DE69227380T2 - Verfahren zur bestimmung und behandlung von alzheimer-krankheit - Google Patents
Verfahren zur bestimmung und behandlung von alzheimer-krankheitInfo
- Publication number
- DE69227380T2 DE69227380T2 DE69227380T DE69227380T DE69227380T2 DE 69227380 T2 DE69227380 T2 DE 69227380T2 DE 69227380 T DE69227380 T DE 69227380T DE 69227380 T DE69227380 T DE 69227380T DE 69227380 T2 DE69227380 T2 DE 69227380T2
- Authority
- DE
- Germany
- Prior art keywords
- determining
- alzheimer disease
- treating alzheimer
- treating
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU9438/91 | 1991-11-12 | ||
AUPK943891 | 1991-11-12 | ||
AUPL337492 | 1992-07-08 | ||
AU3374/92 | 1992-07-08 | ||
PCT/AU1992/000610 WO1993010459A1 (en) | 1991-11-12 | 1992-11-12 | A method for assaying and treating alzheimer's disease |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69227380D1 DE69227380D1 (de) | 1998-11-26 |
DE69227380T2 true DE69227380T2 (de) | 1999-04-08 |
DE69227380T3 DE69227380T3 (de) | 2007-01-11 |
Family
ID=25644152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69227380T Expired - Lifetime DE69227380T3 (de) | 1991-11-12 | 1992-11-12 | Verfahren zur bestimmung und behandlung von alzheimer-krankheit |
Country Status (7)
Country | Link |
---|---|
US (2) | US5705401A (de) |
EP (1) | EP0613560B2 (de) |
JP (1) | JP3277211B2 (de) |
AU (1) | AU669493B2 (de) |
CA (1) | CA2123211C (de) |
DE (1) | DE69227380T3 (de) |
WO (1) | WO1993010459A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005037298A1 (de) * | 2005-08-08 | 2007-03-08 | Christine Jaschek | Verwendung von Kalium-, Magnesium-, Calcium- und Zink-Elektrolyten zur Behandlung des Elementemangel- und Austrocknungssyndroms Alzheimer und anderer Demenzen |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993010459A1 (en) * | 1991-11-12 | 1993-05-27 | The University Of Melbourne | A method for assaying and treating alzheimer's disease |
DK1060750T3 (da) * | 1993-03-29 | 2006-01-09 | Univ Kingston | Propan-1,3-disulfonsyre og dens farmaceutisk acceptable salte til behandling af amyloidose |
US20040208875A1 (en) | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
US5789426A (en) * | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
DE19518845A1 (de) * | 1995-05-23 | 1996-11-28 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Phytinsäure |
JPH0925234A (ja) * | 1995-07-12 | 1997-01-28 | Wakunaga Pharmaceut Co Ltd | 脳疾患改善剤 |
WO1997009976A2 (en) * | 1995-09-01 | 1997-03-20 | Washington University | Method of reducing neurotoxic injury with zinc chelators |
IL115465A0 (en) * | 1995-09-29 | 1995-12-31 | Yeda Res & Dev | Assay for the diagnosis of dementia |
AUPN649395A0 (en) * | 1995-11-10 | 1995-12-07 | Ramsay Health Care Pty Ltd | A method for diagnosing alzheimer's disease |
GB9610829D0 (en) | 1996-05-23 | 1996-07-31 | Medical Res Council | Screening of agents for treatment of azlheimers disease |
CA2264097C (en) * | 1996-08-13 | 2007-11-27 | P.N. Gerolymatos S.A. | Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of alzheimer's disease |
EP1007048A4 (de) * | 1997-03-11 | 2004-09-22 | Gen Hospital Corp | Identifizierung von mitteln zur behandlung der alzheimerischen krankheit |
US7045531B1 (en) | 1997-03-11 | 2006-05-16 | The General Hospital Corporation | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator |
JP2001513558A (ja) | 1997-08-21 | 2001-09-04 | パイ・ニュー・ゲロリュマトス・ソシエテ・アノニム | アルツハイマー病を治療するためにファンキノンを使用する方法 |
US5980914A (en) * | 1997-08-22 | 1999-11-09 | P.N. Gerolymatos S.A. | Clioquinol for the treatment of Parkinson's disease |
US5994323A (en) * | 1997-12-31 | 1999-11-30 | P.N. Gerolymatos S.A. | Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof |
US6183981B1 (en) | 1998-03-05 | 2001-02-06 | Board Of Regents, The University Of Texas System | Diagnostic assay for late-onset Alzheimer's disease |
US20020025944A1 (en) * | 2000-04-28 | 2002-02-28 | Bush Ashley I. | Use of clioquinol for the therapy of Alzheimer's disease |
US6638711B1 (en) | 1999-04-29 | 2003-10-28 | The General Hospital Corporation | Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation |
US20050112543A1 (en) * | 1998-03-11 | 2005-05-26 | The General Hospital Corporation | Method of screening for drugs useful in treating Alzheimer's disease |
