CA2365818A1 - Personal care compositions - Google Patents

Abstract

Personal care composition suitable for use in skin care application, which effectively deliver and/or deposit various benefit agents into and onto the skin and which are relatively non-~ and thus suitable for use by people having sensitive skin and eyes comprising at least one ester and a water dispersible component.

Description

I~alsowAl. cA~ coMl~mo~s ~I~os~ I~c~ m 1~4'I~fo ~caTN~l This e~pp~Eion b a Catdnue~lart-krpert or u.s. Oe~3ei No. 081~04,tirr63. ~vd .June 27, 2000, u,. disdowre of whlOh is hare6y hoorporabari by ref~enco.
dACIC~OF T1~ INVENTION
1. P~aL~.l The awet>tbn roletra to ootrtpvsitiuns suitabb for uao h pensonpt can apptkasdorts, rind In peedOUAa akin oan oomposkions, whkh daNwr irrdl~Cr deposd various bar~alit apartts into and onlu the skin and ere rdodvaiy non.htit~irp and thus aui~ble !or' tJSe by people having ~na~re siW1 and ayes.
>:. .P~C~
Because d the vide ru~ly of skin. hair and n011 prob~ns fiatwid by wnwrnaa, IS cororumers have ktttg sclupht cae produob v~hloh can ardor deposit barulrt nwloao~s ttaa aliwiats suctr . In order to be ei~lw, the ~r:arr~ oaro prodvoes tress 4d oir stabiliahg the bend!! agent M addithn to delivllyinp an0l~or 0eptmldrtp Ihrs bs~aM. Most delhraly iys~ sracrilice aesliw~ h ortlOr to aohlwe stabiiky.
Further.
beosuso sane bsrrsllt ads. srrclr as, arttNWcJdattts, and-a0k~ rrraterieits, are pa~iouieriy uratabNt. U my mar roved to be dollr'ared Mta the outer laysr~r ryf the slot ridlar lt~an onto the skin to pn~vtda d»» Thus, not wrlr rrterat tM personal oero p<oakbt be capable of atb~p ha bsrtsflt Wit, bu! also must ba capable of elfecav~iy daitverirp arrdlor ~posidrp the bettetil spent. Furthermore, such produces shoWd be ofi very kyw h~itar~y to the shh, h pardadtr where ttra art to be used on the facxr, and even more parHoulurly, h ~3 the vrary sensN#vo repioxts ourroumedng the eyes.
A~ordlrtply, il word be d~4~a6~ 1e ornate each a oorrtposdiQrr irrrit is capable of delivsryinp anriMr depasldn0 varbUS 8cdve agtrrrts ~ and onto the skin. It wand also be das~eble to a~oate auoh a compositlort hawing a bw degree of ocular std skin imtlatbn, We bawl swrprisirt0ly found thot psfao«al Care oomposNlvn~t comprtshp i Cof1'tbktalJOf'1 of a watwr d~p~sbla component artd en ester provtds the degree of oosthetiocx and s~ 60 the rrrost sensitive use, while at the sarme time hrdnp a su~bis waftlde 1br delivery skin crae benaatftt matstlals. including skin-care t~snetit metorbts of poor staWky.
SUMMAR1I t71~ THE IIWLNTIO~I
fn scaQMwnce wlitt this ~tion, ttte~e is prcwlcJerd a peraond ogre oont~pooidon corrrpri,ing a wator diaperctble component awrrrt am eater.

~ TOTHL F~GE.49 ~

Anotttar wnbod~M 0f the IrnrvnUun is di'vcfsd to a ooro slrafvnn v. a water diapem~blo component:
b. an ~d~;
c, rva~r;; and d. a pdyneuric emul~itl~ endlcx thick.
Yet anothw embodinrwnt of the pit invanhon is to s m~lad Ibr makhp ~1 oil-h wafer atnul~o~n cw«pr'isvd of ne~a~rtp is llYa~Op~c ~ck~~ pvtN in a hydtaphiNa phavv oompriesd of v poiymvrie vmulaMor with en vftecliw amount at s izer t~ oon~laWnt ar6K
tt Ilpc~l dlic ph~e was comldned with fhe hyd~pt~lio phssv.
Yet anobtw' ernbodhrtent of the phsont trwention to dtrootod to a n~hod for rnaldng a water-in~otf arnulsion oompri~u~d of:
nartrallaina a hydroph>ffic thlckonMp aft fn a hydrOptwllc ~e comprtsld of a pdyrrtlrlc emutsMer with an v(teaaivo amount of a noutrdisvr under aonditiona vu~ont befara combing a UpOphitic phase with the hydrophNlo Phase.
Yet anal wnbodimont of the ~M invendon is did to a ~rteW od fa dep~l~w tvrrtarGt agants into ahd onto 1t~ ~dn oor~e~Od vf:
LOpiIGdly aaptyhlb an es(rodive amotmt of the bsnarHt Font with s opt~osit3On oompnsed of an opdonel liquid silioc~nw, a water dilfplrs~Dle CMnport111t, end en aster to a drsired location.
Ytit ano:A~ emtmdlmont or u.w proaant Invention fm diva~led tc o rtwdhod tbr dvpos~np a bvneflt vpnnt Mtc andlar onto the vein. hair atrtdor n ells awr~sin9 e~ir~it~ a composition oomprtsing~
23 a, en c~rtion~ Nquid allbaw, o. a wstm atsps~slbta compvrm~t, c. an eater.
d. v polymeric omvisttivr vrsilor t~citenor; and e. an eifeottve amount of o test a~vnt 1v a rlis~d location on a human or enimsl.

2 Th0 001~0~~10f1s 0f t~if i~111H0~1 aro ti a d~VCiy dl~lf~ifl~ ~ld~ar depo11t1~'~ ts~oik agents hte and onto the skin, hMr and ns~ Wis'iotrt slpttl8~y ifl~ tr1 .
DEeCRIPT10N CF THE DItItWINI,iS
S The tip of thk patent oontsins at I~t one d11~r1~ iXllGUtad In c:rlor.
Copies of this patent wiM valor drawing(:) vr~l1 be pravkiad by the Pa~tsnt and Tradsmwrk t.7111oe upon request and psynwsnt of fha nsassslry rla.
The will is man Any ut~d :f0 idvantsgas wllll braonre apparwnt when roNerance Is madd to the ib~owing did dssaipt;on or the irnrer~tinn and the aoeompanying tn whk:h:
f1t33. 1 (s) and (bj aro roprosvrd~ions that ifhuebrate the t>pht side (F10 1(v)) and left side (FIB 1 (b)) at s sV~ect's teas p~ iv (rsstment as visw~ a CG-3D5 FHtwr.
F109. 1 (e) anrl (d) are tsprdeantstlons thwt Sustrate the right sib (FIG 1 (o)) and leh sWo (!'10. ~ (d)) of a eubJoot's fisoa while possessing the fomlulatbn of 2 as vtewrrd under s LC~i-3os i~er.
FIG. 1 (a) is a npresentnlon that ~fusirates the right silo of a w~ss fae~s ear the Irssiof G~urprla 2 was rtnsod iharafirom tee viewed a CG~ !~, fIG. t(0 is a rsproaerrtelian that ifhrstrsbss ttw Isl! skiu oaf a aub~t;t's tars atllr tfia trrsbnsnt of Essmpls 2 was wips0 therdhom x: viewed under s CCi-S86 F~rr.
FIGS. ~ (aj and (bj sro reprsserttsla0ns the ill~skr Me right side (FIG. 2(0)) and leh side (1'1G. 2(b)) or a subJeot's faos prior to traatrnent aye vundlr t CG~
F~tac .
FNCiS. 2(c) arKJ (d) are representations that Nlustrate the right soda (FIt3.
Z(C)~ and loft :id. (FIG. Z(d)) of a rurqlect's flees while WuuwassirG the fbrnurlation of G~a~mplo Z as viewed undor s CC~-X96 FlKar.
FIO. Z(v) is a representation that iUwtratos tts right side ef a subject's ilCe alter tM tnstrrsnt of E~ple 2 was itnied n'Ilre(rorn :a vilswsud under a CG-3!'6 Falor.
F16. 2(~ is a rop~ntaHOn Ihat i~ls~ ~1p leAt Nda ~ s sv~d's too :dter t1»
tne~ututtt or l:xsmp~ 2 waa wiped thar~ori~m as viewed under a CCx-X51-titer.
FiG. ~(a) is 8 of aur~bn or retinal in the tormu~tbn of Exen~ple 2 w~
pt~l k~snsibr cts~.
F10. 3(b) is a graph of corsantnstjon of ndinol in the (pnri~lon of Exs3 vsisus pbcoi hsensny crienga_

3 rBP-537 In tNt9 embodyr»1t of the present km~vrl, dts psrsa~nd cars oompostbon aooocdtng to ttro imenUon may suirabiy c~r~priss. oonsiret cf, a oora~st asaftaeitlr of, ba»0 uDOn the tiohl wniW fl crf I!ro personal care c~r~sition, e) from d~out 1 Q psrosnt to about ti4 psr~esM, and prefi~ably lrofn aDCUt 1 t! percent to eDOUt 48 (~rcsnl of s wbtwr dispersible axnponsnt;
and b~ fi~an about 20 parcant tp about 90 pint. s~ pr'aNr'doly from t~ plr0ent to about ta0 percent vt are e~~. t~nsnity, the retb of wabrr diys~hs oompasont to asbsr ragas from about 151 tn mutt 4:1, more preterebpl. 1t"0m about 1:9 to about 1:1, most prdfi~uaWa from about 1:8 to about 1:$.
Ttm firrct component of the paraorrel cue composition of the pnssat irnmntbn is a water die oompr~nsnt, wt»h is p~rebl~l a water ao~le scivad. As wad t>erein, the term l~w~lor ditporatblo oomponatrr' shsu enosn a matsrNl tt~ pase~ a Wcxm, dear a hlzy, mbduro whop vvrnbinad wtih et Nest a wsipM eqvi~lsrd of water. ExompNs d suitsble water dispsnNla c~amp~nts nonexdust0h~de polya#hrlene glyccil 400.
I S haxylarro giyool, propyfano drool, PolyPropys 9lyed.l0 msttrylpluco:e ettrwr, N~. ~a ~9. :~ ~
sthar, polyathylana ~IYcot-8 ~xytldaprb piyar~as. 3-rratthoxy~trletlryt-1-butand.
din~erUiyt iiosabide, and mtxiuroa ttroreof. Mast praforrrd water disparsleN
oomponsnts tndude heocyNne ~yc~l, dtmathyl ~osorDl48. i~~Yt~m glycd-8 caprylk/capric ~yceride, ZO end mixtures thshol.
Ths saaond orsont of the parsons) can Composition of >ha invantian b a ItpopfllUC cart~ponsnt that profdreWy is a liquid ostsr. Prefierred eaten for use In !ha oornpwition of this irwantion Mduds those Iktuid esters that either Possess a oral moans tbr ensuring firs li~idity or aro hetaropanoous in naturo. Exarnplas of such strucNral 25 mean~a dts peasanos of "ntatruptions". such aa: 1j d~aln brarwl~w, Z) oNfkoic unasturation; S) ihs p~nsenoa of sa pdyathar a a moraetiooxyiaM in fhs streudure: or 4) the prrWnve of b sulnrtiturmt, e.g. an athaocylstad or propwq~labo~l nor.
bonded bin fha acid prcup and the group. t3y "he~ntWty," it is rnllnt met the ~OphUic componerd is oompritod o! a mbcfrrne of oompaunds that vary M tho number of carbon atoms 30 in thNr rospe~rre dadns.
Examples of suitable )stir) Ilorlexolusiwly dude:
a) a brandrod Co ~o C~ alkyl alrnhd e:tet of an irorttaNO add:
b) a st~ght-chatnod or bronofied C, to C~ slkyl acid asters of ap3lona~r echyrocylalod/propWCylatsKl prrlyals having from about 3 carbon atoms ~ about 7 oorbon 35 stems;

4 JH~'-339 c) btanChld C, to G", dkyi abOtwl r~te~rs of brarrohed pvtyaGids:
d) hnanchred c>r etralpht-d~afned C,to C~ Aliqll 8dd satsra of a'lnch4d andbr wrsetuesbed Cs to C~ alkyl alootrole;
a) brsnctrnd er w~aturaired Cato C~ dityl sk#roi esters of en said sobvbod from the S flrcxrp arxrrriatlnp of adlpic acki, auoattrC add. malefic sd0. s~dC add, and mbcbrres U~errf n polyedrrr interrupted fatty arid esters;
g) bennob add safer of hemropeneow alcohol: hsvinp from about 8 wrbr~r~
sEorrra to about 22 carbon atorhc: acrd h) mixhrra: , with steatgh~dratr»d or branched C"bo C~ alkyl f war of opaonaUy aU~ro~xytatedJpropo~c~rtatad polyols. tmrrzek add wtoro of t>rtaropeneoKra a~#rois, and mbcbtma thereof being partkulahy preNenad.
8uibble trrand~wrt Cs to C~ sllprl alodlct estef8 d an aroKtll>ac ado k~rde fhwa srtrersin the sromolto odd b benzoic acid. Praf~ably, the alcohol of this ester 6e 13 bnal~d ix tnitad, amt nwy tae either a prirnar)r akdrol or a seaorrdary alcohol with the fomrer b~ preferred. Optionally. the ~rrcanrrtiC add may be sufiabd~DaQ
Whh hydroxy or alkyl groups hravirrp from about 1 carbon atom to bout 4 carbon ahomc. Spedfie pies of ttrase estexs norr~tdwnldy tnduda, butyloccyt satlcytad~; hvxyld~fGyl trmcra~; and butyloolyt benzoate. which an st< svaAable from C P HaH Co. under the tradermrrta.
'I~fISiar," and miacb~rros thereof, with a rnbrhrro of hoxyldooyl ber>:oale and butyloayl Anoltrer witebls ester tndudere ~r ~nlpht-chained of bald C~ to G" alkyl add es~ of oirtfurrcrily ethyoxylatedlpropoxylated polyols, wherein Iho polyolo oonhh from about 3 r~cbon atoms to about T carbon atoms. Pr~erablY, If the polyd vroatear a bn~rychirrq profM.
then the acid group may be stntght-chained. Suitable s~rla ur:td to lbmr thaw wtsrs typically have fiom about a cautrun stoma to about 22 c~bon atoms, end p~erably from about R ~.afinn wtcxns to at~out 18 cewrb0rf atoms, and moat ptetbraQly from adorn a rwbOn atoms to cheat 12 aorborr atorr~, and errs either sWurstsd or unsstue~rteci.
wllh c~wnoic acid, cupric add. Is'ta mbctures theKSOf bring prrrtwrred. such suitable adds aro either stroipht-chained or branctred, and are lar~bly aliphatic. Suits pohr0ls used to Term ~aeo esters typioWly have from about 3 oorbon atoms b about 30 carbon storms. and protarabty iron abort ~ GrC~on atoms t0 about T s~rbon atarruc. lxnrtr~s of such :ukable poiyola nonoxdwiwly include neopeniyl srkxrire~t; polyol~ e.q. digly0l~i. ~.
hexagfyvrxul, oral do~litcxroi, vrheroin the polygiyoerol nssy oonboin from abort ~ to abou!

plyairul otnups: glycerh: sorbibarr; mothyl gkravsv; trirr»ttrylolprnpane: and mixt~
ttarrwni NeopsnqA aled~ol. , trimelttylolpropar~a, and mixtures thereof aro the prefimod pa~yok. Examples of suibitie eretars na~nsfaCiu11Ve1y h~t~1 DetftBerY
n08te; trkrtrfhylvlprupane triocfanoate; trioaiianoin: po~s~ylhe~kyl btrspe~rgan~v:

5 sorbitan trioleate: a~pryticlcepric ron~ycell<!o: nseperuyt tetrauctsnoate, and mbctunes thereof. with oaprylio/caprio tMglyceride; penterrryfhrttoi tRtrrroctsnoats;
trhnltttyl0tpr~0pa~e trlxtattolte: and psntlerythrthl tatraPe~rr yor'rate being more preferred.
AnoMsr Sui~l1 the trrwx~n~d C~ t0 C~ alkyl alcohol ssbre of brWed polyodd4 ouch as the trt-esters. tQb~a-cetera, pants-asEersi. and mntNn~
tlaa'sof.
!0 An axa111p1e of such a ~lyactd is cihriG scid. s9ultebie olkyl oloohols i~or vrestlng !base esier>:
are optionally suluet. e.g.. ealo»lated or propa~qll:ted. vtmtaif~ from about 3 carbon atoms to about ?2 oerbon atoms, and profarably thorn about 3 cari>nn ~ to about 8 carbon ate, seta are elltar straigl a-d>rined a~ tuanohed, with a,o branchMg t~raine per. 'These atrx>hols may ear ha Ixirrany or seooft0lty. arid may dther bra saturated 13 or unsaturated. w~h saturated being profarad for stabilNy reasons.
exarrrlriwre of reulMble estanl nonexdusiwly Include tHoayldud~l curate: trltsopropyloif~ts;
and rnb~
Arath,r suitable actor inatudee the brane~ted or stnirrwri ~'.~ to G~, sNHi acid esrtrmr of brandied or unaaturstvd trlkyl atcohols wherein the alkyl group of the atoohol has from about 1 carbon stems to about 1 B exrrtran atoms, and proferably fiom eAOUrc 4 carbon atoms lu about 10 e.~bon atoms, provided that the total number of exirborr atoms in th~r rrretwr fe at ie~aat rout ti. 8uttabla aol0s for use h makDyp these cetera farpioelly have fnmn about 2 carbon !tome to about 22 carbon atoms. and pror from about a aNDOrt ~0rrrs oo about 10 catrbon atoms. liowsver, if the number of add carbon atoms exceeds thv number of 35 r atoms in ttsrr alrx~hd. then th aCiO preferably ~rnelns ir~t abcttrt 8 c~ttmn adorns to stout 18 carbon otomas and the alcohol prrafQnbly eontsrinre frrxn about 1 c~bon amm t0 about 8 Carbon atoms. It tire number of sdd carbo<r atoms is kxta Bran the number of carbon atoms in the atoo~ha~l, then the ardd prafarsbly contains from about 2 Carbon stems to about >!
rxrrborr atones and the alcohol proibrobly oafs from about 8 carbon atoms tn ~xrut 18 3t) carbcm sterns. Prefa~ly. eldm: 11 Ura rderohol group or the add group has bnenohing endla urrsoturastion. i.a. bath tiw alcohd and the rrdd see not atralphtrchalned: or 2) tht ester poesearses~r so asymmetrical alkyl distribution. By "aeymmetricel alkyl distribution " tt is meaxrt That the star Ire made teem. for eXarnpl~. a short c:l cola alcohol, i.e. hsvina from about 1 carbon stem to about 8 carbon ahorrrs, and a IonO rhwin add. i.e.. having Man 33 about 8 carbrxr alwrre, such as, e.g. butyl steersto, x ks~ pre~biy the aster ie made learn, a krng chafn afcorWal, i.e. hwinp greater titan about 8 CsrAon atoms. and a siwrt chrain acid, i.e. having from about 1 carbon atom to about 8 carbon atoms Fxrunptas of atudt suttabfa

6 ~~5~7 esters rbnexdushroly dude hideayl necrpanmnorta, ~oscf~yi P11. Cnyl rlClnoleate.
cetyl ocmnoata, isononyl iaononenoete, butyl , ootyldodeayl soyete, tr~ecyi enrcate, oeoyl encosn , and mlxteres tlrdrdut, widt otityl octanoste. 1 palmitate, isonor>yl isononenoale. end mi~eturns t~teol' and b~np d.
Mold eurb~O oeia Inoludso the branched or unss<unted C,1o Cue, a~liCyl alovtai leis of in scid s~d'Itom thd group wrwieditp of ac~pb acid, ldd, ertaleio acid.
sebaeic acid. and mbctures thsraaf The akx>tutl of thaw esters. which has from about 3 carbon afoma iso about 18 oereon , rind proforobty from about 3 a~bon atoms to at~out 8 carbon atoms, Is p~aDIY txartched or unaatur~e~te0. OCamptes of such wtlable ~ohoi oabera not~colus~y mdude d~opropyl sdipabr:, diodyrl seam, rNrx~y! rux, diodyl rrralreiNs, diiaoeleeryl adipsts, diethyl eebacale. end mbdurae t~oo~f. with dialtyl aebcoots, dioe~yl rhr, and diryl adipett batnp iNetarTed.
Another srrka6le ~r k~dudes polydlver I~rnrpdd fidty add eslars. Exerftplea at such eWtat~lu Mare none~wkvsively inckidr: 1 ) laursth-2 banao~e; 2) C~ to C~
i~r aliq~l Iapti~y polypropylenpap~) pdyeifiyler>eaxy csfta~pll~o esters darfvad from an aicotal hrwinp from about 1 carbon atom to about 22 carbon atorrts, Is efthwr atr~ipht or brrndtad, end may din a ptrdrryt group; rind 3? mixturos tttenaof, wla't Ce lo G~ ffstbr eNcyl Ioptic~n~ally t~yProt~~Y) t~l~Y carbwpAara eaters fadrtp 0f~1ns0, SpocMc exerr>rrlos of pre~nred esbra norwoodwin~aiyr indude i:opropyt pr~opytene ply~oal.2-isodeaeih-

7 cite. such as 'Ydsan CBPS' arui utlurr commercidly avdtsble materials sold tar Ssndoz under the tr~rriRnamA, "Val:an Mother avitsbie ester indudas the t>enmic acid estais ~ habropeneous alcohols havlnp irvm atwut 8 r:arburt crams to about 22 cbrbon atoms, such ea the ester mbdarrea avalla~ frram t=inetax under the t1101~1erne. "rmsoiV' anQ prlf~eraOlY la the C" to C", akohofs bensoeta tic fhom Finotax under the ~Hnanw, 'Finsolv TN' Prahrr~ed comf~etieona of cetera tndude et least ono. prof~orabhr at boot iwo, ~d mnrw pr~a~r tAres of the : a1 t~l'BnChed G, to Gn taNcyl ~vttol alas of err onomodO ootd: b) bro~fohed or straight-chadnad C~ to c~ slkyl add estrrs of trrandted or unssalkyl alovtwla; and c) straight-drained «~ lxanched C~ to C~ alkyl add eaters of optionally a~yoxylatedlpropoxylatpri ~nlynlrr In s preferred embodhnsnt, the ester contains, based upon the total weight poroont of tho ostora, from about 30 paroent to about 80 per~clnt of Dranohed or sualpht-chained Gs la C~ mlkyl sci~i wcera of tmer~hed or unssturstsd Ci to C,~ a~Cyl aloohots; from about 10 pwr~rnt to about 50 pars~t apt branched Cf to C~ aNtyl ateahol estsns of an aromoNc add: and from about 10 peroent b about 60 3s perc~c of stralptttor branded cø tv Cue, ralkyi ~rcid ~tws of option~ly ethyoxy~tvdlpropoxyleted polyois. In a mores prafin~ed en~hc~hnwnt, thw Aatt~
onntains, tweed ~ott itrs total weight p.reent of ttrs el~lsrs, frotrr about 16 psrnwnt to srlratt 50 pse~oent I~onorOrl Isorwrranwta, frvn~ at>vut 1!s ~rrc~nt to ab~r! 60 psr~nt isoatebryl pelota, from sborrt 1!t psrcant to about 50 percent csiy! OGZln~te. end from shout 15 pertxnt to about 30 peroen! penieerthritol btrsootanolrts.
M optlonwl car>ponaxrt of the psrsa~nsl oero ooarposition of the prosont ~ror~dai is a vole or nonvdatlis Irfnl~ sNroor>e, with the tbrtner t>ekrp pr~srred. The siticarrd ovmponsnb~ adds to aoathotioo, s.e., less pussy feel, of the oomposlhons acoordtrrU to the InValbon. Jsxan~s of suitattla auk~ra~ rnrrrwcdwlvdy Include tire poty~dim~hyl slloxanea and dsrlvativo~t itranof such s: hexsmsthylreWtstrute, dimetttioone.
dlrnetfrtcoflol. and oyclarne~k~ne, wl<h oyolometffiaorh being prsfert~sd. Exsnnples of suitable cydorr~nioonss nonexoluslvely >r>auds cyavt~sa~rclkrwtly s~oxau»; cydop.ntadrt siloacene. cydohoxadhrr~hyl ailofasne, cyck~reptadyl siftoOCane. and mbchs~e thsrrtot.
P~ er~srably, the s~icone has a viscosity of from stout 0.26 op to about 360 op.
Anotr» ernb~odirrwnt of the prrxsanl wnren8orr Is d~ectsd to a peraorrsl cars syatom comp~skrg, oonsisdnp, or ~tlelly rrF, used upon the fetal w~eipht at the psraot>~I
csrs system, o) e! least shout S percent and pratorobly at least about 6 percent of the pses:onal care oo~mpo~eith, aabove: b) flram ~tart TO ~ar~yt kr a~hwt sic psrosnt, snd pnrh~rably from tbout 8o psrr:en! ~ about 9Q paranr of watra'; r:) fmm s~hrnrt I1.1 Er~sr~t to 5 pest, . from shout 0.6 peroorrt to shout 1.6 paoorrt of a polyrrrsrk emulslMr, s 211 thirlcsner. a r~chrra tt>srem: snd opd0n~ly e) from about O.W1 to ebottt d p9nosrrt of a trorrefit ~ In oruo orr~odtrrwnt, the personal cars sysbsm may camprtse, !sand upon the toirl wai01 rt ur lildr psraorarl cars systan.1bm about 0.1 ie eibout 6 pa~ro~t. end pra~srably thorn abort 0.5 peroerrt to 1.6 ns~rrt of w ix~lyn~C emulst>~ sndlor from about U.U1 plrcorrt to about 2 percent, and prstsrably from oboe! 0.01 psrosnt to about t).6 porosrrt d a Ihicksrrsr.
23 Moro ~eferab~t, the personal wn say:terrr uur rlains, trssed upon the tout weigh d the part0n11 Can! s:yslorn, from ~Oltt S perbflt t0 7~tx111t 30 plf~lnt Gt th~
plfiCflll CanB
The per:ro~ cant syalsm wry 1~ kr unr romr of arr oil~watsr snxdsion. a wa~M-oil errrulsion. or s di'spersk,~n 30 In oddRbn m the poreard oars oortrpawitbn, Ere psrsonsi ears system is turltwr oompr'fald of pdyrrrexic drnutatfidrs arnYur thidtanors. As used ta,reirr, the term "polyrtwrK
errudrJ~ar" shall rnasn those corrrpounds cepldil of e~mui~ilyinp sy~ns wtten~by the polyrnerb srrwlrritiors hava o nxloourar war! at at N~sst about 6000, and pnsfo~by aro block copolyrrrsrs travkrg v hydrophNa portion arrcJ a InnJ~nphoaic portion. Vlfiron used at arrrorsrb 35 wtfaraiw ibr srrruidfyfrfp the personal tie ayatlm. the polymeric emul:>tiers stxprfsirrUly do not owes aye ahnU, i.e., whon !ho arxrbifer ~ aorrrposHion was used by si0

8 consumers h tits tys ores. rep mors Ithn about 6% of such r>sers esprossod disoxniort around the oyo area. of suitable omulslfiara noneooduslvaty include polyethylene gfyoot-30 dipotyrrydrroxyataor~r ~Ilalrla rrom unicteme udder tree tntdenerr~e.
~Macsl F-135;" dhe~t,lcone copolyoi, uA,i~, is e~rlrl. from Cioidachrrddt Chorrriool Corporation under ttro 4sdenome, "llbil EM !xY': au~idrted eorylabts such as riroso warlsbw firom The Ooodridi CortxnaUun under the tradenerne. 'PSrtluten": area rnam.irere itrwroot, wibr P
Examploo of suiisblo hydrophUio thidconara nonexawshrdy include cixbotnars ava~We frnn, e.P. ~rk~h under the trsGeinsme. "Cerbopd ETD Z0'10". ~yle~
io oop~dymlrs, hydroxyethylaW Ire modtUed with cwttrl ether groups ~~ from Nar<oubo under the tradensmo, "Notroaol Plua". polyvinylmethyl otherlmalek anhydridd (PVMIMA) docadierrd orvsspdymer avoUSble from Incernstronsl Spec~l Productse under me tradename. "Stsdiw~w taM." and copdymers and mbcduoa lhoroof, with oarbomoro boinp prefomod. Exemptes of suitable awYlate copd~rrrres~ nvnsxdusivsly Induas eayl~
copolymers avall~ie fran Roam ~ Haas under tha tradenamo, "Aculyn 33;
ecryisst~rJerrthosa~rlatQS copolymer availsbio from Notfonai 8 Chemical Company under the tnuienamo. "91r'uritur as Plus; srcaylete8/st~earetn-20 i~onats COpalyrrfor evaUabIQ
fiom NsriOnai Starch i~ Chemical Company ~rnrdr the tradename, "Sbrrcture 2001,"
ecryfabslc~th~0 itecons~te oopolymor avoilablo from Nationerl t3tarch 8 Chonti~l Company under itrrr ~dename, "StnlatJro 3001," s~a~yl~stsauath-20 mete copolymer avai~le from Rahm 14 Naaa undo~r the tradoname, "Aculyn 22," and oopalymors and madures theroot.
The psrsonel ca~r~r system of the present InVentlon may ado opbonaUy c:or~bin w stsDillty entt6nCOr for the purpose of wrrharrcinp the sts~ility of the bMedt agent and/or iho ooslhetios of the porr:onol oars system. t3enoraliy, the atabllity enharrrxr la sml~ted from a rronionk omulalliee, ~ esssrttlsily non"trteminsl surfac~nt Or mbttures thereof. Exwrrspies of suttaOle nonioNc emulsiRane inrJ~rde isooeth:th-20, oleth~, mbcturo of PEG-40 hydrogallted ~r oil o<rd bidaoeth-9 evoilsb~le from OregoCO Inu. urrrlar th1 tredettams, -Dfepo00 SdubUicer 2/OtalQO; P0107csmer 1134, l8uretn-4. sorbitan trinle~, furtyQxyethylene-(21 oloyi rettrwr, sorbitan steerottr, cetoaryl giuooside, glyooryl olosto, bideoebt-8, poltrothylono'~ll~orrl-hydrogenated castor oil, end rrrixtunoc thereof.
Exaertples of sultsbis as9entieNy non-l~lminp surfactsnM include non-foarninp nonionic rrurfaaMnts ouch as sucrose esters, e.g., au~ooo oooo~s, sucrose s~tosrste and mixtures thoroof, with aucroeo toccata being pro~ra r dc!. Dy 'ess~tty non-folmhp," n ~s 35 meant Urrst Urts surfactant, wMn used with the compcxcitinrr of the prosent invention, hays a column hwipht of less than about 20 mm as deterrninod by the Roaa-Miles f'o~am aona'ition

