CA2362769A1 - Microcapsules for sustained release of drugs - Google Patents

Microcapsules for sustained release of drugs Download PDF

Info

Publication number
CA2362769A1
CA2362769A1 CA002362769A CA2362769A CA2362769A1 CA 2362769 A1 CA2362769 A1 CA 2362769A1 CA 002362769 A CA002362769 A CA 002362769A CA 2362769 A CA2362769 A CA 2362769A CA 2362769 A1 CA2362769 A1 CA 2362769A1
Authority
CA
Canada
Prior art keywords
drugs
microcapsules
sustained release
plasticiser
interested
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002362769A
Other languages
French (fr)
Other versions
CA2362769C (en
Inventor
Antonio Parente Duena
Josep Garces Garces
Angel Bonilla Munoz
David Cumillera Colome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GP Pharm SA
Original Assignee
Lipotec, S.A.
Antonio Parente Duena
Josep Garces Garces
Angel Bonilla Munoz
David Cumillera Colome
Gp Pharm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipotec, S.A., Antonio Parente Duena, Josep Garces Garces, Angel Bonilla Munoz, David Cumillera Colome, Gp Pharm S.A. filed Critical Lipotec, S.A.
Publication of CA2362769A1 publication Critical patent/CA2362769A1/en
Application granted granted Critical
Publication of CA2362769C publication Critical patent/CA2362769C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/22—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of calcitonin

Abstract

Micro-capsules for the slow release of drugs, consisting of a lactic-co-glycolic copolymer to which a plasticiser has been incorporated and which contain a drug of pharmaceutical interested within them.
CA002362769A 1999-12-17 2000-12-15 Microcapsules for sustained release of drugs Expired - Lifetime CA2362769C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP9902768 1999-12-17
ES009902768A ES2169980B1 (en) 1999-12-17 1999-12-17 MICROCAPSULES FOR THE PROLONGED RELEASE OF PHARMACOS.
PCT/ES2000/000475 WO2001043724A1 (en) 1999-12-17 2000-12-15 Microcapsules for sustained release of drugs

Publications (2)

Publication Number Publication Date
CA2362769A1 true CA2362769A1 (en) 2001-06-21
CA2362769C CA2362769C (en) 2008-09-09

Family

ID=8310957

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002362769A Expired - Lifetime CA2362769C (en) 1999-12-17 2000-12-15 Microcapsules for sustained release of drugs

Country Status (13)

Country Link
US (3) US20020187196A1 (en)
EP (1) EP1151746B1 (en)
JP (1) JP5021880B2 (en)
AT (1) ATE234608T1 (en)
AU (1) AU774680B2 (en)
BR (1) BRPI0008197B8 (en)
CA (1) CA2362769C (en)
DE (1) DE60001717T2 (en)
DK (1) DK1151746T3 (en)
ES (2) ES2169980B1 (en)
MX (1) MXPA01008348A (en)
PT (1) PT1151746E (en)
WO (1) WO2001043724A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
EP1871348A4 (en) * 2005-03-01 2012-08-01 Sun Pharma Advanced Res Co Ltd Sustained release pharmaceutical compositions
EP2359809B1 (en) * 2005-12-22 2019-08-14 Novartis AG Sustained release formulation comprising octreotide and two or more polylactide-co-glycolide polymers
ES2324009B1 (en) * 2007-11-23 2010-05-21 Gp Pharm S.A. PHARMACEUTICAL COMPOSITION OF SUSTAINED RELEASE OF SOMATOSTATINE OR AN ANALOG OF HIS.
CN105267153B (en) * 2015-11-27 2018-05-11 上海苏豪逸明制药有限公司 A kind of Triptorelin sustained-release microparticle and preparation method thereof
CN110954491B (en) * 2019-12-09 2022-11-15 北京博恩特药业有限公司 Method for measuring in-vitro dissolution rate of goserelin acetate sustained-release implant
JP7371519B2 (en) 2020-02-14 2023-10-31 村田機械株式会社 Automatic warehouse

