CA1099637A - Gel composition for topical application - Google Patents
Gel composition for topical applicationInfo
- Publication number
- CA1099637A CA1099637A CA305,913A CA305913A CA1099637A CA 1099637 A CA1099637 A CA 1099637A CA 305913 A CA305913 A CA 305913A CA 1099637 A CA1099637 A CA 1099637A
- Authority
- CA
- Canada
- Prior art keywords
- ether sulfate
- composition according
- alkyl ether
- composition
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
ABSTRACT OF THE DISCLOSURE
The invention relates to gel compositions which are suitable for topical application to the skin or hair, the com-positions containing as gel forming components an anionic sur-factant, a nonionic surfactant and a polar solvent such as water. The composition also includes an active ingredient, for example an agent for the treatment of parasitic infestations of the skin. The ratio of anionic surfactant to nonionic sur-factant is preferably between about 1:3 and 3:1 and the amount of the surfactants in the total gel composition is preferably between about 20-60% by weight.
The invention relates to gel compositions which are suitable for topical application to the skin or hair, the com-positions containing as gel forming components an anionic sur-factant, a nonionic surfactant and a polar solvent such as water. The composition also includes an active ingredient, for example an agent for the treatment of parasitic infestations of the skin. The ratio of anionic surfactant to nonionic sur-factant is preferably between about 1:3 and 3:1 and the amount of the surfactants in the total gel composition is preferably between about 20-60% by weight.
Description
: `
BACKGROUND OF THE INVENTION
The known cosmetic gels are generally pourable gels formed either by adding an inorganic salt to an alkyl ether sulfate or by the inclusion in the cosmetic composition of cellulose, an alginate or another known gum-type thickener.
In the treatment of headlice, bodylice and other parasitic infestations of the skin and in the treatment of other skin disorders, it has been found desirable to treat the body or the hair with an active ingredient which is insoluble in water. Such active ingredients include, for example, carbaryl, piperonyl butoxide and malathion.
Activeingredientsof this type have been combined in cream- Z
type compositions which have found great acceptablility and use in temperate climates, but which present considerable problems in more tropical climates. Thus, in tropical climates the anionic surfactant generally used, ~or example sodium lauryl sulfate dissolves in the preparation to form a liquid rather than a cream. On subsequent cooling of the preparation the surfactant crystallizes out of solution to give a product containing short needle-like crystals. This is obviously un-acceptable to the user.
Gel compositions for other purposes than for topical application cannot be used for topical application purposes because the components thereof are irritatlng, for example to the skin, causing dermatitis and ~ to the eye, causing conjunctivitis.
;' ~ O
X
.. .
, ' 11;)99637 SUM~RY OF THE INVENTION
l!
Generally speaking, in accordance with this invention a gel composition for topical application is provided comprising as gel forming components a mild anionic surfactant, a nonionic surfactant and a polar solvent such as water. The ingredients are selected and the proportions of ingredients are selected so that the composition does not irritate human or animal skin.
It is a primary object of the present invention, therefore, to provide gel compositions which have a gel structure over whatever temper-ature range may be encountered by the product, although the composition may decrease somewhat in viscosity with increasing temperature.
It is another object of the present invention to provide gel compositions which can be used topically on animal or human skin without the risk of causing skin or eye irritations.
It is still a further object of the present invention to provide L
gel composittons for topical administration which can be used as a vehicle for water insoluble active ingredients, such as for the treatment of parasitic infestat1ons and the like.
Other objects and advantages of the present invention will be apparent from the further reading of the specification and of the appended claims.
With the above and other objects in view, the gel compositions of the present invention mainly comprise a mild anionic surfactant, a nonionic surfactant and a polar solvent, preferably water.
The anionic surfactants used ~n the gel compositions of this invention are mild anionic surfactants which do not cause irritations when applied to animal or human sk~n and thus do not cause complaints ~', ~ :2 ~
' ' -1(~99~37 such as dermatitis and con~unctivitis.
Among the suitable anionic surfactants of this type are straight chain or branched chain alkyl ether sulfates. These straight chain or branched chain alkyl ether sulfates are preferably used in the form, for example of their alkali metal salts, such as sodium or potassium salt, or their organic amine salts such as the monoethanol amine and the diethanol amine salts of alkyl ether sulfates containing alkyl groups of 8 to 18 carbon atoms. Sodium salts of straight chain alkyl ether sulfates in which the alkyl group contains 10-15 carbon atoms are preferred. Most preferred are sodium lauryl ether sulfate and sodium myristyl ether sulfate.