9 l set. t,3ae 1tt (i.) C» a Soap 99 - 1132 (1941 M"i~s~Mibs resr~ whkJ, is keCOrpontled by rsferenos herein. The personal oars oornpowitaon and the personal osss eysbem stay either !rd ~ k Wltr wtll ~ wa4u w may tar wipecl~ofl'. Pref~ly. the essentieWy. non-toamin2 surfsdeMs arse used in eurhxxtim~ whErwin thw pws<x~l r~nyNtm nr ~ p~wseswl ccmw S composition io rinemablo wllh wator. Fs oxarr~plO. o proiorro~d oombinotion of hydrophiik ~npor~ , tied upon the tots weight percent of ttte petsoned care oat>posltlat or system, from about 0.1 percw,t to bout a.o percent of hexylena glycd, room shout O.s percent to about 9.0 percent of sucrose cocoas non foaming swh~nt, and from about 0.s pen~ern to about 3.U p~aetu of po~ooqre~yl~te-6 c~pr~Mclceptic triplyceride~ M
eotample of a suitable stabii'~ty enhanoer ir>clude a rnixhrro of sorbltsn stoaeaee and sucrose oo~ooata a~~ebte fiom tJnkterna under the trada~e~ne.'Arietone 2121 "
Wttert des~~. ttte p~~ao~l Cars sysam ~r~fs. band upon the 1olal weight of the personal carp system, no mots than shout 8%, and prefirtably 5%, of the st~ebilky onhenoers riot ueem rcrmuletions end no moro then ebtwt 296, end preferably no mores lhen 1 % of the staenlpr ennanars tn thm look tormulanons.
The persorvai cane system and pe~rsonei care cart~sition may also opdortelty conta~ a foaming sub The fo~Q aurfadant ms~r be non-Ionic, cationic, atnpt~ot~ic, ar artbNC: nor~lc $tt1 ere pt~eaamed. hay "~aml~v k is tetaant ~t fns surlac~nt, When used with the composition of the p~roswnt Invaraton, has a ~xr~ height of foam grossest ihen about 20 mm as debsm'dned 6y the Ra~ss-IY~se Test As used heroin. the term ~arnoiw' shall mean: , l motewles that conts~ Moth aaotc arse t~tc sues wdm, for oxsrnpiv, an amino sdd oor~f~g both amine (bae~) and scid (e.2., carbootywo add, acidic) Rx~bnel groups; a 2) swktarionic mW be wtAd~t possess bdh positlee ared rt~vs dsapws within the same molearis. The chairpas of the isltor matt' ha eiM~wr dep~rdrnt on or independent of the pH of the oompositicn. Eaemples of swillerionio rna~eriale include, but are not itrnkea to. alkyl band amldoalkyl pets. F~mploe of sulao~e arse pnarirred suiiachntts nay be shard in intemetional Pelt Apptie~tiOn Nurnt~er V1~87/01198, is inoorporalsd by r~er~e in its herein.
'fhe persvnel vero syslrvrn a~~d pdrscuwl oero oompo:ttlon ~r Arrtha contsdn one a 3U mon benefit agent: or phmnsceutk:ally-eccep6abla salts fhaneof. As used hvrpln, the term "benefit agent' includes any adlve ingrodient that is to be dated into and/or onto the skin, hair or nab at a desired location. such as a cosmatk: spent or a pttarmsceutical a0sht. dy "cosmetic spent," it is meant any ingredient that is appropriate for cosmeti~Ny baatir~p, providing nubients to, andlor conditioning the hair, nail, and/or skin via topbal eppliceGw'i.
By -phsm~acsuticsl dent: it is mean any dnrp that is either hydrophobk: or hydroptttiic m nature eu~ri aNte for t~k~l use. As used ttereu~ -madicsrmmt apsr~b' incieula those rt~urts oapabb of prorrroting r~vary fit injury and I~nooa.
The bonofit agents usoful horotn msy be oetegori:ed by ttaslr thaa~utk bsne?It or their poslulalrd mode of satin. hiowawr, it iS Do 0e un dli~stood that Ma t~en~tt agents 3 useful herein may, in arx~ drcurrntanars, provi~s rr~n than one thsroopoutb benefit or opsrato vla greater ehon one mode of action. Thereta~re, the parllwler classMuitfata provkied hrnsin are 1~1 for the slKe of convenience and nrw not intendod to limit tiw bwaflt to ~s particular applicption(s~ fisted. In oddlfiOn, the oornpounds, whictr area kientMed below es beMg suilalrla fvr use as benefit agents. nlay be use0 tn en amount rover rn0 lbove the amount that they may bw used t~ other purposes in tho persond cars oornpositlon or psnonsl corn systm.
E~ntphr~r of sultabla benetlt al~le~tttl Include. Dv: aro not IkrMed to, d~ipmenbtion dents: 1"etlec~nts: detanplfnQlwat corr~bhp agaeds; !!lm farrrkrg polyrnero;
turrrreotsrrts:
amino acids and !hair derivativoa: antimiorobiel ; albngy inhibiirxa; anti-sate anti-~g agents; entMntinWktp agents. antiseptics: ~alpui~; Rntitussiv~os:
antipruriiics:
kx~l an~hretic~; anti-hair loss agents; hair growth promoting opents; hair Qro~rth inhibitor agents, s'ntihist~ninsa such as Mandragara Vrrrn~C, Txrm PaIt111nium ~ thw tike;
antlinfactlves such es Ace~1 Catechu. Alor Brrrluacie~nsis, Conwllaria Ma~alis, Eohinoooa, Euc~trrs, Menthe Pipvrlta, Rosa Canine, tsaaoafroS Albidum, end the like;
inils~t~rraUpr~
inhibitors: anti-~nedcs: anlir:l wline~ka; vasoooilserMOOrs: vasoailetors;
wound healing promoters: , polypeptkies anti rrc~teins; deodorants and anti-perapinnts;
m~iicamsnt agwrts: akM wmoUients and akin moWturizers; skin M»irw , halt oonditjoners; hair softerrrrxs; heir moWtu; vitamins: tsnMnp ~tx; ckin iiphtoniny agents: ,ntffuripals such as r~antaur~ Cyanus, K.slmi:a L.ztifolia and anliiungals for foot pnpan~ons: dspilo~trrg agents; shsvin~ preparatiats; ~eucteunirl ertdp9SICa:
perfUmaae;
cwrntertrrltair'ib; tremorr?10klsls: InSeCbddes: poison ivy pmritrds: poison oak prosiwote; bum products: anti- riisr~rr rash sgoerts: P~'~Y h~ ~ ~~p P: vitarrrkrs;
xnino aokia and their derivatives; herbed axtracls; mlNoids; fleverlplds:
senaatas: aMi-vxidarns; sKln Conditioners: natr Ian; r:hwirrtieb agents: osll tumovsr enhonoara;
cnlnrin0 aptnts; pigments; sunscreens, thooo trotiw inprodknts disclosed Gr Urtl~d Steles F'at~f! No. 13,089,397, wtrich Is Incprppreted herein by rat, s~rrti.edama agarrts, CWiaQen enhlincess. and mixturwra thereof.
Exarr>plos of aultoblo anti-aderna speirrts nonexdusivwiy include b~lb~olol nltdrrel.
synfhaGc trot. and mbctunes thereof.
~3 t.xert~fles of sultablR v~rstriaf~ours nonexctusiwly inoludo horse oheritrrut extrett, prickly ash, end mbcturss thereof.

~amplat ~':vadla anti~inflamfr»toty :pants non~oolwivehr k~dude benou~'u~n.
cxtntalla attatkht, bisabolol, foverfiw (whole), w (~ar~tortollde frla), proelt t1a extract.
geoen t~ eoneextt~ate, i~ydro01t1 peroxide, lyCOpens lndudin0 "Lyao-PM' aVailabie from Ly0oRe0 Natural Produrlt Industries. Ltid., oat off, chomomlls, and nrirxbrros th~twl:
S Ex~ut~ples of odlagcn entumtens no~eutdua~iveuy htdlJde VlserrM't A. vitamin C, and mbcturee Htereof.
Es of suid~ble okMt tlrn>hp sg~t Wshraly ode dimethylamhoethanoi ('DMLAE').
Exampiet of auitab~e an~rmities end aide pr~oai~n~~ls non~noduelvaiy ~t~ude oatrt~l. t»mgiuean, teVerfew, soy end doriVSdves tlterwvf, alcarbonsfs of sod.
aolloida!
o~m~l, aur~nt bawnt cvtbldef pamlael dsMS~. Anapwllls Anwrnis, Oonothsra eiennb. V~sna Otf~nwi~. and the INaa. These ontiprurifks may be aced &i an amount, bawd upon ttw tobd weight of the ptrsonrrl acre wmpaaltlort, fiom aDOUt 0.01 p~rant to about 40 percent, any! pwfsra»y fiom about 1 peroant to about 5 percent.
As used hweain, oolbidal o~n~l moons bte rosultir~ (rout ttta prkl~np and prooesatng a~ whois oat grab nUnheG Stat9t 8vndawde fipr Numbar 1 a Number 2 oats. The GOUO~is! hat a size distribution as tollowo: not men:
than 3 pwrrwnt of the tobl partbies weoeed 160 micrometers h miaa an0 not more Nfllt ZO
perosnt of eho total parades exosecJ re micromet~a In side. Examplsw of sutteYble ool~ida>
oettnealu tr~auda. trot aro not nnttwrt to.'Tech.Ow eva8able from the Beooon Corpaatiamnd c~lloklal oatrnaals aVaiable from Cuakar.
Examples of auitablu raliec~IS nonaxattliVehr ktd~xla re~ica, ~rmina, ario~n eilicate. dloloata, ghrcoi dittearatee, silbe, oodh,im m~nesium flucxeslNoete, anG
mbdares thervoi.
9ulta~ gltngA~let oonlDltlp agents ncx~anadutiv~siy indude polyqtr~smium-10, f>y0rooqrprcpylMmonium guar, dioleo~Aomldosth~ri hydro~itylnmnium mdtrl0tutla~. di-(ooyoylelhyi) hydroopratiaylrranfum m~rttwacutf~s, hydr0xy~hyl bltlenmnlrinp~ropyl di~non~t~n ddorida, adealkontum CnlOride. p01y4uetemium.d7, abr~iloonium ohlorido.
4iostylmonivtn dtlalda, and trsbebrres the.
Sulhble fin iortr~n~ polymers into those that. agar drying. Produce a avbsttr~aly cordk~ous Opatktg a film cm the hair, sWn, or nslle. Nonexolusiva sarart>plet v< ~abwe t1k11 fcxminp polymerv i~udo aaylemidopropyi trimadum chloflQo/aayl~nlde cropalymsr:
corn atoenh! aayiamidel ~cedlum aCfytBte Copolymer. Esrnlum-10; Pi<un.~7:
pdyvat~tlmethylat~lmaleic snhydride copolymer; atyrenelacrylatas copolyrnem;
er~0 :~5 mixtunn thereof.
Con~xnenxally ~v~lflt~rnecta~s vant of prong moisturtattion and axMeOnhp prcparlie, to the personal core oomposkion ate :vitabirr tbr use kl tile ptetettt invendOn. The hurt~fft is preferably in sn amatrnt of from about 0 panoont to nbou~t ~roent, morn phhrabiy from ataout 0.6 pvrosnt to about 6 pvrnent, arsi most pt~etb~aDly from about O.S perosret to about 3 pant, based on tt» overall wWpht of My composition.
of stile ht~rrs~ntR ushrvly hducb: 1 ) wo~to~ sohrbls liquid potyols 5 aallvcbad ir~orn !hw group oompriskrg o. pcopybtre ~yarl, Imxylsne plyi0ol.
0u4AaM
. P. dklvPIgf~Cd. and mixoxaa ftwreof; 2) Pah~ll~nO gHooi of Iho 1L:
HO~(R"Oj~-H 1.
whence i~' is art allq~hxw group hsnrkll~ fi01r1 about x to about 4 arrb~on elopes

10 and b Is 8n In tlpsr of from about 1 tc W f 10. such ~ PEG 4; ~) polye~yiono plyaal ~ of n~hyl gkroosv of farrr~ 11.:
OHrCaH,aO~(CCH=~h~.Oht II.
a is ~ from atxurt s to aaotrt zs:
4) u<~; d) htrcsodr 6) pitlOOes; 7) honey; 8) I~c rs~; 9) rrral6osvt; 10~
soekum ghroeervnllr;
13 sled 11 ) m6dtrnse fhsreof, wllh 9batng 8tw Prdon~ed huh 6~rila~v sm~o aced ages W indude ammo adc~ dlrn~d !fin thre hydrolysk of viirbus pfDtelni is Well a1 thE; salts. ~R, a!'b aryl dleiVatti~re'a ~of.
E~merlples of sudl amino add sgsnb norrvxduohroly include ernphotark amH m ids such as aliQrlsoirdo a~lkylarnines. c.a. atesryt acetyl glutamate, caprylayl sNk antlrlo add.
ceheylayl n err>ho adds; clDryloyi klrat~ arninn acids; ceprybyl pee emitto acids; oocodimonium teydro'qrpropyl wk amino eoida; cam auten aunlrw fib; c~sktr. ~ansc add:
plye~e:
hrdr keratin arn~v scads; amino ecid8 such as asparHr: add, threoninv. aatrhv, glutomio void, . sel~ilwl, c11s~1~. valhe, rrmHetananv, iso~~,~dfly levdw, tyroelne.
phsnylalonino, oyatoic add, lysine, nisUdJnei, arpin~l, Cystefn~. t~yptophen, dtnulline: ~inv;
silk aurora adds, whllt amino adds: and mbchmas thereof Suibhlw protins ~cludv Ihas1 polyrrsas chef have a long chvin, i.e3. at last about 10 oorbon stems. and a high nwlsrvllr wefpM, 1.1, at least ~otrt 100D, ~ art formed by ~If-candensatWOn of am~n0 adds. Notutxrluaive sxampivs of such prota~ns Include roll, dvoecyribonudvesv. iodised cam proteM; mWc prom; Mulewa; serum protein: silk:
sw~f almond protein; ~rvlawt perm pr0~t~In: wheat protein: alphme arui beta hdtx of kvn~ protobts;
hair pr~otens, such rue inte~rrr>vdiata fiarnvnt proteins, high-euffw proteins. ultras sigh-stHNr prvtotns, intermodilts it~emant-sssoci~rUrd proteins, ht~h-tyros~er proteJns.
high-plydno tyrosine prerlutn;. hloa~tyalln, and rrlixturss thereof.
~7csntples e! Buihable vitemtn~c nonoxdusivsly Indudv vibemin 8 c~nplex, irxludlnp thlarr~rts, ni~nio said, tiiartin, pantoUiernic eCid, choMna. ribo?lavlfl.
vitamin 8!!, u~min B1Z, pyridW a. hosllol, Camirlrrte: vitamins A,C,L7,P,K and their dawivstivvs wets as vitamin A

