CN101785786B - Chlorine dioxide ointment used for treating dermatophytosis - Google Patents

Chlorine dioxide ointment used for treating dermatophytosis Download PDF

Info

Publication number
CN101785786B
CN101785786B CN2010101125896A CN201010112589A CN101785786B CN 101785786 B CN101785786 B CN 101785786B CN 2010101125896 A CN2010101125896 A CN 2010101125896A CN 201010112589 A CN201010112589 A CN 201010112589A CN 101785786 B CN101785786 B CN 101785786B
Authority
CN
China
Prior art keywords
ointment
chlorine dioxide
agent
parts
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2010101125896A
Other languages
Chinese (zh)
Other versions
CN101785786A (en
Inventor
高源�
曹丽莲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BEIJING OKEANOS TECH Co Ltd
Original Assignee
BEIJING OKEANOS TECH Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BEIJING OKEANOS TECH Co Ltd filed Critical BEIJING OKEANOS TECH Co Ltd
Priority to CN2010101125896A priority Critical patent/CN101785786B/en
Publication of CN101785786A publication Critical patent/CN101785786A/en
Application granted granted Critical
Publication of CN101785786B publication Critical patent/CN101785786B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Abstract

The invention relates to a chlorine dioxide ointment used for treating dermatophytosis, which comprises the following compositions by weight percentage: 1-50 parts of bactericide precursor, 10-100 parts of emulsifier, 100-400 parts of skin care grease, 0.5-20 parts of chelant, 1-40 parts of hygroscopic agent, 1-60 parts of thickening agent and 1000 parts of purified water. The ointment is suitable for treating various types of skin fungus infection and is particularly applicable for the patient who is not recovered by adopting other medicines; the patient administrates the ointment once everyday and can be recovered after the sustained administration for one week, and the recovery rate is 100% without recurrence.