US6323218B1 (en) * | 1998-03-11 | 2001-11-27 | The General Hospital Corporation | Agents for use in the treatment of Alzheimer's disease |
EP1140090B1 (de) | 1999-01-07 | 2004-12-22 | P.N. Gerolymatos S.A. | Verwendung von phanquinon zur behandlung und vorbeugung von gedächtnisschwund |
DE19909357A1 (de) * | 1999-03-03 | 2000-09-07 | Gerd Multhaup | Kupferagonist, der an die Kupferbindungsstelle von APP bindet und/oder eine hemmende Wirkung auf die Freisetzung des Amyloid-Aß-Peptids ausübt |
US6087118A (en) * | 1999-03-04 | 2000-07-11 | Bristol-Myers Squibb Company | Method for diagnosing alzheimer's disease |
US7592304B2 (en) | 1999-10-01 | 2009-09-22 | Dmi Life Sciences, Inc. | Metal-binding compounds and uses therefor |
US6608042B2 (en) * | 2000-03-28 | 2003-08-19 | Aventis Pharma, S.A. | Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof |
WO2002005634A2 (en) | 2000-07-13 | 2002-01-24 | University Of South Florida | Transgenic animal and methods |
US20020172676A1 (en) * | 2001-05-16 | 2002-11-21 | George Jackowski | Method of treatment of alzheimer's disease and device therefor |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US7517868B2 (en) * | 2004-07-19 | 2009-04-14 | Ip-6 Research Inc | Phytic citrate compounds and process for preparing the same |
BRPI0519243A2 (pt) | 2004-12-22 | 2009-01-06 | Neurochem Int Ltd | mÉtodos e composiÇÕes para tratar doenÇas relacionadas a amilàide |
PT1954718E (pt) | 2005-11-30 | 2014-12-16 | Abbvie Inc | Anticorpos anti-globulómeros aβ, suas porções de ligação ao antigénio, correspondentes hibridomas, ácidos nucleicos, vectores, células hospedeiras, métodos de produção dos ditos anticorpos, composições compreendendo os ditos anticorpos, usos dos ditos anticorpos e métodos para uso dos ditos anticorpos |
SG10201706600VA (en) | 2005-11-30 | 2017-09-28 | Abbvie Inc | Monoclonal antibodies and uses thereof |
JP5419131B2 (ja) * | 2005-12-12 | 2014-02-19 | エーシー イミューン ソシエテ アノニム | 治療的特性を有するβ1〜42特異的モノクローナル抗体 |
MX2008008213A (es) | 2005-12-22 | 2008-09-03 | Neurochem Int Ltd | Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias. |
TWI551607B (zh) * | 2006-07-14 | 2016-10-01 | Ac免疫公司 | 人類化抗體 |
FI3851447T3 (fi) | 2006-10-12 | 2023-11-15 | Bellus Health Inc | Menetelmiä, yhdisteitä, koostumuksia ja vehikkeleitä 3-amino-1-propaanisulfonihapon vapauttamiseksi |
US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
CL2007003793A1 (es) * | 2006-12-22 | 2008-07-25 | Genentech Inc | Metodo para inhibir union del receptor de muerte 6 (dr6) a la proteina precursora amiloide (app) que comprende uno o mas antagonistas del dr6; uso de dichos antagonistas; metodo para identificar una molecula de interes que inhibe la union del dr6 a l |
US20100311767A1 (en) * | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
TW201518320A (zh) * | 2007-06-12 | 2015-05-16 | Ac Immune Sa | 特異性結合β-類澱粉蛋白之抗體及相關核酸分子、表現載體、細胞、組合物、套組、方法及用途 |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
RS53174B (en) * | 2007-10-05 | 2014-06-30 | Genentech Inc. | USE OF ANTIAMYLOID BETA ANTIBODY IN THE EVENT OF ANY DISEASE |
WO2009048538A2 (en) * | 2007-10-05 | 2009-04-16 | Genentech, Inc. | Humanized antibody |
CA2726118A1 (en) * | 2008-06-12 | 2009-12-17 | Anatoly Nikolaev | Method for screening for compounds that inhibit neurodegeneration |
US8501178B2 (en) | 2008-11-25 | 2013-08-06 | Biogen Idec Ma Inc. | Use of DR6 and p75 antagonists to promote survival of cells of the nervous system |
WO2011060246A2 (en) * | 2009-11-12 | 2011-05-19 | Genentech, Inc. | A method of promoting dendritic spine density |
MX336196B (es) | 2010-04-15 | 2016-01-11 | Abbvie Inc | Proteinas de union a amiloide beta. |
RU2607368C2 (ru) | 2010-07-30 | 2017-01-10 | Ац Иммуне С.А. | Безопасные и функциональные гуманизированные антитела |
WO2012024187A1 (en) | 2010-08-14 | 2012-02-23 | Abbott Laboratories | Amyloid-beta binding proteins |
WO2012027794A2 (en) * | 2010-09-01 | 2012-03-08 | The Mental Health Research Institute Of Victoria | Method of treatment and agents useful for same |
US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
WO2012142666A1 (en) * | 2011-04-19 | 2012-10-26 | The Mental Health Research Institute Of Victoria | Method of modulating amine oxidase activity and agents useful for same |
