cosmetic foam Substances 0.000 title abstract 3
- 239000008255 pharmaceutical foam Substances 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 claims abstract 21
- 239000004094 surface-active agent Substances 0.000 claims abstract 21
- 239000002537 cosmetic Substances 0.000 claims abstract 18
- 230000002209 hydrophobic effect Effects 0.000 claims abstract 15
- 239000002904 solvent Substances 0.000 claims abstract 15
- 239000006260 foam Substances 0.000 claims abstract 12
- 239000002671 adjuvant Substances 0.000 claims abstract 8
- -1 aliphatic alcohols Chemical class 0.000 claims abstract 8
- 239000003349 gelling agent Substances 0.000 claims abstract 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 8
- 239000000203 mixture Substances 0.000 claims 89
- 239000013543 active substance Substances 0.000 claims 29
- 238000000034 method Methods 0.000 claims 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 20
- 208000035475 disorder Diseases 0.000 claims 14
- 239000002736 nonionic surfactant Substances 0.000 claims 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims 9
- 229930195729 fatty acid Natural products 0.000 claims 9
- 239000000194 fatty acid Substances 0.000 claims 9
- 150000004665 fatty acids Chemical class 0.000 claims 9
- 150000002191 fatty alcohols Chemical class 0.000 claims 9
- 239000000516 sunscreening agent Substances 0.000 claims 8
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 6
- 239000007854 depigmenting agent Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 230000003779 hair growth Effects 0.000 claims 6
- 239000003974 emollient agent Substances 0.000 claims 5
- 239000002480 mineral oil Substances 0.000 claims 5
- 229920002545 silicone oil Polymers 0.000 claims 5
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims 4
- 239000003921 oil Substances 0.000 claims 4
- 235000019198 oils Nutrition 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000002352 surface water Substances 0.000 claims 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 3
- 208000012641 Pigmentation disease Diseases 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 239000003945 anionic surfactant Substances 0.000 claims 3
- 230000003110 anti-inflammatory effect Effects 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 235000010446 mineral oil Nutrition 0.000 claims 3
- 239000003380 propellant Substances 0.000 claims 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 3
- 230000037317 transdermal delivery Effects 0.000 claims 3
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 206010011985 Decubitus ulcer Diseases 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 206010048768 Dermatosis Diseases 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 208000008454 Hyperhidrosis Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000031888 Mycoses Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 208000004210 Pressure Ulcer Diseases 0.000 claims 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 206010048222 Xerosis Diseases 0.000 claims 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000000172 allergic effect Effects 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 2
- 239000002280 amphoteric surfactant Substances 0.000 claims 2
- 239000002269 analeptic agent Substances 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 2
- 229940121375 antifungal agent Drugs 0.000 claims 2
- 229960000271 arbutin Drugs 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 150000001277 beta hydroxy acids Chemical class 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003093 cationic surfactant Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 230000006003 cornification Effects 0.000 claims 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 2
- 230000002538 fungal effect Effects 0.000 claims 2
- 210000003780 hair follicle Anatomy 0.000 claims 2
- 230000003054 hormonal effect Effects 0.000 claims 2
- 206010021198 ichthyosis Diseases 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000000077 insect repellent Substances 0.000 claims 2
- 239000002917 insecticide Substances 0.000 claims 2
- 239000002563 ionic surfactant Substances 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 229960003512 nicotinic acid Drugs 0.000 claims 2
- 235000001968 nicotinic acid Nutrition 0.000 claims 2
- 239000011664 nicotinic acid Substances 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims 2
- 230000003071 parasitic effect Effects 0.000 claims 2
- 239000003961 penetration enhancing agent Substances 0.000 claims 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 claims 2
- 150000004492 retinoid derivatives Chemical group 0.000 claims 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims 2
- 210000001732 sebaceous gland Anatomy 0.000 claims 2
- 210000003491 skin Anatomy 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 230000035900 sweating Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 2