~p-ss?
paarr3ebo end pno~ritamins, c.g. (l.c. rrol (pro vit~r~n f83) end p.rNMnol trieow~s) and mi~cturea tt>ensof.
Exaa>plss of suitable sntll agae~r narrsaadu*hroiy bacitrs~ir~, erythrcrnydn. noomycirr, tetracycline, chla~tetracycline, banz~arium chloride.
Phanol, atb 3 muc~a~es tneroot.
fexunpivs of *u~s6ls skkr omo~fe~ and sloirr mvierronsxdusiwly krvluds rninr~ai o11, iandin, vegetable ofls, Isostnryl fsostetrats, glyoeryl laursts, msthyt Qlucsth-10, n~hyl ~1 t~. and mhrhrraa ih~f.
Exomplos of suitoblo hofr oortditktrrsrs nonexakrsivNy include qustsmizsd compounds such as tmtlonamldofxOpyl PG-ads, cncsfyimonkrm ddxbe.
dih~fro~rrated tenadosttr~A hydroylmonium uffsbs, and mbceuros t~of as woll as lipophilic compounds like ostyl eloohd, ateerryl doohol, hydrogenated poiydeoorre, and macaws >fte~p~:
M example of a suibbls heir softener noneoodusiwly induder silicone oompourrds, such de Ihtrrsr ur~rt rrrrr ~riliter rtorrwrlalihs ur vc~ld anc! thvW~ Ihet art's water svkrbre or webr' ~sduble. Examples of suitable sAiinclude apana.sub*ttdrbd pdyribxarr~, whkh are Wths~r 1)nsar or oydia polyrrtWS of monomsrio oilktonolaxypen monomoro and which nonexcluslwly hdrals onyl dknetttborte; amyl vlett~emmorNum WmetNICOrIS
Copolyol phthdata; cycacxnMhicrrrrrr; dhrAthkxurR eopolyol: dimethioone copolyd isc~sts; hydroly~d 10 soy proteirrldimothiporw oopolyol ooobtO; siNoono qulbmiurrr 13;
stlsrrikonhrm dimeefEhioone ~Ya~ ~atalse: stearaml4opropyl 0imsdllc~one; and mhcaxes .
Examples of suitable hs;r moisturizers nonexdus'rvely fndude panthenyl sAhyl sttrsr, phybsntrlol. end rr>bctt,rrea t!»fi.
Exsmples of sunscreen snanexdusively ben~oph~enonss, horn~orra, bvlyl Pa6a, cinnamfdoprnpyl irimsttry! ammonium ohkxide. dkodkurr distyrylbipherryl d~ulfortelei, pat~a, putax~lunr nrr~ltrwcyc~nnemate, ttulyl methoxydib~zoyln~etttane, oCCYI
methoxydnnamate, oxybenzone. aotor:rylene. octyi sali~sts. ~nylben~imWe'ab erdnOnic acid. ethyl hydroxypropyi aminoesnzoete, mmrthyl arrttrrarrttoto, ominobcttzoio sold, cinaocats, dlatltanolamlne methoxydrmsmate, plycBlyl amlnot)snzoetl. titarllUm dioxide. zinc 3t1 rnckle, Qxybenzone. padtrtatte O. red pdb~ofehrm, and mucfarres ther~sa~:
M exempla of a auitebis tenninp agent nonoxdushroly includes dihydroxysce~one.
Exe~es of sidn Ifphtening eg~lts ~nexdusiveiy include phone, cdachd and Its derivstiv~s, ssoorbk: add end fts derivatives. end mbtturss thereof.
Cxamplee of auilabls irraectlcfdea (including insect r'sptlUsrtts, snU-aua~lriras acrd rirntl 33 Ice treatments) naneoadusively Include perrrfsthrh, p~yn~thrin , pirwr~xryl tauboxkis.
imidedoprid, N,N-distityl toluarrrida, which r~sferc to the material oontahinp pn3damk~n~y the W

mete bonier, i.e., N,N.disthyl-rn.toluimida, yV111d111 adso krfown as DEFt';
oo~r~pounds of tho i~Dn11t11e III.
111.
Wherol~
R, is a brarrohed or unbnr~ohvd dicyl group having a6rout 1 to bout b aarbort atana;
R, ~ H, rtlsthyl or ethyl;
~nS a blanched or unbrsnched alkyl or N~qr group having t~rOm about 1 bo about 6 ocvbon atoms; and K b a -CN or a -COOK, ~. whbfei~l R, Is a tuand~ted or unt~ranvlkyl group hfrom shout 1 to 13 about 6 carbon atoms, nabuwl or vlic pynedxoids, whensby the nshud pynethroida aro oonw4wd in pyrstllrumv the eoc~d of the ground Ik~wms of Chlyemum c~rtev~arisenr f: setmr, ~d mbcttm~ ttlerept. Within the sbvch~ro of Fom~t,~ls III. are ethyl 3-(N-butylscvtarnidd)propiansts, wtR~ la a c1 h groerp, Rs is an r r~ulyl !stoup.
R, is ti. K is 2o coon, and R, is edhyl, HfilCh is avanaole corntnarcrslly from luencic KGaA
or Dsmnotodt, Ciernliny under the nwma. "Insact R~vll~t 3636 An lx~nplp of sn errtf fungal for hoot prepars~lo~ norraxc~rstvlly hen.
Examples of suitrrlrlrr depilsdnp agents rtonexdusiwly include fhiogiycdatv, mepnealum ~io9lyCOiate, pots~e~m thioglyaolat~r, strontium thiogiyoo~te, end mbcturas ZS th,raof Exarnplax of sultsble e~dvrTt81 snap and Inca! tho6cs nonao~cdusivsly mdudw t>Anzoeahe, d~uesfinv, banxyi akaohol, oarnp~r, eapssidn, ~rps~rm, CapsiCUm oleorosln, juniper tar, memhd, rrrtslhyl nICOthlel~l. methyl ialfllCytete.
phwnol. rQSOrcirrol, lurpentirte oU, aced mixwrso thereof.
3Q Exa~lvs of suitable antiperaplrenta end deodormrrls noNvely Inauds alurninnJrm ohlorohydratas, elurnMium zlrrxrtlum chloroAyarstss. and mbchm~
thvroof.
Examples of suitable countarinttsrnts nonexdusivviy include camphor, menthol, methyl oalkylata, Mt and dove ors, iG~tammol, and nd~c4rre~ the.

An ef~ItTlpls of a oultsdiR trr~mmrlrtbn inhibkor nonsxctuslwly ink hydrocortison:, Fragarts Vssoo, Motrioaria GhomomiUs, and t3alria OMcinalis.
Examples of suitaWd toidal producxs nonlrxdusively mdude the anestttaflat such as benmcainw, pramoxfns hydnxhlorido, and mixtunas thereof; and suoh es bsr>zvthonium ohlorido: amtrts sash as sins oxide, bismuth site, tam Pen ~, sod nrixturaec Itrenof; skin protec~ant8 such as coo ~IVSr dl. vepebblEe nit, and mixtures thwrwnt Most pbenefit ana~sxc~usivety trHCitrds DMAE, soy and aenvaflvss thanof, ooNoldat ostrrt~l. stm~,atad etr:afa nil, olive loot, slubiol, s.~1-pipwid'rryl~~,4 pyrimidfrrodisunins.3-oxide. flneObrido, kotooonosols, saiiayiio acid, ztno pyritl'tione, art tnr, benxoyl p~dder seisniunr sulfide. hydrooortlsonm, sulfur. rrtstltttol.
pt~rra~cinl nyGtoCttIoPide. tric~ertylmrmhrm chloride, polyquatvrntum 10, pa~s~wl, panftrortd trtaostate, vitamin A and derwotivos th~f, vitertrM O arid dsrivattvss tip, vltamltt C end derivatives thrr'dut, vitsmtn D and d~IIMIVIi fllar'BOt. VItitNn E and drrrithsrsodf, vimrrdrr K and derhratirras thereof, keratin, lysine. arpinlno, hydvrhsat proteins, hsilk proteins, octyl msttroxyrannarrtsts, oxylrr~rtxc~ns, rrll. tit~rtium dioad0e, drw dkutido, rethtd, erpxOnlycUrt. trBtinOin. area muct<xes thencf.
One pntforrsd type of bonsflt aunt ir~oiudoa thoooo thsrepsutic con>ponents that am offo~vs in the troatment of dandruff, sstxxrtrdk: derrrtatltls, ~tn0 prsoriasis 11 w111 as the symptoms assoCMtlad the. Exs;mplws of such sui#abis bsnaflts agsMs nono~oowrsivoly irrckrdo xinc pyrtttriono, anthralin, aholo oil and dsriyedvss thsraryf such atr erulfbr>ated shale oil, aelenkurl sulfide. sulfur, salicylic scid; coal tar, p0vldone-ipGlns, tmmch as KeooCOnatole. arcnlon>ptrtrrryl imidazolodioxalan, which is oomrtroroblly available lhom Janssan Phsrrrraoouttao. N.V., under the hlrdsname, 'EIubiGi', clvtrtmrsxole.
IGIt00~1Zds.
miconazolw, clhrrt»ols, tkxmnazote, suloatazole, butaconazole, fluconazois, mfconezols nitrate s~rui tray possible stlrso and derivativos thanr~ page olsmirre (Oa6opirox); solsnium sulfide; dolopiroot olaminrt; or rU~cxl~sla age11t1 lsuCh its vlttltt>Ir1 D
arrak~s, a.g. calClpotl'Id. calCitriol. al'Id tacateitrnl: vitamin A analogs such as esters of vitsmin A, o.g. vitamin A ppimftats, rotinoida, rotinole, and retMoic sold:
cafkxxstnroids such as hydrooorlisone, clobetasor>d, butyrate, clodstasol propionate a~ mbctt~re:
than~f.
The amount of banwtit a~tt to be combh>od with tha pwsond caro aom paskion or the srnuision may vary doponding up<rn, for example, the abUtly vi the benoflt spent to penetrate tluoupl r Qrn skin, hair or natl. the speci8t; spent e~oserr, the paxdcx~r ttenefrc aesrad, thw s~xtsitivlty of the user to the banNit agent, tha hsohh condition, ape, and skin, hsk. andlor trail condition of the war, and the lifer. h~ rsurn, tt»
benefit ipntt Is used in a 'safe and stiexaivm rdmvunt," whiCtl Is at1 amount ttfat to hfQtl encuph to deliver s doshwd skin, hair or narti b~sflt or to modify a certain oonditfon to ba trsetad, but is low enov~r to avoid asnoua nilde ei!lieds, ant a rr~sonabb risk to bandit relic v~tf~in the ataope of sovnll medket judgrrlont. Urns o6»rwiso exprsss~rd I larekl. typically the Dehi?It spent Is present in thafr pwa~wl cue canposlflron or perlonal Care system in wn amount, trasad upon the tobl waipht of the con~position/systsrn, from about 0.01 paroerat io shout 6.0 percexri, a~
S pretsroby from ataout 0.01 percent t0 alruul Z.0 psr>atrft, arl0 more pro~e~l0hr iron abort 0.01 pIr»nt DD ib0ut 1.U p1~11t.
DptforatllY. oorramY orrifa6to de~el~nt twaker>wre Illat aro wpel~ie d tllps~0 the epproprisis rbool~r ts~ corrdNonirrg corrlposltions are sv~bls 1br uaa in Ihk kr~ntbn. If use0. U1e decsrgarlt thbkenara should be pn~sant in 1ha oompo~ia~e in an amount svEldsnt Iv raise the Bro~oldtdd visoosKy d t1» oomposiitirm k~ a value d between abort 6017 t0 about 10,000 oerdTpobs. Examples d deler0lnt thi~laer~l~e nrxleocdusiwly ktcklde:
mono or hers of pn~hylana glycol of fomxrb 1V.
HO-(CI~1=CHsOI~H IV.
1 t is en ttnm ~ 8 to about zoo:
istty acids asxrtirlklg from about 16 t0 odour ~ cixtlon ohms: tfsfly sadd esisn cf ~
poly0ls; ell'fO~qrIatBd da~atHa~ of mono and diosbxs of taKy and giyo~kae;
ttydnoocyellqii oollados~ alkyl oobuloas; hydro~cy~lk~rl allqA o~ukrs~ and m~dtmos c1~10~ Morn spadllc~y.
aukarble drl~gtlnt thkeri 1'IOnexcJusIVlly alkt~nium ctrbrtde; ootyl slootfol, quaternusn-46, hydl~xyefhyl oolluloeo, cooodimoniaxn chide, polyy~temlumØ
Z0 t~olyqlratornium-~. qareternium-18, r!3-18 giycard al~dcoCOSle. a of e~ylateiJartesr~t-t10 a~aylate ~Olynur, latrneth.3 and propylene 9lyooi, vd~ioh b comr»on~a~tly eveNaWo Mom Goldsohmidt under the traderaenln "AntN y" a tr~c<errio of ooosrnidoprnpyibeteh~r and glyoe~A lltNSb vrfirGl is oommandaWy swibblo Pram Go101dtmidt unQlr the tradenarrw, "AntA HS80' a ~rre of propylene glycol, PEO
36, and propylor>o glycol , which is aorturlerdally arvauadle nom Odasdlml0t under the tnlldolwne, 'Anlll 4 t 4 lit~uid," imC mixtures nlen0?. Pr~e~errr~d liw~rgettt lhidc~ea hod p0lysltpAsfle glyod ~. rrnd men prafirably PEG-160 disboedo wMoh b ave~able ttvm the Sbepan Canpony of Nvrlhtleid, INkloisi w Gcxrl Comlsl, S.p.A. of Boloplte.
Italy under the trmdenanr~s, "PE3 00~ OS'.
'rhe abavw dasaibad pwsaaol oero oampoeabn and pl~oraorell wno sys6sm may be ~opanod by vanbinirrg the deeirad c~mpot>ents in a su6sble container end map 6rem under ambient ooncfitions m any oonvantkxaal mixing means wdl known M the art, :uch as a modernieally stirred prope~or. pod~e, end iho Nke.
in onother pnfimed anbodiment u! Um persvnel care sy6t~T1 Ot the prat inveMlon whr~rdin a polyrnerlC ururlsalrar reacts as, for Qxempb, poi giycol.3p dlpdyhydreseysbeararla (heneinaltor "PEG 90"j or dbnathloone copdynl, an uardd arid veer is JBp-s3~
used as ttta vnhide, an oiNn.arator emulsbn may be produosd. Ab~ofh the PEa 30 and dimeehioona oopolyoi ero mpii~strd for use ~ fiorWtk~g wal~rol aaimpositUOns. vw haw umaxpd~iy ioVnd that 0N-k1ellt'll~bns may 6e a~atwr! rW~ ix fhe pn0 GPs ~d ions omployad herds. hbrs apeaiHoefly, we I~OUr~d that when a s Ihbkoning agent, pn~ferably a hydrophliK: Ihidcen<no agent, h netted in the ny~Dp~ic phssa of trig pn»t tlon Canpa pnlyrfu~,eio emuisifiar prbr !o adding the IipophRio phas d the pnsvnt invention thorobo. the re'uhk~g ~nulsion Is In the hcxm of a watar'kroN
emulsion. Conversely, wlain a ihichenlr~ agent, pretarebN a hy~ro~hiBc ihidcaninp spent, is r~itt'ea m thrr hycirophUie phasQ of the pn~t irwar~tion oomprioing a poiyenerie emulaMer sflor fhe lipophilio phase of tho gravest invention is eckJdd to the hydrophllk W>aia. the resulting aernrtvion Is unly In the lbrm of a olhin-~ler emulsion.
Pen» care syshrrrr of tfx~ pe~eean! invention that arv arnuisions may eor~to~n. twared upon iha total weight of the o~on, from about 0.01 peroont to a<xxrl 2 pe~'wrtt, and pro~a~y from snarl 0.01 pert to at~It 0.5 paroent of trydrophilic Ihickanars.
Suitable i s neutt~lit~ers hduda any Imown t~a.as, such as .cd~m h'rdne~e, or oxide.
sash as bdlc sad, that aro ~a6~le of noubnol~ing the hydropt~lie thkle~~r~y sy t, ~mitixr the hydnoptIWIC prtase (if a wdsr-an -~A vmulsbn Is due) or a mmurw ref bath the hydrophilic pha~ ~d the lipephilie pie (if an oily emulsion is deekod) of the present hvwn~on to a pH
of snout 6 to at~rt 7 ur~rJsr ambient temperature. In and eenb~odkrafr~t, hydrppltllic tnidcanars il~rdinp acxylatallamlnoaCtylatas oopoNmar, acrylataolstearoth..ZO iboonate oopolymor, su~ylabssh~b~-ZO itaoonarte oopoiymor, aro preferably neutnliud wrih gun acid, xuch as ia~ia void. I hrdroph~k thiGcwnus hrcU,~dl~ carbomlr8, modllied hy0foxyaf~rlcallvica~e, pdyvinlHSCatsteJmaleie rmhydrfde (PVAIMA) docadiene orooopo~rmar, end aayls~ls-ZO meth~ylato oopolyn~er. are pre~EeraWy neru4etkerd with a tease.
such as sodium hydroxidrr (2016).
In one e~dtmant, the hydrophUk: may be eompW ad of one or moro vt the fnibwing components: water, ihiokener, otabiUiy enhenoer, song surtsct~rr~t, and water d4perslble campoi«it, end the IlpophalC DI'w~se rney I~ comprised of ana nr nxxa of tho followtnp Components: sllacanw, aster. and polyrr~ic emulsMer.
Wv have also s~ found that the p~sor~ai care compoaHion arKi pwsond care system of the p~vnt inwnliun pvssasses g0o0 I~d>~C Dn»I'd~ without rswrsinp any sIgnMCartt ocular disCOrrttort to the u~r and am parflul~ly suitable fa uao on ~e aroa sumovmdHg the eye. It b wolf-~nm in the art that most aryl having a rolldV~y bw molecular vr~l~t era irtitating re~r~0ks1 of their hydroph~lc It~anrw ('HI.B") va~ee.
33 How~ewa', vv! have surprt:mply tkxmd that whop the parson~d cue ayst~n o!
!he prosent invar~on is produood using the partkulsr tic r~nWlfiers andl or thkiclnlrs 9~