Description

A kind of chlorine dioxide ointment that is used to treat beriberi
Technical field
The invention belongs to drug world, particularly relate to a kind of chlorine dioxide ointment that is used to treat beriberi.
Background technology
" beriberi " is the modal infectious disease of department of dermatologry, medically is being called " tinea pedis ", be that a kind of superficial skin fungus is sick, the 70%th, because trichophyton causes.Tinea pedis is the most difficult radical cure, the easiest recurrence or the disease that infects again in the tinea, and patient's quality of life and publilc health health all had influence in various degree." beriberi " is because life is not at ordinary times noted, infects superficial mycosis and causes, shows as between toe or vola skin pruritus, erythema, pimple, desquamation, or vesicle is arranged, and severe patient can be rotten to the corn, ooze out, or secondary produces " erysipelas " of pedal skin.Tinea pedis very in the subtropical zone more sees that China's southern area is more common than northern area, the infection that tinea pedis also can other positions of secondary.If treat not actively, very easily cause the fungal infection at other positions of health after the scratching, like the tinea manuum, tinea corporis, tinea capitis etc.
Treat beriberi, people can expect the antifungal products that popularity such as daktarin, Pevisone, Lan Mei express are higher, certain effect is arranged naturally.Daktarin and Pevisone all are that gloomy product is raised in Xi'an, and the both adopts imidazoles broad-spectrum antifungal medicine as main component, and only the latter has added and has glucocorticoid-triamcinolone acetonide antipruritic, anti-allergic effects; The main component that Lan Mei expresses is a terbinafine HCl, it always in antifungal drug market in occupation of the leading position, be that a new generation has the medicine of killing fungus effect.
To antifungal, except medicine, much folk prescriptions that also spreading among the people, allegedly Bulbus Allii, potassium permanganate, vinegar, Radix Raphani, Pericarpium Zanthoxyli, Alumen etc. can both be controlled foot gas; No matter be which kind of method, all require people patient, can persist because in case lose vigilance, fungus just can breed the extended treatment time again very soon.
Domestic patent about the treatment beriberi is also of common occurrence, useful Chinese medicine prescription, also there is Chinese medicine to combine to process ointment with Western medicine.Such as CN10239096A, in open day on August 13rd, 2008, a kind of Chinese medicine ointment of the treatment beriberi of being processed by Radix Glycyrrhizae, ethanol, glycerin, Magnesiumaluminumsilicate, water is disclosed; CN1977859A in open day on June 13rd, 2007, discloses a kind of specific beriberi cream of being made up of Zinc Undecylenate, undecylenic acid, menthol, salicylic acid, glycerol, Pulvis Talci, essence; CN1286109A; On open day March 7 calendar year 2001, a kind of a kind of beriberi paste of treating tinea pedis that is formed through hybrid modulation by TRIAMCINOLONE ACETONIDE ACETATE, miconazole nitrate, polygynax, four kinds of Western medicine of econazole nitrate and Radix Aristolochiae, golden rattan perfume, leaf of Flos Lonicerae, Mi Kang, Rhizoma Polygoni Cuspidati, Semen sojae atricolor, seven kinds of Chinese medicines of red green vegetable leaf is disclosed.CN101337007A in open day on January 17th, 2009, discloses a kind of ointment for treating beriberi of being processed by Colophonium, Lignum Aquilariae Resinatum, Borax, Borneolum Syntheticum, chlorphenamine, zinc oxide, zinc stearate, Pulvis Talci, vaseline, Camphora.
The mechanism of action of imidazoles antifungal drug is to act on the somatic cells film, changes its permeability, stops nutraceutical picked-up, causes its death; The hydrochloric acid spy than the mechanism of action of naphthols be optionally suppress fungus synthetic with reproductive process in necessary Squalene Cycloxygenase, thereby reach the effect of killing and suppressing fungus.The imidazoles antifungal drug has an inborn deficiency, and promptly fungus can produce drug resistance to it, and this phenomenon is very general; The hydrochloric acid spy is more much better than imidazoles antifungal drug than the toleration of naphthols; But it and imidazoles antifungal drug have a common defective, may produce certain side effect to human body, because they can absorb by percutaneous; Pass through renal metabolism, excrete through urine.
Can in the patent beriberi paste, herbal medicine efficacy be slow especially, kill fungus and must say in addition; The patent that has is said and can be controlled beriberi, but its functional component just has certain inhibitory action to the breeding of fungus; With the ointment that Chinese medicine and western medicine combines, though effect can access certainly, processing technology is more loaded down with trivial details, is unfavorable for suitability for industrialized production.
