WO2006035157A3 - Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques - Google Patents

Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques Download PDF

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Publication number
WO2006035157A3
WO2006035157A3 PCT/FR2005/002390 FR2005002390W WO2006035157A3 WO 2006035157 A3 WO2006035157 A3 WO 2006035157A3 FR 2005002390 W FR2005002390 W FR 2005002390W WO 2006035157 A3 WO2006035157 A3 WO 2006035157A3
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Prior art keywords
lipid
benzyl
substituted
treatment
glucidic
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PCT/FR2005/002390
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English (en)
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WO2006035157A2 (fr
Inventor
Christophe Masson
Karine Caumont-Bertrand
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Genfit
Christophe Masson
Karine Caumont-Bertrand
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Application filed by Genfit, Christophe Masson, Karine Caumont-Bertrand filed Critical Genfit
Publication of WO2006035157A2 publication Critical patent/WO2006035157A2/fr
Publication of WO2006035157A3 publication Critical patent/WO2006035157A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Abstract

La présente invention concerne des dérivés du type N-(benzyl)phénylacétamide poly- substitués de formule (I); les compositions pharmaceutiques les comprenant, leurs applications thérapeutiques comme ligands de PPAR, notamment dans les domaines de la santé humaine et animale pour le traitement des dérèglements du métabolisme lipidique et/ou glucidique. La présente invention a également trait a un procédé de préparation de ces dérivés.
PCT/FR2005/002390 2004-09-27 2005-09-27 Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques WO2006035157A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0410192A FR2875805B1 (fr) 2004-09-27 2004-09-27 Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
FR0410192 2004-09-27

Publications (2)

Publication Number Publication Date
WO2006035157A2 WO2006035157A2 (fr) 2006-04-06
WO2006035157A3 true WO2006035157A3 (fr) 2006-06-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/002390 WO2006035157A2 (fr) 2004-09-27 2005-09-27 Composes derives de n- (benzyl) phenylacetamide substitues , preparation et utilisations comme ligands des ppar dans le traitement des dereglements lipidiques et/ou glucidiques

Country Status (3)

Country Link
US (1) US20060079696A1 (fr)
FR (1) FR2875805B1 (fr)
WO (1) WO2006035157A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2898894B1 (fr) * 2006-03-24 2008-06-06 Genfit Sa Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations
DK2125711T3 (en) 2007-03-08 2014-02-17 Albireo Ab 3-Phenylpropionic AND THEIR USE IN TREATMENT OF Inflammatory Bowel Disease
JP5731385B2 (ja) * 2008-08-22 2015-06-10 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ ポリマーベンジルカルボネート誘導体
EP2511273B8 (fr) * 2011-04-15 2019-06-26 Hivih Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques
EP2736329A4 (fr) * 2011-07-29 2015-03-25 Tempero Pharmaceuticals Inc Composés et méthodes
EP2747560A4 (fr) * 2011-07-29 2015-02-25 Tempero Pharmaceuticals Inc Composés et méthodes
EP2821104A1 (fr) 2013-07-05 2015-01-07 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques
JO3719B1 (ar) 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
CN105001133B (zh) * 2015-07-07 2017-04-19 武汉励合生物医药科技有限公司 一种医药中间体二芳基硫醚化合物的合成方法
CA3050187A1 (fr) 2017-01-27 2018-08-02 Genfit Derives de n-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide et composes apparentes utilises en tant que modulateurs de ror-gammapour le traitement de maladies auto-immunes
JP7224293B2 (ja) * 2017-01-27 2023-02-17 ジェンフィ Ｒｏｒガンマモジュレーター及びその使用
MX2019008919A (es) * 2017-01-27 2019-12-09 Genfit Moduladores de rorgamma y usos de los mismos.
CN111808047A (zh) * 2020-07-21 2020-10-23 江西博雅欣和制药有限公司 一种制备瑞格列奈中间体的新方法

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2541342A1 (de) * 1975-09-17 1977-03-31 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben
EP0147850A2 (fr) * 1983-12-30 1985-07-10 Dr. Karl Thomae GmbH Dérivés d'acide phénylacétique, médicaments contenant ces composés, et procédé pour leur préparation
US5312924A (en) * 1983-12-30 1994-05-17 Dr. Karl Thomae Gmbh Phenylacetic acid benzylamides
WO1995005358A1 (fr) * 1993-08-14 1995-02-23 Boehringer Mannheim Gmbh Utilisation de phenols et de derives de phenols comme medicaments a effet reducteur du facteur i de coagulation
US5872282A (en) * 1990-12-07 1999-02-16 Virginia Commonwealth University Allosteric modifiers of hemoglobin
WO2002044130A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitués
WO2003048116A2 (fr) * 2001-12-03 2003-06-12 Dr. Reddy's Laboratories Ltd. Nouveaux composes et leur utilisation en medecine, leur procede de preparation et les compositions pharmaceutiques les contenant
WO2003074495A1 (fr) * 2002-03-01 2003-09-12 Smithkline Beecham Corporation Activateurs de hppars
WO2004000790A1 (fr) * 2002-06-20 2003-12-31 Astrazeneca Ab Derives de l'acide benzoique ortho-substitues destines au traitement de l'insulinoresistance
WO2004108673A2 (fr) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibiteurs du papillomavirus
WO2004113270A2 (fr) * 2003-06-18 2004-12-29 Astrazeneca Ab Derives carboxyliques

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2541342A1 (de) * 1975-09-17 1977-03-31 Boehringer Mannheim Gmbh Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben
EP0147850A2 (fr) * 1983-12-30 1985-07-10 Dr. Karl Thomae GmbH Dérivés d'acide phénylacétique, médicaments contenant ces composés, et procédé pour leur préparation
US5312924A (en) * 1983-12-30 1994-05-17 Dr. Karl Thomae Gmbh Phenylacetic acid benzylamides
US5872282A (en) * 1990-12-07 1999-02-16 Virginia Commonwealth University Allosteric modifiers of hemoglobin
WO1995005358A1 (fr) * 1993-08-14 1995-02-23 Boehringer Mannheim Gmbh Utilisation de phenols et de derives de phenols comme medicaments a effet reducteur du facteur i de coagulation
WO2002044130A1 (fr) * 2000-11-29 2002-06-06 Kyorin Pharmaceutical Co., Ltd. Dérivés d'acide carboxylique substitués
WO2003048116A2 (fr) * 2001-12-03 2003-06-12 Dr. Reddy's Laboratories Ltd. Nouveaux composes et leur utilisation en medecine, leur procede de preparation et les compositions pharmaceutiques les contenant
WO2003074495A1 (fr) * 2002-03-01 2003-09-12 Smithkline Beecham Corporation Activateurs de hppars
WO2004000790A1 (fr) * 2002-06-20 2003-12-31 Astrazeneca Ab Derives de l'acide benzoique ortho-substitues destines au traitement de l'insulinoresistance
WO2004108673A2 (fr) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibiteurs du papillomavirus
WO2004113270A2 (fr) * 2003-06-18 2004-12-29 Astrazeneca Ab Derives carboxyliques

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Publication number Publication date
US20060079696A1 (en) 2006-04-13
FR2875805A1 (fr) 2006-03-31
WO2006035157A2 (fr) 2006-04-06
FR2875805B1 (fr) 2006-12-29

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