WO2007118963A3 - Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations - Google Patents
Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations Download PDFInfo
- Publication number
- WO2007118963A3 WO2007118963A3 PCT/FR2007/000512 FR2007000512W WO2007118963A3 WO 2007118963 A3 WO2007118963 A3 WO 2007118963A3 FR 2007000512 W FR2007000512 W FR 2007000512W WO 2007118963 A3 WO2007118963 A3 WO 2007118963A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phenethyl
- substituted
- preparation
- benzamide derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
La présente invention concerne des dérivés du type N-(phénéthyl)benzamide poly-substitués, les compositions pharmaceutiques les comprenant ainsi que leurs applications thérapeutiques, notamment dans les domaines de la santé humaine et animale. La présente invention a également trait à un procédé de préparation de ces dérivés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0602587 | 2006-03-24 | ||
FR0602587A FR2898894B1 (fr) | 2006-03-24 | 2006-03-24 | Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007118963A2 WO2007118963A2 (fr) | 2007-10-25 |
WO2007118963A3 true WO2007118963A3 (fr) | 2007-12-21 |
Family
ID=37440693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2007/000512 WO2007118963A2 (fr) | 2006-03-24 | 2007-03-23 | Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2898894B1 (fr) |
WO (1) | WO2007118963A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
WO2011157827A1 (fr) | 2010-06-18 | 2011-12-22 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2012120054A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
EP2683704B1 (fr) | 2011-03-08 | 2014-12-17 | Sanofi | Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation |
WO2012120055A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
WO2012120052A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2154739A1 (fr) * | 1971-10-01 | 1973-05-11 | Boehringer Mannheim Gmbh | |
EP0305890A2 (fr) * | 1987-09-01 | 1989-03-08 | Roche Diagnostics GmbH | Utilisation du bézafibrate pour le traitement du diabète |
WO1993000337A1 (fr) * | 1991-06-21 | 1993-01-07 | Dr. Karl Thomae Gmbh | Acides (s)(+)-2-ethoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoique |
US6528525B1 (en) * | 1997-10-02 | 2003-03-04 | Sankyo Company, Limited | Amidocarboxylic acid derivatives |
WO2003074495A1 (fr) * | 2002-03-01 | 2003-09-12 | Smithkline Beecham Corporation | Activateurs de hppars |
WO2006035157A2 (fr) * | 2004-09-27 | 2006-04-06 | Genfit | Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques |
-
2006
- 2006-03-24 FR FR0602587A patent/FR2898894B1/fr not_active Expired - Fee Related
-
2007
- 2007-03-23 WO PCT/FR2007/000512 patent/WO2007118963A2/fr active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2154739A1 (fr) * | 1971-10-01 | 1973-05-11 | Boehringer Mannheim Gmbh | |
EP0305890A2 (fr) * | 1987-09-01 | 1989-03-08 | Roche Diagnostics GmbH | Utilisation du bézafibrate pour le traitement du diabète |
WO1993000337A1 (fr) * | 1991-06-21 | 1993-01-07 | Dr. Karl Thomae Gmbh | Acides (s)(+)-2-ethoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoique |
US6528525B1 (en) * | 1997-10-02 | 2003-03-04 | Sankyo Company, Limited | Amidocarboxylic acid derivatives |
WO2003074495A1 (fr) * | 2002-03-01 | 2003-09-12 | Smithkline Beecham Corporation | Activateurs de hppars |
WO2006035157A2 (fr) * | 2004-09-27 | 2006-04-06 | Genfit | Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques |
Non-Patent Citations (4)
Title |
---|
BARBARA S. GROSS ET AL.: "Peroxisome Proliferator-Activated Receptor beta/delta: A novel target for the reduction of atherosclerosis.", DRUG DISCOVERY TODAY:THERAPEUTIC STRATEGIES, vol. 2, no. 3, 2005, Elsevier Ltd., pages 237 - 243, XP002409544 * |
HIROYUKI MIYACHI: "Analysis of patent applications relating to peroxisome proliferator-activated receptor(PPAR) ligands in 2004", EXPERT OPINION THERAPEUTIC PATENTS, vol. 15, no. 11, 2005, Ashley Publications, GB, pages 1521 - 1530, XP002409543 * |
WEIGAND ET AL: "Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 15, no. 20, 15 October 2005 (2005-10-15), pages 4619 - 4623, XP005064664, ISSN: 0960-894X * |
YANFANG LIU ET AL.: "Ligands to peroxisome proliferator-activated receptors as therapeutic options for metabolic syndrome.", DRUG DISCOVERY TODAY:THERAPEUTIC STRATEGISE, vol. 2, no. 2, 2005, Elsevier Ltd., pages 165 - 169, XP002409545 * |
Also Published As
Publication number | Publication date |
---|---|
FR2898894A1 (fr) | 2007-09-28 |
FR2898894B1 (fr) | 2008-06-06 |
WO2007118963A2 (fr) | 2007-10-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2007118963A3 (fr) | Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations | |
WO2008087367A3 (fr) | Derives de (phenylthiazolyl)-phenyl-propan-1-one et de (phenyloxazodyl)-phenyl-propan-1-one substitues, preparations et utilisations | |
WO2008012470A3 (fr) | Derives d'imidazolones substitues, preparation et utilisations | |
NO20085338L (no) | Substituerte 1,3-difenylpropanderivater, sammensetninger og anvendelser derav | |
WO2007038459A3 (fr) | Composes de carboxyamine et leurs methodes d'utilisation | |
WO2007062078A3 (fr) | Composes modulant l'activite thrombopoietine et procedes correspondants | |
WO2006059234A3 (fr) | Amides bicycliques comme inhibiteurs de kinases | |
IL195030A (en) | IV dpp inhibitor assemblies | |
WO2007149406A8 (fr) | Polypeptides facteurs ix de la coagulation modifiés et leur utilisation thérapeutique | |
EP2450360A3 (fr) | (S)-N-Méthylnaltrexone | |
BRPI0607198A2 (pt) | composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica | |
WO2006099941A8 (fr) | 8-n-benzimidazoles a substitution aminocarbonyle, leur procede de production, et leur utilisation en tant que medicaments | |
WO2006035157A3 (fr) | Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques | |
ZA200809864B (en) | Pharmaceutical formulations for the sustained release of active ingredients(s), as well as their applications, especially therapeutic | |
IL178425A0 (en) | Carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them | |
WO2008087366A3 (fr) | Derives de 3-phenyl-1-(phenylthienyl)propan-1-one et de 3-phenyl-1-(phenylfuranyl)propan-1-one substitues, preparation et utilisation | |
TW200738699A (en) | 4-Substituted pyrazoline compounds, their preparation and use as medicaments | |
MY149854A (en) | Novel aminoalcohol-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments | |
WO2008087365A3 (fr) | Derives de 1,3-diphenylpropane substitues, preparations et utilisations | |
IL195813A0 (en) | Substituted aminopyrazolopyridines and salts thereof, their preparations and pharmaceutical compositions comprising them | |
WO2007093880A3 (fr) | Nouveaux dérivés d'indolopyrone et leur procédé de préparation | |
WO2009071689A3 (fr) | Dérivés d'oxindole substitués par halogène en position 5 et leur utilisation pour traiter des maladies liées à la vasopressine | |
WO2007012479A3 (fr) | Composes | |
WO2009032843A3 (fr) | Aminoalcools substitués | |
WO2009053628A3 (fr) | Nouveaux composes, préparation et utilisations |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07731195 Country of ref document: EP Kind code of ref document: A2 |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07731195 Country of ref document: EP Kind code of ref document: A2 |