Fungus generally is communicated by contact; The fungus vitality that causes beriberi is extremely strong, under pH value 3.0~10.0 conditions, all can grow, though vulnerable to high temperature (more than 45 ℃); But the temperature below 4 ℃ there is very strong adaptive faculty, ultraviolet, lonizing radiation etc. is also had suitable resistance; Fungus likes best under the condition of 22 ℃~36 ℃ of temperature, humidity 95%~100% and breeds; Why fungus can be at the human body survival and reproduction; Be because people's perspiration is the best culture medium of fungus; People's sole not only provides suitable temperature and humidity for fungus, but also nutrient substance such as sodium, potassium, chlorine, magnesium, calcium, phosphorus, carbamide, lactic acid are provided.
Because fungus does not almost have requirement to the conditions of existence; So want to treat the skin of fungal infection; It is far from being enough only leaning on the inhibition fungus, this also just beriberi treat reasons for seizure repeatedly repeatedly, so want thoroughly to treat beriberi; Must thoroughly kill the fungus that exists in skin shallow-layer and the deep tissues, not stay the chance of any regeneration breeding to it.
Chlorine dioxide is safe, efficient, the wide spectrum disinfective agent of generally acknowledging in the world at present; It can kill all microorganisms; Comprise bacterial propagule, bacterial spore, fungus, mycobacteria and virus etc., up to now, do not find to have the pathogenic microorganism that to resist chlorine dioxide and not be killed as yet; And these antibacterials, virus can not develop immunity to drugs to it; Chlorine dioxide does not have teratogenesis, carcinogenic, mutagenicity effect to organism, is classified as the agent of AI level efficiently and safely disinfecting by The World Health Organization (WHO), has wide spectrum, quick-acting, characteristics such as consumption is few, drug effect is long.
The bactericidal effect of chlorine dioxide is good, cure rate is high, safe and reliable, but use very inconveniently because it is a kind of gas, should not directly use; Chlorine dioxide is processed chip solid, need during use to use water dissolution earlier, the bad control of concentration, effect is also unstable, uses liquid stabilising property chlorine dioxide, has the problem of activation and dilution again, uses very inconvenience.
Summary of the invention
The objective of the invention is successfully to be applied to chlorine dioxide in the emulsification system; The chlorine dioxide ointment for preparing can act on human body skin; Killing the fungus while that exists on the skin; Can also nursing skin, thus a kind of safe, reliable, the foodcare ointment that can kill fungus fast is provided, to solve the above-mentioned defective that prior art exists.
The present invention provides a kind of chlorine dioxide ointment that is used to treat beriberi, and this ointment comprises following composition by weight percentage:
Antibacterial precursor 1-50 part
Emulsifying agent 10-100 part
Skin protection oils and fats 100-400 part
Chelating agen 0.5-20 part
Hygroscopic agent 1-40 part
Thickening agent 1-60 part
Purified water is mended to 1000 parts.
Preferably, this ointment comprises following composition by weight percentage:
Antibacterial precursor 2-40 part
Emulsifying agent 15-80 part
Skin protection oils and fats 120-380 part
Chelating agen 0.8-15 part
Hygroscopic agent 2-30 part
Thickening agent 2-50 part
Purified water is mended to 1000 parts.
More preferably, this ointment comprises following composition by weight percentage:
Antibacterial precursor 3-30 part
Emulsifying agent 20-60 part
Skin protection oils and fats 150-350 part
Chelating agen 1-10 part
Hygroscopic agent 5-20 part
Thickening agent 3-40 part
Purified water is mended to 1000 parts.
Wherein, said antibacterial precursor is selected from one or more in barium chlorite, magnesium chlorite, sodium chlorite and the potassium chlorite.
Said emulsifying agent is selected from PEG-20 tristerin, alkyl-glucoside, ceteareth, PEG-100 stearate, glycerol monostearate, stearic acid citric acid glyceride, ceteareth phosphotriester, acrylic ester/C 10-30Among alkyl acrylate cross-linked copolymer, polyoxyethylene fatty acid polyglycerin ester, 22 carbon alcohol ethers-25, methyl glucoside sesqui-stearate, polyoxyethylene ether methyl glucoside sesqui-stearate, nonionic emulsifing wax, 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium, hexadecanyl phosphate, hexadecanyl phosphate potassium salt, Span60, Tween 60, Span 80 and the Tween 80 one or more.
Said skin protection oils and fats is selected from one or more in lanoline, vaseline, white oil, caprylic/capric triglyceride, iso-octyl palmitate, isopropyl palmitate, Jojoba oil, Oleum Vitis viniferae, Paeonia suffruticosa oil, tea tree oil, cetin, squalane, vitamin E acetate, C12-13 alkyl maleic acid diester, fruit acid, hydrogenated lanolin, aloe, dioctyl succinate, diisopropyl adipate, maleic acid Semen Ricini grease, isopropyl myristate, dicaprylyl carbonate and the silicone oil.
Said chelating agen is selected from ethylenediaminetetraacetic acid, disodiumedetate or tetrasodium ethylenediamine tetraacetate.
