DE60001717D1 - Mikrokapseln mit verzögerter freisetzung von wirkstoffen - Google Patents

Mikrokapseln mit verzögerter freisetzung von wirkstoffen

Info

Publication number
DE60001717D1
DE60001717D1 DE60001717T DE60001717T DE60001717D1 DE 60001717 D1 DE60001717 D1 DE 60001717D1 DE 60001717 T DE60001717 T DE 60001717T DE 60001717 T DE60001717 T DE 60001717T DE 60001717 D1 DE60001717 D1 DE 60001717D1
Authority
DE
Germany
Prior art keywords
microcapsules
active substances
delayed release
plasticiser
interested
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60001717T
Other languages
English (en)
Other versions
DE60001717T2 (de
Inventor
Duena Antonio Parente
Garces Josep Garces
Munoz Angel Bonilla
Colome David Cumillera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GP Pharm SA
Original Assignee
Lipotec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipotec SA filed Critical Lipotec SA
Application granted granted Critical
Publication of DE60001717D1 publication Critical patent/DE60001717D1/de
Publication of DE60001717T2 publication Critical patent/DE60001717T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5015Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin
DE60001717T 1999-12-17 2000-12-15 Mikrokapseln mit verzögerter freisetzung von wirkstoffen Expired - Lifetime DE60001717T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES9902768 1999-12-17
ES009902768A ES2169980B1 (es) 1999-12-17 1999-12-17 Microcapsulas para la liberacion prolongada de farmacos.
PCT/ES2000/000475 WO2001043724A1 (es) 1999-12-17 2000-12-15 Microcapsulas para la liberacion prolongada de farmacos

Publications (2)

Publication Number Publication Date
DE60001717D1 true DE60001717D1 (de) 2003-04-24
DE60001717T2 DE60001717T2 (de) 2004-03-18

Family

ID=8310957

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60001717T Expired - Lifetime DE60001717T2 (de) 1999-12-17 2000-12-15 Mikrokapseln mit verzögerter freisetzung von wirkstoffen

Country Status (13)

Country Link
US (3) US20020187196A1 (de)
EP (1) EP1151746B1 (de)
JP (1) JP5021880B2 (de)
AT (1) ATE234608T1 (de)
AU (1) AU774680B2 (de)
BR (1) BRPI0008197B8 (de)
CA (1) CA2362769C (de)
DE (1) DE60001717T2 (de)
DK (1) DK1151746T3 (de)
ES (2) ES2169980B1 (de)
MX (1) MXPA01008348A (de)
PT (1) PT1151746E (de)
WO (1) WO2001043724A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US20090110744A1 (en) * 2005-03-01 2009-04-30 Sun Pharma Advanced Research Company Limited Sustained release pharmaceutical compositions
EP2359809B1 (de) * 2005-12-22 2019-08-14 Novartis AG Zusammensetzung mit verzögerter Freisetzung enthaltend octreotide und zwei oder mehr polylactide-co-glycolide polymere
ES2324009B1 (es) * 2007-11-23 2010-05-21 Gp Pharm S.A. Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo.
CN105267153B (zh) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 一种曲普瑞林缓释微粒及其制备方法
CN110954491B (zh) * 2019-12-09 2022-11-15 北京博恩特药业有限公司 用于测量醋酸戈舍瑞林缓释植入剂体外溶出度的方法
JP7371519B2 (ja) 2020-02-14 2023-10-31 村田機械株式会社 自動倉庫

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2151185A (en) 1936-01-16 1939-03-21 Carbide & Carbon Chem Corp Esters of glycol monoesters and acylated hydroxy acids
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0052610A1 (de) 1980-05-29 1982-06-02 NICKLAUS, Helen Carol Verfahren und gerät zum saiteninstrumentunterricht
GB2132887A (en) * 1982-11-15 1984-07-18 Procter & Gamble Enteric-coated anti-inflammatory compositions
CH661206A5 (fr) 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
CH665558A5 (en) 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
CH679207A5 (de) 1989-07-28 1992-01-15 Debiopharm Sa
IT1243390B (it) 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
SE9100610D0 (sv) * 1991-03-04 1991-03-04 Procordia Ortech Ab Bioresorbable material for medical use
CH683149A5 (fr) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
EP0644756A4 (de) 1993-03-15 1996-02-28 Univ Michigan System zur kontrollierten freisetzung von antiarrhythmischen wirkstoffen.
EP0858772B1 (de) 1995-10-05 2008-10-29 Kabushiki Kaisha Toshiba Röntgen aufnahme vorrichtung
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
DE19545257A1 (de) * 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
WO1998041190A1 (fr) * 1997-03-18 1998-09-24 Sunstar Inc. Composition conçue pour former des particules solides
GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels

Also Published As

Publication number Publication date
EP1151746A1 (de) 2001-11-07
DK1151746T3 (da) 2003-07-21
US20020187196A1 (en) 2002-12-12
JP5021880B2 (ja) 2012-09-12
ATE234608T1 (de) 2003-04-15
EP1151746B1 (de) 2003-03-19
ES2194793T3 (es) 2003-12-01
US20050123618A1 (en) 2005-06-09
ES2169980B1 (es) 2003-11-01
BRPI0008197B8 (pt) 2021-05-25
BR0008197A (pt) 2002-01-22
JP2003516960A (ja) 2003-05-20
BRPI0008197B1 (pt) 2017-05-09
ES2169980A1 (es) 2002-07-16
AU2173501A (en) 2001-06-25
DE60001717T2 (de) 2004-03-18
CA2362769A1 (en) 2001-06-21
CA2362769C (en) 2008-09-09
PT1151746E (pt) 2003-07-31
WO2001043724A1 (es) 2001-06-21
MXPA01008348A (es) 2004-03-19
US9789064B2 (en) 2017-10-17
US20080233198A1 (en) 2008-09-25
AU774680B2 (en) 2004-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GP PHARM S.A., BARCELONA, ES