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2151185A (en) 1936-01-16 1939-03-21 Carbide & Carbon Chem Corp Esters of glycol monoesters and acylated hydroxy acids
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
WO1981003565A1 (en) 1980-05-29 1981-12-10 H Nicklaus Stringed musical instrument teaching device and process
GB2132887A (en) * 1982-11-15 1984-07-18 Procter & Gamble Enteric-coated anti-inflammatory compositions
CH661206A5 (en) 1983-09-23 1987-07-15 Debiopharm Sa PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF HORMONDEPENDENT DISEASES.
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
ATE61935T1 (en) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd PROCESS FOR PRODUCTION OF MICROCAPSULES.
JP2551756B2 (en) 1985-05-07 1996-11-06 武田薬品工業株式会社 Polyoxycarboxylic acid ester and method for producing the same
CH665558A5 (en) 1985-10-09 1988-05-31 Debiopharm Sa Phase sepn. prodn. of microcapsules for water soluble pharmaceuticals - using fluoro-substd. aliphatic hydrocarbon as non-solvent in the hardening stage
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
CH679207A5 (en) 1989-07-28 1992-01-15 Debiopharm Sa
IT1243390B (en) 1990-11-22 1994-06-10 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION.
SE9100610D0 (en) * 1991-03-04 1991-03-04 Procordia Ortech Ab BIORESORBABLE MATERIAL FOR MEDICAL USE
CH683149A5 (en) * 1991-07-22 1994-01-31 Debio Rech Pharma Sa Process for the preparation of microspheres of a biodegradable polymeric material.
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
JPH07509735A (en) 1993-03-15 1995-10-26 ザ　ボード　オブ　リージェンツ　オブ　ザ　ユニヴァーシティ　オブ　ミシガン System for controlled release of antiarrhythmic drugs
WO1997012549A1 (en) 1995-10-05 1997-04-10 Kabushiki Kaisha Toshiba X-ray imaging apparatus
SE505146C2 (en) * 1995-10-19 1997-06-30 Biogram Ab Particles for delayed release
DE19545257A1 (en) * 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
WO1998041190A1 (en) * 1997-03-18 1998-09-24 Sunstar Inc. Composition for forming solid particles
GB9718986D0 (en) * 1997-09-09 1997-11-12 Danbiosyst Uk Controlled release microsphere delivery system
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels

Also Published As

Publication number Publication date
PT1151746E (en) 2003-07-31
US20050123618A1 (en) 2005-06-09
DE60001717T2 (en) 2004-03-18
ATE234608T1 (en) 2003-04-15
MXPA01008348A (en) 2004-03-19
US20020187196A1 (en) 2002-12-12
AU2173501A (en) 2001-06-25
EP1151746B1 (en) 2003-03-19
DE60001717D1 (en) 2003-04-24
WO2001043724A1 (en) 2001-06-21
DK1151746T3 (en) 2003-07-21
BRPI0008197B8 (en) 2021-05-25
US9789064B2 (en) 2017-10-17
JP2003516960A (en) 2003-05-20
JP5021880B2 (en) 2012-09-12
ES2169980A1 (en) 2002-07-16
EP1151746A1 (en) 2001-11-07
ES2169980B1 (en) 2003-11-01
BR0008197A (en) 2002-01-22
CA2362769C (en) 2008-09-09
ES2194793T3 (en) 2003-12-01
US20080233198A1 (en) 2008-09-25
BRPI0008197B1 (en) 2017-05-09
AU774680B2 (en) 2004-07-01

Similar Documents

Publication Publication Date Title
EP1287822A3 (en) Mesalazine controlled release oral pharmaceutical compositions
AU5335698A (en) Pharmaceutical formulations with delayed drug release
CA2232450A1 (en) Oral pharmaceutical composition containing antimicrobial actives and sustained release pantoprazole
AU5680100A (en) Controlled release and taste masking oral pharmaceutical compositions
IE871584L (en) Sustained release capsule.
AU3076700A (en) 2h-phthalazin-1-one derivatives and drugs comprising these derivatives as the active ingredient
JP2002511411A5 (en)
HUP0200248A3 (en) Oxamic acids and derivatives as thyroid receptor ligands, pharmaceutical compositions containing them as active ingredient and their use
AU8009998A (en) Method for producing orally administered, solid pharmaceutical products with controlled release of the active substance
WO1999036099A8 (en) Sustained release compositions, process for producing the same and utilization thereof
AU2003286994A1 (en) Modified release pharmaceutical composition
WO2000041681A3 (en) MEDICINAL FORMULATIONS CONTAINING AN OPIOID AND AN α-ANTAGONIST
CA2307018A1 (en) Osmotic medicament releasing system
AU7962200A (en) Novel indole derivatives and drugs containing the same as the active ingredient
AU2002238947A1 (en) Triazaspiro[5.5]undecane derivatives and drugs containing the same as the active ingredient
HK1048986A1 (en) 2'-Substituted 1,1'-iphenyl-2-carbonamides, methodfor the production thereof, use thereof as medicament and pharmaceutical preparations containing said compounds.
HRP20010632A2 (en) Matrix tablet enabling prolonged release of gliclazide after administration by the oral route
HK1027563A1 (en) Novel 2-(iminomethyl) amino-phenyl derivatives, preparation, application as medicines and pharmaceutical compositions containing same.
CA2255052A1 (en) Sustained release preparation of prostaglandin i derivatives
CA2350659A1 (en) Pharmaceutical composition for modified release insulin sensitiser
CA2362769A1 (en) Microcapsules for sustained release of drugs
AU3669700A (en) 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient
AU1650501A (en) 1,3,4-oxadiazoline derivatives and drugs containing these derivatives as the active ingredient
AU5139596A (en) Pharmaceutical matrix pellets, tablets and composition for the preparation thereof
CA2382359A1 (en) Pharmaceutical preparation containing nanosol

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20201215