Although any nonionic surfactant can be used for the purposes of the present invention. the preferred nonionic surfactants are of the polyoxyethylene type, for example polyoxyethylene alkyl ethers containing alkyl groups of 8-22 carbon atoms and 1-8 oxyethylene units, as well as polyoxyethylene alkyl phenyl ethers containing alkyl groups of 8-18 car-bon atoms and 1-8 oxyethylene units. Polyoxyethylene (4-6) nonylphenyl ethers and polyoxyethylene ~3-5) dodecyl ethers are particularly pre-ferred. Commercially available nonionic surfactants which can be used 2Q include Antarox* C0630, Fomescol* V27, Texafor* F85 and Volpo* N5.
In addition to the gel forming components of the components of the composition, namely the mild anionic surfactant, the non~onic surfactant and the polar solvent such as water, the gel compositions of this invention can include and carry therein an active ingredient such as an active ingredient for the treatment o~ parasiticinfestqtionsof the skin and other disorders, lanolin, a foam synergist, a colorant and a ; perfume.
* Trade Mark , ... .. ' ' The preferred active ingredients for the treatment of body and headlice are carbaryl, piperonyl butoxide malathion and mixtures thereof. L
The foam synergist which may be incorporated in the composition is preferably a mono- or diethanolamide, for example lauric diethanolamide or coconut diethanolamide.
The best gel composition effects are obtained according to the present invention by maintaining the preferred ratio of the anionic sur-factant to the nonionic surfactant between about 1:3 and 3:1. The most preferred ratio is 2:1.
; 10 Furthermore, the comfined percentage of the anionic surfactant and the nonionic surfactant in the total gel composition is preferably b maintained between about 20-60% by weight~ .
Since the presence of other formulation excipients in the gel compositions of the invention may affect the viscosity of the final composition, adjustment is necessary to determine the optimum percentage : and ratio of the anionic surfactant and nonionic surfactant in the final formulation~
Although the invention is not meant to be limited to any theory as to ho~ the gel composition of suitable properties-is obtained according to the present invention, the follow~ng theory is given in the hope that it will aid further investigation in this field. f It is thought that the combination of the anionic surfactant w:ith the nonionic surfactant in the water or other polar solvent creates a co~micelle phase within the solvent which leads to gel formation by an increase in the bulk volume of the co-micelle phase. Thus, the bulk volume of tKe two surfactants or combined percentage of the two surfactants f determines~the gelling point of tKe composition, and it is for this reason that the preferred combined percentage of the anionic surfactant and the f X~ ~
.
nonionic surfactant in the gel composition ranges between 20-60% by weight.
The gel compositions of the invention are prepared by heating the anionic surfactant paste (in the form of a concentrate in water, for example a 70~ concentrate) with the nonionic surfactant (in pure liquid form), adding water (or other polar solvent) and mixing to form a clear solution. On cooling a product is formed which, depending on the proportions of the two surfactants, may range from a viscous liquid to a hard gel. If an active ingredient is present, this .is dissolved in the nonionic sur-factant before the nonionic surfactant is heated with the anionic surfactant.
Similarly, the other optional ingredients are dissolved in whichever phase (surfactant or aqueous) they are most soluble. Any perfume which is added as a final ingredient is added at as low a temperature as possible.
DESCRIPTION OF PREPERRED EMBODIMENTS
The following examples are given to further illustrate the invention. The scope of the invention is not, however, meant to be limited to the specific details of the examples.
; EXAMPLE 1 ; Ingredients Weight in grams 20 Carbaryl 1.0 `~ Nonylphenoxypoly(ethyleneoxy)ethanol 12.5 Sodium lauryl ether sulfate (70%) 25.0 Coconut Diethanolamide 1.0 Ethoxylated Lanolin 1. 5 r Colorant - F.D. and C Yellow No 5 0.01 Perfume - Glarland Flora 0.2 Water To lOO gm.
~;
r .. . .
' ' ', ,. . ' . 105~9~37 The sodium laurylethersulfate, coconut diethanolamide and ethoxylated lanolin are mixed together at a temperature of 70 to 80 C.