Said hygroscopic agent is selected from one or more in Pulvis Talci, zinc oxide, zinc stearate, Borax and the Alumen.
Said thickening agent is selected from one or more in sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, polyvinylpyrrolidone, acrylate copolymer, Acusol772 Acusol771, methyl vinyl ether, card ripple, xanthan gum and the gelatin.
The present invention also provides the method for the above-mentioned chlorine dioxide ointment of preparation, comprises the steps: chelating agen, thickening agent, hygroscopic agent and antibacterial precursor are dissolved or dispersed in the purified water, stirs, and gets the A phase; Weighing emulsifying agent, skin protection oils and fats get the B phase in another container; With A, B is biphase is heated to 60-75 ℃ respectively, with A, the biphase mixing of B and emulsifying 5-10mins, be cooled to 25 ℃ then and promptly get.
The present invention further provides the method for using of prepared ointment: every night with ill skin with hot water clean dry after, get these article and be applied in disease sites in right amount, dry naturally and get final product.
The chlorine dioxide ointment that the present invention is used to treat beriberi has following beneficial effect:
1) utilize the nanostructured of emulsified body, successfully chlorine dioxide precursor is wrapped in wherein, form a natural slow-releasing system, the concentration of chlorine dioxide is controlled, can prepare the mastic of different chlorine dioxide contents according to state of an illness needs; In use, ointment can outwards discharge chlorine dioxide lentamente;
2) in prescription, add hygroscopic agent, can keep the drying of disease sites, help improving therapeutic effect;
3) the prepared pure white exquisiteness of mastic of the present invention is glossy, spread upon on the skin after, have and moisten and dry and comfortable sensation; Mastic National standard, physical and chemical index all can meet the demands;
4) with can be antipruritic rapidly behind these article, safe and reliable to the skin nonirritant, these article can be killed the fungus of skin surface in use in back 10 minutes rapidly, continue to use the fungus that can kill deep skin, and without any side effects to human body;
5) patient is not recurred after using Ointment in Treatment beriberi of the present invention, and fungus has no drug resistance to it, and the patient can use at any time.The prepared beriberi paste of the present invention can thoroughly be killed fungus, and is no matter be which kind of type, all applicable;
6) these article are applicable to the various types of cutaneous fungal infection of treatment, are particularly suitable for the invalid patient of the Drug therapy of other types, once a day, adhere to using a week to fully recover, cure rate 100%, and can not recur.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Raw materials usedly among the following embodiment be commercially available acquisition.
Embodiment 1
The chlorine dioxide ointment that the present invention is used to treat beriberi comprises following component: potassium chlorite 1g, sodium chlorite 1g, alkyl-glucoside 10g, glycerol monostearate 10g, lanoline 20g, white oil 30g, iso-octyl palmitate 50g, Oleum Vitis viniferae 40g, silicone oil 10g, disodiumedetate 1g, Pulvis Talci 10g, sodium carboxymethyl cellulose 30g, xanthan gum 30g, purified water 1000g.
Its preparation method is following: above-mentioned chelating agen, thickening agent, hygroscopic agent and antibacterial precursor are dissolved or dispersed in the purified water, stir, get the A phase; Weighing emulsifying agent, skin protection oils and fats get the B phase in another container; With A, B is biphase is heated to 65 ℃ respectively, with A, the biphase mixing of B and emulsifying 6mins, be cooled to 25 ℃ then and promptly get.
Embodiment 2
The chlorine dioxide ointment that the present invention is used to treat beriberi comprises following component: sodium chlorite 25g, stearic acid citric acid glyceride 50g, white oil 50g, caprylic/capric triglyceride 60g, isopropyl palmitate 45g, dicaprylyl carbonate 45g, Jojoba oil 50g, tea tree oil 50g, ethylenediaminetetraacetic acid 10g, zinc oxide 10g, zinc stearate 10g, polyvinylpyrrolidone 20g, sodium hydroxyethyl cellulose 10g, purified water 1000g.
Its preparation method is following: above-mentioned chelating agen, thickening agent, hygroscopic agent and antibacterial precursor are dissolved or dispersed in the purified water, stir, get the A phase; Weighing emulsifying agent, skin protection oils and fats get the B phase in another container; With A, B is biphase is heated to 60 ℃ respectively, with A, the biphase mixing of B and emulsifying 10mins, be cooled to 25 ℃ then and promptly get.
Embodiment 3
The chlorine dioxide ointment that the present invention is used to treat beriberi comprises following component: magnesium chlorite 25g, sodium chlorite 25g, ceteareth 50g, PEG-100 stearate 50g, white oil 50g, vaseline 60g, lanoline 40g, iso-octyl palmitate 50g, Paeonia suffruticosa oil 40g, tea tree oil 100g, Jojoba oil 60g, disodiumedetate 5g, zinc oxide 20g, Borax 20g, card ripple 1g, gelatin 0.5g, purified water 1000g.
