USRE33643E - Pulse oximeter with circuit leakage and ambient light compensation - Google Patents
Pulse oximeter with circuit leakage and ambient light compensation Download PDFInfo
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- USRE33643E USRE33643E US07/513,421 US51342190A USRE33643E US RE33643 E USRE33643 E US RE33643E US 51342190 A US51342190 A US 51342190A US RE33643 E USRE33643 E US RE33643E
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- radiation
- operational amplifier
- arterial blood
- time varying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
Definitions
- This invention relates generally to medical instrumentation, and more particularly to an electronic device for measuring and indicating the percentage of one or more constituents of arterial blood.
- the Biox device thus requires a number of channels of substantially similar electronic devices equal to the number of light sources required to uniquely identify the constituents being measured. Generally speaking, the number of radiation sources of different wavelength needed to measure n constituents is n+1.
- This replication of electronic circuitry in plural channels naturally increases the cost of the instrument and also can adversely affect the device's accuracy, given the fact that component values in one channel can shift with time relative to corresponding components in another.
- the transmitted or reflected (scattered) light is picked up by a photo-sensitive device and the resulting pulse modulated signal is fed through a logarithmic amplifier to produce a voltage which is a logarithmic function of the current from the sensor.
- This voltage is then divided so as to be processed by separate signal processing hardware in separate individual channels, the number of channels corresponding to the number of blood components (and individual light sources) employed in the system.
- the Hewlett-Packard device also tends to be costly as the number of channels increases.
- the Biox and Hewlett-Packard devices also are subject to error introduced by extraneous light sources or other noise which is picked up by the photo detecting device and fed through the plural channels along with the desired signal produced by the separate light sources utilized in the apparatus.
- extraneous light sources have been known to impact the accuracy of the instrument by as much as ten percent or even more.
- Another object of the invention is to provide a pulse oximeter which is simpler in its design and implementation than known prior art systems.
- Yet another object of the invention is to provide a pulse oximeter not only having a lower cost of manufacture but of significantly increased accuracy over known prior art systems currently available in the marketplace.
- Still another object of the invention is to provide a pulse oximeter which is designed to effectively exclude adverse effects due to noise and other ambient or surrounding conditions at a point in the circuit which obviates the need for extensive and costly filtering or other remedial circuit configurations.
- a plurality of light sources of differing wavelengths are provided and are switched on and off in accordance with a desired program via control signals emanating from a microprocessor.
- the light (radiation) from the multiple sources is sequentially directed along a common path through a portion of the body and a photo-detector is used to produce an electrical output proportional to the intensities of the light transmitted through the body as well as a contribution due to background noise, including ambient light.
- a specially designed logarithmic amplifier is connected to receive the photo-detector output and functions to provide a voltage proportional to the logarithm of the net of the total received signal less the background and ambient signal contributions.
- the voltage signal is suitably amplified to compensate for differing D.C.
- an analog-to-digital converter circuit of a unique design converts the output from the pulse amplifier into a digital format and the digitized signals are applied to a microprocessor suitably programmed to perform band-pass filtering, peak-to-peak measurements and, ultimately, the constituent determination computation.
- the output from the microprocessor may be used to generate audio/visual alarms either at the instrument or remotely therefrom.
- the computer output may be converted to an analog form and used to drive a strip recorder for a hard-copy presentation.
- the output information can be directly displayed on a suitable LED, liquid crystal or CRT device.
- the design of the present invention includes means for removing the extraneous background signals so that only a voltage proportional to the logarithm of the .Iadd.intended .Iaddend.light signal is provided to the downstream signal processing circuitry.
- the design also requires only a single channel for sequentially processing the signals from all of the plural light sources of differing wavelengths.