The carbaryl is dissolved in the nonylphenoxypoly(ethyleneoxy) ethanol by warming to a temperature of 40 to 50 C. The mixture is stirred to form a clear solution. The resulting solution is added to the mixture of sodium lauryl ether sulfate, coconut diethanolamide and ethoxylated lanoline and stirred to produce a homogeneous solution.
The colorant is completely dissolved in the calculated amount of water and the resulting solution is heated to a temperature just below boiling point and then slowly added to the above-prepared homogeneous solution. The resulting mixture is maintained at a high temperature to allow air to escape. The mixture is then cooled to 55 to 60 C and the perfume slowly stirred into it. On cooling to room temperature a gel is formed which retains its gel form and shape for at least two years when stored at room temperature or 30 C.
Ingredients Weight in grams ~ , Malathion 1.10 Nonylphenoxypoly(ethyleneoxy~ ethanol 20.00 ~20 Sodium lauryl ether sulfate (70%~ 25.00 Coconut Diethanolamide 2.50 Ethoxylated lanolin 1.25 Colorant - F.D. and C Yellow No 5 0.01 Perfume - May & Baker No 1658 0,2 Dilute Hydrochloric acidQ.S. (to pH 5.2) Water To 100 gm.
The sodium lauryl ether sulfate, coconut diethanolamide and L
ethoxylated lanolin are mixed together at a temperature of 70 to 80 C.
. ~.
, , ' -"'' lOg9637 The nonylphenoxypoly(ethyleneoxy) ethanol is then added to the mixture which is stirred to produce a homogeneous solution. The colorant is completely dissolved in the calculated amount of water and the resulting solution heated to a temperature just below boiling point and then slowly added to the above-prepared homogeneous solution.
The resulting mixture is maintained at a high temperature to allow air to escape. The mixture is then cooled to 55 to 60 C and ad-justed to pH 5.2 with dilute hydrochloric acid. The malathion and perfume are then slowly stirred into the mixture. On cooling to room temperature a gel is formed which retains its gel form and shape when heated to a temperature of at least 30 C.
Ingredients Weight in grams !
Carbaryl 1.00 Piperonyl Butoxide 5.00 Alkyl Phenol Polyoxyethylene Ether 12.50 Sodium Lauryl Ether Sulfate 30.00 , Isopropyl myristate 3,00 Coconut Diethanolamide 1.00 20 Ethoxylated Lanolin 2.00 Colorant F.D. and C Yellow No 5 0.0025 F.D. and C Blue No l 0.0025 Perfume - Freska 0.4 Water To 100 gm.
The sodium lauryl ether sulfate, coconut diethanolamide and ethoxylated lanolin are mixed together at a temperature of 70 to 80 C.
The carbaryl, piperonyl botoxide and isopropyl myristate are dissolved in the nonylphenoxypoly(ethyleneoxy)ethanol by warming to a temperature ~ .
~. , , ,, ' ' : .
.
' ' '-' ' . : ' ~09~637 of 40 to 50 C. The mixture is stirred to form a clear solution.
The resulting solution is added to the mixture of sodium L
lauryl ether sulfate, coconut diethanolamide and ethoxylated lanolin and stirred to produce a homogeneous solution. The colorant is completely dissolved in the calculated amount of water and the resulting solution heated to a temperature just below boiling point and then slowly added to the above-prepared homogeneous solutton. The resulting mixture is maintained at a high temperature to allow air to escape. The mixture is then cooled to 55 to 60 C and the perfume slowly stirred into it.
On cooling to room temperature a gel is formed which retains its gel form and shape when heated to a temperature of at least 30 C.
While the invention has been ~llustrated with respect to particular compositions it i5 apparent that variations and modifications thereof can be made.
, ~i, ,
BACKGROUND OF THE INVENTION
The known cosmetic gels are generally pourable gels formed either by adding an inorganic salt to an alkyl ether sulfate or by the inclusion in the cosmetic composition of cellulose, an alginate or another known gum-type thickener.
In the treatment of headlice, bodylice and other parasitic infestations of the skin and in the treatment of other skin disorders, it has been found desirable to treat the body or the hair with an active ingredient which is insoluble in water. Such active ingredients include, for example, carbaryl, piperonyl butoxide and malathion.