US10709784B2 (en) * | 2011-06-08 | 2020-07-14 | Chelation Partners Incorporated | Metal chelating compositions and methods for controlling the growth or activities of a living cell or organism |
WO2015006453A2 (en) * | 2013-07-09 | 2015-01-15 | Mayo Foundation For Medical Education And Research | Pet imaging of zinc transport |
EP3039431A4 (de) * | 2013-08-27 | 2017-05-03 | CRC for Mental Health Ltd. | Verfahren zur identifizierung von biomarkern neurologischer krankheiten und diagnose von neurologischen krankheiten |
EP3761783A4 (de) * | 2018-02-26 | 2021-12-15 | The Trustees of Columbia University in the City of New York | Zinkassoziierte behandlung und diagnose von kachexie |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
US4419365A (en) * | 1981-12-21 | 1983-12-06 | Ciba-Geigy Corporation | Method of treating Alzheimer's disease |
US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
US4837219A (en) * | 1987-11-05 | 1989-06-06 | Jeffrey Hutterer | Medication for Alzheimer's disease |
US4837164A (en) * | 1988-04-27 | 1989-06-06 | Bionix Corporation | Methods for diagonosing, monitoring and controlling the onset and progression of certain dementias and impeding memory loss or improving impairment of memory |
US5234814A (en) * | 1989-06-01 | 1993-08-10 | Du Pont Merck Pharmaceutical Company | Diagnostic assay for alzheimer's disease |
JPH05507470A (ja) * | 1990-04-12 | 1993-10-28 | アクゾ・エヌ・ヴエー | Mca28a32によって認識される抗原ctaa28a32 |
CA2079880A1 (en) * | 1990-04-24 | 1991-10-25 | William E. Van Nostrand | Purification, detection and methods of use of protease nexin-2 |
AU8215391A (en) * | 1990-06-29 | 1992-01-23 | Case Western Reserve University | Diagnostic and prognostic methods based on soluble derivatives of the beta amyloid protein precursor |
WO1992003542A1 (en) * | 1990-08-17 | 1992-03-05 | Boston University | PROTEASES CAUSING ABNORMAL DEGRADATION OF AMYLOID β-PROTEIN PRECURSOR |
JPH04126095A (ja) * | 1990-09-14 | 1992-04-27 | Asahi Chem Ind Co Ltd | 新規モノクローナル抗体及びそれを産生するハイブリドーマ |
ATE286971T1 (de) * | 1991-01-21 | 2005-01-15 | Elan Pharm Inc | Prüfung und modell für alzheimers-krankheit |
JPH04252956A (ja) * | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | タンパク質の測定方法、試薬及びキット |
JPH04252955A (ja) * | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | 蛋白質の測定方法、試薬及びキット |
JPH04252954A (ja) * | 1991-01-29 | 1992-09-08 | Asahi Chem Ind Co Ltd | タンパクの測定方法、試薬及びキット |
WO1993010459A1 (en) * | 1991-11-12 | 1993-05-27 | The University Of Melbourne | A method for assaying and treating alzheimer's disease |
TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
-
1992
- 1992-11-12 WO PCT/AU1992/000610 patent/WO1993010459A1/en active IP Right Grant
- 1992-11-12 DE DE69227380T patent/DE69227380T3/de not_active Expired - Lifetime
- 1992-11-12 AU AU29263/92A patent/AU669493B2/en not_active Ceased
- 1992-11-12 JP JP50882493A patent/JP3277211B2/ja not_active Expired - Fee Related
- 1992-11-12 EP EP92923431A patent/EP0613560B2/de not_active Expired - Lifetime
- 1992-11-12 US US08/240,720 patent/US5705401A/en not_active Expired - Lifetime
- 1992-11-12 CA CA002123211A patent/CA2123211C/en not_active Expired - Fee Related
-
2003
- 2003-11-19 US US10/716,924 patent/US20040265847A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005037298A1 (de) * | 2005-08-08 | 2007-03-08 | Christine Jaschek | Verwendung von Kalium-, Magnesium-, Calcium- und Zink-Elektrolyten zur Behandlung des Elementemangel- und Austrocknungssyndroms Alzheimer und anderer Demenzen |
Also Published As
Publication number | Publication date |
---|---|
JPH07503316A (ja) | 1995-04-06 |
WO1993010459A1 (en) | 1993-05-27 |
US20040265847A1 (en) | 2004-12-30 |
EP0613560B1 (de) | 1998-10-21 |
AU2926392A (en) | 1993-06-15 |
US5705401A (en) | 1998-01-06 |
AU669493B2 (en) | 1996-06-13 |
DE69227380D1 (de) | 1998-11-26 |
JP3277211B2 (ja) | 2002-04-22 |
EP0613560A1 (de) | 1994-09-07 |
DE69227380T3 (de) | 2007-01-11 |
CA2123211A1 (en) | 1993-05-27 |
CA2123211C (en) | 2008-09-16 |
EP0613560A4 (de) | 1995-05-17 |
EP0613560B2 (de) | 2006-06-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PRANA BIOTECHNOLOGY LTD., SOUTH MELBOURNE, VICTORI |
|
8366 | Restricted maintained after opposition proceedings |