- 239000008158 vegetable oil Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 239000002888 zwitterionic surfactant Substances 0.000 claims 2
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 claims 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
- MVQVNTPHUGQQHK-UHFFFAOYSA-N 3-pyridinemethanol Chemical class OCC1=CC=CN=C1 MVQVNTPHUGQQHK-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 1
- 229940124091 Keratolytic Drugs 0.000 claims 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 1
- USSFUVKEHXDAPM-UHFFFAOYSA-N Nicotinamide N-oxide Chemical compound NC(=O)C1=CC=C[N+]([O-])=C1 USSFUVKEHXDAPM-UHFFFAOYSA-N 0.000 claims 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 229930002945 all-trans-retinaldehyde Natural products 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000003255 anti-acne Effects 0.000 claims 1
- 230000003266 anti-allergic effect Effects 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 230000001153 anti-wrinkle effect Effects 0.000 claims 1
- 239000000043 antiallergic agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 229940072107 ascorbate Drugs 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000007844 bleaching agent Substances 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 229960003260 chlorhexidine Drugs 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003581 cosmetic carrier Substances 0.000 claims 1
- 229940120503 dihydroxyacetone Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000012676 herbal extract Substances 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 150000002497 iodine compounds Chemical class 0.000 claims 1
- 230000001530 keratinolytic effect Effects 0.000 claims 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims 1
- 229960004705 kojic acid Drugs 0.000 claims 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000019136 lipoic acid Nutrition 0.000 claims 1
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 1
- 239000003589 local anesthetic agent Substances 0.000 claims 1
- 210000004379 membrane Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- FJCFFCXMEXZEIM-UHFFFAOYSA-N oxiniacic acid Chemical compound OC(=O)C1=CC=C[N+]([O-])=C1 FJCFFCXMEXZEIM-UHFFFAOYSA-N 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002428 photodynamic therapy Methods 0.000 claims 1
- 229940068041 phytic acid Drugs 0.000 claims 1
- 235000002949 phytic acid Nutrition 0.000 claims 1
- 239000000467 phytic acid Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000002516 radical scavenger Substances 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 229960003471 retinol Drugs 0.000 claims 1
- 235000020944 retinol Nutrition 0.000 claims 1
- 239000011607 retinol Substances 0.000 claims 1
- 229960000342 retinol acetate Drugs 0.000 claims 1
- 235000019173 retinyl acetate Nutrition 0.000 claims 1
- 239000011770 retinyl acetate Substances 0.000 claims 1
- 229940108325 retinyl palmitate Drugs 0.000 claims 1
- 235000019172 retinyl palmitate Nutrition 0.000 claims 1
- 239000011769 retinyl palmitate Substances 0.000 claims 1
- 201000004700 rosacea Diseases 0.000 claims 1
- 229960004889 salicylic acid Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229960002663 thioctic acid Drugs 0.000 claims 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims 1
- 238000001035 drying Methods 0.000 abstract 1
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/16—Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/04—Preparations for care of the skin for chemically tanning the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q7/02—Preparations for inhibiting or slowing hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/242—Exothermic; Self-heating; Heating sensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a hydrophobic solvent, a foam adjuvant agent, a surface-active agent and a water gelling agent. The cosmetic or pharmaceutical foam carrier does not contain aliphatic alcohols, making it non-irritating and non-drying. The alcohol-free foam carrier is suitable for inclusion of both water-soluble and oil soluble pharmaceutical and cosmetic agents.
Claims (87)
1. An alcohol-free foamable pharmaceutical or cosmetic carrier, comprising:
(a) a foamable composition comprising:
about 2-75% by weight of composition of a liquid, non-volatile hydrophobic solvent;
about 80-98% by weight of composition of water;
about 0.1% to 5% by weight of composition of a foam adjuvant agent selected from the group consisting of fatty alcohols, fatty acids, hydroxyl-substituted fatty alcohols, hydroxyl-substituted fatty acids, and fatty acids and fatty alcohols including at least one double bond in its carbon atom chain;
about 0.1% to 5% by weight of composition of a surface-active agent; and about 0.1% to 5% by weight of composition of a water gelling agent.
and (b) a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical or muscosal administration.
(a) a foamable composition comprising:
about 2-75% by weight of composition of a liquid, non-volatile hydrophobic solvent;
about 80-98% by weight of composition of water;
about 0.1% to 5% by weight of composition of a foam adjuvant agent selected from the group consisting of fatty alcohols, fatty acids, hydroxyl-substituted fatty alcohols, hydroxyl-substituted fatty acids, and fatty acids and fatty alcohols including at least one double bond in its carbon atom chain;
about 0.1% to 5% by weight of composition of a surface-active agent; and about 0.1% to 5% by weight of composition of a water gelling agent.
and (b) a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical or muscosal administration.
2. The foamable carrier of claim 1, wherein the hydrophobic solvent comprises about 5-10% by weight of composition.
3. The foamable carrier of claim 1, wherein the hydrophobic solvent comprises about 10-20% by weight of composition.
4. The foamable carrier of claim 1, wherein the hydrophobic solvent comprises about 20-75% by weight of composition.
5. The foamable carrier of claim 1, wherein the hydrophobic solvent comprises a mixture of mineral oil and an emollient in a ratio between 2:8 and 8:2 on a weight basis.
6. The foamable carrier of claim 1, wherein at least 2% of the foamable composition is a silicone oil.
7. The foamable carrier of claim 1, wherein the surface-active agent is selected from the groups of non ionic surfactants, cationic surfactants, amphoteric and zwitterionic surfactants.
8. The foamable carrier of claim 1, wherein the surface-active agent is a mixture of a non ionic surfactant and an anionic surfactant in a 20:1 to 1:1 ratio.
9. The foamable carrier of claim 1, wherein the surface-active agent is a mixture of a non-ionic surfactant and an ionic surfactant in a 100:1 to 6:1 ratio.
10. The foamable carrier of claim 1, wherein the surface-active agent consists essentially of one or more non-ionic surfactants.
11. The foamable carrier of claim 1, wherein the surface-active agent has HLB
value of more than 9.
value of more than 9.
12. The foamable carrier of claims 7, 8, 9, or 10, wherein the non-ionic surfactant comprises a sucrose ester.
13. The foamable carrier of claim 1, wherein the hydrophobic solvent is selected from the group comprising vegetable oils, marine oils, mineral oils, emollients, silicone oils, plant-derived therapeutic oils and mixture thereof.
14. The foamable carrier of claim 1, wherein the combined amount of foam adjuvant agent, surface-active agent and water gelling agent is less than about 8% (w/w).
15. The foamable carrier of claim 1, wherein the combined amount of foam adjuvant agent, surface-active agent and water gelling agent is less than about 5% (w/w) of the foamable composition.
16. A pharmaceutical or cosmetic composition, comprising:
(a) a foamable composition comprising:
about 2-75% by weight of composition of a liquid, non-volatile hydrophobic solvent;
about 80-98% by weight of composition of water;
about 0.1% to 5% by weight of composition of a foam adjuvant agent selected from the group consisting of fatty alcohols, fatty acids, hydroxyl-substituted fatty alcohols, hydroxyl-substituted fatty acids, and fatty acids and fatty alcohols including at least one double bond in its carbon atom chain;
about 0.1% to 5% by weight of composition surface-active agent; and about 0.1% to 5% by weight of composition water gelling agent;
(b) a therapeutically effective amount of an active agent;
and (c) a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical or muscasol administration.
(a) a foamable composition comprising:
about 2-75% by weight of composition of a liquid, non-volatile hydrophobic solvent;
about 80-98% by weight of composition of water;
about 0.1% to 5% by weight of composition of a foam adjuvant agent selected from the group consisting of fatty alcohols, fatty acids, hydroxyl-substituted fatty alcohols, hydroxyl-substituted fatty acids, and fatty acids and fatty alcohols including at least one double bond in its carbon atom chain;
about 0.1% to 5% by weight of composition surface-active agent; and about 0.1% to 5% by weight of composition water gelling agent;
(b) a therapeutically effective amount of an active agent;
and (c) a liquefied or compressed gas propellant in a container, which upon release provides a breakable foam suitable for topical or muscasol administration.
17. The pharmaceutical or cosmetic composition of claim 16, wherein the hydrophobic solvent comprises about 5-10% by weight of composition.
18. The pharmaceutical or cosmetic composition of claim 16, wherein the hydrophobic solvent comprises about 10-20% by weight of composition.
19. The pharmaceutical or cosmetic composition of claim 16, wherein the hydrophobic solvent comprises about 20-75% by weight of composition.
20. The pharmaceutical or cosmetic composition of claim 16, wherein the active agent is a drug.
21. The pharmaceutical or cosmetic composition of claim 16, wherein the active agent is a cosmetically effective agent.
22. The pharmaceutical or cosmetic composition of claim 16, wherein the hydrophobic solvent is selected from the group comprising vegetable oils, marine oils, mineral oils, emollient, silicone oils, plant-derived therapeutic oils and mixture thereof at any proportion.
23. The pharmaceutical or cosmetic composition of claim 16, further comprising excipients selected from the group consisting of antioxidants, humectants, flavoring, colorant and odorant agents.
24. The pharmaceutical or cosmetic composition of claim 16, wherein the hydrophobic solvent comprises a mixture of mineral oil and an emollient in a ratio between 2:8 and 8:2 on a weight basis.
25. The pharmaceutical or cosmetic composition of claim 16, wherein at least 2% of the composition is a silicone oil.
26. The pharmaceutical or cosmetic composition of claim 16, wherein the surface-active agent is a mixture of a non ionic surfactant and an anionic surfactant in a 20:1 to 1:1 ratio.
27. The pharmaceutical or cosmetic composition of claim 16, wherein the surface-active agent consists essentially of one or more non-ionic surfactants.
28. The pharmaceutical or cosmetic composition of claim 16, wherein the surface-active agent is a mixture of a non-ionic surfactant and an ionic surfactant in a 100:1 to 6:1 ratio.
29. The pharmaceutical or cosmetic composition of claim 16, wherein the combined amount of foam adjuvant agent, surface active agent and water gelling agent is less than about 8% (w/w).
30. The composition of claim 16, further comprising an effective concentration of a penetration enhancer.
31. The pharmaceutical or cosmetic composition of claim 16, wherein the combined amount of foam adjuvant agent, surface active agent and water gelling agent is less than about 5% (w/w).
32. The pharmaceutical or cosmetic composition of claim 20 wherein the drug is selected for the treatment of a disease, the etiology of which is bacterial, fungal, viral, parasitic, inflammatory, autoimmune, allergic, hormonal, malignant and combinations thereof.
33. The pharmaceutical or cosmetic composition of claim 20, wherein the drug is selected for the treatment of a superficial condition.
34. The composition of claim 20, wherein the drug is selected for the treatment of a disorder of the skin, mucosal membrane, vagina and rectum.
35. The composition of claim 20, wherein the drug is selected for the treatment of a disorder, selected from the group of dermatosis, dermatitis, bacterial Infections, fungal Infections, parasitic infections, viral infections, disorders of hair follicles and sebaceous glands, acne, rosacea, scaling papular diseases, benign tumors, malignant tumors, reactions to sunlight, bullous diseases, pigmentation disorders, disorders of cornification, pressure sores, disorders of sweating, inflammatory reactions, xerosis, ichthyosis, allergy, burn, wound, cut, and non-dermatological disorders, which respond to transdermal delivery of said drug.
36. The composition of claim 20 wherein the drug is selected for the treatment of wounds, burns, cuts and ulcers.
37. The composition of claim 20 wherein the drug is antibacterial.
38. The composition of claim 20 wherein the drug is antifungal.
39. The composition of claim 20 wherein the drug is antiviral.
40. The composition of claim 20 wherein the active agent is an insecticide.
41. The composition of claim 20 wherein the active agent is an insect repellent.
42. The composition of claim 20, wherein the drug is an anti-inflammatory or antiallergic agent.
43. The composition of claim 20, wherein the drug is an anticancer agent.
44. The composition of claim 20, wherein the drug is a photodynamic therapy agent.
45. The composition of claim 20 wherein the drug is a local anesthetic.
46. The composition of claim 20 wherein the drug is a nonsteroidal anti-inflammatory drug (NSAID)
47. The composition of claim 21, wherein the active agent is a retinoid.
48. The composition of claim 21, wherein the active agent is an anti-wrinkle agent.
49. The composition of claim 20 or 21, wherein the active agent is a skin-whitening agent.
50. The composition of claim 20 or 21, wherein said active agent is selected from the group comprising sulfur-containing amino acids, thiol compounds, alpha hydroxy acids, lactic acid and its derivatives and salts, glycolic acid and its derivatives and salts, beta-hydroxy acids, salicylic acid and salicylic acid salts and derivatives, phytic acid, lipoic acid, lysophosphatidic acid, skin peel agents, phenol, resorcinol, vitamin B3 compounds, niacinamide, nicotinic acid and nicotinic acid salts and esters, tocopheryl nicotinate, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxide and niacinamide N-oxide, retinoids, retinol, retinal, retinoic acid, retinyl acetate, retinyl palmitate ,retinyl ascorbate, caffeine, theophiline, pentoxyphilline, dihydroxy acetone kojic acid, arbutin, nicotinic acid and its precursors, salts and derivatives, arbutin, ascorbic acid and salts and derivatives thereof.
51. The composition of claim 20 or 21, wherein the active agent is an herbal extract.
52. The composition of claim 20 or 21, wherein the active agent is a radical scavenger.
53. The composition of claim 21, wherein the active agent is a self-tanning agent.
54. The composition of claim 20 or 21, wherein the active agent is an anti-acne active agent.
55. The composition of claim 20 or 21, wherein the active agent is a skin whitening agent.
56. The composition of claim 20 or 21 wherein the active agent is a figure forming agent.
57. The composition of claim 21, wherein the active agent is an agent that influences hair growth.
58. The composition of claim 21, wherein the active agent is a hair growth stimulating agent.
59. The composition of claim 21, wherein the active agent is a hair growth inhibiting agent.
60. The composition of claim 16, further comprising a sunscreen agent.
61. The composition of claim 16, further comprising an inorganic sunscreen agent.
62. The composition of claim 16, wherein the active agent is a combination of a skin whitening agent and a sunscreen agent.
63. The composition of claim 16, wherein the active agent is a combination of a skin whitening agent and an inorganic sunscreen agent.
64. The composition of claim 20 wherein the drug is intended for transdermal delivery.
65. The composition of claim 16, further comprising a decontaminating agent selected from the group comprising an oxidizing agent, iodine and iodine compounds, chlorohexidine, bleaching agents and surface-active agents.
66. A method of treating, alleviating or preventing a dermatological disorder, comprising:
administering topically to a subject having said dermatological disorder a therapeutically effective amount of a breakable foam composition comprising:
(a) a foamable composition comprising:
about 2-75% by weight of composition of a liquid, non-volatile hydrophobic solvent;
about 80-98% by weight of composition of water;
about 0.1% to 5% by weight of composition of a foam adjuvant agent selected from the group consisting of fatty alcohols, fatty acids, hydroxyl-substituted fatty alcohols, hydroxyl-substituted fatty acids, and fatty acids and fatty alcohols including at least one double bond in its carbon atom chain;
about 0.1% to 5% by weight of composition of a surface-active agent; and about 0.1% to 5% by weight of composition of a water gelling agent.