Activeingredientsof this type have been combined in cream- Z
type compositions which have found great acceptablility and use in temperate climates, but which present considerable problems in more tropical climates. Thus, in tropical climates the anionic surfactant generally used, ~or example sodium lauryl sulfate dissolves in the preparation to form a liquid rather than a cream. On subsequent cooling of the preparation the surfactant crystallizes out of solution to give a product containing short needle-like crystals. This is obviously un-acceptable to the user.
Gel compositions for other purposes than for topical application cannot be used for topical application purposes because the components thereof are irritatlng, for example to the skin, causing dermatitis and ~ to the eye, causing conjunctivitis.
;' ~ O
X
.. .
, ' 11;)99637 SUM~RY OF THE INVENTION
l!
Generally speaking, in accordance with this invention a gel composition for topical application is provided comprising as gel forming components a mild anionic surfactant, a nonionic surfactant and a polar solvent such as water. The ingredients are selected and the proportions of ingredients are selected so that the composition does not irritate human or animal skin.
It is a primary object of the present invention, therefore, to provide gel compositions which have a gel structure over whatever temper-ature range may be encountered by the product, although the composition may decrease somewhat in viscosity with increasing temperature.
It is another object of the present invention to provide gel compositions which can be used topically on animal or human skin without the risk of causing skin or eye irritations.
It is still a further object of the present invention to provide L
gel composittons for topical administration which can be used as a vehicle for water insoluble active ingredients, such as for the treatment of parasitic infestat1ons and the like.
Other objects and advantages of the present invention will be apparent from the further reading of the specification and of the appended claims.
With the above and other objects in view, the gel compositions of the present invention mainly comprise a mild anionic surfactant, a nonionic surfactant and a polar solvent, preferably water.
The anionic surfactants used ~n the gel compositions of this invention are mild anionic surfactants which do not cause irritations when applied to animal or human sk~n and thus do not cause complaints ~', ~ :2 ~
' ' -1(~99~37 such as dermatitis and con~unctivitis.
Among the suitable anionic surfactants of this type are straight chain or branched chain alkyl ether sulfates. These straight chain or branched chain alkyl ether sulfates are preferably used in the form, for example of their alkali metal salts, such as sodium or potassium salt, or their organic amine salts such as the monoethanol amine and the diethanol amine salts of alkyl ether sulfates containing alkyl groups of 8 to 18 carbon atoms. Sodium salts of straight chain alkyl ether sulfates in which the alkyl group contains 10-15 carbon atoms are preferred. Most preferred are sodium lauryl ether sulfate and sodium myristyl ether sulfate.
Although any nonionic surfactant can be used for the purposes of the present invention. the preferred nonionic surfactants are of the polyoxyethylene type, for example polyoxyethylene alkyl ethers containing alkyl groups of 8-22 carbon atoms and 1-8 oxyethylene units, as well as polyoxyethylene alkyl phenyl ethers containing alkyl groups of 8-18 car-bon atoms and 1-8 oxyethylene units. Polyoxyethylene (4-6) nonylphenyl ethers and polyoxyethylene ~3-5) dodecyl ethers are particularly pre-ferred. Commercially available nonionic surfactants which can be used 2Q include Antarox* C0630, Fomescol* V27, Texafor* F85 and Volpo* N5.
In addition to the gel forming components of the components of the composition, namely the mild anionic surfactant, the non~onic surfactant and the polar solvent such as water, the gel compositions of this invention can include and carry therein an active ingredient such as an active ingredient for the treatment o~ parasiticinfestqtionsof the skin and other disorders, lanolin, a foam synergist, a colorant and a ; perfume.
* Trade Mark , ... .. ' ' The preferred active ingredients for the treatment of body and headlice are carbaryl, piperonyl butoxide malathion and mixtures thereof. L
The foam synergist which may be incorporated in the composition is preferably a mono- or diethanolamide, for example lauric diethanolamide or coconut diethanolamide.
The best gel composition effects are obtained according to the present invention by maintaining the preferred ratio of the anionic sur-factant to the nonionic surfactant between about 1:3 and 3:1. The most preferred ratio is 2:1.
; 10 Furthermore, the comfined percentage of the anionic surfactant and the nonionic surfactant in the total gel composition is preferably b maintained between about 20-60% by weight~ .