- FIG. 1 is a block diagram of the preferred embodiment of the invention
- FIG. 2 is an electrical circuit diagram of the preferred logarithm amplifier used in the system of FIG. 1;
- FIG. 3 is a circuit diagram of a preferred pulse amplifier used in the circuit of FIG. 1;
- FIG. 4 is a circuit diagram of the analog-to-digital converter portion of the circuit of FIG. 1;
- FIG. 5 depicts a series of timing diagrams useful in understanding the mode of operation of the analog-to-digital converter circuit of FIG. 4.
- the blood constituent analyzer is indicated generally by numeral 10 and is seen to include a source of light energy 12 which includes two or more sources of radiation, preferably light-emitting diodes (LEDs), which are arranged to be switched on and off sequentially rather than in parallel by control timing signals applied to them via a control line 14 emanating from a microprocessor 16.
- a pulse oximeter is a device for detecting the percentage O 2 saturation of the blood. Two separate light sources are required in its implementation, one emitting light in the red portion of the visible spectrum and the other emanating in the infrared portion of the spectrum.
- the number of light sources required is one greater than the numer of such constituents.
- the light energy from the LED network 12 is optically coupled to a body part, such as a patient's finger, the finger being identified by numeral 18.
- the light from the desired light sources in the network 12 is represented by the light ray 20 while extraneous ambient light is represented by the rays 22. Both the desired component and the extraneous or background component then pass through the body part 18 as indicated by the ray 24. It is also possible that ambient light may reach the sensor without first passing through body tissue. While in the configuration of FIG.
- the light is shown as being transmitted through the body member, it is, of course, possible to locate the optical sensor on the same side of the body member as the light source and in that configuration, light energy reflected or scattered by the pulsatile blood flow through the body part is what is picked up by the sensor.
- the photo pickup or sensor device is indicated by numeral 26 and typically may be a suitable photo-diode, many types of which are known in the art.
- a suitable light filter as at 28, designed to block out most of the light in the visible range while transmitting the red and infrared wavelengths therethrough.
- Wratten filter is admirably suited to the instant application.
- the output from the photo sensor 26 appearing on line 30 is thus a pulse modulated current of two discrete amplitudes: (1) the component of that signal due to the passage of the longer wavelength light (infrared) and (2) the component due to the shorter wavelength light (red).
- the modulation envelope on these signals is due to the pulsatile flow of blood in and out of the body member 18 due to the beating action of the patient's heart.
- the current signal emanating from the photo sensor 26 and appearing on line 30 is a composite due to the switched light sources and due to the ambient light as well as any noise developed internal to the photo sensor circuitry 26 itself.
- This signal waveform is then applied to a suitable RF low-pass filter 32 which is included to filter out any radio frequency interference which might be present in the environment in which the system of the present invention is used.
- the low-pass filter 32 may effectively filter out RF interference which might be generated by electrocautery equipment or the like.
- the cut-off frequency of the low-pass filter 32 might typically be set in the range of from 100 to 300 KHz, although limitation to this particular frequency is not intended.
- various forms of discrete component low-pass RLC filters for RF signals are known in the art, it has not been felt necessary to specifically depict and describe such a device.
- the signals emanating from the RF filter 32 are next applied to a specially designed logarithmic amplifier 34.
- the logarithmic amplifier 34 is specially designed to subtract off the signal components due to the ambient light or background (B) from the current component (I) which is due to the red and infrared LED light sources in the network 12. Because of the unique design of the logarithmic amplifier used herein, the resulting output signal is a voltage directly proportional to the logarithm of the input current, but with the component due to background noise, including ambient light, removed therefrom.
- the signal output from the logarithm amplifier 34 is next applied to a pulse amplifier circuit 36, also of unique design.
- a pulse amplifier circuit 36 also of unique design.
- one of the key aspects of the present invention is the elimination of the need for plural signal processing channels and attendant replication of signal processing circuitry in each of these channels.
- pulse amplifier 36 used herein that permits the time multiplexed sharing of a single channel of downstream electronics. To do this, pulse amplifier 36 must function to effectively amplify only the AC components, i.e., the modulating envelopes while subtracting out the DC levels on which the AC component is superimposed, i.e., the offset.