(b) at least one active agent, which is intended to prevent, alleviate or cure said disorder; and (c) a liquefied or compressed gas propellant.
administering topically to a subject having said dermatological disorder a therapeutically effective amount of a breakable foam composition comprising:
(a) a foamable composition comprising:
about 2-75% by weight of composition of a liquid, non-volatile hydrophobic solvent;
about 80-98% by weight of composition of water;
about 0.1% to 5% by weight of composition of a foam adjuvant agent selected from the group consisting of fatty alcohols, fatty acids, hydroxyl-substituted fatty alcohols, hydroxyl-substituted fatty acids, and fatty acids and fatty alcohols including at least one double bond in its carbon atom chain;
about 0.1% to 5% by weight of composition of a surface-active agent; and about 0.1% to 5% by weight of composition of a water gelling agent.
(b) at least one active agent, which is intended to prevent, alleviate or cure said disorder; and (c) a liquefied or compressed gas propellant.
67. The method of claim 66, wherein at least 2% of the composition is a silicone oil.
68. The method of claim 66, wherein the hydrophobic solvent comprises a mixture of mineral oil and an emollient in a ratio between 2:8 and 8:2 on a weight basis.
69. The method of claim 66, wherein the surface-active agent is selected from the groups of non-ionic surfactants, cationic surfactants, amphoteric and zwitterionic surfactants.
70. The method of claim 66, wherein the surface-active agent is a mixture of a non-ionic surfactant and an anionic surfactant in a 1:1 to 20:1 ratio.
71 71. The method of claim 66, wherein the surface-active agent is non-ionic.
72. The method of claim 66, wherein the surface-active agent has HLB value of more than 9.
73. The method of claim 66, wherein the non-ionic surfactant comprises a sucrose ester.
74. The method of claim 66, wherein the drug is intended for the treatment of a disease, the etiology of which is bacterial, fungal, viral, parasitic, inflammatory, autoimmune, allergic, hormonal, malignant and combinations thereof.
75. The method of claim 66, wherein the drug is selected from the group comprising antibacterial, antifungal, anti-inflammatory, antiallergic, nonsteroidal anti-inflammatory, retinoid, alpha hydroxy acid, beta hydroxy acid, keratolytic, antiproliferative, anticancer and anti-pigmentation drugs.
76. The method of claim 66, wherein the drug is selected from the group comprising an insecticide of an insect repellent.
77. The method of claim 66, wherein said compound is applied topically to an affected area.
78. The method of claim 66, wherein said dermatological disorder comprises dermatosis, dermatitis, bacterial Infections, fungal Infections, parasitic infections, viral infections, disorders of hair follicles and sebaceous glands, scaling papular diseases, benign tumors, malignant tumors, reactions to sunlight, bullous diseases, pigmentation disorders, disorders of cornification, pressure sores, disorders of sweating, inflammatory reactions, xerosis, ichthyosis, allergy, burn, wound, cut, and non-dermatological disorders, which respond to transdermal delivery of said active agent.
79. The method of claim 66, wherein the active agent is a figure forming agent.
80. The method of claim 66, wherein the active agent is an agent that influences hair growth.
81. The method of claim 66, wherein the active agent is a hair growth stimulating agent.
82. The method of claim 66, wherein the active agent is a hair growth inhibiting agent.
83. The method of claim 66, further comprising a sunscreen agent.
84. The method of claim 66, further comprising an inorganic sunscreen agent.
85. The method of claim 66, wherein the active agent is a combination of a skin whitening agent and a sunscreen agent.
86. The method of claim 66, wherein the active agent is a combination of a skin whitening agent and an inorganic sunscreen agent.