Since the presence of other formulation excipients in the gel compositions of the invention may affect the viscosity of the final composition, adjustment is necessary to determine the optimum percentage : and ratio of the anionic surfactant and nonionic surfactant in the final formulation~
Although the invention is not meant to be limited to any theory as to ho~ the gel composition of suitable properties-is obtained according to the present invention, the follow~ng theory is given in the hope that it will aid further investigation in this field. f It is thought that the combination of the anionic surfactant w:ith the nonionic surfactant in the water or other polar solvent creates a co~micelle phase within the solvent which leads to gel formation by an increase in the bulk volume of the co-micelle phase. Thus, the bulk volume of tKe two surfactants or combined percentage of the two surfactants f determines~the gelling point of tKe composition, and it is for this reason that the preferred combined percentage of the anionic surfactant and the f X~ ~
.
nonionic surfactant in the gel composition ranges between 20-60% by weight.
The gel compositions of the invention are prepared by heating the anionic surfactant paste (in the form of a concentrate in water, for example a 70~ concentrate) with the nonionic surfactant (in pure liquid form), adding water (or other polar solvent) and mixing to form a clear solution. On cooling a product is formed which, depending on the proportions of the two surfactants, may range from a viscous liquid to a hard gel. If an active ingredient is present, this .is dissolved in the nonionic sur-factant before the nonionic surfactant is heated with the anionic surfactant.
Similarly, the other optional ingredients are dissolved in whichever phase (surfactant or aqueous) they are most soluble. Any perfume which is added as a final ingredient is added at as low a temperature as possible.
DESCRIPTION OF PREPERRED EMBODIMENTS
The following examples are given to further illustrate the invention. The scope of the invention is not, however, meant to be limited to the specific details of the examples.
; EXAMPLE 1 ; Ingredients Weight in grams 20 Carbaryl 1.0 `~ Nonylphenoxypoly(ethyleneoxy)ethanol 12.5 Sodium lauryl ether sulfate (70%) 25.0 Coconut Diethanolamide 1.0 Ethoxylated Lanolin 1. 5 r Colorant - F.D. and C Yellow No 5 0.01 Perfume - Glarland Flora 0.2 Water To lOO gm.
~;
r .. . .
' ' ', ,. . ' . 105~9~37 The sodium laurylethersulfate, coconut diethanolamide and ethoxylated lanolin are mixed together at a temperature of 70 to 80 C.
The carbaryl is dissolved in the nonylphenoxypoly(ethyleneoxy) ethanol by warming to a temperature of 40 to 50 C. The mixture is stirred to form a clear solution. The resulting solution is added to the mixture of sodium lauryl ether sulfate, coconut diethanolamide and ethoxylated lanoline and stirred to produce a homogeneous solution.
The colorant is completely dissolved in the calculated amount of water and the resulting solution is heated to a temperature just below boiling point and then slowly added to the above-prepared homogeneous solution. The resulting mixture is maintained at a high temperature to allow air to escape. The mixture is then cooled to 55 to 60 C and the perfume slowly stirred into it. On cooling to room temperature a gel is formed which retains its gel form and shape for at least two years when stored at room temperature or 30 C.
Ingredients Weight in grams ~ , Malathion 1.10 Nonylphenoxypoly(ethyleneoxy~ ethanol 20.00 ~20 Sodium lauryl ether sulfate (70%~ 25.00 Coconut Diethanolamide 2.50 Ethoxylated lanolin 1.25 Colorant - F.D. and C Yellow No 5 0.01 Perfume - May & Baker No 1658 0,2 Dilute Hydrochloric acidQ.S. (to pH 5.2) Water To 100 gm.
The sodium lauryl ether sulfate, coconut diethanolamide and L
ethoxylated lanolin are mixed together at a temperature of 70 to 80 C.
. ~.
, , ' -"'' lOg9637 The nonylphenoxypoly(ethyleneoxy) ethanol is then added to the mixture which is stirred to produce a homogeneous solution. The colorant is completely dissolved in the calculated amount of water and the resulting solution heated to a temperature just below boiling point and then slowly added to the above-prepared homogeneous solution.