- the AC signal containing the information and contributed individually by the separate light sources is maintained in the same amplitude range, allowing the downstream A/D converter 38 to digitize both samples.
- the analog-to-digital converter 38 is designed to provide an output whose pulse width is proportional to the amplitude of the input signal.
- the microprocessor 16 receives this variable width pulse and, using a suitable counting technique, converts it to a multi-bit digital representation so that it can be treated as an operand during the execution of the software instructions stored within the memory portion of the microprocessor 16.
- the microprocessor 16 is specifically programmed to execute a series of signal processing steps on the thus formed operands.
- the input to the microprocessor is .[.hipass.]. .Iadd.highpass .Iaddend.filtered, which is effective to minimize artifacts such as from body movements, and following that, peak-to-peak measurements may be made with the peak information allowing subsequent rate measurement and the peak-to peak amplitude being used to determine the percentage of a given constituent.
- a constituent percentage such as O 2 saturation of the hemoglobin
- the threshold may be entered into the microprocessor 16 by appropriate setting of the hard-wired switches represented by the block 40 in FIG. 1.
- the microprocessor 16 is also shown as configured to provide signals over the bus 42 for initiating either an audible alarm 44 packaged within the oximeter housing itself or, alternatively, also providing an alarm at a remote location, such as a nursing station or the like, via alarm 46.
- the computer 16 may also drive a suitable alpha/numeric display device 48, such as a seven-segment display implemented either with LEDs or liquid crystal media. This display would typically be presented on the face plate of the housing containing the circuitry of the pulse oximeter.
- the digital output from the microprocessor 16 may be routed through a D/A converter 50 to create an analog representation of the quantity being measured and that analog representation can then be recorded on a strip recorder 52, thereby providing a hard-copy output.
- microprocessor 16 by providing appropriate control signals over the bus 42, can illustrate one or more indicator lights 54 to reflect the operating state of the equipment or to signal the condition for which an alarm may be sounded.
- FIG. 2 shows a preferred implementation of the log (I-B) circuit 34 of FIG. 1.
- this circuit is specifically designed to eliminate the signal component emanating from the RF filter 32 which is due to ambient light from the desired components attributable to the red and infrared LED light sources in network 12.
- This composite signal is applied to the inverting input of a high gain operational amplifier 56 whose non-inverting input is tied to ground.
- a semiconductor diode 58 is employed as a feedback element for protection of the circuit against out-of-range reverse voltage signals and, as such, couples the output junction 60 of the operational amplifier 56 back to its inverting input terminal 62.
- a resistor 64 is coupled in series between the junction 60 and a junction point 66 and coupled between the junction point 66 and the inverting input terminal 62 of the operational amplifier 56 is a NPN transistor 68 connected to function as a diode by having its collector and base electrodes tied in common to the inverting input of op amp 56.
- the output from op amp 56 is also coupled through a FET switch 70 to a junction point 72 which is common to the non-inverting input of a unity gain operational amplifier 74 and to a RC network, including resistor 76 and capacitor 78, one terminal of the capacitor 78 being connected to ground.
- a conductor 80 joins the output terminal 82 of the operational amplifier 74 back to its inverting input.
- a further NPN transistor 84 whose collector and base electrodes are commonly coupled, is connected between the output terminal 82 of the unity gain amplifier 74 and the inverting terminal 62 of the high gain amplifier 56.
- a further FET switch 86 is included which has its gate electrode coupled to a common junction 88 with the gate electrode of the FET switch 70, its source electrode connected to the output line 90 and its drain electrode coupled to ground.
- a signal from the microprocessor indicated by wave form 92 turns on the FET switches 70 and 86 thus assures that the voltage at junction 66 will be zero and, thus, there will be no current flowing through the transistor 68.
- the direct output signal from operational amplifier 56 is applied to the non-inverting input of operational amplifier 74.