Its preparation method is following: above-mentioned chelating agen, thickening agent, hygroscopic agent and antibacterial precursor are dissolved or dispersed in the purified water, stir, get the A phase; Weighing emulsifying agent, skin protection oils and fats get the B phase in another container; With A, B is biphase is heated to 75 ℃ respectively, with A, the biphase mixing of B and emulsifying 5mins, be cooled to 25 ℃ then and promptly get.
Embodiment 4
Method for preparing is with embodiment 1
The chlorine dioxide ointment that the present invention is used to treat beriberi comprises following component: sodium chlorite 20g, magnesium chlorite 20g, PEG-20 tristerin 20g, ceteareth 40g, dioctyl succinate 50g, vaseline 80g, white oil 50g, maleic acid Semen Ricini grease 60g, diisopropyl adipate 50g, tea tree oil 50g, second edta 1g, zinc stearate 10g, Borax 5g, acrylate copolymer 10g, xanthan gum 5g, purified water are to 1000g.
Embodiment 5
Method for preparing is with embodiment 1
The chlorine dioxide ointment that the present invention is used to treat beriberi comprises following component: sodium chlorite 30g, 22 carbon alcohol ether-25 20g, nonionic emulsifing wax 30g, hydrogenated lanolin 20g, isopropyl myristate 50g, C12-13 alkyl maleic acid diester 40g, cetin 60g, fruit acid 40g, aloe 60g, tetrasodium ethylenediamine tetraacetate 2g, Alumen 8g, Borax 8g, Acusol772 Acusol771 10g, gelatin 5g, deionized water are to 1000g.
Experimental example 1
1 subjects
Volunteer to suffering from dissimilar beriberi has carried out proof test; Observe 200 examples altogether; Wherein blister squama type beriberi patient 80 people, hyperkeratotic pattern beriberi patient 40 people, dipping erosive type beriberi patient 80 people, these patients suffer from the days of beriberi and also differ, and short is ill at 1-2; The ill 3-10 that has, what have illly reaches 10 years even more than 20 year.
2 tests are divided into groups
By being divided into three groups days, first group, fungal infection is in 2 years with the patient, and second group, fungal infection is in 10 years, and the 3rd group, fungal infection is more than 10 years.
3 test drugs
Receive reagent: gained ointment among the embodiment 3.
4 usages and effect
Treat the simplyst for first group, spread ointment after foot bath every night, spreading can be antipruritic; Logotype three days, symptom disappears basically, consolidates three days again; Enlarge therapeutic domain,, advise that simultaneously the patient will change old footgear in the past on every side seeming normal skin also spreads ointment; Keep the foot health, the treatment back was observed 6 months, and beriberi is never recommitted.
Second group of Therapeutic Method is identical with first group basically, and only dosage is bigger slightly than first group, and administration time is long slightly.The patient of this group uses these article after one week, and symptom disappears basically, continues medication, enlarges sphere of action, one week of after treatment, advise that simultaneously the patient changes old footgear in the past, and keep the foot health, the treatment back was observed 6 months, and beriberi is never recommitted.
The 3rd group of patient be because sick time is oversize, and the skin of fungal infection has Hyperkeratotic phenomenon, with before the ointment earlier with hot water foot bath 15 minutes, then Hyperkeratotic dead bark is removed with blade gently; And then be coated with and apply ointment, helping ointment like this and absorb, dosage suitably strengthens according to the state of an illness, and enlarges the scope of smearing; After treating for two weeks, the no longer long pachydermia in affected part is the same with normal skin basically; Medication one all after treatments again are almost recovered, and advise that simultaneously the patient changes old footgear in the past; Keep the foot health, the treatment back was observed 6 months, and beriberi is never recommitted.
Experimental example 2
Table one
Subjects (example) Trial drug
50 Embodiment 1 gained ointment
55 Embodiment 2 gained ointment
60 Embodiment 4 gained ointment
80 Embodiment 5 gained ointment
Except subjects changes other volunteer into, change embodiment 1-2 into test drug, outside the 4-5 gained ointment, other process is with experimental example 1; The result shows: through many cases volunteer's in the his-and-hers watches 1 individual character treatment; All cure, cure rate 100%, and with after do not recur; Fungus has no drug resistance to it, and the patient can use at any time.The prepared beriberi paste of the present invention can thoroughly be killed fungus, and is no matter be which kind of type, all applicable.
Though, the present invention has been done detailed description in the preceding text with general explanation and specific embodiments, on basis of the present invention, can to some modifications of do or improvement, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.