The resulting mixture is maintained at a high temperature to allow air to escape. The mixture is then cooled to 55 to 60 C and ad-justed to pH 5.2 with dilute hydrochloric acid. The malathion and perfume are then slowly stirred into the mixture. On cooling to room temperature a gel is formed which retains its gel form and shape when heated to a temperature of at least 30 C.
Ingredients Weight in grams !
Carbaryl 1.00 Piperonyl Butoxide 5.00 Alkyl Phenol Polyoxyethylene Ether 12.50 Sodium Lauryl Ether Sulfate 30.00 , Isopropyl myristate 3,00 Coconut Diethanolamide 1.00 20 Ethoxylated Lanolin 2.00 Colorant F.D. and C Yellow No 5 0.0025 F.D. and C Blue No l 0.0025 Perfume - Freska 0.4 Water To 100 gm.
The sodium lauryl ether sulfate, coconut diethanolamide and ethoxylated lanolin are mixed together at a temperature of 70 to 80 C.
The carbaryl, piperonyl botoxide and isopropyl myristate are dissolved in the nonylphenoxypoly(ethyleneoxy)ethanol by warming to a temperature ~ .
~. , , ,, ' ' : .
.
' ' '-' ' . : ' ~09~637 of 40 to 50 C. The mixture is stirred to form a clear solution.
The resulting solution is added to the mixture of sodium L
lauryl ether sulfate, coconut diethanolamide and ethoxylated lanolin and stirred to produce a homogeneous solution. The colorant is completely dissolved in the calculated amount of water and the resulting solution heated to a temperature just below boiling point and then slowly added to the above-prepared homogeneous solutton. The resulting mixture is maintained at a high temperature to allow air to escape. The mixture is then cooled to 55 to 60 C and the perfume slowly stirred into it.
On cooling to room temperature a gel is formed which retains its gel form and shape when heated to a temperature of at least 30 C.
While the invention has been ~llustrated with respect to particular compositions it i5 apparent that variations and modifications thereof can be made.
, ~i, ,
Claims (14)
OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A gel composition for topical application comprising as gel-forming components a topically acceptable non-irritating salt of a straight chain or branched chain alkyl ether sulfate, a non-ionic surfactant and water, the ratio of alkyl ether sulfate salt to non-ionic surfactant being between about 1:3 and 3:1, the total amount of alkyl ether sulfate salt and non-ionic surfactant being between about 20 - 60% by weight of the composition.
2. A composition according to claim 1 wherein the ratio of alkyl ether sulfate salt to non-ionic surfactant is about 2:1.
3. A composition according to claim 1 wherein the alkyl group of the alkyl ether sulfate salt contains 8 - 18 carbon atoms.
4. The composition according to claim 3 wherein the alkyl ether sulfate salt is the monoethanol amine or diethanol amine salt.
5. The composition according to claim 3 wherein the alkyl ether sulfate salt is the sodium or potassium salt.
6. Composition according to claim 1 wherein said anionic surfactant is selected from the group consisting of sodium lauryl ether sulfate and sodium myristyl ether sulfate.
7. Composition according to claim 1, 3 or 5 wherein said nonionic surfactant is a polyoxyethylene alkyl ether wherein the alkyl group has 8 - 22 carbon atoms and containing 1 - 8 oxythethylene units.
8. Composition according to claim 6 wherein said nonionic surfactant is selected from the group consisting of polyoxyethylene (4-6) nonylphenyl ethers and polyoxyethylene (3-5) dodecyl ethers.
9. Composition according to claim 1 and including an active ingredient for the treatment of the skin.
10. Composition according to claim 9 wherein said active ingredient is selected from the group consisting of carbaryl, piperonyl butoxide, malathion and mixtures thereof.
11. Composition according to claim 9 and also including a foam synergist.
12. Composition according to claim 11 wherein said foam synergist is selected from the group consisting of lauric diethanolamide and coconut diethanolamide.
13. Method of producing a composition of claim 1 which comprises heating a paste of the alkyl ether sulfate salt with the nonionic surfactant in liquid form, adding the water thereto, mixing to form a clear solution and cooling.