- the op amp 74 functions as a buffer to source or sink the current into it.
- the voltage developed across semiconductor device 84 is such that all of the current flowing through transistor 84 will be sinked by operational amplifier 74. That current, of course, is all of the current flowing into the input junction 62.
- the microprocessor applies a signal to the gate electrodes of the FET switches 70 and 86, as represented by the .[.wave form.]. .Iadd.waveform .Iaddend.92, so that both of these FETs are non-conducting.
- the sample-and-hold network comprising resistor 76 and capacitor 78 will maintain the voltage that had been present on the input to amplifier 74 so that the output voltage therefrom does not change and the same current flow is maintained through the semiconductor device .[.14..]. .Iadd.84.
- the function of the amplifier 36 is to provide level compensation for multiple sequential signals.
- the sequential signals themselves arrive from the log (I-B) circuit 34 and are applied to the non-inverting input of an operational amplifier 94.
- the output from amplifier 94 appearing at junction 96 is fed back through a resistor 98 to the inverting input to that amplifier, which is coupled to junction point 100.
- a further resistor 102 is coupled between junction 100 and junction 104 to which a plurality of series-connected capacitors and FET switches are also joined by way of a conductor or bus 106.
- capacitor/FET combinations are determined by the number of blood constituents to be monitored. It will be recalled that where only the saturation level of O 2 is of interest, two light sources are sufficient and, thus, two series-connected capacitor/FET combinations are required. Specifically, a capacitor 108 is connected in series with the source or drain electrode of a FET 110 whose other electrode is tied to ground. The gate electrode of FET 110 is coupled to receive timing or gating pulses from the microprocessor corresponding to the on/off state of the LED devices used in network 12. Likewise, a capacitor 112 is connected in series with the source or drain electrode of a FET 114 whose other electrode is also tied to ground.
- the gate electrode of FET 114 also receives a gating signal from the microprocessor corresponding to the on/off state of a particular one of the LED .[.device.]. .Iadd.devices .Iaddend.in network 12.
- the component value of resistor 98 is much greater than that of resistor 102 and, as such, amplifier 94 provides .[.unity gain for DC levels while the gain for fluctuating components may typically be approximately 100..]. .Iadd.a typical AC gain of 100, and a DC gain of unity due to the component configuration.
- the red LED device when the red LED device is active, the alternating component of the logarithmic output from the circuit 34 due to the pulsatile blood flow through the body member in question will be highly amplified while the DC level on which this fluctuating component appears is suppressed.
- the IR LED when the IR LED is active and FET 114 is turned on, the alternating component due to modulation of the IR component of current occasioned by pulsatile blood flow will be amplified.
- additional blood constituents are to be monitored and additional series connected capacitor/FET circuits are coupled in parallel between bus 106 and ground, the particular component due to the activated light source will be amplified while its DC component will remain unaffected by the level compensation circuit 36.
- the RC time constant of the resistor 102 and the capacitors 108, 112, etc. determines the effective time constant which, when considered in connection with the duty cycle of the gating pulses, determines where the AC gain of the op amp 94 begins to drop off towards unity.
- the gating pulses themselves may be approximately 100 microseconds in length with the period being approximately 13.33 milliseconds, corresponding to a switching rate of 75 Hz.
- the A/D converter 38 shown in FIG. 4 comprises a dual slope integrator which includes a first operational amplifier 116 whose non-inverting input is tied to ground and whose inverting input is adapted to receive the output from the pulse amplifier 36 via a switching FET 118 and a series coupled resistor 120.
- the operational amplifier 116 is provided with a feedback circuit including an integrating capacitor 122 which is shunted by a further FET switch 124. When performing its signal integrating function, the switch 124 is open but when it is desired to reset the integrator, an appropriate pulse turns on the FET switch 124 to short out the integrating capacitor 122.
- the inverting input of the op amp 116 is provided with a positive bias via voltage source +V and a series connected resistor 126.