87. The method of claim 66, comprising an effective concentration of a penetration enhancer.
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US60/429,546 | 2002-11-29 | ||
PCT/IB2003/005527 WO2004037225A2 (en) | 2002-10-25 | 2003-10-24 | Cosmetic and pharmaceutical foam |
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CA2502986A1 true CA2502986A1 (en) | 2004-05-06 |
CA2502986C CA2502986C (en) | 2011-08-23 |
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EP (1) | EP1556009B2 (en) |
JP (1) | JP2006505583A (en) |
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2003
- 2003-10-24 EP EP03772600.7A patent/EP1556009B2/en not_active Expired - Lifetime
- 2003-10-24 JP JP2004546318A patent/JP2006505583A/en active Pending
- 2003-10-24 US US10/532,618 patent/US20060140984A1/en not_active Abandoned
- 2003-10-24 WO PCT/IB2003/005527 patent/WO2004037225A2/en active Application Filing
- 2003-10-24 AU AU2003279493A patent/AU2003279493B2/en not_active Ceased
- 2003-10-24 NZ NZ540166A patent/NZ540166A/en not_active IP Right Cessation
- 2003-10-24 MX MXPA05004278A patent/MXPA05004278A/en active IP Right Grant
- 2003-10-24 ES ES03772600T patent/ES2532906T5/en not_active Expired - Lifetime
- 2003-10-24 CA CA2502986A patent/CA2502986C/en not_active Expired - Lifetime
- 2003-10-24 KR KR1020057007173A patent/KR101108439B1/en active IP Right Grant
- 2003-10-24 BR BR0314916-1A patent/BR0314916A/en not_active Application Discontinuation
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2005
- 2005-04-28 US US11/116,761 patent/US8840869B2/en active Active
- 2005-05-04 IL IL168399A patent/IL168399A/en not_active IP Right Cessation
-
2007
- 2007-08-20 US US11/894,715 patent/US20080138293A1/en not_active Abandoned
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2013
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2014
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2016
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2017
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2018
- 2018-03-29 US US15/939,415 patent/US20180214558A1/en not_active Abandoned
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2019
- 2019-05-17 US US16/415,087 patent/US20200101164A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
---|---|
EP1556009B2 (en) | 2021-07-21 |
US20190307887A1 (en) | 2019-10-10 |
US20200101164A1 (en) | 2020-04-02 |
JP2006505583A (en) | 2006-02-16 |
US9713643B2 (en) | 2017-07-25 |
ES2532906T5 (en) | 2022-03-23 |
MXPA05004278A (en) | 2005-10-05 |
US8722021B2 (en) | 2014-05-13 |
BR0314916A (en) | 2005-08-16 |
US20130183250A1 (en) | 2013-07-18 |
US8840869B2 (en) | 2014-09-23 |
CA2502986C (en) | 2011-08-23 |
AU2003279493A1 (en) | 2004-05-13 |
US20060140984A1 (en) | 2006-06-29 |
US20140241998A1 (en) | 2014-08-28 |
US20180214558A1 (en) | 2018-08-02 |
US20160354473A1 (en) | 2016-12-08 |
WO2004037225A2 (en) | 2004-05-06 |
IL168399A (en) | 2011-12-29 |
US20080138293A1 (en) | 2008-06-12 |
WO2004037225A3 (en) | 2004-12-29 |
EP1556009A2 (en) | 2005-07-27 |
KR101108439B1 (en) | 2012-01-31 |
ES2532906T3 (en) | 2015-04-01 |
KR20050083826A (en) | 2005-08-26 |
AU2003279493B2 (en) | 2009-08-20 |
EP1556009B1 (en) | 2014-12-24 |
IL168399A0 (en) | 2009-02-11 |
US20050271598A1 (en) | 2005-12-08 |
US20170274084A1 (en) | 2017-09-28 |
NZ540166A (en) | 2007-06-29 |
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