14. Method of producing the composition of claim 13 which comprises heating the alkyl ether sulfate salt in the form of a paste with the nonionic surfactant in the form of a liquid, an active ingredient being dissolved in the surfactant in which it is soluble, adding the water, mixing to form a clear solution and cooling.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB28722/77 | 1977-07-08 | ||
| GB2872277 | 1977-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1099637A true CA1099637A (en) | 1981-04-21 |
Family
ID=10280057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA305,913A Expired CA1099637A (en) | 1977-07-08 | 1978-06-21 | Gel composition for topical application |
Country Status (13)
| Country | Link |
|---|---|
| AR (1) | AR222305A1 (en) |
| BE (1) | BE868239A (en) |
| CA (1) | CA1099637A (en) |
| DK (1) | DK306678A (en) |
| FI (1) | FI70136C (en) |
| FR (1) | FR2396546A1 (en) |
| GR (1) | GR65307B (en) |
| IL (1) | IL54972A (en) |
| MX (1) | MX5148E (en) |
| NL (1) | NL7805745A (en) |
| NO (1) | NO148136C (en) |
| PT (1) | PT68078B (en) |
| SE (1) | SE7806690L (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265384B1 (en) | 1999-01-26 | 2001-07-24 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE932516C (en) * | 1943-02-07 | 1955-09-01 | Dehydag Gmbh | Process for the production of jelly-like preparations |
| BE565499A (en) * | 1957-03-07 | |||
| FR1365793A (en) * | 1963-08-08 | 1964-07-03 | Shiseido Co Ltd | Process for preparing jelly-like toilet articles and articles obtained by this process |
| DE2436028C3 (en) * | 1974-07-26 | 1980-08-21 | Eduard Gerlach Gmbh Chemische Fabrik, 4990 Luebbecke | Use of diethylene glycol to destroy lice and their eggs / nits Eduard Gerlach GmbH Chemische Fabrik, 4990 Lübbecke |
| JPS5235204A (en) * | 1975-09-16 | 1977-03-17 | Kao Corp | Clear high viscous liuid shampoo composition |
-
1978
- 1978-05-11 GR GR56209A patent/GR65307B/en unknown
- 1978-05-19 AR AR272241A patent/AR222305A1/en active
- 1978-05-24 PT PT68078A patent/PT68078B/en unknown
- 1978-05-26 NL NL7805745A patent/NL7805745A/en not_active Application Discontinuation
- 1978-06-07 FI FI781815A patent/FI70136C/en not_active IP Right Cessation
- 1978-06-08 SE SE7806690A patent/SE7806690L/en unknown
- 1978-06-19 BE BE188666A patent/BE868239A/en not_active IP Right Cessation
- 1978-06-21 CA CA305,913A patent/CA1099637A/en not_active Expired
- 1978-06-22 IL IL54972A patent/IL54972A/en unknown
- 1978-07-05 MX MX787205U patent/MX5148E/en unknown
- 1978-07-07 DK DK783066A patent/DK306678A/en unknown
- 1978-07-07 FR FR7820324A patent/FR2396546A1/en active Granted
- 1978-07-07 NO NO782373A patent/NO148136C/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265384B1 (en) | 1999-01-26 | 2001-07-24 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
| US6303581B2 (en) | 1999-01-26 | 2001-10-16 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pedicul ostatic agents |
| US6350734B1 (en) | 1999-01-26 | 2002-02-26 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
| US6541455B2 (en) | 1999-01-26 | 2003-04-01 | Dale L. Pearlman | Methods and kits for removing, treating, or preventing lice with driable pediculostatic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| FI781815A (en) | 1979-01-09 |
| NO782373L (en) | 1979-01-09 |
| NL7805745A (en) | 1979-01-10 |
| FR2396546A1 (en) | 1979-02-02 |
| AR222305A1 (en) | 1981-05-15 |
| MX5148E (en) | 1983-04-04 |
| GR65307B (en) | 1980-08-01 |
| IL54972A0 (en) | 1978-08-31 |
| DK306678A (en) | 1979-01-09 |
| FR2396546B1 (en) | 1983-07-29 |
| SE7806690L (en) | 1979-01-09 |
| PT68078A (en) | 1978-06-01 |
| NO148136B (en) | 1983-05-09 |
| FI70136C (en) | 1986-09-15 |
| FI70136B (en) | 1986-02-28 |
| BE868239A (en) | 1978-10-16 |
| IL54972A (en) | 1981-11-30 |
| NO148136C (en) | 1983-08-17 |
| PT68078B (en) | 1979-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |