DE59912722D1 - Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse - Google Patents

Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse

Info

Publication number
DE59912722D1
DE59912722D1 DE59912722T DE59912722T DE59912722D1 DE 59912722 D1 DE59912722 D1 DE 59912722D1 DE 59912722 T DE59912722 T DE 59912722T DE 59912722 T DE59912722 T DE 59912722T DE 59912722 D1 DE59912722 D1 DE 59912722D1
Authority
DE
Germany
Prior art keywords
continuous method
separating substances
molecule size
methods
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59912722T
Other languages
English (en)
Inventor
Lothar Britsch
Michael Schulte
Jochen Strube
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE59912722T priority Critical patent/DE59912722D1/de
Application granted granted Critical
Publication of DE59912722D1 publication Critical patent/DE59912722D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/1828—Simulated moving beds characterized by process features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
    • B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
    • B01D2215/023—Simulated moving beds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
DE59912722T 1998-12-19 1999-12-04 Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse Expired - Lifetime DE59912722D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59912722T DE59912722D1 (de) 1998-12-19 1999-12-04 Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19858892A DE19858892A1 (de) 1998-12-19 1998-12-19 Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
DE59912722T DE59912722D1 (de) 1998-12-19 1999-12-04 Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse
PCT/EP1999/009495 WO2000037156A1 (de) 1998-12-19 1999-12-04 Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse

Publications (1)

Publication Number Publication Date
DE59912722D1 true DE59912722D1 (de) 2005-12-01

Family

ID=7891862

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19858892A Withdrawn DE19858892A1 (de) 1998-12-19 1998-12-19 Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
DE59912722T Expired - Lifetime DE59912722D1 (de) 1998-12-19 1999-12-04 Kontinuierliches verfahren zur trennung von stoffen nach molekülgrösse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19858892A Withdrawn DE19858892A1 (de) 1998-12-19 1998-12-19 Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße

Country Status (7)

Country Link
US (1) US6551512B1 (de)
EP (1) EP1140316B1 (de)
JP (1) JP2002532730A (de)
AT (1) ATE307649T1 (de)
CZ (1) CZ20012183A3 (de)
DE (2) DE19858892A1 (de)
WO (1) WO2000037156A1 (de)

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NZ563078A (en) * 2002-09-13 2009-07-31 Biogen Idec Inc Method of purifying polypeptides by simulated moving bed chromatography
CA2506317A1 (en) * 2002-11-18 2004-06-03 Taurus Hsa Llc Method for continuous, automated blending of solutions from acids and bases
KR100735738B1 (ko) 2003-12-05 2007-07-06 학교법인 인하학원 Ｓｍｂ 크로마토그래피를 이용하여 단백질을 재접힘시키는방법
US7087177B2 (en) * 2004-04-16 2006-08-08 Baxter International Inc. Methods for determining flow rates of biological fluids
US20060062889A1 (en) * 2004-09-17 2006-03-23 Solae, Llc. Soy protein-containing composition
US7169425B2 (en) * 2004-09-17 2007-01-30 Solae, Llc Size exclusion chromatography process for the preparation of an improved soy protein-containing composition
US7544293B2 (en) 2005-09-26 2009-06-09 Semba Inc. Valve and process for interrupted continuous flow chromatography
US20080031475A1 (en) 2006-07-08 2008-02-07 Personics Holdings Inc. Personal audio assistant device and method
US7790040B2 (en) 2006-08-30 2010-09-07 Semba Biosciences, Inc. Continuous isocratic affinity chromatography
US8807164B2 (en) * 2006-08-30 2014-08-19 Semba Biosciences, Inc. Valve module and methods for simulated moving bed chromatography
EP4023330A1 (de) * 2009-12-15 2022-07-06 Waters Technologies Corporation Vorrichtung und verfahren zur durchführung einer grössenausschlusschromatographie
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
FR3018450B1 (fr) * 2014-03-11 2016-04-15 Lab Francais Du Fractionnement Procede de preparation de proteines plasmatiques humaines
JP6900378B2 (ja) * 2015-12-22 2021-07-07 ビーエイエスエフ・ソシエタス・エウロパエアＢａｓｆ Ｓｅ ポリエーテルブロックコポリマーの精製方法
BR112021003420A2 (pt) 2018-08-31 2021-05-18 Genzyme Corporation resina cromatográfica estéril e uso da mesma em processos de manufatura
EP3742160B1 (de) * 2019-05-24 2023-08-09 Sartorius Stedim Biotech GmbH Chromatografieverfahren, verfahren zur bestimmung der konzentration von mindestens einer verbindung in einem chromatografieverfahren und verfahren zur gewinnung von mindestens einem chromatografieverfahrensparameter

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3010816B2 (ja) * 1991-08-22 2000-02-21 ダイセル化学工業株式会社 光学分割における光学異性体と溶媒との回収方法、溶媒の循環使用方法、および光学異性体の再利用方法
DE4316136A1 (de) * 1993-05-13 1994-11-17 Merck Patent Gmbh Verfahren und Träger für die Gelpermeationschromatographie
US5465748A (en) * 1994-05-24 1995-11-14 Millipore Corporation Sanitizable slider diaphragm valve
US5630943A (en) * 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
DE19611094C2 (de) * 1996-03-21 1999-06-17 Dresden Arzneimittel Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
US6063284A (en) * 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
US5968362A (en) * 1997-08-04 1999-10-19 Controlled Enviromental Systems Corporation Method for the separation of acid from sugars
US5939565A (en) * 1997-11-03 1999-08-17 Cultor Food Science, Inc. Recovery of γ-pyrones
US6293999B1 (en) * 1999-11-30 2001-09-25 Uop Llc Process for separating propylene from propane

Also Published As

Publication number Publication date
EP1140316B1 (de) 2005-10-26
EP1140316A1 (de) 2001-10-10
US6551512B1 (en) 2003-04-22
ATE307649T1 (de) 2005-11-15
CZ20012183A3 (cs) 2002-02-13
JP2002532730A (ja) 2002-10-02
WO2000037156A1 (de) 2000-06-29
DE19858892A1 (de) 2000-06-21

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Legal Events

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