1a 1 Hh-537 herein, die rasultxrp rxxrrposiNon is gerrde end possesses a low degree c~
ocular and skin hrt~on.
Another embodiment of tl~ preertt b>wntlon Is daarsed to 1 rr~hod for a benefit aplnt onto the skin, hair and/w naUc oomprleod of applyirrQ either Ure adore-s descxtbad ps~rsonel wre system or personal can carrpvsitton wlel In et'IxdVe arrkxmt of benvtit spent be a dasher! Iocadon on a tuuratn or ar~r~sl. lNh~ the frequOnoy and ~x~nount of tAe b~etit a~nt~ontainlng personal ooro oomposiHonhystem to trri applied yl~t depend upon, fior example, the type and amount of benefit client availadle. the intandsd usage of the ihral vvrrrposttlon. i.e. therapeutic we$us malrdsnance nplmsn, the e<rrount arai type of deterpant pn~uent, and the sensitivi~r of the individud wet to iho oariporNiort/emulsion, tyPk~lly the benefit spent-contairrh~ personal Care CotltpositioNaya~tem of the pneeM
irrverretion sttouid be topically ~rppl(ed to aid body parts et regular intexvah, and prni~xl~blY from sbord ~ to about 14 ties per waek. More iNSl~aradly, the oompoaltianlemulsiorr is aped more frequently druinp HZe hHtal stapes of hoeerbnt, eg.
1 S from about 5 to about 7 Hrnes per weak until the decked e1t'ect is ad rirswd, alert less fmquQnily ~ rrraMtsnoneo is desired, e.g. trurn ebvut 2 t0 about b tlmas par weak.
We haw ~e~e~diy tbund ZAat the ataove.daaaibed perswtal ca» oomposltiaon and persorr8l care sysllm are crps~taie of altbierdly rnedfatir~p the depoeitbn and Irewrrteatbn of varinrr$ benefit sgentrs, woh os sntidandruff t~enta, onto and Into the skin following ZO topk~el administration thereto. More ipecMtaHIy, w have surprisingly fiound that when benefit epants an aanbinad with vliher ttw peroarrd oaro oomposilbn or tires p.rsattat Cero Rysterrr of the present invax>tiort, the amount of Irur uillt a~erss dlpositsa onto and/or into the skin, hidr, arr<Jlar naUs Is abmrt bU% pnat~er than the amount of b~roflt agents depasiissd onto arldlor tMo thA $kin, hairy andlor naii0 oRer eppikatton of lu~uwn, oorrrellirrdal benefit ZS aperrl'ooed~Nr~ Its.
An shrrtatlVe prey embn<ilment of the pnssent lnvantiat b dto a rn~tOd for treating heir loss, such se hair lees resulth~g from alopeda, cvmprlslnp Ny iho above-daeribsd perm cue 00mpo~KIONsysbm and the had loss benefit spent to a disked on an animal nr human, wherNn the benefit agent is ours ~ pre 30 a amount of a hair low treatment agent a~n:lmac minoxlCN or mlxturw therool. As aced herein, "heir law trrfatment " shall iru~mfe agents capable of grouting hair ar rd/vr fof pravantinp the lees of hdr. By "effaotivs amowrl," it la r1191t1t an 8motmt offectiw for treating hdr loss end prefm at~tY may range fiom. bpi upon the total weight oI
the personal wre system, ftom (bout O.fIfH percent to abouk 20 percent, and pr~ehw'~rWy prom 33 about 1 penamt to atsxrt 5 per'ceM.
~mrnplss of benefit agents suitable to tr~ep hair ~ Include, but an not limited to ppta~turn channel 0perlefs or 1 vasodilabus such as minaxidN, dlazuxide, aria )HP 537 asr~nds such as N~-ayeno-N-(bs~peMylrN'-3hty~uandini ('P-107") as dloalosed in tJnitsd Patent No.: 5,244.964. vi: Irreorporslsd hsxn~ by rofot~roe;
vltarnkrs, such ai vitamin F and vitamin C, and derivothroo then~ot such as vilrur~n E aceta0t and vibn~r C palmitste: homrones, rruah as ertMropoietut. proshglandins, such as pnosapisndkt CI bnd proiClg~na111 FZ-alpha: fatty sods, such as ahiio acid:
dYuradd such ai spironolacUOtre; tit shook proteins ('HSP"), s,roh as H3P Z7 end ti:sP T2:
Cak~um channN bloakaa, such ss~ verapamtl HGL, nltldiphe, trnd dm~orido;
immurruatuppnes8ant drugs, such rur rsydosporirr snd Fk-6~8; 6 olphe-retiur~ase inhlWtas such rrs tirrsstsride; growth ioctors ouch as, EOF, ItJf brtd Pt;~;
tfartsfotmtng growth factor bozo: tumor necroats fair: non-st~oN~ anti-wttlar~rrramry alts such :as beno~caprofen;
rotkrolds sWCh aS t~Ittnoln: eyfiokines, such ~ IL.6, iL~ 1 olphe, ernd IL-1 beta, rill sdhesbn molecules such as ICfiNI; gluooncortlcdds such as betarnlttrsone; ~anical wx~s~ts such as ales, slow, gir~rrrg, rvtWrtannls, swrettia, sweet orrrerpw, zur4roocytum.
Serenoo aspens (saw paltTtetto). Hypoxis ra~rErri. st4rging nettle, pumpWn seeds. and rye pulidrr:
ether Dotsrtkml exbacls inaludtng sandiewood, red trddt root, rWNyNtnherntun. t osamsrry, burdock root and other hair grcrwtfr protri0~r aft?Naton which are disdosed in DE d3305AT whid~
is ktccup0fated by ice in its entirety herein; harreopathk: iUtri as Ka~m Phosphorioum DZ, Aaadkw~i~li indk:a t72, and JoDOrandi DI; pet>es for cyrokinas, growth isctors, and malahddrr~eat gds such as ketoaonsaols estd elubiol;
antibiMk;s such as sbiptamyoin; proms hrhibitors s~ctt as cydottexitnkfe:
acab~ZOlsmide:
bonoxapro~lsn; corttaorre; dutlazem: nt~obea~erfe; hyrlyattoin; nifedipine;
penloWlamine:
plrrsralhalaaJrtis: Prnaaidil: Ptm~ens, vsrsapsmil; sldovudino: dphs-glucosylat~rd rutirt having at least ono of the flolkrwkig rrdins: qusrrxtkt, isoquendtrkl. hsspeddin, naringin, and mettry~espertdirl, and tlavorloids ins tran~iycrxaiditad deriwtNes dx~f whirl, sro an 2S dIn JP 7009577, which is inoorpomtod by ro~nOe in its entirety herein:
rrnrt mbrhrrws fheroof.
Pry hall' loss t!'llNtsM aparris ire r~nooddW. 8 (i-Pr2.4-Pl~Winedhmtn~3.oacide, N'-cyano-N-ItyINd'-3-pyrkJktyl-gttel'lidlne. hnas, nWnoida and demradvvs arrirnof, ketotxlflaZOle. olubiol or mixtures thereof.
Anotnlr amOOdhnent crf the prssQnt inver>tion is dkoobd to s method for inhlbldnp rutir pr~oMrth oomarishg topically applyf<y n» aoovs-descrttred p~on.l care compositbNsystem r~xnblned With a benltlt spent tn a deafred anaa on an onimel or human far InhIDIdnQ haW" growth, wherein the benefit agent is comprised of em efhctive amount of a hair gnwlh Inhibking agent, In a pr~rfrrrrexi emb~imlnt. thp persorrel ere system conlaino, hosed upon ~a lQttl weltltlt of tt» Deraorral pare ~oeitbn<eyotom, from about 0.~1 percent t0 about 20 perrant, end preferably from obout 0.01 pen~ent lu about !i pir~oertt hair t.

Examples of bsMfit amts su~~rbts for usd irr ktdnp haft prowdl Ihdtldl: swine prataasse such as trypein: vitamins suds as alpha-taxpttwnal (vitarrUn E) srrd derivatives thereof such s~ tocophend its and tooophonol palmita6s; andnca~slio spenis, such as do~orsrb~in, cydophaepharnide, chlanrotlrMv, ntsthotrexeEe. fluorouradl, vinCrrstkte.
3 daunoruDldll. bleomyan and hydroxyrarbamidw; anticoaQulanb, such se hspartn, heparir>oids, coumasrins, dotran and indondtonos: antithyrdd drubs, such as iodine, thiouracila and c~ubkrrvcvle: lithium and Ilthltun carbonate: inl~MhOns, such are mterieron alpha, Intl~ron alpha-2a anti interrferon taipha-?b: nrtina~rds, such ~ rethd (vihomin A), isotreNnoin: gluoooortiooids such as betan~Uu~ccmv. and dax~th0sone:
rtuuWryptrritptda~rrt~ drul~i. st~h as dip~an01 and dof~e: thaNium; mwrcxrry:
alhsr>dazols:
aNopurirtol: ernkxi: amphetamirrsa; andraQona: tmamcoriptino: butyra~phenanos;
caebarr>azspine; d'rolsrstyrarnin~: cimstidiras; r~af~rabte; danaml: des~al~:
dbeyraZine:
athambuoa~; edMtamide: ftuoDC~tte: 0~~~, t1~ : hydantoins: lbuprvhrn:
impramine; immunIMs; indandlonae; indomatheaM; Intnvconamle; ivvadopa;
1 S rr>apnodlhe; methysr~y&Jd; rnvtoprobl; rrtetyrapons: nadoloi: rl~IntC
acid:
thio~~ranate: propranolol: pyridrrstimine: sdbcybtss: sultaaaaazlns:
ter~nadins;
thtamphsniool: thiouraoifs: trimethadiorro: tropansnd; vaiproic add; and mixtw'ss li~vf.
~r erfrirrvd hair groMrdt Inhibitory e~eNlis Ittc~rde serene pmteeses, ra2inol, rsQa'sdndn, betafrtsthroisonw, rrl f~hstooop~nol end dsrivatwes thereof, or mbctwos thereof.
Ar>oihor prafemed embod~nt d' the pr~s~rrrt ~rvention is dlnEx~ to a frllthad tbr tr~rling acrts and for redudng the sKlnt of ~inp. Le. wrinkly. fine liras, and other manifrastalians of photodamage, comprishg topiceuly appiyinp tho e~bove-desodbed pwsonal oars oamposidoNsrscem and then relevt'urt bvrrefit went to the skin of an enlmd or human st a d~U~eO aria, Wheteltl th1 benefit apart ire nnmp~ of sin efhelive amount of an anti 15 acre agent or an snti~aplnp apart, rwpeotivoly.
Exarr~p~os of suilralnv anti-aplrrg agerltt Include, but are red Ilmhed try irrorpanic sunscreens suds as titanium dioxkia ~rnd zinc oxide: organic sunsorssns auoh as ootyl-meThoxy dnnarrrates end derivoti,ros thereof; rotirtvids; vitamins such as vtlbrrrirt E, vhmal A, vit~rnrin G, vitamkt D, an0 derivatives tf~reot such ac vitamin F , vitsimin C
palmitate, and thw Itke; antioxkiants including bore carotene, dpha hydrmcy colds such as glyoa~ic acid, citric mid, lactic acid, rrralk; add, mandelic add, as~bic sdd.
alphs-hydroxybutyrlc add, alpha-hyGfoxyisobutyric acid, satpha.hydroroic add.
~rt<roloodc xiri, alpha-hydroxyisovalsric add, ethyl pyruvoto. fc acid, fllucohsptorrk:
add, glucoheptono i,~t-lactonv, gtuwrrk: add, gluconolBCtone, plucuronic cad, gluananolr~cttane.
plycollc add, isopropyl Dyruvate, methyl pyre rvaM. Music acid, pyruvic sdd, saoohmlo ao~, rra~tar~ acid 1,4.Ixlone, tartaric add, and tartrvnEo acid; belie hydroxy acids such tar bvtr hydrox~rbutyrte acirJ, Lnrta-ptronyl-lactic aGO, b~ta-phenytpyNVtC acid; ical Rxtr~e~s such as praerrt tile. lGy. mllK thisflr. . W angalioa, b~ 0rattgm, Cd~l, p0idtllflad.
U. . honoyauoWe, Jo~b'a tsars, iith~IrUfum. lriu. Peony. Pu~~ nioo.
eofllower, and mbdw~r It>stea~t.
F~Ilhnbd g agsnta k~dudo , antf-oockltrnts, ~t>s-hy0taaxl~ adds and bebl-hydroxy add v~ith round snd tnllrwin bsitt0 most pr:terrad.
9uitabia atttourtts Of antt~apin0 atpenb induda, based upon !he bola! ~ruhht of the deitxibed pwrsonsl can coenpbsltfoNaysterrr, from ahwrt 0.01 psrcalt to a6nrd 10 psrosrtt, and pnrtarabty from about 0.04 Irarcsrtt to adotlt 5 petcsnt.
E~warph~ of suitlblw anti-eats agents indtrde, but are rat Nrnibd to tai na»ds (tnli~in, isotra~oin, rr>orrodnide, adapilar~a, t~u~ota~. amlaic acid, ratinoi); salicyi~ odd;
beruoyi parc~ide; ri; antibiOtfCS such ss tetracydlna and isomers urarriof, eryUuotrnfdtl, and thA snWnitammatory agenb such iw ilrruptvfixt, ~apr0~r~
hrtprofen:
lx~Mrrical axtrsots ovate es atnus, arrrita, >I~rtisl~ , ssiosana~n root, bir~ir.
aolo~rle. d»norrrlle, cT1i011,1m, 00rntray, fennel, galls ~. hswthom, Ircsrlriryrtis, hypartGttn, jWubw. khwi, Ikoriov, mogftdts, dire..p~rmMt. phffodarxlron, sahris. s~
dbo.ntarginalo; imldazolsa such al keto00rts~ols and alubbi, and those desorlbad in OolMick, H at al. f 96(1) DertTtetdopy i~bac~ous Glands, Hone end Related Olsorderi. 171i-15~ (l9Wi~. which is inceeporatod by reference tin, ana rrtbcurrel thsnnf.
Proferrod ~i-acn~r age Irtdude blnzoyl pwnoadde. ratirtol. eiublol, errsbicrtics, and salicylic: acid, wldt ntktol and iroHr~ b~ m00# prsfe~rrad.
Quitabls amour! of ans-acne agents tndude, t~e0 uptm t!hw !alai vwipht of the dasoribod paraond card systltn, from about 0.01 percent to about t0 penosryt, and prtlarably ftOftt about 0.(14 pen»nt to about 6 peroecrt.
Anott~r preferred embodirrwru of the pfasent ttwerttiton is dinx~d to a ntsfhod for ~S dog iha skin, oomprisittg toPicaliY p to skin at a desired area the above-dperraonal can compovibon or systenrr and an effective amount of the dapipmenkrdon benefit agent. Suitable efilcdve amounts of depigmantation agents Inoludw, based upon Urer total weight 0t the dasrxibed personal ooro syaterrr, from about 0.09 t t0 ~bou! 1 t1 percent, and prefsrobly from abpul 0.04 pamet'1t to aDOut 5 parcwnt.
~D f~mmmplss of suttabld doplpnfsl~ItenOn aperdrs induds. but arcs not lirr~ed to soy imd derhrt~pp~. r~nakis such as rr!lnd; Itojic scid and itmr derlVnives such as, f~
e~rtlMs, kojic dipa<mitotp; hydroquinorie and it ae~vat~lis such ac arbutin;
transaxsmic add; vimrnins such eat niacin, vitstrnn C ancf Its dariwtiv~c; azolaic add;
plara~ia; liCOrke;
axtratxs such as eh~momila end graon toe, and mtxtur a~ ItWOf, with nltinol.
Knjic acid, and 35 hydroquinans, being prefen~sd.
M alterrtaltve pt~eferted ~nbodiment of the pn~nt ~lven~ion is directed to a twos for tr~asttr,~ the symptoms andlor the diaeasets or a>Andrufl.
ssborri>teie dsrma3iUs i2 JHP-53?
arrdlor , M51 ~P~Y ePP~9 ~ sb~vrr-d~Did pl~a1 scan composi~on or oyotmm end the relevant benetlt agent to a loo desired wherein ~
benefit agent is cxrmpriseQ of an etMc~lve s~rr~puM of a d~druff ant agent, a selxarll~Ic derttlatl~ trw~lment agent, or a p~ooeissis tr~stm~t t, respeteirely. I~ urend herein, ~C~f~dfV~f t~bYtlnt ~lflt,"'t~tlprThelC 01f1~it~lS VeBt~nellt alt," 0i ~
"p~0~1s1i ~IIINt agent," rvspecdvelY. stllll includes agents apabla of trootinp the s~r~ans and/or the dies of dendrufit, sobormefc dsnr~ptitie, and ifs, rlfpeCslveiy. By "si~iw amount " it is meant an amount stfaahre for Mw~p rtes dheese and/or the symptOrns assodeled therawsh end may range irom, t1 upon the total w~ei0ht of the 111 panroetll cans oar>pQeitlon or sysbsiti, from at>oVt O.OU1 pet~cent M
t~bout t0 pen~snt, end prer 1bm atrout 0.01 percent to aboVt 5 Exarrof bansf9t agents auit.ble la tip symp~ and/or ~ dues of dancpuff, aoborrheic denrtetlits andpx peoriests, resp~isel~r.
nonmodusiw~ly k>dud.
those oral Iwth ettoVe with el'lale oW and darivatiwe thereof, afubid, ic~xone~a~, coal tlr.
13 sali<:yfk smid, zhc pyrNhfone, ootsni~m sul110e, hyclns;atlsate. sulN~.
me~~l. prar~dno hydroohloridl, snd mid ltd belnQ peraWlarly prrfr~ed-The cahpaaltipne of the ant may bo direotsd applied Wr the slat or mry be applied or>bo other delivory implerr>enta sub ms dry or wet wipes, aponpaa.
tuustua, and Iho silo by means lawn it iha art. The oompeslibns mny ba used in ~eignad to be tell 20 cxr the sicln. wiped 'from the skin, or rinsed off of the skin.
Tlra hwnHon Wudadoaed harekl W~eOhl may ba prad~d in the abtaroe d air c~on~pOnent, ingredient, or step wtdd~ is not speal~tly dbobaed . Several eot~r>pies ans ewt forth below to terrlhor il~nats the netu~u of tfte kvendon and t!>rt rrw'mw of arryb~g tt out. , the invmUort should not Im Catsiderwci as being lirr~i6sd to the detaws fr.'xA
~"Lip,fi~sE;
20 g of tpairra~e, ava~ble from graoks Irxhrstrtes, under the traderwtrrs "l.rxonste OP,' 2x1 g d isoncx~yl ituonananoab, o~o~rle fi~om Akoo, k e:.
under the tradsrtame, "Wiakenol 161; ZO g of ooiyl oa~enoete, avaifa~ 1bm !~n00ks Inaurehie~s, undair the trodonorr~e "~orenebs CIO," 20 g oT p~fttlery~oi tetrarx:tanoam aveilabie li~om Brooks IndusLtrac, un0lr the tradeiwne 'Loransbe P'r,~ and Z0 ~ of oydomethioone availeGle ft~om t7o~w tominp tmcl~
the tradrr~arno. "Dow 34G FlukJ were c~mbirasd into a place beaker at a tsmponture of 2G 'C
and ~cUrtsd ursll homogeneau.

Into a peirr>.ry glass beaker rininp tiA6.7 p df dsbnizsd water. 6 g oif oarhomer sale item H.F. a0oarich. hc:, under iho tradae~rr~s, "Carbopol Ultrs~' watr d1a<1to whir stlnirrg at a tcmpereturo of 25 'C unto HomopaltOUS. Into s bssiker was added 7.8 g, of saxx~s o~oooate tmm Cncda. Inc. urrder flro bad~rirr~e, "Crodaaia SL-40;
7.b p. of PEG ..~'i CaprkJapfylb gbroorfda~ avraileble itnro Ctnda. Inc. under the tradrnanta, 'Olyamravc ~e"J,' 10 g of hexyhts piyood. 3 p. of rtrett~riparrbsn and 0.5 g of p~ylpa~r with hand stirrlnp unpl trottlogettaars to produce a pro-m6ehu~o. Tire prod w~ Aten a0ded to the primary ~ be~or wish oo~ns~rrt etirrkrg uMA the rastrldnp n~eturw was hornogMaous.
AIt<K the lf.8 p. of r~ 209G aqur~ sokrtlon of sodi~r haydroxide was iced t0 tire trydtaph~ic phases wish oorrsren! atkrirrg st 26'C until homoplneoua, the ~pt~fe phase was added the~o with st~rinp at a t.mporaturo o! HIS °C. Ths rowlNrrg rrtirC4rr~ w~ Iflln mi>aa0 for ! 5 15 minutes.
pp~dl~oaodiI~~EG~Ia~

11 g of P~G3p dipdyhyJrwcys~era~. avatllWa fiam Uniqerna, irro. rxrdor the traderhnre "Ar~rawt t~-135." 50 0 of ~ott~yyl ~eanonar>oalr. availoble teem N~oo, N'ic. urrdat' the ~densne. 'Vlnckersrt 151 " and 50 ~ of a rrr~c4rr~e of heoryldacyl trsntroace urri brutybct~
banmaibsw ovailsble from C.P. t~Wl Cotnpsrty Under thw tradonama, wia~r I1B"
wero cxrrnbktsd wl0t vpn~notrs mhdnp in a ves~l and he~sbod to a tsanparaturo ~
4b'i: urrdl horno~noous. After the rnirdttm was ooo~d to s tempar~hrro ~ Z5 °C, 60 g of ayolonadlrkorhr ava~We from Dow Coming under the tradonaKne, "t7ow 3~t4 Fluid" aru! 6.A p o1 a macWne ~
vit~in A a~Ohc~ and poiysor4ale 20 in a 1:1 waigtrt ratio W~lne atldad t~raio w~h con~nuous mixing under an Arg<xr blanket errd under ydinw eight into a glass corttainkrg a ~xop~r stkrsr Whit rtotrtopanaous. IW subsequwrt prooadt~s whir this NpophUk phtroe v~rrre cxxMfudsd under tfre~oo oonditfons o~t ~u~ur ~ blanket snd ysllcrw light urdil the formufstion is pteoad hbo w wc~tgen and light impermWartrle conbsinw.
IMo a p~r>ory gha basher o~rrlairttnp TAtf p of 0alprltzed . nih~n wss budb~d th~roin unto the sulr~a4uenc a0dttion of the iipoph~ phase ~Or~o so as to ~rtirr~ lure t0 0tqlgen. 5 p of PEa-8 capryl~ooprio available front Triv~tt Ine. under the j~3p.537 tredefW~ls. "Trsraw~ BW" wss than added t~erobo wllh sthinp at 23'C unlw httrtt0pet11aNS. t-0<
alaNnp in d~pa~on d the in the fiDmtulatbll. 4 p d cettxx~rc foam B.F.
tloodric.~ti, 1~. under fife trsdenanw. 'Carbopot ll~v~' waro added bo 30 g of d~t~ylisoeorbi~ oval~bts from Uniqarna, Inc. under' Uses tnadanaml, 'AAhdre OMI" tn s saporabo bs~er wl~ hand mllntng. N><o ~ dkneS'pNi~orbidw mixhm was than added 2 g. of nssltrylp~aibell and 1 p of propylpsroben with hand sip unto homogeneous to ~xaducs a pro.rrtixSrro. The p~n~bauro wss then added to tt~ p~kraay beeklr w1~ cans~nt sikrirp unl~ the Irilxlurm tHl6 h0T0penS0US.
The IlpcptiAiv phea~r was then eDMd ~ the hylk: phas with eenstant atlfrinp ~ 25"C unto eous. 2 g of trolomina a~ lho~nn U«bn Ges0i4~ un0e~ the tradenarM~ 'Trolamine 98%' was V mn idd80 ~o the mtxhm with stirrh~p uMN
homogerrovus. The float amulsan ~ntains the componrnto as sst l~rth in Table E:

I~la~:..Emui~ka~r~rt~~uc~
Cthwniaa! ~ Trade Nrone ~

i'ECiaO ~polyhycaoaqlsti~tArlacal P~ . 1.1 ~~

Isononyl 110nonanoalsWidosnd 5.0 r~onaecyt e~n~re t~um~ Ae ao Gy~dorr~elhioc~r~o Dvur s141~II~t s.tf -VJHmin A akx~iwl and lZebrbl O.dR

Wafer W~ ~.8,t Clrbomer' Corbopal II~SZ 0~0 dp~y~o~aprio gttyooridesTriverad DW p.5i0 b - -M M
th i l pore effhl en pertl0sn e y p:10 olmetrtyi i~aa~de pMl 3.0 _ _ - --Trietharlofamina Tr~arNne g9% 0.2 2' 11 p of PEG~O dipolyhydrorcystesrate. ava~We fholll lJrtpema. Inc: t,rnder iha tradanama "Arisoel P-135, 30 g of Isono~yl ic0nanano~yble from Abw, Ino. under the trv, "Vend 151 " and ~0 p of a of hexyldecyl bvr~astvs and buprloCprl Darocaaie, afrom C.~. Hall Coy y under the Mme, "Hal~tar AO" ware ownbtned kt a vdssd wtdl mbcxlq end heated to a teertperatwe o~ 45 °C
unit hornc~neou~.
Attar the riding Was cooled to s tan~tre or 26°c.:, ;i0 p of eydarrtethioone ewdabie from Otnnr Coming u0der U~a trs~clenan~, "Dew 344 acid' and 0.9 g of a mi>dtns of vllam~l A aloohnl end pdysorbate ZO in a 1:1 weight ratio ware addod lhereoo with ao~c~th~
mbdn8 under an Ark biaMaet arid wider yellONV ilpM rnln w Olets bedurr ooe~irp a propel~-st6ror wrlil homq'tlal~Ui. A~ at~e~gqu~rt procedurre wiltr thin lipoph0ic phew w~ss t:0ndut3ld undlr thw cnndillaons of argon 6bnket and ye~ow ilal~t urttll the ~ormNls~on is load Into an oxypOn end Ifght impair ~ ~bla mntalrter.
is kvtn a prlrnary pisso boaloer oorda~hirp 563.2 g of dei0niz~ad wMar. nitrogen was bubbled thorein in orc~r tG eliminate dnoqrawn aont~ned thanrk~. The nitrngwy ca W wed to Des b~bled therein untal the subir~ra~t ed~n of the Npvph~lc phfse thereto. !t Z0 p of PEt~-8 caprylieloaprio plyoerides awdlsWe itom Ttivertt Inc. urxiwr thQ thdanarno, 'T~osd OW eras Ordn adt>ed Ihe~eto with stkrktp et Z5'C untl! hp~lo~eneoua.
For ddhp h1 d~pe~n ef the thiCkaner &~ tho forrrwialion, 4 y of ambdner svar~bfe firm B.F.
Goodrloh, Ino, undor the tradenarr~e, "Catb~pol Ulr~' were addart to 10 p of M
Isopropyl citrate avail~le from P~tra~enbc Ct>Bnucd Company under tho bbdename, "PELEMOL TtPC" rrt a swparats 25 baskwr w~h bond sbirra~. Into the tri~pnap)A C~'~e mixture was than added 2 a. of mothytperaben antJ t g of pr0p~ptl~eu~ with hwid sderir~ uMp hoenoponeous to Nrc~duce a prd-rnixttxe. Th~ pn~-mixtures Was then added 1o the prkru~ plpss ~Ilcer With OOrlstant etkrkrg unW the rosufting mixture was homog~un~ous.
30 ~tion 2 g 0t tristlvmc~mir~ avaibbie Irom Unbn C~erbida under the ff~Irtama, "'1'roiarr~
~°JG" was then added to ihta hydnoptHItC pheae with constant stl~ et 2,~~'C urtsi>
hon~i. 1 ne rosulHnp mlxd.ira was thorn added to the IrNc~rrrMc pta~ at oonatwnt terrlperetura with stirring until hornoper~eoua. l1 ~a Md emultiion s the eompononts is 35 set forth tn Table F:

.I HY-537 Digibl imog~ of the rlaht situ and the left stile of a Catitataiwn woman's f~
wao taken usirp a distal a~Iwble from Fujix (Mod,l No.: DCti 6G6) equlppsd with a t10 mm mscm Irons under strobe light conditions at F8 and 1/125 seoorKls. Tn1 camera lens w~ i9lt~nd with a CG-39G fifty, and tla3 s~be lipnt :dmae roes fNMf~d with a oombhotion of a UO-11 filter and a KO-b fester. Thnaw imams are itluatn~tsd in FIC. 1(a) and 113. t(b).
rew~u~iveiy-After appr~dmahrly 0.09 grams of then 0.3% retied formulatbri prepared in Exempla 1o w~ apPll~ to aboert a 20 a~ site on the suborb9sl (oheak) area of the rlptlt sly al'td the left side of the women's faoa, digital irnaq,~ were taken thereof tinder the above condltiono as iUumtrated in fIG.. 1 (C) and t-IG. t (d), raspeaivaly. Using PHOTOSI IOP
software evasaCile from Adobe Inc., thw digital image of each sitar was ~inelyZld for averapw nixal intrnsiiy or luminosity. luminosity, al used tfarain. is en indicatinri ni<
bri~tnass of a ~iwn area ss measuidd on a scale of 1 to 266. wh~in the isttor Is the moat lumin~cant. U~in~
en1 0.3% nHnd o~c~antratbn v~uo, the plied f~snsily cfiart0e, as deteftriined by the T~le !~: t~mu~~

d~nnA fn pbcsl intensity between !ho baoc surfsoe and the b~aartsd uurtace, ibr both th1 right side and aft side or Ilro face was pkaOeQ as a lion thereof rnr Nfusiratsd In FIG. Z (a).
The fiocttxrlatiort woo then rinsed fnorn the riBM side of Ure face, an0 a digital kt>wge was taken of the sfte unrlrs' the above oondltiorts as diWtt'~ated in FIG.
1(e). The finrenulstbrr was than wiped tw~CS uslnp a Kimwipe tissue ~nraNable from Kimberly Clark from the left aide of the face, and rr dtglW Imago wan taken of Urn write under area above Conditlorts as illustrated h FIO. 1(~. The pDcel intensity ctl~pe for the rirrrund right side and the loft side ovate rrMttsd on the graph of FIG. 2(0), ~ the resplapo~silrd radnol oonoontrotlons waro inbrpolated titer afrom to be 0.144% and 0.196, Ibspacfivaiyr.
Thla lxilmpls stfatAlld that thm farmrstriion of the present Mveniion olhodvehl deposits acNvs spenar, srust oo rodnol, onto !he sWn. A si~nilk:ant arrrourn of the apentt ron~hsd on the skin e~fber U rd torrrxrlatlon wits removed therefrom.
Me>ranver, this Example hiphlbhtisd tltlt when tale pal rarn composition of the present invention oattains a 0.396 rstirrol active went, it deposited the acme en>our d vi retinol on the akin a1 a leave.art product cartakranp 0.14496 retstot tWhen the car>>pOSiHorrs wr~s ntmncvvd via with v~rl arid a leave-on prexhrct oontatrring a 0.196 r~inol (when the oomposiHorr was rwrwved via wiping).
ThQ proosd<r~s set forth in E~asmplo 4 was na~p~atdd using ms feottnuletiort at Exarttpis 3 instead of that of exempla 2. The pr1-tr6at~rflent irtrsp~ are iNustratsd in FIO.
1 (a) and FIC3. 1 (b). r~aspaedlveiy.
The formufa0on~ocntslnin8 irrtepes are INustrstrxi in FIG. 1(t:) (right slQa) and FIG. 1 (d) (left sloe). Usby the 0.396 retinol concentnrtinn value, tfrs pixel intensity ohanpe for tM
treated ripM xirie artd IQit side of the twee was plowed ea a It~dvt ~
Nluacfstld ~
FIO. Z (d).
Tire ~Cd htape of the wrartrr~d sits is illustrsted in FI4. 1(a), artd i~
irns~ps of tfte w~wrf side is illustrated in FIG, 1 (f). The pixel intensely ahangs fur the rtnseQ rlphrt side and the wiped Mft stds was plotter) un the graph M FIG. 2(b). theft the rwspecdvr!
deposited redttoi Conoerrtratrons were interpolated theretro~m to be 0.156% and 0.072%, nosy.
This Gxrarrtple ohowed that the formulation of Use presCnt it>tvention eitertitrely deposited amts, such se rldnol. onto thv skin. Thasree r0ents rerrrained present on the sK~f afar the fcrmuwss removed there~Om. Moreover, Ihis Exarrrp~
hiphllOtted thae wtrorr the peroonol oars oorrrpostdan of drew presarrt Invst~rti0n ooMas'11d a 0.396 rwHnol native agent, tire r~rrrrWoaltlort det70stted the semrr amount of ro~ol on the skin as s leawe-on product cnnlainin0 0.13596 retinol (when the oomposiilons was n~rrroveuJ
via rlrtaktg wNh 2~

11~P-537 wteder) ana a Lanrro-or, pmducc vcnnt~mir>D a o.o729G nlinoi (when the cartposUl~l was narrroved via wi~rfn~).
f~pi~p~,~eHiic Phase:
p of rrblor~2 eve~te firm Clnkilirttil under' the to "Brij 'Tx', tL0 p rf bc,-2o siso avaabis anm uniqacrw urn th. trodsn.Kne -Arlaea~ro 200", ~o ~. d fsonalyt bano~W cola aveie~e from Afro. Ma, urttler' ~fle tlfdenr~rrre'Widrenol 161', 10 0. d lei paknNsh awUeble Phony dtodcs Irldustrias War ~ bwdonetrrle totrmde OP', 1 V p 10 of oetyi oo~rro~s, avafiom Brooks ~tclustiies, under the lradarlaml 'Zorocrdrr CIO' 1Q
p of Vrmta~ythntd tetraodanoebc else ava~a from Brooks ice. the keden~rya 'Lc><onabs f~1'," and 10 p of cycaatrrsdllDOr>, awi~le firm Dew Coming urrdrrr the trado~t~rre, 'Dow 345 fkkridd" wens oomdirra~d krtv a shoo b~loer at a termpatauxr art SO
°C sod stirred unfit 1 s ~,~,o:
002.6 a of 4aionaact waver won woi0tled kliao a prlrrlvy bwalaK and hemrbod to y0-82°C. WitEr ant epibnon. 4 a d PVMIMA uac~tdien. crosepor~,ma~r araUtyWe ltan ISf~' under the trarirnaml. 'Stall" was eddod ttlarrrbv and tlaki at 78~AxC urrlli nOrr>oparrous. Thk rr>ktrxe was th~xt cooks ~0 40-5~°C, du~tg which dole, 1 0. d dl~OdIt~ITI
2o EDTA, 1o Q. d t»cylarle Opecol, 7.5 p. of P~o-i capryilrha~prisr flly~ffdes r~obt from Ctuda, lnG. urldsr the tradenerrlo, "Giy~wc 70T. and 10 p. of P6G~160 pentasryfM~tyl tetrss~erals dso afrom Grod1 undirr life b~adansrrre, "Cro~c L.fcpt(d,- wet~1 added to the prtrnery haaiCer vwdl rUrttrlp.
25 dVfierr both this iv: ptrasa aria tile hydrophUic phase wero ei a tsmplrr~tire d' 40'C -60~C, If rer Ip~oi~iC phase was added bo the hydro~~c phase wlltt ath~inp. In a separ~ tres~r. 90 p. of Z-(~me~tlykxrdno) l3harlol. svadabf! from f3A6F
tu~aler Ure traalmi~rlls oMAE, oral t~ ~. d Layr~osyte svl~M from I~r~noto under the trad~t~rrs 'L
Tyrr>siM" ~
to i00 ~. nt wamr, and nr~ted until tnorrropeflous. This c was thon added ~
the 3o prinrrAry f>Wlcer with oonatarlt stkrlng. 1v 0 of Nybn.la ava~Obb from Kflt~a . Mc., undor the tradw»xrre 'SN-10'. ~ p of mlo ctvaUaek fr um luZnnIC Amsti~ ut~dan the b adenarne. "1111bxlsar Talc 06", 1 v g of ai111xxts quiDernlum-i ~ available !torn Biosii N
wxier the tradertorrts, "BiosA Desks SPQ." end 10 ~trvs of a ph~sno~dnetl tarrol, nllAhytparafern, bulytperabert, eUtylpar~l end prapylparabon so(uliat arreHeDls tmm NNpa undor the 35 trsdarlams 'Phxtonip" were added se~uately to the prirrray beaker wlltt vonaterlt atirrinp. Ttte ~r-s3~
erklre mixtru~e wn i~r4d to a pH af'7.0-7.G vvitlt a 7~0% a4tJ~us ~0hrbon of plyooUe add, ind horrtoaertPaod frx 2 at nredkxll piwll~ wkll a Lill~xd-lNooct homogent~.
After aDa~rt 1 rN m about 10 ml of 1ho raeuldrrg i~nmlatiaW appNlO to the fadt~l skin of c~rrnsurrwrs. tho oortaturrera percatve Drat their flfidal skill appenrr:
and hale flrrrra r~
liRod Example T: P~arat~n of i~N In Wi~rler Furry p~ta~fism.plL~i~:
into a pr~rary glass boonfohkrp 830.70 g or Jeriont~o watef: top of Collddal Oat Flora wiUebw from ccr~ vras sorted a,ent~ watr sUnirrp it 2ac unaW
rrarroper rebus, rr<rroolh skNly w8s a~v~ 2.5 g. of A~oeyle~C40,90 Nic~rl Aaytelv Grosdpolyltlar svrrUable tr'dn A.F GoodrNdl, Ino. urrdor the trade~rwrrua, "~rtlull~e'I Thc-Y rxut 2.5 g. of Carbomer, t~lso avoilabia Chain B.F. Oovdltch, Inc. Under lira hrutlertartu "Cirbopol l8trsx"
were V text adf» IA
lire pllnltriy beaker and mh~aed with siowr agiisl9on unH homu0rtnara. IrltD s 6e!NaK
was sddsd 7.b g. of suanoee ooaoata aveplDia iham Groda, Mc. tmdar ttrn teadrxrama, "ce~odesta aL~IO; T.S p. of 1'~a ~ t'.a~klc~piylio glyooridos a~rWeble irorn Croda, Mc. under the >ta0etiame, 'filyci~c 78'1," 10 a of trexyleno glycx~l= 3 O. of r~t~sr~rn ind 0.5 p of 7G prapyfparabon wklr hand stjrtbtg ur>GI h0nfopanaolrs to produce i pn~mlxturo. Tht pne-rr~durs was trrexr added ro the pt~a beiksr~ with oonemnt stirring untA trio reauldrip mi~crurw was horrroprsasorae.
2s ztl p of leaa~ryl per, ava8eble Gwn 8rodol Nxitaarirs. under lira tradinsrrre "Loron~s OP; 20 g of borwry leonohenoats, avsilr tfram Aleo, Inc. under ltti trad~rrtr~rr>., "Wic~'wi 181; 20 p Of o~yl oc~ta, evaAieie horn Brooks InrJusbi~, under tA1 esf»larrrr "l.annatw CI~ " 20 g of pentoayHrteol noate avttram Bmoks Industries, urtdar th4 badoname "Laronete PT," anti 20 Q at cydortrathioorra wauebls from Dow Comit tv under 30 the t~tridrrame. 'Dow 946 i'kktlrl"' wero rich edtiod ~epe~ehr to tire prlrtlery t>ratkar with ca,idant sttrrinO at za~c unto honwger>eous. z.s g of Tatrasodium EDTA and , 6.9 8. of d 2076 aquutrus ion of sodium h~oo~~ woo then added thaalv wkh nirrlnp at a iun of ~S'c. Tho roeultihp trtbcturas was than mbc~ tcrr 1 s minutrs.

Exam~a~ a: Pr~awrallbn of ON 1fo w~~lsr E~n~n 4 A d . 1 A d Pr'oPSt~tls~bl~fl. 7.6 A 0f h'~G~B C~7rl~pr~tc glyosridss avellebb lronl Croda. Inc. under the tradsnama, "Olyosrox T6T," ?.6 A of euoroso ca~os~e also avasilsbis from Crads, Ma. tinder then lrad~ame. "Crodsrrla 5L-40," end 10 Q
o? heoplllrte ply~COI
were oorr~ir~l with tnbdnp unGSr embisrtt corutttirrns until homoganrous.
M1o a prtrr~r~r ASS bealaer tptttairtir>9 ~.3 g d P~t~lrut Wstsr (U9P). 10p al caloa~l oar Four ~m ,~wra add.a wuh ~ ~boue zoo rpm 1 S and a oornpsratlxe d shout 20 'C to about 30 'G urtGl s tron~~sotrs, sn100~11 s~ny wee ZO
achie~ned. ?.s g. of AuylAtssIClU-~U A~ll~qti Asryl~ C.rrasspolyrtm ava~able fro~r» B.F.
Ci000riCtl. Inc. under' thw tradlname, "PTR-1" and 2.6 g. d Csrbomer, also ~rv~abls fran a.F. OoodtiOh, Ino. under the trsdensma "Cnrt~pd Wtra~" mars dle~n aeasd Ihe~o srtd nixed w~h slower ip~lon until homopsnotee Ai~' adding tM PronrvsWa Prs-blend wllh Iricressad W dnp ~tt l~bout Z00 rpm fheremo, Iho ~NO~rinp oomp~onsrrts wens are~Cran~lly addeQ
thereto with oortstsnt et~rrirtA et shout ZO°C to B~DoIA 3Q'C tudl harttnpst~. with inlsewis of b minutes bin thw addition of each rsspeobiw oomponort~ 20 g of ilor~ort~i isax~retnods, waailabis f~oen Nxo, Ino. under the tradsnsmrs, ~lNk,~enol 161." 20 g of qrdameb'da~
fiwn Dew Gomi~ under the trsrlpnafrte, "Dew 3.4.5 Fk~ld" , 20 g of bas~otr~rl pahrt~, w~wit~le from Brooks Industries, under the tredsrtame "L.orotwtd Or;
20 A 0~ oltyl oatanoabo. sw~eble thorn Brooks Irrt<JJustrivs, under the trsdensms 1 ononsls CIO: ZO g of pen~er~mtd teareoCtlnoate availwble firan Brooks industrtss, un~r the b~edensrrw'L.onorwbr PT " 2.3 p of Tetrasodium BATA and enough of a a 20% tryuaous soaltbrl of sOatUtfl hydroxide wtss then atkJex! thexwto west stirtkrp at a hrr~rah,rre of about ZO°C ho shout 30'C to prodtxa s ~I nthchiro ha ing a pH of 6.A to 6.6. The resuninp mbcrut~s was than mbe4Q ts1<W
horrtopenoous.

t8P 537 ZO g of y1 per, a1r~01a Iron Brc~oka Ir~duslries, under ~ tradensrne "L~xvnsls tJP.' 20 p of isot~rl Isor~on. frern ~o, lnc, utwsr the ifadlrfama, "lllfick~r~ol 131," ZO p of oNyl odar>anta, ~nre~lable thafl18ro01c8 I~. under tha tradenorne "Loranabe CIO; 20 p of petttserylhf9ol t~xtanoaba a~labla from 8raohs Industriae, urxJe~
tde trarienearw 'toronabe PT ~ were eombined bylu a bed at a thxr~ d Z5 °C
and elLsed unto horntrgerwuus, to Imn a prh~y glaae bad oonl~hg 0.19.7 g a~ Qelo~tlzeo Yroier, ~ o of carbomer av~bls font B.F. Goodrich, H't"tc. t~114er tha trntienarrra, °Cofbo~pol E1'D 2020" , and 1 p of G10-C30 alipll aaylaWcmsspolyrntr oommoroieihr avaitet~le ttau B.f. CiOOdl~ldl t~ndlE 11»
tradenarrw, °Pcmulen TR1" wens ~Sd tflel~o wM slirrkip sit a temparotura of 28 °C t,mW
dl~ted. While h~ttna the to 76 °C, 1.2 g of lnwl~ItHrnlne, 1a d tDTA.
7.F~ g. a~
PEG -S CapriaJaopiylia g~roeridee availadls Anom Crotil. Mc. unrt~ the tradensms, °QI7oe~ooc 78T " 10 g o1 hexylene ~yCOI. 4 p. et r»elhylperabon and 1 g of propylparabw 1 wa<a addld wbh 5~if~f~ lJrltif 11'1! ro~r~ /fld~ Mlds h01'Y~rt/pll~. ~r 1~ ITIhGhNe falChld i1 br~eratun of T6 °C. 10 g. of a mbcturo of sotbnirt sier~rhe end :uerosv coooate avaasbbe i~rom lMiq~nrm urn' the tradwnart~e, "Iirta6one 2121; wero added tharuto vr9t1 stitrln0 to 30 mhutae at oorrsb~nt tarnpwW re.
At~x the Npophdic p~ war iced to o tn~penebme vt Ta °C, It was theft addaei to th4 hydrophna phase with vxx~t s!~ at T6°G unfN homogeneous. Nor the mbcha~e ors them oodeG to 35 °C. 20 g of foone ava~ble firvm Dow COmtIO ~mdlr the tredenomc. "dour 34G Ftuiv!" was a~ manrtn AfE~r the m~u9s wpe ooolad to 23 'C, 0.4 g.
of trome~t~atnine wnx then added wNh stirring ail cent t~plratun ~ecxh that the :ii1 rasuithp rf~xlure hod a pf 1 of 6.~.
3~

JBP-ss~
20 Q of ~ioa>! svs~lal~ ihom tho Dow Comhg Crxpasi~on ttfla tmd~lama. "oOW cORNiNG 346; 15 p crf Mxyle~s ~yoot. one as 0 of a mbelcrn o!
haxyl de~yl beruoei~s ~d buM 0ay1 bOhZOate wrle from th. c.P. Non C~ompan~r under lira s tfadenitTtl. "Halixtar AB' aro saquar added to a vesaol wtllWnp at stl~t 100 rpm under aslant condidvna unto the final mixttu~e Is I>anopsnenus.
About 1 ml to about 10 ml of the r~ul~r~ pataonol oars composlHorr rrwy be applied to the akin as rr laiw"on oompositiorr wtihout the ~aad for rln:klp.