- the output from the integrating amplifier 116 is applied to the inverting input of a further op amp 128 whose non-inverting input is also tied to ground.
- the output from op amp 128 acts as a threshold comparator and is coupled to a first input of a NAND gate 130 and the second input to that comprises an "inhibit input” signal applied to junction 132 from the microprocessor.
- This "inhibit input” signal is inverted at 134 and the inverted signal is applied to the gate electrode of the switching FET 118 as illustrated.
- the integrator comprising op amp 116 and is feedback capacitor 122 operates in a well known fashion to integrate the current flowing into junction point 121, which is either via the resistor 120 or the resistor 126.
- integration of the signal takes place when the FET 118 is turned on.
- the input signal current charges the capacitor 122 in such a way that the output from the amplifier 116 is proportional to the amplitude of input signal and the time that the transistor 118 is turned on.
- Transistor 118 is turned on for a fixed period of time and, thus, the voltage at junction 123 will be proportional to the input voltage from the pulse amplifier.
- transistor 118 is next turned off by the "inhibit input” signal fed through the inverter 134.
- capacitor 122 begins to discharge through resistor 126 to the +V source.
- the time it takes for the capacitor to discharge back to zero is, therefore, proportional to the amount of voltage which was across the integrating capacitor 122 and, as indicated earlier, that voltage is proportional to the input signal from the pulse amplifier 36.
- the ramp down of the integrating capacitor is identified numeral 136 in FIG. 5 and is seen to define the length of the output signal 138.
- the reset signal applied to FET 124 is indicated by waveform 140 and it can be seen that the transistor 124 is turned on to hold a zero voltage condition across capacitor 46 until such time as the integration operation is to begin.
- the reset is not released until after the input signal 142 has stabilized.
- the delay between the start of the input signal and the release of the reset is controlled by the microprocessor.
- the FET 118 is turned off before the end of the input signal where it begins to fall off.
- the microprocessor At the time that the microprocessor generates the "inhibit input” signal, it also initiates an internal timer which continues to run until the ramp 136 reaches its zero-crossing point as determined by op amp comparator 128 and, thus, the count developed in the timer will be proportional to the amplitude of the input signal. It can be seen, then, that the circuit of FIG. 4 is capable of performing an amplitude-to-pulse width conversion on the signal arriving from the pulse amplifier 36 and that, in combination with the internal circuitry of the microprocessor (not shown), allows the pulse width to be digitized, forming a multi-bit operand proportional to the amplitude of the time varying signal developed at the output of the pulse amplifier 36.
- the microprocessor is also programmed to compute the percentage oxygen saturation. More particularly, if Y R and Y IR are the logarithmic peak-to-peak values due to the red and infrared samples, respectively, then the ratio (Y R /Y IR ) is equal to the ratio of the absorption of the arterial blood components.
- the O 2 saturation can then be computed in accordance with the Lambert-Beer law equation: ##EQU1## where A, B, C and D are constants which depend upon the specific absorption of oxygenated hemoglobin and reduced hemoglobin at the wavelengths of the red and infrared radiation used.
Abstract
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Priority Applications (1)
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US07/513,421 USRE33643E (en) | 1987-04-30 | 1990-04-10 | Pulse oximeter with circuit leakage and ambient light compensation |
Applications Claiming Priority (2)
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US07/044,329 US4773422A (en) | 1987-04-30 | 1987-04-30 | Single channel pulse oximeter |
US07/513,421 USRE33643E (en) | 1987-04-30 | 1990-04-10 | Pulse oximeter with circuit leakage and ambient light compensation |
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US07/044,329 Reissue US4773422A (en) | 1987-04-30 | 1987-04-30 | Single channel pulse oximeter |
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US07/513,421 Expired - Lifetime USRE33643E (en) | 1987-04-30 | 1990-04-10 | Pulse oximeter with circuit leakage and ambient light compensation |
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