Claims (9)

1. a chlorine dioxide ointment that is used to treat beriberi is characterized in that, this ointment comprises following composition by weight:
Antibacterial precursor 1-50 part
Emulsifying agent 10-100 part
Skin protection oils and fats 100-400 part
Chelating agen 0.5-20 part
Hygroscopic agent 1-40 part
Thickening agent 1-60 part
Purified water is mended to 1000 parts;
Said antibacterial precursor is selected from one or more in barium chlorite, magnesium chlorite, sodium chlorite and the potassium chlorite.
2. chlorine dioxide ointment according to claim 1 is characterized in that, this ointment comprises following composition by weight:
Antibacterial precursor 2-40 part
Emulsifying agent 15-80 part
Skin protection oils and fats 120-380 part
Chelating agen 0.8-15 part
Hygroscopic agent 2-30 part
Thickening agent 2-50 part
Purified water is mended to 1000 parts.
3. chlorine dioxide ointment according to claim 1 is characterized in that, this ointment comprises following composition by weight:
Antibacterial precursor 3-30 part
Emulsifying agent 20-60 part
Skin protection oils and fats 150-350 part
Chelating agen 1-10 part
Hygroscopic agent 5-20 part
Thickening agent 3-40 part
Purified water is mended to 1000 parts.
4. according to each described chlorine dioxide ointment of claim 1-3; It is characterized in that said emulsifying agent is selected from PEG-20 tristerin, alkyl-glucoside, ceteareth, PEG-100 stearate, glycerol monostearate, stearic acid citric acid glyceride, ceteareth phosphotriester, acrylic ester/C 10-30Among alkyl acrylate cross-linked copolymer, polyoxyethylene fatty acid polyglycerin ester, 22 carbon alcohol ethers-25, methyl glucoside sesqui-stearate, polyoxyethylene ether methyl glucoside sesqui-stearate, nonionic emulsifing wax, 1-isobutyl-3,5-dimethylhexylphosphoric acid potassium, hexadecanyl phosphate, hexadecanyl phosphate potassium salt, Span60, Tween60, Span 80 or the Tween 80 one or more.
5. according to each described chlorine dioxide ointment of claim 1-3; It is characterized in that said skin protection oils and fats is selected from one or more in lanoline, vaseline, white oil, caprylic/capric triglyceride, iso-octyl palmitate, isopropyl palmitate, Jojoba oil, Oleum Vitis viniferae, Paeonia suffruticosa oil, tea tree oil, cetin, squalane, vitamin E acetate, dodecyl maleic acid diester, fruit acid, hydrogenated lanolin, aloe, dioctyl succinate, diisopropyl adipate, maleic acid Semen Ricini grease, isopropyl myristate, dicaprylyl carbonate or the silicone oil.
6. according to each described chlorine dioxide ointment of claim 1-3, it is characterized in that said chelating agen is selected from ethylenediaminetetraacetic acid, disodiumedetate or tetrasodium ethylenediamine tetraacetate.
7. according to each described chlorine dioxide ointment of claim 1-3, it is characterized in that said hygroscopic agent is selected from one or more in Pulvis Talci, zinc oxide, zinc stearate, Borax or the Alumen.
8. according to each described chlorine dioxide ointment of claim 1-3; It is characterized in that said thickening agent is selected from one or more in sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, polyvinylpyrrolidone, acrylate copolymer, Acusol772 Acusol771, methyl vinyl ether, card ripple, xanthan gum or the gelatin.
9. the method for preparing each described chlorine dioxide ointment of claim 1-8 comprises the steps: chelating agen, thickening agent, hygroscopic agent and antibacterial precursor are dissolved or dispersed in the purified water, stirs, and gets the A phase; Weighing emulsifying agent, skin protection oils and fats get the B phase in another container; With A, B is biphase is heated to 60-75 ℃ respectively, with A, the biphase mixing of B and emulsifying 5-10mins, be cooled to 25 ℃ then and promptly get.
CN2010101125896A 2010-02-20 2010-02-20 Chlorine dioxide ointment used for treating dermatophytosis Expired - Fee Related CN101785786B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2010101125896A CN101785786B (en) 2010-02-20 2010-02-20 Chlorine dioxide ointment used for treating dermatophytosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2010101125896A CN101785786B (en) 2010-02-20 2010-02-20 Chlorine dioxide ointment used for treating dermatophytosis

Publications (2)

Publication Number Publication Date
CN101785786A CN101785786A (en) 2010-07-28
CN101785786B true CN101785786B (en) 2012-09-05

Family

ID=42529260

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010101125896A Expired - Fee Related CN101785786B (en) 2010-02-20 2010-02-20 Chlorine dioxide ointment used for treating dermatophytosis

Country Status (1)

Country Link
CN (1) CN101785786B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519341A (en) * 2017-10-11 2017-12-29 广州美犀智能科技有限公司 A kind of Chinese medicine nursing liquid for treating tinea pedis and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384134A (en) * 1988-05-06 1995-01-24 Alcide Corporation Anti-inflammatory formulations for inflammatory diseases
CN101600348A (en) * 2006-12-04 2009-12-09 S.K.药物公司 The Synergistic antimicrobial preparations that comprises chlorite and hydrogen peroxide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384134A (en) * 1988-05-06 1995-01-24 Alcide Corporation Anti-inflammatory formulations for inflammatory diseases
CN101600348A (en) * 2006-12-04 2009-12-09 S.K.药物公司 The Synergistic antimicrobial preparations that comprises chlorite and hydrogen peroxide

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
孙玉卿等.消毒用二氧化氯产品研究进展.《中国消毒学杂志》.2003,第20卷(第2期), *
易玉峰等.稳定性二氧化氯的制备及应用研究进展.《北京石油化工学院学报》.2005,第13卷(第2期), *

Also Published As

Publication number Publication date
CN101785786A (en) 2010-07-28

Similar Documents

Publication Publication Date Title
CN101244016B (en) Application of aurantiin in preparing oral cavity nursing health products
CN104666621B (en) A Chinese medicinal composition with hemostatic, antiinflammatory and antibacterial effects, and toothpaste containing the same
HU229230B1 (en) Medical composition for the treatment of herpes simplex virus and other infectious diseases
CN113081928B (en) Plant antibacterial gel and preparation method and application thereof
CN101491492B (en) Full aloe gelatin
CN104127358A (en) Honeysuckle extract and preparation method thereof as well as floral water and preparation method thereof
CN111557877B (en) Toothpaste containing centella extract and preparation method thereof
Nunes et al. Potential therapeutic of olive oil industry by‐products in skin health: a review
WO2008104076A1 (en) Electrocolloidal silver and echinacea root antimicrobial formulation
CN105056051A (en) Plant polypeptide compound gel for treating gynecological diseases and preparation method thereof
CN102335287A (en) Mixture capable of removing acnes and acne scars
CN104435069B (en) It is a kind of improve pig immune function animal medicinal composition, using and preparation method thereof
CN101785786B (en) Chlorine dioxide ointment used for treating dermatophytosis
CN103930121A (en) Composition for preventing and treating overactive bladder syndrome
DE102008059070B4 (en) A composition for the therapeutic or prophylactic treatment of diarrheal diseases and / or for the maintenance and / or restoration of the natural intestinal flora, dosage unit, packaging unit and use of the composition
KR100839030B1 (en) Composition for improving atopic dermatitis or acne
Kannan et al. Comparative evaluation of antifungal activity of Cocos nucifera oil against Candida albicans
CN102397307A (en) Compound oil-in-water cnidium fruit oil nanoemulsion composition and preparation method thereof
CN105101817B (en) Edible composition and preparation method thereof and the food comprising said composition
CN111040896A (en) Antibacterial, anti-inflammatory and skin-beautifying handmade soap
CN103550406A (en) Anticoccidial compound origanum oil oral nano emulsion for poultry and preparation method thereof
CN114177160A (en) Foot patch for treating dental ulcer and preparation method thereof
KR102105256B1 (en) Cosmetic composition containing Taeniam extracts wrapped in cubic phase lipidic nanostructure for sensitive skin care and thereof producing method
KR102115668B1 (en) Cosmetic composition having anti-acne activity comprising probiotics fermentation product
CN102166253A (en) Oil-in-water type elsholtzia oil nano emulsion preparation and method for preparing same

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120905

Termination date: 20140220