Claims (50)

We claim:

1. A personal care composition comprising a water dispersible component and at least one ester.

2. The composition of claim 1, wherein the composition is comprised of, based upon the total weight of the composition, b. from about 10 percent to about 80 percent of the water dispersible component;
and c, front about 20 percent to about 90 percent of the ester.

3. The personal care composition of claim 1, wherein the ratio of water dispersible component to ester ranges from shout 1:9 to about 4:1.

4. The personal care composition of claim 1, further comprising a silicone component.

5. The personal care composition of claim 1, wherein the water dispersible component is selected from the group consisting of polyethylene glycol 400, hexylene glycol, propylene glycol, polypropylene glycol-10 methylglucose ether, ethoxydiglycol, polyethylene glycol-8 caprylic/capric glycerides, ethylene glycol monobutyl ether, triisopropyl citrate, polyethylene glycol-8 caprylic/capric glycerides, 3 mothoxy-3-methyl-1-butanol, dimethyl isosorbide, polyethylene -8 caprylic/capric triglyceride, and mixtures thereof.

6. The personal care composition of claim 5, wherein the water dispersible component is selected from the group consisting of hexylene glycol, dimethyl isosorbide, polyethylene glycol 6 caprylic/capric glycerides, and mixtures thereof.

7. The personal care composition of claim 1, wherein the water dispersible component is comprised of, based upon the total weight percent of the personal care composition, a) from about 5 percent to about 16 percent of hexylene glycol:
b) from about 5 percent to about 10 percent of polyethylene-6 caprylic/capric triglyceride.

8. The personal care composition of claim 1, wherein the ester is selected from liquid esters that either possess a structural means for ensuring the liquidity of the ester or are heterogeneous in nature.

9. The personal care composition of claim 1, wherein the ester is selected from the group consisting of a) a branched C8 to C22 alkyl alcohol ester of an aromatic acid;
b) a straight-chained or branched C8 to C22 alkyl acid esters of optionally ethyoxylated/propoxylated polyols having from about 3 carbon atoms to about 7 carbon atoms:
c) branched C8 to C22 alkyl alcohol esters of branched polyacids:
d) branched or straight-chained C8 to C22 alkyl acid ester of branched and/or unsaturated C8 to C22 alkyl alcohols;
e) branched or unsaturated C8 to C22 alkyl alcohol esters of an acid selected from the group consisting of odipic acid, succinic acid, sebacic acid, maleic acid, and mixtures thereof~
f) polyether interrupted fatty acid esters:
g) benzoic acid ester of heterogeneous alcohols having from about 8 carbon atoms to about 22 carbon atoms; and h) mixtures thereof.

10. The personal care composition of claim 9, wherein the ester is selected from the group consisting of straight-chained or branched C8 to C22 alkyl acid esters of optionally ethyoxylated/propoxylated polyole; benzoic acid esters of heterogeneous alcohols; and mixtures thereof.

11. The personal care composition of claim 9, wherein the ester is selected from the group consisting of butyloctyl salicylate; hexyldecyl benzoate; and butyloctyl benzoate; alkyl benzoates having from about 12 carbon atoms to about 15 carbon atoms; and mixtures thereof.

12. The personal care composition of claim 11, wherein the ester is selected from the group consisting of hexyldecyl benzoate, butyloctyl benzoate, and mixture thereof.

13. The personal care composition of claim 9, wherein the ester is selected from the group consisting of pentaerythyritol tetraoctanoate; trimethylolpropane trioctanoate;
trioactonoin; pentacrythrityl tetrapharganate; sorbitan trioleate;
caprylic/capric triglyceride;
neopentyl alcohol tetraoctanoate, and mixtures thereof.

14. The personal care composition of claim 13, wherein the ester is selected from the group consisting of caprylic/capric triglyceride; pentaerythritol tetranctanoate;
trimethylolpropane trioctanoate; pentaerythrityl tetrap~largonate; and mixtures thereof.

15. The personal care composition of claim 9, wherein the ester is selected from the group consisting of branched alkyl alcohol esters of branched polyacids, wherein the alkyl~~

alcohol is optionally substituted and contains from about 3 carbon atoms to about 22 carbon atoms.

16. The personal care composition of claim 15, wherein the ester is trioctyldodecyl citrate and mixtures thereof.

17. The personal care composition of claim ~, wherein the ester is selected from the group consisting of tridecyl neopentanoate, isostearyl palmitate, cetyl ricinoleate cetyl octanoate, isononyl isononanoate, butyl stearate, octyldodecyl soyate, tridecyl ~, octyldodecyl ~/alcosil ~, and mixtures thereof.

18. The personal care composition of claim 17, wherein the ester is selected from the group consisting of octyl octanoate, isostearyl palmitate, isononyl isononoate, and mixtures thereof.

19. The personal care composition of claim 0, wherein the ester is selected from the group consisting of diiosopropyl adipate, dioctyl sebacate, dioctyl succinate, dioctyl maleate, diisostearyl adipate, diethyl ~, and mixtures thereof.

20. The personal care composition of claim 1~, wherein the ester is selected from the group consisting of diethyl ~, dioctyl ~ diisostearyl adipate, and mixtures thereof.

21. The personal care composition of claim 9, wherein the ester is selected from the group consisting of laureth-2 benzoate; C8 to C22 fatty alkyl (optionally polypropylenoxy) polyethyleneoxy carboxylate esters derived from an alcohol having from about 1 carbon atom to about 22 carbon atoms; and mixtures thereof.

22. The personal care composition of claim 21, wherein the ester is isopropyl propylene glycol 2-isodeceth-7 carboxylate.

23. The personal care composition of claim 9, wherein the ester is selected from at least two of the following esters.

a) branched C8 to C22 alkyl alcohol esters of an aromatic acid;
b) branched or straight-chained C8 to C22 alkyl acid esters of branched or unsaturated C8 to C22 alkyl alcohols; and c) straight-chained or branched C8 to C22 alkyl acid esters of optionally ethyoxylated/propoxylated polyols.

24. The personal care composition of claim 9, wherein the ester is a mixture of, based upon the total weight percent of the esters,:

a) from about 30 percent to about 80 percent of branched or straight-chained C8 to C22 alkyl and esters of branched or unsaturated C8 to C22 alkyl alcohols;
b) from about 10 percent to about 50 percent or branched C8 to C22 alkyl alcohol esters of an aromatic acid: and c) from about 10 percent to about 50 percent of straight-chained C8 to C22 alkyl acid esters of optionally ethyoxylated/propoxylated.

26. The personal care composition of claim 9, wherein the ester is a mixture comprised of, based upon the total weight percent of the ester,.

a) from about 15 percent to about 50 percent isononyl insononanoate;
b) from about 15 percent to about 50 percent isostearyl palmitate;
c) from about 15 percent to about 60 cetyl octanoate; and d) from about 15 percent to about 50 percent pentoerthritol tetraoctanoate.

26. A personal care system comprising:

a. the personal care composition of claim 1;
b. water; and c. a polymeric emulsifier and/or a thickener.

27. The personal care system of claim 26 comprising, based upon the total weight of the personal care system;

a. at least about 3 percent of the personal care composition of claim 1;
b. from about 70 percent to about 98 percent of water; and c. from about 0.5 to about 1.5 percent of a polymeric emulsifier and/or thickener.

28. The personal care system of claim 26, wherein the polymeric emulsifier is polyethylene glycol-30 dipolyhydroxystearate; dimethicone copolyol;
substituted acrylates; and mixtures thereof.

29. The personal care system of claim 26, wherein the thickener is selected from the group consisting of carbomers, acrylate copolymers, hydroxyethylcellulose modified with octyl ether groups, polyvinylmethyl ether/maleic anhydride (PVM/AA) decadiene crosspolymer, and mixtures thereof.

30. The personal care system of claim 26, wherein the thickener is selected from the group consisting of acrylates/aminoacrylates copolymer, acrylates/~-20 methacrylate copolymer, acrylates/~-20 ~ copolymer, acrylates/~-20 ~
copolymer, carbomers, modified hydroxycellulose, polyvinylacetate/maleic anhydride (PVA/MA) decarilene crosspolymer, and mixtures thereof.

31. The system of claim 30, further comprising a benefit agent.

32. The system of claim 31, wherein the benefit agent is selected form the group consisting of vasoconstrictors collegen enhancers, anti-edema agents, depigmentation agents; reflectants; detangling/wet combing agents; film forming polymers;
humectants;
amino acid agents; antimicrobial agents; allergy inhibitors; anti-acne agents;
anti-aging agents: anti-wrinkling agents, ~; analgesics; antitussives: antipruritics:
local anesthetics: anti-hair loss agents; hair growth promoting agents; hair growth inhibitor agents;
antihistamine, antiinfectives: inflammation inhibitors; anti-ametics;
anticholinergics:
vasoconstrictors; vasodilator; wound healing promoters: peptiden, oolypeptides and proteins; deodorant and anti-perspirants: medicament agents: skin emolients and skin moisturizers; skin firming agents, hair conditioners; hair softeners; hair moisturizers;
vitamins; tanning agents, skin lightening agents; antifungals; dapilating agents; shaving preparations; externa analgesics; perfumes; counterirritants; homorrhoidals;
insecticides;
poison ivy products: poison oak product; burn products; anti- diaper rash agents; prickly heat agents; make-up preperations, vitamins; amino acids and their derivatives: herbal extracts; retinoids; flavenoids; ~; anti-oxidants; skin conditioners; hair lighteners;
chelating agents; cell turnover enhancers; coloring agents: pigments:
sunscreens and mixtures thereof.

33. The system of claim 31, wherein the benefit is selected from the group consisting of ~, ~ ~, olive leaf, wheat protein, oat oil, lycopeno, DMAE, soy and derivatives thereof, colloidal oatmeal, sulfonated shale oil elubiol, 6-(1-piperdinyl)-2.4-pyrimidinediamine-3-oxide, finasterido, ketoconazole, salicylic acid, zinc pyrithlone, cool ler, benzoyl peroxide, selenium sulfine, hydrocortisone, sulfur, menthol, pramoxine hydrochloride, tricetylammonium chloride, polyquaternium 10, pantehnol, pantenol triacetate, vitamin A and derivatives thereof, vitamine B and derivatives thereof, vitamine C and derivatives thereof, vitamin D and derivatives thereof, vitamin E and derivatives thereof, vitamin K and derivatives thereof, keratin, lysine, arginine, hydrolyzed wheat proteins, hydrolyzed silk proteins, octyl methoxycinnamate, oxybenzone, minoxidil, titanium dioxide, zinc dioxide, rotinol, erthromycin, tretinoin, and mixtures thereof.

34. The system of claim 31, wherein the benefit agent is present in an amount, based upon the total weight of the system, from about 0.001 percent to about 5.0 percent.

35. The system of claim 28, further comprising a stability enhancer selected from a nonionic emulsifier, an essentially non-foaming surfactant, and mixtures thereof.

36. A method of treating hair loss comprising topically applying the system of claim 26 with an effective amount of a hair loss treatment agent to a desired location on an animal or human.

37. The method of claim 38, wherein the hair loss treatment agent is selected from the group consisting of minoxidil, 6-(1-piperdinyl)-2,4-pyrimidinediamine-3-oxide, N'-cyano-N-(tert-pentyl)-N' 3-pyridinyl-guanidine, finasteride, retinoide and derivatives thereof, ketocunazole, elubiol or mixtures thereof.

38. A method for inhibiting hair growth comprising topically applying the system of claim 26 with a hair growth inhibiting agent to a desired area on an animal or human for inhibiting hair growth.

39. The method of claim 38, wherein the benefit agent is selected from the group consisting of serine proteases, retinol, isotretinoin, betamothoisone, alpha-locophenol and derivatives thereof, and mixtures thereof.

40. A method for treating acne comprising topically applying a mixture of the system of claim 28 and an effective amount of an anti-acne agent to the skin of an animal or human at a desired area.

41. The method of claim 40. wherein the anti-acne agent is selected from the group consisting of benzoyl peroxide, retinol, elubiol, antibiotics, salicylic acid, and mixtures thereof.

42. A method for reducing the signs of aging and other manifestations of photodamage comprising topically applying a mixture of the system of claim 26 and an effective amount of an anti-aging agent to the skin of an animal or human at a desired area.

43. The method of claim 42, wherein the anti-aging agent is selected from the group consisting of retinoids, anti-oxidents, alpha-hydroxy acids, beta-hydroxy acids and mixtures thereof.

44. A method for depigmenting the skin comprising topically applying the system of claim 26 and an effective amount of a depigmentation benefit agent to the skin of an animal or human of a desired area.

45. The method of claim 44, wherein the depigmentation agent is selected from the group consisting of retinol, Kojio acid, hydroquinone, and mixtures thereof.

46. A method for treating the symptoms and/or the diseases of dandruff, seborrheic dermatitis and/or psoriasis, comprising topically applying a mixture of the system of claim 26 and an effective amount of a benefit agent capable of treating the symptoms to the skin of an animal or human at a desired area.

47. The method of claim 46, wherein the benefit agent is selected from the group consisting of shale oil and derivatives thereof, elubiol, ketoconazole, coal tar, salicylic acid.

zinc pyrithiona, selenium sulfide, hydrocortisone, sulfur, menthol, pramoxine hydrochloride, and mixtures thereof.

48. The system of claim 26, wherein said system is in the form of a gel, a bath, a wash, a mousse, a shampoo, a rinse, a lotion, a cream, a dry wipe, a wet wipe, a brush, a sponge, or a spray.

49. The system of claim 26, wherein said system is in the form of an oil-in-water emulsion.

50. A method of delivering a benefit agent to be hair, skin or naile comprised of applying the composition of claim 31 to a desired location.